Article
Acoustics
Kaleb A. Lowe, Wolf Zinke, M. Anthony Phipps, Josh Cosman, Micala Maddox, Jeffrey D. Schall, Charles F. Caskey
Summary: Research on focused ultrasound (FUS) stimulation directly applied over the macaque frontal eye field (FEF) through a craniotomy revealed that FUS can modulate saccadic responses in monkeys, affecting their saccade response times and error rates. FUS was found to have a regulatory effect on directing eye movements towards targets in visual search tasks.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Keith R. Murphy, Jordan S. Farrell, Juan L. Gomez, Quintin G. Stedman, Ningrui Li, Steven A. Leung, Cameron H. Good, Zhihai Qiu, Kamyar Firouzi, Kim Butts Pauly, Butrus Pierre T. Khuri-Yakub, Michael Michaelides, Ivan Soltesz, Luis de Lecea
Summary: We developed a system that can monitor the neural activity of specific cell types in the deep brain using focused ultrasound. By selectively adjusting the parameters, we were able to increase the activity of inhibitory neurons while suppressing the activity of excitatory neurons. This inhibitory effect was confirmed to be localized in the hippocampus through metabolic imaging.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Norman M. Spivak, Joseph L. Sanguinetti, Martin M. Monti
Summary: This article summarizes the use of focused ultrasound in neuromodulation and discusses different approaches for targeting, delivering, and validating focused ultrasound. It focuses on the parameter space and ongoing theories of ultrasonic neuromodulation. Furthermore, it explores the current and future applications of this technique.
Article
Clinical Neurology
Jurgen Germann, Gavin J. B. Elias, Clemens Neudorfer, Alexandre Boutet, Clement T. Chow, Emily H. Y. Wong, Roohie Parmar, Flavia Venetucci Gouveia, Aaron Loh, Peter Giacobbe, Se Joo Kim, Hyun Ho Jung, Venkat Bhat, Walter Kucharczyk, Jin Woo Chang, Andres M. Lozano
Summary: In this study, the relationship between lesion location and long-term outcome in obsessive-compulsive disorder patients treated with focused ultrasound was investigated. Successful relief of symptoms was associated with lesions including a specific area in the dorsal anterior limb of the internal capsule. Resting-state functional MRI analysis confirmed the key role of areas 24 and 46 in clinical outcomes, providing considerations for target improvement in focused ultrasound treatment for obsessive-compulsive disorder.
Article
Clinical Neurology
Seongyeon Kim, Yehhyun Jo, Geon Kook, Cristina Pasquinelli, Hyunggug Kim, Kipom Kim, Hyang-Sook Hoe, Youngshik Choe, Hyewhon Rhim, Axel Thielscher, Jeongyeon Kim, Hyunjoo Jenny Lee
Summary: By crossing two ultrasound beams of commercially available piezoelectric curved transducers, a dual-crossed transducer system achieved high axial resolution without the need for complex microfabrication. In vivo animal experiments demonstrated the high target specificity of the system, with a focal volume under 0.52 mm(3) and successful brain stimulation observed in wild-type mice.
Article
Chemistry, Multidisciplinary
Ching-Hsiang Fan, Hong-Chieh Tsai, Yi-Sheng Tsai, Hsien-Chu Wang, Yu-Chun Lin, Po-Han Chiang, Nan Wu, Min-Hwa Chou, Yi-Ju Ho, Zong-Hong Lin, Chih-Kuang Yeh
Summary: This study investigates the use of MoS2 NS to convert ultrasound energy into localized electrical stimulation for neural activation. The results demonstrate that a single pulse of ultrasound can effectively stimulate cells surrounding MoS2 NS without causing cellular damage. The proportion of responsive cells is influenced by the acoustic pressure, number of ultrasound cycles, and concentration of MoS2 NS. This method shows high spatial precision and potential for selective modulation of targeted brain circuits.
Article
Engineering, Biomedical
Hongchae Baek, Yaoheng Yang, Christopher Pham Pacia, Lu Xu, Yimei Yue, Michael R. Bruchas, Hong Chen
Summary: This study aimed to compare the motor responses induced by focused ultrasound (FUS) neuromodulation under mechanical and mechanothermal effects. Brain tissue temperature rise was quantified, showing a greater range in the mechanothermal group. Evoked electromyographic responses indicated different temporal dynamics between mechanical and mechanothermal effects.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Benjamin U. Hoffman, Yoshichika Baba, Stephen A. Lee, Chi-Kun Tong, Elisa E. Konofagou, Ellen A. Lumpkin
Summary: This study successfully modulated the activity of peripheral neurons using targeted ultrasound stimulation and electrophysiology in mouse ex vivo skin-saphenous nerve preparations. The findings showed that high-intensity, millisecond ultrasound pulses reliably evoked action potentials in peripheral neurons, and there was a discrete range of parameters capable of exciting different types of neurons. Additionally, ultrasound stimulation could be targeted to cutaneous receptive fields or peripheral nerves, expanding the therapeutic range of ultrasound-based peripheral neuromodulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Engineering, Biomedical
Vismaya S. Bachu, Jayanidhi Kedda, Ian Suk, Jordan J. Green, Betty Tyler
Summary: HIFU is an emerging and increasingly useful modality in the treatment of cancer and other diseases, using high-energy ultrasound pulses to target specific areas while minimizing damage to surrounding tissues. Its wide applications across various tumor types and organ systems, along with its potential future pathways, highlight the growing importance of this technology in biomedical fields.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Acoustics
Samuel Pichardo
Summary: BabelBrain is an open-source application designed for neuromodulation studies using transcranial-focused ultrasound. It calculates the acoustic field in brain tissue, considering distortion effects caused by the skull barrier. The simulation is prepared using MRI and CT scans, and it also calculates thermal effects based on ultrasound parameters. The tool works with neuronavigation and visualization software, and supports multiple GPU backends. It is particularly optimized for Apple ARM64 systems in brain imaging research.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Neurosciences
Jiande Guo, Xizi Song, Xinrui Chen, Minpeng Xu, Dong Ming
Summary: In this study, a mathematical model was constructed to calculate ultrasound attenuation, taking into account the thickness of the skull. The research found that the skull is the main influencing factor for ultrasound attenuation, and the attenuation of the mathematical model increases with increasing skull thickness. The experimental results show that the proposed mathematical model is suitable for different initial pressures and different skulls.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mengyue Chen, Chang Peng, Huaiyu Wu, Chih-Chung Huang, Taewon Kim, Zachary Traylor, Marie Muller, Pratik Y. Chhatbar, Chang S. Nam, Wuwei Feng, Xiaoning Jiang
Summary: This study investigated the wave propagation of low-intensity transcranial focused ultrasound (tFUS) on human skulls using experimental measurements and numerical modeling. The results showed that ultrasound frequency and FUS transducer aperture size significantly affected transmission efficiency and beamwidth. These findings have important implications for clinical applications of ultrasound neuromodulation and the development of advanced ultrasound transducers as neural interfaces.
Article
Optics
Yueming Li, Ying Jiang, Lu Lan, Xiaowei Ge, Ran Cheng, Yuewei Zhan, Guo Chen, Linli Shi, Runyu Wang, Nan Zheng, Chen Yang, Ji-Xin Cheng
Summary: This study reports on a technique called optically-generated focused ultrasound (OFUS) that allows for non-invasive brain stimulation with ultrahigh precision. The researchers demonstrate the effectiveness of OFUS neurostimulation in vitro and in vivo, showing its potential for neuroscience studies and disease treatments.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Acoustics
Yi Huang, Peng Wen, Bo Song, Yan Li
Summary: This study numerically investigated the ultrasound wave propagation and energy distribution within brain tissues using customized single element focused ultrasound transducers (SEFT) targeting the hippocampus. The study found that ultrasound neuromodulation targeting the deep brain tissue of the hippocampus can be a potential alternative method to non-acoustic brain stimulation modalities.
Article
Clinical Neurology
Francesco Sammartino, John Snell, Matthew Eames, Vibhor Krishna
Summary: This study aimed to define the thermal dose and spot size thresholds associated with TN during FUSA. The thermal dose threshold for TN was found to be 0.67 CEM, equivalent to 30 seconds of thermal exposure at 43 degrees Celsius, and the spot size threshold was determined to be 2.46 mm.