Article
Cell Biology
Thorbjorn Soren Ronn Jensen, Tina Binderup, Markus Harboe Olsen, Andreas Kjaer, Kare Fugleholm
Summary: Anti-inflammatory treatment reduces the risk of recurrent chronic subdural hematoma (CSDH), but clinical implementation is improper due to side effects. This study aims to investigate the associations between cytokine levels and the risk of recurrence in CSDH patients and identify potential medical targets. The study found elevated levels of interleukin-1 receptor antagonist (IL-1ra) in recurrent CSDH patients, suggesting IL-1ra as a possible target for medical treatment.
Article
Medicine, General & Internal
Gao-Jian Su, Jie Gao, Chu-Wei Wu, Jun-Feng Zou, Di Zhang, Dong-Liang Zhu, Jun Liu, Jie-Hua Zhang, Xian-Jian Huang
Summary: This study investigated the mechanisms underlying the development of CSDH and found that MMP-8 and MMP-9 may play important roles in the pathophysiology of CSDH.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Piotr Szpakowski, Dominika Ksiazek-Winiarek, Malgorzata Turniak-Kusy, Ilona Pacan, Andrzej Glabinski
Summary: Astrocytes, once considered passive brain cells, have been found to play a more active role in the central nervous system. This study aimed to evaluate the production of inflammatory chemokines and neurotrophic factors by primary human astrocytes after inflammatory or anti-inflammatory stimulation. The results showed that only astrocytes induced by inflammatory mediators produced certain chemokines, and pro-inflammatory conditions decreased the release of a neurotrophic factor while anti-inflammatory cytokines increased its production.
Review
Biochemistry & Molecular Biology
Martin Vychopen, Erdem Gueresir, Johannes Wach
Summary: This meta-analysis investigates the impact of anti-inflammatory drug therapy on patients with chronic subdural hematoma. The results indicate that anti-inflammatory therapy is associated with lower recurrence rates, but higher mortality rates in patients undergoing surgery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Natalia Lehman, Wioleta Kowalska, Michal Zarobkiewicz, Marek Mazurek, Karolina Mrozowska, Agnieszka Bojarska-Junak, Radoslaw Rola
Summary: Monocyte subpopulations in glioma patients' peripheral blood were analyzed based on CD14, CD16, and SLAN expression. The study found different profiles of monocytes with varying cytokine expression. The presence of these different profiles might hinder the effectiveness of immunotherapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Dimah Hasan, Omid Nikoubashman, Rastislav Pjontek, Andrea Stockero, Hussam Aldin Hamou, Martin Wiesmann
Summary: This study aimed to describe the MRI characteristics of chronic subdural hematoma (cSDH) and determine various MRI patterns. Results showed that the signal characteristics of cSDH on T1- and T2-weighted images were heterogeneous, with the majority of hematomas displaying internal septations. Contrast enhancement along the outer membrane adjacent to the cranium was observed in all hematomas, and contrast enhancement along the inner membrane adjacent to the brain was seen in approximately one-third of the hematomas. Around 62% of cSDH showed mass-like enhancement. Most hematomas appeared partially hypointense on T2*-GRE and/or susceptibility-weighted imaging (SWI), and restricted diffusion was detected in approximately one-third of the hematomas. Consistent contrast enhancement, triangular-shaped contrast enhancement at the borders of the cSDH, and infrequent enhancement of the inner membrane may be helpful in distinguishing cSDH from other entities.
FRONTIERS IN NEUROLOGY
(2022)
Review
Chemistry, Medicinal
Narges Navaei-Alipour, Mohadeseh Mastali, Gordon A. Ferns, Maryam Saberi-Karimian, Majid Ghayour-Mobarhan
Summary: Honey contains flavonoids and phenolic acids that may have important implications for human health due to their antioxidant and anti-inflammatory properties. Studies have shown that honey can inhibit the expression of pro-inflammatory factors in conditions such as cancer and neuro-inflammatory disorders. However, more high-quality research is needed to firmly establish the clinical efficacy of honey and understand the specific mechanisms of its anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2021)
Article
Clinical Neurology
Zahra Aghelan, Saeed Karima, Seyed Hosein Abtahi, Habibolah Khazaie, Yahya Salimi, Reza Khodarahmi
Summary: A growing body of literature suggests that cytokines can play an important role in chronic insomnia disorder (CID). This study found that levels of proinflammatory mediators, including IL-12, IFN-gamma, and ICAM-1, were elevated in CID patients compared to healthy controls. The duration of REM sleep was also found to decrease with increased concentrations of IL-12 and IFN-gamma. Additionally, a lower serum concentration of IL-1ra was negatively correlated with the severity of insomnia in CID patients. These findings indicate that an imbalance of proinflammatory mediators and anti-inflammatory cytokines is important in the pathogenesis of CID.
Review
Medicine, General & Internal
Muh-Shi Lin
Summary: The study aimed to investigate the pathologic mechanisms of subdural fluid collection and the pathogenesis of chronic subdural hematoma (CSDH). It was found that different clinical situations contributed to subdural fluid collection and the formation of CSDH, and the recurrence rate was still high even after surgery. Understanding the different pathological mechanisms of subdural lesions and applying appropriate interventions will be important in the future.
Article
Multidisciplinary Sciences
Asma Ahmed, Himanshu Tripathi, Krista E. van Meijgaarden, Nirutha Chetan Kumar, Vasista Adiga, Srabanti Rakshit, Chaitra Parthiban, J. Sharon D'Souza, George D'Souza, Mary Dias, Tom H. M. Ottenhoff, Mihai G. Netea, Simone A. Joosten, Annapurna Vyakarnam
Summary: This study characterized the mechanisms of BCG revaccination-induced trained immunity in India and found that revaccination can induce immune responses but does not enhance control of mycobacterial growth. After vaccination, enhanced immune responses to fungal, bacterial, and viral stimuli were observed.
Article
Clinical Neurology
Kazuma Yokota, Takatoshi Sorimachi, Hideki Atsumi, Takuya Yonemochi, Shunsuke Shioyama, Mitsunori Matsumae
Summary: Posterior fossa chronic subdural hematoma (CSDH) was observed on MRI in a minority of patients with supratentorial CSDH. Risk factors for posterior fossa CSDH included anticoagulant treatment, cerebrospinal fluid leak, and lack of previous trauma. CT failed to detect hematomas in some cases, and all posterior fossa CSDH improved after supratentorial CSDH drainage.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Daniel Dubinski, Sae-Yeon Won, Svorad Trnovec, Kseniya Gounko, Peter Baumgarten, Philipp Warnke, Daniel Cantre, Bedjan Behmanesh, Joshua D. Bernstock, Thomas M. Freiman, Florian Gessler, Steffen Sola
Summary: This study found that recurrent chronic subdural hematoma (CSDH) may be associated with clinically inapparent low-grade infections, with the majority of identified bacteria belonging to the staphylococcus genus.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Thorbjorn Soren Ronn ip Jensen, Mette Haldrup, Mads Hjortdal Gronhoj, Rares Miscov, Carl Christian Larsen, Birgit Debrabant, Frantz Rom Poulsen, Bo Bergholt, Torben Hundsholt, Carsten Reidies Bjarkam, Kare Fugleholm
Summary: In this national trial involving patients with chronic subdural hematoma who underwent burr hole evacuation, there were no significant differences in recurrence or death rates between those who received 24-hour or 48-hour passive subdural drainage. Complications, hospital stay length, and other outcomes were also similar between the two groups.
JOURNAL OF NEUROSURGERY
(2021)
Review
Geriatrics & Gerontology
Nathan A. Shlobin, Jayanidhi Kedda, Danielle Wishart, Roxanna M. Garcia, Gail Rosseau
Summary: Surgical treatment of chronic subdural hematoma in older adults is superior to conservative management, leading to favorable neurological outcomes. However, older adults may face increased risk of mortality after surgery.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)