Article
Cardiac & Cardiovascular Systems
Ana Rubina Perestrelo, Ana Catarina Silva, Jorge Oliver-De La Cruz, Fabiana Martino, Vladimir Horvath, Guido Caluori, Ondrej Polansky, Vladimir Vinarsky, Giulia Azzato, Giuseppe de Marco, Vita Zampachova, Petr Skladal, Stefania Pagliari, Alberto Rainer, Perpetua Pinto-do-O, Alessio Caravella, Kamila Koci, Diana S. Nascimento, Giancarlo Forte
Summary: The study reveals that the remodeling of cardiac extracellular matrix (ECM) during heart failure (HF) leads to cardiac fibroblast activation and focal adhesion protein expression through hyperactivated YAP signaling, impacting cell homing.
CIRCULATION RESEARCH
(2021)
Article
Pediatrics
Haichu Wen, Hongzhao You, Yulin Li, Ke Ma, Meng Jiao, Shaowei Wu, Shijie You, Jie Huang, Junwu Su, Yan Gu, Zhiyuan Wang, Ping Zheng, Guanghou Shui, Yuan Wang, Mei Jin, Jie Du
Summary: The study found that serum LysoPA can predict LVRR in PDCM patients, and when combined with the LVEDD z-score, it may help ascertain the prognosis and monitor the effects of anti-heart failure pharmacotherapy.
FRONTIERS IN PEDIATRICS
(2021)
Review
Cell Biology
Christine Mages, Heike Gampp, Pascal Syren, Ann-Kathrin Rahm, Florian Andre, Norbert Frey, Patrick Lugenbiel, Dierk Thomas
Summary: This review highlights the pathomechanisms underlying arrhythmogenicity in patients with heart failure, such as myocardial fibrosis and ion channel remodeling. It emphasizes the association of dysregulated ion channel expression with cardiomyopathy and arrhythmia development, and discusses potential therapeutic options.
Article
Cardiac & Cardiovascular Systems
Nobuyuki Enzan, Shouji Matsushima, Tomomi Ide, Hidetaka Kaku, Takeshi Tohyama, Kouta Funakoshi, Taiki Higo, Hiroyuki Tsutsui
Summary: The use of beta-blockers in recovered DCM patients can prevent deterioration of left ventricular systolic function, with female patients showing a greater benefit from beta-blockers.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Suyon Chang, Kyunghwa Han, Yonghan Kwon, Lina Kim, Seunghyun Hwang, Hwiyoung Kim, Byoung Wook Choi
Summary: This study aimed to develop and validate models using radiomics features on a native T1 map from cardiac magnetic resonance (CMR) to predict left ventricular reverse remodeling (LVRR) in patients with nonischemic dilated cardiomyopathy (NIDCM). The radiomics score showed good predictive performance in internal validation.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Vincenzo Nuzzi, Anne Raafs, Paolo Manca, Michiel T. H. M. Henkens, Caterina Gregorio, Andrea Boscutti, Job Verdonschot, Mark Hazebroek, Christian Knackstedt, Marco Merlo, Davide Stolfo, Gianfranco Sinagra, Stephane R. B. Heymans
Summary: This study aimed to evaluate the prognostic implications of left atrial volume index (LAVI) reduction and found that a decrease in LAVI was associated with a reduced risk of mortality, heart transplantation, and heart failure hospitalization. The findings suggest that LAVI reduction may be an important parameter in risk stratification for patients with dilated cardiomyopathy.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Meng-Ting Shen, Yuan Li, Ying-Kun Guo, Yue Gao, Li Jiang, Rui Shi, Zhi-Gang Yang
Summary: Hypertension has a detrimental impact on left ventricular function and remodeling in non-ischemic dilated cardiomyopathy patients. Hypertension is independently associated with LV strain and remodeling, while male sex, heart rate, blood pressure, and presence of myocardial infarction are independent determinants of LV strain and remodeling.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Matteo Ponzoni, Luca Zanella, Elena Reffo, Annachiara Cavaliere, Alice Pozza, Biagio Castaldi, Giovanni Di Salvo, Vladimiro L. Vida, Massimo A. Padalino
Summary: This study investigated the left ventricular (LV) rehabilitation process in children with dilated cardiomyopathy (DCM) undergoing pulmonary artery banding (PAB). Results showed that LV ejection fraction increased by 10% after 30-60 days and almost normalized after 120 days. LV end-diastolic volume decreased significantly. Follow-up examinations revealed sustained LV improvement, but myocardial fibrosis was detected in all patients. PAB can promote LV remodeling, but the prognostic significance of residual fibrosis remains uncertain.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zsofia Gregor, Anna Reka Kiss, Kinga Grebur, Liliana Erzsebet Szabo, Bela Merkely, Hajnalka Vago, Andrea Szucs
Summary: This study compared the left ventricular MRI characteristics of dilated cardiomyopathy and left ventricular noncompaction patients, finding similarities in volumetric, global strain parameters, and rotational patterns, but higher TPMi values and significantly lower apical circumferential strains in LVNC patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Kakeru Ishihara, Yoshiaki Kubota, Junya Matsuda, Yoichi Imori, Yukichi Tokita, Kuniya Asai, Hitoshi Takano
Summary: This study aimed to identify the predictive factors for dilated phase (DHCM) progression in patients with hypertrophic cardiomyopathy (HCM), and to investigate the effects of percutaneous transluminal septal myocardial ablation (PTSMA) on DHCM development. The study included 291 HCM patients and found that baseline atrial fibrillation, nonsustained ventricular tachycardia, and left ventricular diameter at end-systole were significant predictors of DHCM. PTSMA did not have a significant effect on long-term left ventricular ejection fraction changes or DHCM development. However, further validation with a larger population is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Beatrice Musumeci, Giacomo Tini, Domitilla Russo, Matteo Sclafani, Francesco Cava, Alessandro Tropea, Carmen Adduci, Francesca Palano, Pietro Francia, Camillo Autore
Summary: While most patients with hypertrophic cardiomyopathy (HCM) exhibit a stable phenotype, certain patients may experience progressive changes in left ventricular (LV) wall thickness, cavity size, and function, overall defined as LV remodeling. Various pathophysiologic mechanisms, from genetic factors to myocardial ischemia and fibrosis, contribute to this process. Different patterns of LV remodeling have specific impacts on the clinical course and management of the disease, underscoring the importance of serial multimodal evaluations to identify and characterize LV remodeling. A more comprehensive definition of disease stages may offer opportunities to improve management of HCM patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yuanwei Xu, Weihao Li, Ke Wan, Yaodan Liang, Xincheng Jiang, Jie Wang, David Mui, Yangjie Li, Siqi Tang, Jiajun Guo, Xinli Guo, Xiumin Liu, Jiayu Sun, Qing Zhang, Yuchi Han, Yucheng Chen
Summary: The study revealed that the absence of late gadolinium enhancement, lower T2, and extracellular volume values at baseline are significant predictors of LVRR in patients with idiopathic DCM. Furthermore, after guideline-directed medical therapy, patients with LVRR showed significant decreases in myocardial T1, matrix, and cell volume.
CIRCULATION-HEART FAILURE
(2021)
Article
Medicine, General & Internal
Mitsuhiro Watanabe, Takeshi Kashimura, Mitsuo Ishizuka, Mayumi Kase, Ryohei Sakai, Shinya Fujiki, Tsugumi Takayama, Shiro Ishihara, Kazuyuki Ozaki, Takayuki Inomata
Summary: This study examined the predictability of left ventricular reverse remodeling (LVRR) in newly diagnosed dilated cardiomyopathy (DCM) patients with spontaneous mechanical alternans (MA). The study found that the probability of LVRR after optimal medical therapy (OMT) was similar in DCM patients with and without spontaneous MA. In the MA group, patients who achieved LVRR had significantly higher baseline systolic aortic pressure, while the baseline heart rate did not show a significant correlation with LVRR. In contrast, LVRR in the non-MA group was unrelated to the baseline aortic pressure or heart rate.
Article
Cardiac & Cardiovascular Systems
Deanna K. Sosnowski, K. Lockhart Jamieson, Ahmed M. Darwesh, Hao Zhang, Hedieh Keshavarz-Bahaghighat, Robert Valencia, Anissa Viveiros, Matthew L. Edin, Darryl C. Zeldin, Gavin Y. Oudit, John M. Seubert
Summary: This study reveals the alterations in PUFA metabolites in DCM hearts, indicating that increased expression of CYP enzymes and epoxide hydrolases are associated with mitochondrial dysfunction, which can be improved by administration of exogenous EpFAs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yuanwei Xu, Jiayi Lin, Yaodan Liang, Ke Wan, Weihao Li, Jie Wang, Yanjie Zhu, David Mui, Lili Wang, Yuancheng Li, Wei Cheng, Jiayu Sun, Qing Zhang, Yuchi Han, Yucheng Chen
Summary: The left ventricular remodeling index (RI) is an independent predictor of all-cause mortality, heart transplantation, and HF readmission in patients with idiopathic dilated cardiomyopathy (DCM), providing additional prognostic value beyond traditional measures like left ventricular ejection fraction (LVEF) and late gadolinium enhancement (LGE) presence.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2021)