Article
Biochemistry & Molecular Biology
Tatiana F. R. Costa, Amy Goundry, Alexandre Morrot, Dennis J. Grab, Jeremy C. Mottram, Ana Paula C. A. Lima
Summary: This study reveals the mechanism of Trypanosoma brucei rhodesiense penetration through the blood-brain barrier and causing sleeping sickness. The Cathepsin L-like cysteine peptidase and its endogenous inhibitor ICP play important roles in the infection process and regulate inflammatory responses. The results suggest that ICP helps to downregulate inflammatory responses and control the infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Anna M. Hanttu, Satu Pekkala, Reetta Satokari, Anna K. Hartikainen, Perttu Arkkila, Kirsi H. Pietilainen, Jussi P. Sutinen
Summary: This study investigated gut microbiota before and after a single antiretroviral agent switch in HIV-positive patients. The results showed that switching to raltegravir (RAL) increased microbiota diversity compared to switching to efavirenz or protease inhibitors (EFV/PI). The relative abundance of Prevotella, Phascolarctobacterium, and Bacteroides also changed after switching to RAL. These findings suggest that a single antiretroviral agent switch can alter gut microbiota, which may be associated with reduced inflammation and/or increased weight.
Article
Plant Sciences
Oskan Tasinov, Ivayla Dincheva, Ilian Badjakov, Yoana Kiselova-Kaneva, Bistra Galunska, Ruben Nogueiras, Diana Ivanova
Summary: SE fruits have immunostimulation potential and can reduce ER stress, inhibiting transcription of inflammation related genes and suppressing LPS-stimulated inflammatory markers on transcription and translation levels. The major phytochemicals in SE FAE include hydroxycinnamic acids, proanthocyanidins, and anthocyanins.
Article
Biochemistry & Molecular Biology
Na Mao, Yuhang Fan, Wenjing Liu, Honghao Yang, Yi Yang, Yaqian Li, Fuyu Jin, Tian Li, Xinyu Yang, Xuemin Gao, Wenchen Cai, Heliang Liu, Hong Xu, Shifeng Li, Fang Yang
Summary: The LDHA inhibitor oxamate attenuates glycolysis and ER stress in silicosis, indicating its potential as an anti-fibrotic treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Mehdi Yoosefian, Maryam Zeraati Moghani, Alfredo Juan
Summary: Researchers have discovered a new human immunodeficiency virus (HIV) protease inhibitor called ATV7 through molecular docking and molecular dynamics simulation, which has better antiviral effects and inhibitory ability than the existing drug atazanavir.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hajnalka Majoros, Barbara N. Borsos, Zsuzsanna Ujfaludi, Zoltan G. Pahi, Monika Morocz, Lajos Haracska, Imre Miklos Boros, Tibor Pankotai
Summary: UV-induced DNA damage response and repair processes are extensively studied, with SPB10 identified as a significantly upregulated gene following UV irradiation. While SPB10 is involved in the cellular response to UV-induced stress, it does not have an essential function in cell survival, but may play a role in delaying DNA repair in certain cell phases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Multidisciplinary Sciences
Erica A. Mendes, Yuyang Tang, Guochun Jiang
Summary: HIV infection is a chronic disease that can be effectively suppressed by antiretroviral therapy (ART), but stable viral reservoirs cannot be eradicated by ART alone. Mammalian cells have an integrated stress response (ISR) mechanism to detect and respond to stresses such as nutrient fluctuation, unfolded protein accumulation, and viral infection. Understanding how ISR responds to the off-target effects of ART and persistent HIV infection may help us better understand stable HIV reservoirs and HIV-associated neurocognitive disorders.
Article
Biochemistry & Molecular Biology
Xiangyu Zhao, Guirong Zhang, Liuzhong Wu, Yulong Tang, Chuanbo Guo
Summary: Bone marrow mesenchymal stem cells have pluripotent differentiation capabilities, but inflammation response can impair osteogenic differentiation. TNF-alpha induces oxidative and ER stress, leading to JNK activation and inflammation in BMMSCs. Targeting ER stress may be a potential strategy for improving BMMSCs osteogenesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Food Science & Technology
Jinglin Ma, Yanrong Liu, Yongpeng Guo, Qiugang Ma, Cheng Ji, Lihong Zhao
Summary: AFB1 induces oxidative stress in macrophages by affecting the respiratory chain, leading to increased ROS production. KEGG analysis reveals that AFB1 also affects multiple immune regulatory pathways.
Article
Biochemistry & Molecular Biology
Yaqian Li, Wenchen Cai, Fuyu Jin, Xiaojing Wang, Wenjing Liu, Tian Li, Xinyu Yang, Heliang Liu, Hong Xu, Fang Yang
Summary: Silicosis is the most prevalent occupational disease in China, and currently has no cure. This study found that the drug thalidomide, known for its anti-inflammatory and immunoregulatory effects, has therapeutic potential against silicosis by inhibiting the inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jie Sun, Kangsen Mai, Qinghui Ai
Summary: Endoplasmic reticulum (ER) homeostasis is important for cell physiological functions and disruption of ER homeostasis can lead to ER stress and inflammation. Glucose-regulated protein 78 (GRP78), an ER chaperone, is crucial for maintaining cellular homeostasis, but its effects on ER stress and inflammation in fish are not fully understood. In this study, ER stress and inflammation were induced in macrophages of large yellow croakers by tunicamycin (TM) or palmitic acid (PA), and the effects of GRP78 agonist/inhibitor were examined. The results showed that the TM/PA treatment induced ER stress and inflammation, which were reduced by GRP78 agonist treatment, while GRP78 inhibitor treatment further induced ER stress and inflammation. These findings provide novel insights into the relationship between GRP78 and TM/PA-induced ER stress or inflammation in large yellow croakers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anjali Tripathi, Kruthika Iyer, Debashis Mitra
Summary: This study reveals the mechanism of UPR activation in HIV-1 infection and its relationship with viral replication. The results demonstrate that optimal UPR activation is crucial for viral replication, and both overstimulating or inhibiting UPR leads to viral suppression.
Review
Immunology
Philipp R. R. Esser, Michael Huber, Stefan F. F. Martin
Summary: Maintaining homeostasis is crucial for organismal health. The innate immune system and the unfolded protein response play important roles in inflammation and inflammatory diseases, including allergic contact dermatitis. This review explores the interplay between the innate immune system and cellular stress responses, focusing on the unfolded protein response.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Jingyun Xu, Xiaobin Gu, Yue Xie, Ran He, Jing Xu, Lang Xiong, Xuerong Peng, Guangyou Yang
Summary: This study demonstrates that the recombinant cysteine protease inhibitor (rBsCPI-1) of Baylisascaris schroederi affects the physiological activities and polarization of monocyte-derived macrophages (MDMs) through the TLR2/4 signaling pathway. It interferes with antigen presentation response and induces an immunosuppressive cellular response in CD4+ T cells during the migratory process of B. schroederi.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elizabeth Figueroa-Juarez, Lilia G. Noriega, Carlos Perez-Monter, Gabriela Aleman, Rogelio Hernandez-Pando, Ricardo Correa-Rotter, Victoria Ramirez, Armando R. Tovar, Ivan Torre-Villalvazo, Claudia Tovar-Palacio
Summary: The study demonstrates that pharmacological induction of ER stress in mice leads to kidney structural abnormalities, in situ lipid synthesis, renal lipid accumulation, and functional alterations. Future strategies should focus on targeting renal ER stress to prevent kidney damage and metabolic diseases.
Article
Dermatology
Theodosios Bisdas, Nikolaos Patelis, Georgia Argyrakopoulou, Dimitrios Tsiachris, Aristotelis Kurtis, Panagiotis Gargalianos-Kakoliris, Christodoulos Stefanadis
Summary: The complexity of critical limb ischemia (CLI) requires a dedicated multidisciplinary team for treatment. This study aimed to assess the effectiveness of referring CLI patients scheduled for major amputation elsewhere to a dedicated CLI center. The analysis showed that patients in severe stages of CLI who received a second opinion from a dedicated multidisciplinary team had high limb salvage and survival rates after major amputation.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Pharmacology & Pharmacy
Dimitris Tsiachris, Ioannis Doundoulakis, Panagiotis Tsioufis, Eirini Pagkalidou, Christos-Konstantinos Antoniou, Stefanos M. Zafeiropoulos, Konstantinos A. Gatzoulis, Konstantinos Tsioufis, Christodoulos Stefanadis
Summary: This systematic review compares the effectiveness and safety of class Ic agents for cardioversion of paroxysmal AF and finds that intravenous flecainide is the most effective option. Class Ic agents appear to be safe for pharmacologic cardioversion of AF regardless of the presence of SHD.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Immunology
Wenjuan Yang, Andreas Denger, Caroline Diener, Frederic Kueppers, Leticia Soriano-Baguet, Gertrud Schaefer, Archana K. Yanamandra, Renping Zhao, Arne Knoerck, Eva C. Schwarz, Martin Hart, Frank Lammert, Leticia Prates Roma, Dirk Brenner, Grigorios Christidis, Volkhard Helms, Eckart Meese, Markus Hoth, Bin Qu
Summary: TRAIL expression is increased in cytotoxic T lymphocytes (CTLs) in high glucose environments, potentially contributing to the progression of diabetes. Non-mitochondrial reactive oxygen species, NF kappa B, and PI3K/Akt play crucial roles in the upregulation of TRAIL in CTLs induced by high glucose. TRAIL(high) CTLs induce apoptosis of pancreatic beta cells. Treatment with metformin and vitamin D can reduce the enhanced expression of TRAIL in CTLs caused by high glucose and protect pancreatic beta cells from TRAIL-mediated apoptosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Grayson W. Way, Kaitlyn G. Jackson, Shreya R. Muscu, Huiping Zhou
Summary: Alcohol-associated liver disease is a series of diseases caused by chronic alcohol use, ranging in severity from hepatic steatosis to alcoholic hepatitis and cirrhosis, and potentially leading to hepatocellular carcinoma. The disease has a significant impact on patients' biology, microbiology, physics, metabolism, and inflammation. Current treatment focuses on abstinence and symptom management.
Article
Economics
Jay Pil Choi, Christodoulos Stefanadis
Summary: This article examines tippy network markets that allow price discrimination and finds that under certain conditions, network competition may lead to a unique subgame-perfect equilibrium where the winner's identity is fully determined by its product features. The concept of the dominant value margin is introduced as a metric for the effectiveness of divide-and-conquer strategies. However, the outcome of a market where suppliers with larger dominant value margins can sell to all customers does not necessarily result in social efficiency.
INTERNATIONAL ECONOMIC REVIEW
(2022)
Letter
Cardiac & Cardiovascular Systems
Christodoulos Stefanadis, Christina Chrysohoou, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Panagiota Manolakou, Gerasimos Siasos, Konstantinos Tsioufis, George Panagiotakopoulos, Theoklis Zaoutis, Demosthenes Panagiotakos
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Letter
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Grigorios Chatzantonis, Christos-Konstantinos Antoniou, Haris Lalos, Gregory C. Bogdanis, Pantelis Nikolaou, Anastasios Spanos, Stefanos Karagiannis, Costas Tsiou, Ali Yilmaz, Christodoulos Stefanadis
HELLENIC JOURNAL OF CARDIOLOGY
(2022)
Review
Pathology
Kaitlyn G. Jackson, Grayson W. Way, Jing Zeng, Marissa K. Lipp, Huiping Zhou
Summary: Chronic liver disease is a global public health threat, and chronic activation of endoplasmic reticulum stress is recognized as an important factor in its progression. Abnormal protein folding leads to endoplasmic reticulum stress and unfolded protein response, and maladaptive responses cause inflammation and cell death.
AMERICAN JOURNAL OF PATHOLOGY
(2023)
Article
Cell Biology
Xianshu Bai, Na Zhao, Christina Koupourtidou, Li-Pao Fang, Veronika Schwarz, Laura C. Caudal, Renping Zhao, Johannes Hirrlinger, Wolfgang Walz, Shan Bian, Wenhui Huang, Jovica Ninkovic, Frank Kirchhoff, Anja Scheller
Summary: Acute brain injuries can reprogram oligodendrocytes to activate astroglial genes, leading to their conversion into astrocytes. This conversion is promoted by IL-6 derived from microglia and can be visualized in transgenic mice using imaging techniques. The plastic potential of oligodendrocytes in acute brain trauma highlights the complexity of glial scar formation.
DEVELOPMENTAL CELL
(2023)
Review
Biochemistry & Molecular Biology
Jing Zeng, Jiangao Fan, Huiping Zhou
Summary: Chronic cholestatic liver diseases, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), gradually progress to liver fibrosis, cirrhosis, and failure. Disruption of bile acid metabolism and intrahepatic circulation plays a crucial role in accelerating the progression of cholestatic liver diseases. Bile acids not only act as detergents for nutrition absorption but also function as key signaling molecules that regulate hepatic metabolism and immune responses. This review focuses on the role of bile acid-mediated signaling in cholestatic liver disease.
CELL AND BIOSCIENCE
(2023)
Review
Cell Biology
Sayed Obaidullah Aseem, Phillip B. Hylemon, Huiping Zhou
Summary: Biliary fibrosis is the key pathological process in cholangiopathies, and cholestasis worsens with biliary fibrosis. Dysregulation of bile acid levels and composition is observed in PBC and PSC. Recent studies have shown that bile acids play a crucial role in the progression of biliary fibrosis, and the identification of bile acid receptors has advanced our understanding of related signaling pathways. Further understanding of bile acid signaling may lead to new therapeutic approaches for cholangiopathies.
Review
Biochemistry & Molecular Biology
Yanyan Wang, Jing Zeng, Weidong Chen, Jiangao Fan, Phillip B. Hylemon, Huiping Zhou
Summary: Liver cancer is a major cause of cancer-related death worldwide and has limited treatment options. Recent studies have revealed the significant role of long noncoding RNAs (lncRNAs) in the development of liver cancers, particularly the oncogene H19. H19 affects crucial biological processes like cell proliferation, apoptosis, invasion, and metastasis through epigenetic modifications, the H19/miR-675 axis, miRNA sponging, drug resistance, and downstream pathway regulation. This review focuses on the molecular mechanisms and regulation of H19 in hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), providing perspectives on its potential as a diagnostic marker and therapeutic target for liver cancer.
Editorial Material
Immunology
Renping Zhao, Archana K. Yanamandra, Bin Qu
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Ioannis Doundoulakis, Panagiota Manolakou, Demetrios Sougiannis, Athanasios Kordalis, Konstantinos A. Gatzoulis, Gian-Battista Chierchia, Carlo de Asmundis, Christodoulos Stefanadis, Konstantinos Tsioufis
Summary: Nowadays, cryoballoon (CB) has become an established alternative to radio frequency (RF) ablation for pulmonary vein isolation (PVI), with the ability to isolate PVs in a single application. In a study on over 1000 consecutive patients, our center optimized the CB PVI procedure. It is expected that future guidelines will recommend CB as the first-line PVI for patients with paroxysmal AF and a class I indication. In a long-term follow-up of the EARLY-AF trial, CB showed a lower incidence of persistent atrial fibrillation compared to anti-arrhythmic drugs.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Physiology
Alexis Darras, Hans Georg Breunig, Thomas John, Renping Zhao, Johannes Koch, Carsten Kummerow, Karsten Konig, Christian Wagner, Lars Kaestner
Summary: This study uses three different optical imaging techniques to observe the structures formed by erythrocytes in static blood. The results reveal a dynamic structure of a channeling gel, but with differences in the resolved details among the techniques. Further refinement of the experimental set-ups is required for a quantitative analysis of erythrocyte-related processes and interactions during sedimentation.
FRONTIERS IN PHYSIOLOGY
(2022)