Article
Biochemistry & Molecular Biology
Zarina I. Kakhkharova, Dmitry O. Zharkov, Inga R. Grin
Summary: This study characterized the biochemical properties of two hNEIL2 variants found in the general population, revealing their lower affinity and catalytic efficiency in base excision and DNA repair mechanisms. The P304T variant showed significantly reduced efficiency compared to the wild-type hNEIL2, suggesting its potential role as a cancer risk modifier warranting further epidemiological analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Nan Li, Tao Liu, Shan Zhu, Yi Yang, Zijing Wang, Zhiyue Zhao, Xiang Wang, Wenxiao Qin, Yiqi Yan, Yang Liu, Qingmei Xia, Han Zhang
Summary: This study found that corylin can prevent skin aging by inhibiting oxidative stress through the Keap1-Nrf2 signaling pathway. These findings provide evidence for the discovery of novel therapies targeting skin aging.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Farhana Hassan, Hilal Mir, Amrina Shafi, Firdous A. Khanday
Summary: The Sea buckthorn, named for its tendency to grow close to the water and thorny nature, has been found to enhance the health and shine of horses when fed its leaves, leading to its Latin genus name Hippophae, meaning Shining Horse. It contains bioactive substances such as polyphenols and carotenoids, which have beneficial effects on the human body. This study aims to evaluate the antioxidant potential of Sea buckthorn and its ability to protect DNA from damage.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2023)
Article
Food Science & Technology
Sanja Kostic, Aleksandra Vilotic, Andrea Pirkovic, Dragana Dekanski, Suncica Borozan, Mirjana Nacka-Aleksic, Svetlana Vrzic-Petronijevic, Milica Jovanovic Krivokuca
Summary: This study investigated the cytoprotective effects of caffeic acid on first trimester extravillous trophoblast cells. The results showed that caffeic acid had no cytotoxic effects and could attenuate oxidative damage, reduce cytotoxicity and lipid peroxidation, and restore antioxidant capacity in trophoblast cells.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qingwen Yuan, Renjun Peng, Huijie Yu, Sinian Wang, Zhongmin Chen, Suhe Dong, Wei Li, Bo Cheng, Qisheng Jiang, Yuwen Cong, Fengsheng Li, Changzheng Li
Summary: The study demonstrates that disulfiram, an FDA-approved alcohol deterrent, shows radioprotective efficacy by affecting the cell cycle and regulating the DNA damage response and survival of intestinal stem cells. It could be a promising candidate for preventing radiation-induced intestinal injury (RIII) in cancer therapy and nuclear accidents.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Polina Zhdanova, Alexander A. Ishchenko, Alexander A. Chernonosov, Dmitry O. Zharkov, Vladimir V. Koval
Summary: The study reveals the structural and dynamic features of human endonuclease VIII-like protein 2 (hNEIL2), showing its unique specificity for non-canonical DNA substrates and conformational flexibility in solution.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Hanlin Peng, Mingzhu Zhu, Wei Kong, Chaoshu Tang, Junbao Du, Yaqian Huang, Hongfang Jin
Summary: The results demonstrate that L-Cth exerts inhibitory effects on oxidative stress by reducing superoxide anion, H2O2, and NO levels, as well as iNOS protein expression induced by oxLDL. Additionally, L-Cth treatment significantly enhances the activity of antioxidants GSH-Px, SOD, and CAT, and upregulates the expressions of SOD1 and SOD2 proteins in oxLDL-treated macrophages.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Yiming Qiu, Xianping Xie, Luhua Lin
Summary: This study identified that circFOXO3 protects cardiomyocytes from radiation-induced cardiotoxicity by reducing DNA damage and apoptosis, suggesting circFOXO3 could be a potential therapeutic target against radiation-induced cardiotoxicity.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Environmental Sciences
Huimin Liu, Bingjie Liu, Siqi Zhang, Miao Fan, Xiaoxue Ji, Shouan Zhang, Zhongtang Wang, Kang Qiao
Summary: This study found that lentinan protects C. elegans from fluopyram-induced toxicity through the regulation of the DAF-16 and SKN-1 pathways.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Plant Sciences
Pongrapee Laorodphun, Rada Cherngwelling, Aussara Panya, Phatchawan Arjinajarn
Summary: The study demonstrated that pre-treatment with CUR could alleviate GM-induced nephrotoxicity in rats by restoring kidney function and reducing oxidative stress, as evidenced by decreased levels of creatinine and blood urea nitrogen, increased creatinine clearance, and normalized expression of antioxidant and ER stress markers. CUR's antioxidative properties also contributed to the reduction in ER stress and apoptotic protein biomarkers in the kidney. These findings suggest that CUR could be a potential supplement for preventing nephrotoxicity and other kidney diseases in the future.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Sevil Arabaci Tamer, Selin Akbulut, Irem Peker Eyuboglu, Omer Erdogan, Ozge Cevik, Mustafa Akkiprik, Dilek Akakin, Berrak C. Yegen
Summary: The present study demonstrated that peripherally administered NPW has gastroprotective effects by regulating gastric blood flow, suppressing oxidant damage and inflammation, and modulating COX-induced gastroprotection. The expression of NPW is closely related to the occurrence and development of stress-induced ulcers.
Article
Biochemistry & Molecular Biology
Yanmei Li, Dan Hao, Danfeng Wei, Yue Xiao, Lian Liu, Xiaoxue Li, Lian Wang, Yu Gan, Wei Yan, Bowen Ke, Xian Jiang
Summary: This study investigated the photoprotective effects of CBD against UVB-induced skin damage. The results showed that CBD alleviated cytotoxicity, apoptosis, and cell cycle arrest caused by UVB. CBD also decreased the production of reactive oxygen species and modulated the expression of antioxidant-related proteins. Additionally, CBD mitigated UVB-induced cytotoxicity by activating autophagy. The study also demonstrated that a cream containing 5% CBD was effective in reducing photodamage in a murine model.
Article
Multidisciplinary Sciences
Yuan Yue, Likun Ren, Chao Zhang, Kai Miao, Kun Tan, Qianying Yang, Yupei Hu, Guangyin Xi, Gang Luo, Mingyao Yang, Jingyu Zhang, Zhuocheng Hou, Lei An, Jianhui Tian
Summary: This study reveals the dynamic process of mtDNA methylation during the critical developmental window and its role in maintaining mitochondrial genome stability. The researchers also discovered that DNA methyltransferase 3A and DNMT3B catalyze de novo mtDNA methylation and bind to mtDNA through their unique mitochondrial targeting sequences. The results demonstrate that increased mtDNA methylation functions to protect the mitochondrial genome against damage induced by mitochondrial oxidative stress.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Nobuhiro Akita, Ryu Okada, Kyosuke Mukae, Ryuichi P. Sugino, Hisanori Takenobu, Koji Chikaraishi, Hidemasa Ochiai, Yohko Yamaguchi, Miki Ohira, Haruhiko Koseki, Takehiko Kamijo
Summary: The overexpression of the polycomb protein BMI1 is associated with cancer development and aggressiveness. In this study, we investigated the potential of targeting BMI1 for neuroblastoma (NB) therapy and found that reduction of BMI1 induced differentiation of NB cells and triggered apoptotic cell death. Moreover, BMI1 depletion suppressed NB xenograft tumor growth in vivo. The study also confirmed the involvement of PcG proteins in the DNA damage response of NB cells.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Sooji Song, Yoon-Mi Lee, Yu Young Lee, Kyung-Jin Yeum
Summary: The study demonstrated that oat extract rich in antioxidants has a protective role against oxidative stress-induced keratinocyte injuries, reducing intracellular ROS levels, DNA damage mediating genes, and apoptotic caspase activities.