Article
Medicine, Research & Experimental
Johanna C. Arroyave-Ospina, Manon Buist-Homan, Martina Schmidt, Han Moshage
Summary: This study found that caffeine can protect liver cells from the toxic effects of fatty acids by modulating adenosine receptor signaling. By activating protein kinase A and inhibiting the A1AR receptor, caffeine can reduce lipid accumulation and harmful substances produced by mitochondria, thereby alleviating metabolic dysfunction-associated liver disease.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Xuesong Wang, Willem Jespers, Kim A. N. Wolff, Jill Buytelaar, Adriaan P. IJzerman, Gerard J. P. van Westen, Laura H. Heitman
Summary: This study investigates the role of the adenosine A(1) receptor (A(1)AR) in tumor development and its pharmacological characteristics in different mutations. The results show that certain mutations exhibit enhanced constitutive activity, while others show decreased activity. The activation effects of the mutations are generally consistent between yeast and mammalian systems. This study enriches our understanding of the structure and function of A(1)AR and provides opportunities for precision medicine in cancer patients.
Article
Biochemistry & Molecular Biology
Xuesong Wang, Willem Jespers, Just J. de Waal, Kim A. N. Wolff, Liedeke van Uden, Adriaan P. IJzerman, Gerard J. P. van Westen, Laura H. Heitman
Summary: This study examines the role of the adenosine A(1) receptor (A(1)AR) in tumor development and explores the effects of mutations on receptor activity and pharmacology. Results reveal that mutations in the extracellular loops generally decrease receptor activity and agonist potency, while some contradictory effects are observed for mutations in the intracellular loops. This research enriches our understanding of A(1)AR structure and function, providing insights into the consequences of these mutations in cancer.
Article
Biochemistry & Molecular Biology
Catia R. Lopes, Andreia Oliveira, Ingride Gaspar, Matilde S. Rodrigues, Joana Santos, Eszter Szabo, Henrique B. Silva, Aangelo R. Tome, Paula M. Canas, Paula Agostinho, Rui A. Carvalho, Rodrigo A. Cunha, Ana Patricia Simoes, Joao Pedro Lopes, Samira G. Ferreira
Summary: Moderate caffeine intake can antagonize adenosine receptors and protect neurons without affecting behavior and synaptic plasticity. It increases the metabolic competence of synapses and enhances their antioxidant capacity.
Article
Environmental Sciences
Ying Zhang, Jiaojiao Guo, Ying Chen, Jiangwei Wang, Qian Zhou, Meng Chen, Chonggang Wang
Summary: Exposure to FBZ in zebrafish embryos led to reduced reproductive ability in adult fish, as evidenced by decreased mature gametes and lower fertilization and survival rates of F1 embryos when exposed fish were mated with untreated fish. While transcription of reproduction-related genes in the brain was not significantly changed, key genes in the gonads were downregulated, indicating dysfunction of Sertoli and Leydig cells. Additionally, altered gene expression and methylation levels in germ cells suggest that they are the primary targets of FBZ.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Neurosciences
Hua Shi, Yunjia Tu, Yuanai Li, Chunyan Ma, Adwoa Takyiwaa Gyabaah, Chenyi Yu, Zhijie Li, Jiayi Chen, Zhilin Li, Zhi-Li Huang, Xiaohong Cai
Summary: Caffeine, a widely used first-line drug for treating neonatal apnea, has been found to excite the neurons in the medial parabrachial nucleus (MPB) by blocking A1R receptors. This study suggests that A1Rs in MPB may be potential targets for caffeine in reducing apnea neonatorum.
Review
Pharmacology & Pharmacy
Emily Cash, Amanda T. Goodwin, Amanda L. Tatler
Summary: Pulmonary fibrosis is a debilitating lung condition caused by the abnormal activation of fibroblasts, resulting in the deposition of ECM components and impairment of lung function. Adenosine signalling is believed to play a role in tissue fibrosis, including in the lungs, but the exact molecular pathways are still unknown.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Anatomy & Morphology
Weili Zhang, Weiwei Qiao, Luning Zuo
Summary: This study found that A(1)AR and A(2b)AR can affect ferroptosis of myocardial cells in a rat model of MIR by regulating the expression of GPX4. Activation of the receptors increases the expression of GPX4 and reduces the production of lipid ROS, thereby inhibiting apoptosis of cardiomyocytes.
Article
Neurosciences
Anna L. Pierling, Eva-Maria Elmenhorst, Denise Lange, Eva Hennecke, Diego M. Baur, Simone Beer, Tina Kroll, Bernd Neumaier, Daniel Aeschbach, Andreas Bauer, Hans-Peter Landolt, David Elmenhorst
Summary: Our study found that A(1) adenosine receptor availability is higher in healthy females compared to males even under well-rested conditions, particularly in regions such as the pallidum and anterior cingulate cortex. This difference in receptor availability may partially explain the known sex differences in sleep efficiency and latency, suggesting a potential role of adenosine in sleep-wake control.
Article
Neurosciences
Pandeng Xie, Siqi Liu, Qi Huang, Zhonghua Xiong, Jiahui Deng, Chongyang Tang, Ke Xu, Bo Zhang, Baijian He, Xiongfei Wang, Zhao Liu, Jing Wang, Jian Zhou, Yugang Guan, Guoming Luan, Tianfu Li, Feng Zhai
Summary: Deep brain stimulation (DBS) can reduce spontaneous recurrent seizures (SRS) in epileptic rats by inhibiting ADK and activating A(1) receptors (A(1)Rs).
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
D. Pereira-Figueiredo, A. A. Nascimento, M. C. Cunha-Rodrigues, R. Brito, K. C. Calaza
Summary: Ischemia is caused by insufficient blood flow to tissues, leading to inadequate oxygen and glucose supply, resulting in cell death and secondary damage. Adenosine and caffeine play important roles in CNS pathology, providing neuroprotective effects, but effective treatments are currently lacking.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tuany Eichwald, Alexandre Francisco Solano, Jennyffer Souza, Tais Browne de Miranda, Liebert Bernardes Carvalho, Paula Lemes dos Santos Sanna, Rodrigo A. Foganholi da Silva, Alexandra Latini
Summary: Caffeine administration reduces expression of pro-inflammatory biomarkers and promotes an anti-inflammatory response. It also upregulates adenosinergic receptors and affects DNA methylation patterns. Caffeine treatment attenuates the catabolic state induced by lipopolysaccharide. These effects suggest that caffeine's anti-inflammatory effects in muscle may be mediated through epigenetic modifications.
Article
Multidisciplinary Sciences
Brandon M. Fritz, Fuqin Yin, Brady K. Atwood
Summary: The medial and lateral dorsal striatum play different roles in driving goal-directed and habitual/compulsive behaviors, respectively. Adenosine A(1) receptors in the dorsal striatum regulate excitatory glutamate transmission, potentially influencing striatally-mediated behaviors. The study found that activation of presynaptic A1Rs led to synaptic depression in both DLS and DMS, suggesting a potential role of A1Rs in neuropsychiatric diseases.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Pedro Valada, Sofia Alcada-Morais, Rodrigo A. Cunha, Joao Pedro Lopes
Summary: Theobromine, a metabolite of caffeine, affects synaptic transmission and plasticity by antagonizing adenosine receptors, resulting in improved cognitive function and neuroprotection against disease-related conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Psychology, Biological
M. Crespo, D. A. Leon-Navarro, M. Martin
Summary: Febrile seizures can be classified into simple and prolonged, with controversy surrounding the outcomes of the latter. Research using an animal model shows that prolonged febrile seizures in early life can lead to motor impairments and gait disturbances in adult rats, affecting the adenosinergic system in the cerebellum.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Oncology
Chao Yu, Sheng-Li Yang, Xiefan Fang, Jian-Xin Jiang, Cheng-Yi Sun, Tao Huang
MOLECULAR MEDICINE REPORTS
(2015)
Article
Chemistry, Physical
Jinming Zhang, Ruie Chen, Xiefan Fang, Fengqian Chen, Yitao Wang, Meiwan Chen
Review
Biochemistry & Molecular Biology
Lu Zhao, Xiefan Fang, Maurice R. Marshall, Soonkyu Chung
Article
Physiology
Xiefan Fang, Wenbin Mei, William B. Barbazuk, Scott A. Rivkees, Christopher C. Wendler
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Xiefan Fang, Jone Corrales, Cammi Thornton, Brian E. Scheffler, Kristine L. Willett
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2013)
Review
Biotechnology & Applied Microbiology
Sheng-Li Yang, Xiefan Fang, Zao-Zao Huang, Xiang-Jie Liu, Zhi-Fan Xiong, Ping Liu, Hong-Yi Yao, Chang-Hai Li
Article
Environmental Sciences
Xiefan Fang, Cammi Thornton, Brian E. Scheffler, Kristine L. Willett
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Nicole R. van Veenendaal, Baerbel Ulmer, Marko T. Boskovski, Xiefan Fang, Mustafa K. Khokha, Christopher C. Wendler, Martin Blum, Scott A. Rivkees
Article
Pharmacology & Pharmacy
Jinming Zhang, Yingbo Li, Xiefan Fang, Demin Zhou, Yitao Wang, Meiwan Chen
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2014)
Article
Biochemical Research Methods
Minzhi Peng, Xiefan Fang, Yonglan Huang, Yanna Cai, Cuili Liang, Ruizhu Lin, Li Liu
JOURNAL OF CHROMATOGRAPHY A
(2013)
Article
Medicine, Research & Experimental
Yu-Wen He, Hong-Sheng Wang, Jun Zeng, Xiefan Fang, Hong-Yuan Chen, Jun Du, Xin-yun Yang
Article
Oncology
Sheng-Li Yang, Chao Yu, Jian-Xin Jiang, Li-Ping Liu, Xiefan Fang, Chao Wu
Meeting Abstract
Biochemistry & Molecular Biology
Christopher Wendler, Ryan Poulsen, Xiefan Fang
Meeting Abstract
Medicine, Research & Experimental
Sheng-li Yang, Shu-cai Yang, R. L. K. Ho, Yunfan Sun, Xingrong Yang, Jia Fan, Jian-wei Ren, Xiefan Fang, G. G. Chen, P. B. S. Lai
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2014)