Article
Environmental Sciences
Beibei Sun, Jie Song, Ya Wang, Jing Jiang, Zhen An, Juan Li, Yange Zhang, Gui Wang, Huijun Li, Neil E. Alexis, Ilona Jaspers, Weidong Wu
Summary: This study found that short-term exposure to PM2.5 is associated with nasal inflammation, oxidative stress, and reduced lung function in retired adults. The reduction in lung function and inflammation were more pronounced among subjects with the GSTT1-null genotype.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Xiaochen Xie, Ye Zhang, Zhuo Wang, Shanshan Wang, Xiaoyou Jiang, Hongyan Cui, Tingting Zhou, Zheng He, Hao Feng, Qiqiang Guo, Xiaoyu Song, Liu Cao
Summary: ROS, initially considered pathological, are now recognized as signaling intermediates that promote cellular adaptation to stress through autophagy regulation. ATM protein, activated by ROS, is involved in autophagy regulation, maintaining genome stability and triggering cytoplasmic autophagy as a ROS sensor.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tarun Mahata, Abhishek Singh Sengar, Madhuri Basak, Kiran Das, Arnab Pramanick, Sumit Kumar Verma, Praveen Kumar Singh, Sayan Biswas, Subhasish Sarkar, Sudipta Saha, Suvro Chatterjee, Madhusudan Das, Adele Stewart, Biswanath Maity
Summary: RGS6 plays a critical role in non-alcoholic fatty liver disease by exacerbating oxidative stress and cell death, with inhibition providing a means to prevent or reverse liver damage.
Article
Agronomy
Daniela Eliza Marin, Gina Cecilia Pistol, Cristina Valeria Procudin, Ionelia Taranu
Summary: Food and feed safety is a major concern for both animal and human health, as contamination with pathogens can occur frequently. This study investigated the effects of simultaneous contamination with mycotoxins and bacterial toxins on cell viability, oxidative stress, and inflammation. The results showed significant additive/synergistic effects of co-exposure to fungal and bacterial toxins, suggesting that the concomitant contamination with bacteria and mycotoxins could lead to higher toxicity.
Article
Biochemistry & Molecular Biology
Rosalba Siracusa, Ramona D'Amico, Marika Cordaro, Alessio Filippo Peritore, Tiziana Genovese, Enrico Gugliandolo, Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Roberta Fusco, Rosanna Di Paola
Summary: CDDO-Me demonstrated anti-fibrotic, anti-inflammatory, and anti-oxidative effects in the treatment of endometriosis, effectively suppressing the disease by modulating the Nrf2 and NF-κB pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sulaiman Alalawi, Faizah Albalawi, Dipak P. Ramji
Summary: Atherosclerotic cardiovascular disease (ACVD) is the leading cause of death worldwide. Punicalagin (PC), the main polyphenol present in pomegranates, possesses anti-inflammatory, antioxidant, and anti-atherogenic properties. However, further research and clinical trials are needed to fully exploit the potential of PC and its metabolites in the prevention and treatment of ACVD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Libor Vitek, Alena Jiraskova, Ivana Malikova, Gabriela Dostalova, Lenka Eremiasova, Vilem Danzig, Ales Linhart, Martin Haluzik
Summary: The study showed that serum bilirubin levels are positively correlated with total antioxidant status and negatively related to inflammatory markers. Patients with atherosclerosis have higher levels of oxidative stress and inflammation compared to healthy subjects.
Article
Biochemistry & Molecular Biology
Aleksandra Klisic, Mirjana Bakic, Vesna Karanikolic
Summary: This study compared serum biomarkers of oxidative stress in patients with psoriasis and atopic dermatitis, finding that catalase exhibited good diagnostic accuracy in distinguishing between the two diseases. The results suggest the potential use of antioxidants as a therapeutic strategy for these skin inflammatory diseases.
Article
Agriculture, Dairy & Animal Science
Renato M. Rossi, Faith M. Cullens, Paola Bacigalupo, Lorraine M. Sordillo, Angel Abuelo
Summary: The objective of this observational study was to compare the metabolic status of dairy cows during the last 6 wk of gestation based on colostrum volume and immunoglobulin content. The results showed that colostrum volume was lowest in winter, but no differences were observed among parity groups. Compared with low colostrum producer, high colostrum producer cows had higher concentrations of antioxidant potential and beta-hydroxybutyrate, and lower cholesterol and oxidant status index.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Shasha Chen, Na Hu, Honglun Wang, Yongning Wu, Guoliang Li
Summary: Pn3G5G, derived from LRF, exhibited strong antioxidant capacity and protective effects on CML-treated cells. In aging mice, Pn3G5G improved cognitive impairment, neuroinflammation, and neuronal apoptosis. These findings suggest the potential development of Pn3G5G as a healthcare product or potent dietary supplement with antioxidant and neuroprotective effects.
Article
Environmental Sciences
Fatma Esam, Malik M. Khalafalla, Mahmoud S. Gewaily, Safaa Abdo, Aziza M. Hassan, Mahmoud A. O. Dawood
Summary: This study found that the combined exposure of ammonia and heat stress can cause histological changes in the gills and liver tissues of Nile tilapia, as well as affect the expression of immune and antioxidative related genes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Immunology
Linfeng Zhu, Guoqin Tong, Fan Yang, Yijun Zhao, Guangjie Chen
Summary: Uremic neuropathy in children is a wide range of neurological disorders associated with progressive renal dysfunction. The diagnosis is often made retrospectively, and there are no defining signs or laboratory and imaging findings. These disorders contribute to increased morbidity and mortality among children, making uremia a global public health problem. Mechanistically, retention of uremic solutes, increased oxidative stress, neurotransmitter imbalance, and disturbance of the blood-brain barrier may cause uremic neuropathy. Neuroimmune factors and targeted anti-inflammatory therapy may provide new insights for the treatment of uremia.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Huiyu Luo, Junbin Chen, Chuhong Su, Longying Zha
Summary: Atherosclerosis is a chronic inflammatory disease that poses a threat to human health. Saponins, a type of phytochemicals, exhibit multiple bioactivities that are beneficial for the prevention and treatment of atherosclerosis.
Article
Genetics & Heredity
Tsutomu Shimura
Summary: AT is a disease characterized by extreme sensitivity to ionizing radiation, with AT patients and ATM-deficient mice displaying intrinsic mitochondrial dysfunction. ATM plays a critical role in maintaining cellular redox homeostasis.
Review
Biochemistry & Molecular Biology
Cristina Nocella, Alessandra D'Amico, Vittoria Cammisotto, Simona Bartimoccia, Valentina Castellani, Lorenzo Loffredo, Leonardo Marini, Giulia Ferrara, Matteo Testa, Giulio Motta, Beatrice Benazzi, Fabio Zara, Giacomo Frati, Sebastiano Sciarretta, Pasquale Pignatelli, Francesco Violi, Roberto Carnevale
Summary: Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) is an enzyme complex that generates superoxide or hydrogen peroxide (H2O2) and plays a crucial role in various biological functions. Among its isoforms, NOX2 is widely expressed in different cell types and is involved in regulating immunity and pathologies associated with oxidative stress and inflammation. Modulating NOX2 activity is an important therapeutic strategy to reduce damage caused by its hyperactivation. This review analyzes the mechanisms of NOX2 activation and regulation, its role in innate immunity, pathologies associated with its hyperactivation, and the latest inhibitory strategies.
Article
Materials Science, Composites
Jiyong Luo, Qin Tian, Shuhao Qin, Yating Qi, Jiali Li, Daohai Zhang
Summary: Nanocomposites composed of polypropylene, organoclay, ethylene acrylic acid, and maleic anhydride-grafted polypropylene were prepared and their thermal stability properties were investigated. The addition of organoclay improved the thermal stability and mechanical properties of the nanocomposites.
JOURNAL OF THERMOPLASTIC COMPOSITE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhengjie Yao, Zhenwei Zhang, Jiali Li, Ji Jia, Si Ma, Yongfeng Zhi, Hong Xia, Xiaoming Liu
Summary: A novel diyne-linked porphyrin-based COF with unique properties was successfully constructed, showing excellent reactivity under visible-light illumination, which provides a new approach for catalytic synthesis in this field.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Article
Clinical Neurology
Jiali Li, Hewei Wang, Yujian Yuan, Yunhui Fan, Fan Liu, Jingjing Zhu, Qing Xu, Lan Chen, Miao Guo, Zhaoying Ji, Yun Chen, Qiurong Yu, Tianhao Gao, Yan Hua, Mingxia Fan, Limin Sun
Summary: The study aims to compare the effectiveness of low-frequency rTMS and high-frequency rTMS in subcortical chronic stroke patients with severe hemiplegia, and to investigate the mechanism of brain reorganization following different treatment regimens. The study will use clinical functional assessment, multimodal fMRI scanning, and electrophysiological measurement to observe and evaluate the outcomes.
Article
Biotechnology & Applied Microbiology
Feiyun Chang, Jiali Li, Quan Sun, Shuqing Wei, Yongming Song
Summary: Circular RNA circ_0017639 regulates DDP resistance and tumor growth through modulating SIX1 expression and sequestering miR-1296-5p in non-small cell lung cancer.
Editorial Material
Engineering, Chemical
Xiaonan Wang, Jie Li, Yingzhe Zheng, Jiali Li
Summary: This paper provides an overview of the applications of multi-scale smart systems engineering (SSE) approaches in crucial domains such as materials discovery, intelligent manufacturing, and environmental management. The focus of SSE is to design, operate, and manage multi-scale systems with enhanced economic and environmental performance. The emergence of big data analytics, internet of things, machine learning, and general artificial intelligence has the potential to revolutionize research, industry, and society in the future.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2022)
Article
Plant Sciences
Shijie Zhang, Momi Tsuruta, Chaofeng Li, Lu-Min Vaario, Yan Xia, Norihisa Matsushita, Hiroyuki Kurokochi, Ruiyang Xu, Jiali Li, Chunlan Lian
Summary: This study investigated the effects of nitrogen application on the growth of ectomycorrhizal fungi and the formation of sporocarps, and determined the most suitable nitrogen concentration. The results have important implications for increasing the production of edible ECM fungus sporocarps in natural forests.
Article
Biochemistry & Molecular Biology
Bohao Zhao, Jiali Li, Ming Liu, Naisu Yang, Zhiyuan Bao, Xiyu Zhang, Yingying Dai, Jiawei Cai, Yang Chen, Xinsheng Wu
Summary: This study reveals that lncRNA2919 plays a negative role in hair follicle (HF) regeneration by decreasing HF depth and density. The methylation levels of the lncRNA2919 promoter during different stages of HF cycle were detected, and a key CpG site negatively correlated with lncRNA2919 expression was identified. 5-Aza-dc-induced demethylation upregulated lncRNA2919 expression, and it was found that DNA methylation could prevent the binding of EGR1 to the lncRNA2919 promoter region, thereby affecting lncRNA2919 transcriptional expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Guanjie Yuan, Weinuo Qu, Shichao Li, Ping Liang, Kangwen He, Anqin Li, Jiali Li, Daoyu Hu, Chuou Xu, Zhen Li
Summary: Histogram analysis based on diffusion kurtosis imaging (DKI) is feasible for the noninvasive assessment of renal function and fibrosis in CKD patients.
JAPANESE JOURNAL OF RADIOLOGY
(2023)
Article
Polymer Science
Ji Jia, Jiali Li, Si Ma, Zhenwei Zhang, Xiaoming Liu
Summary: In this study, a new covalent organic framework material, COF-JLU82, is designed and synthesized. It exhibits good electrocatalytic activity for the oxygen reduction reaction (ORR), with better performance compared to the previously reported COF-JLU23. This study enriches the types of COF-based ORR electrocatalysts and promotes the development of more highly efficient metal-free ORR electrocatalysts.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Tiankai Chen, Jiali Li, Pengfei Cai, Qiaofeng Yao, Zekun Ren, Yixin Zhu, Saif Khan, Jianping Xie, Xiaonan Wang
Summary: Rapid and accurate chemical composition identification is crucial in chemistry. Optical absorption spectrometry has limitations in identifying complex chemical compositions, especially in nano-scale research. In this study, a machine-learning-based method is developed to identify the compositions of metal nanoclusters (NCs) from featureless spectra. The method achieves good matches and low error values on optical absorption spectra that are difficult for humans to interpret. This work opens up possibilities for precise identification of nanomaterials based on their optical properties.
Article
Engineering, Environmental
Jun Yin, Jiali Li, Iftekhar A. Karimi, Xiaonan Wang
Summary: Modeling is crucial for reactor or process design, control, and optimization, but developing high-fidelity mechanistic models for complex reactor systems is time-consuming. Machine learning models using data-driven methods can fill the gap between complex systems and limited knowledge. This research presents a machine learning model architecture specifically for dynamic modeling of general flow reactors, achieving higher model accuracy, data efficiency, and model interpretability than commonly used models.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Physics, Applied
Mitu C. Acharjee, Haopeng Li, Ryan Rollings, Bo Ma, Steve Tung, Jiali Li
Summary: In this study, a silicon nitride nanopore-based sensing system was used to measure tau and tubulin monomers and their aggregations in salt solution at a single molecule level. It was found that the nanopore method could differentiate tau and tubulin proteins in their monomer and aggregated forms based on their excluded volumes. The most probable aggregation forms were dimer for alpha- and beta-tubulin and pentamer for alpha beta tubulin plus tau under experimental conditions. The protein excluded volumes measured by the nanopore method depended on the applied voltage, and this could be explained by the nonuniform charge distribution of proteins. The monomer and aggregated proteins were further analyzed using atomic force spectroscopy (AFM), and protein volumes estimated by AFM were consistent with nanopore results.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Plant Sciences
Aijun Huang, Peipei Gu, Ying Wang, Jiali Li, Zhixun Yang, Long Yi
Summary: A multiplex RT-PCR assay was developed for the simultaneous detection and differentiation of four viruses infecting passion fruit. The assay showed high specificity and sensitivity, and was able to accurately detect the viruses in field samples.
TROPICAL PLANT PATHOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Haitao Yang, Jiali Li, Kai Zhuo Lim, Chuanji Pan, Tien Van Truong, Qian Wang, Kerui Li, Shuo Li, Xiao Xiao, Meng Ding, Tianle Chen, Xiaoli Liu, Qian Xie, Pablo Valdivia y Alvarado, Xiaonan Wang, Po-Yen Chen
Summary: This study presents a machine learning approach to design and fabricate high-performance strain sensors. A three-stage machine learning framework is used to automate the design process, with data augmentation and genetic algorithm optimization to improve prediction accuracy. Several data-driven design rules are determined through nanomaterial combinations and experimental validation.
NATURE MACHINE INTELLIGENCE
(2022)
Article
Materials Science, Multidisciplinary
Zekun Ren, Siyu Isaac Parker Tian, Juhwan Noh, Felipe Oviedo, Guangzong Xing, Jiali Li, Qiaohao Liang, Ruiming Zhu, Armin G. Aberle, Shijing Sun, Xiaonan Wang, Yi Liu, Qianxiao Li, Senthilnath Jayavelu, Kedar Hippalgaonkar, Yousung Jung, Tonio Buonassisi
Summary: This article presents a framework for general inverse design that generates new crystals with user-defined properties using generative models. The validity of these generated crystals is verified using first-principles calculations.