Article
Public, Environmental & Occupational Health
Bui Vu Huy, Dang Thi Thuy
Summary: The incidence of dengue is increasing globally, with clinical manifestations becoming more complex and unpredictable. In addition to shock and severe bleeding, damage to organs such as the neurological, hepatic, and renal systems has been linked to severity and mortality of the disease. Acute kidney injury (AKI) is a common complication in dengue patients that contributes to increased mortality rates.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Multidisciplinary Sciences
Chathurani Sigera, Chaturaka Rodrigo, Nipun L. de Silva, Praveen Weeratunga, Deepika Fernando, Senaka Rajapakse
Summary: This study aimed to characterize the direct costs of managing hospitalized patients with suspected dengue infection in Sri Lanka. The findings suggest that confirming dengue diagnosis using subsidized tests for patients presenting in the first three days of fever may be cost-efficient, as non-dengue patients incur a similar cost per day as dengue patients.
Article
Chemistry, Analytical
Pei-Shan Tsai, Pin-Xian Du, Batuhan Birol Keskin, Nan-Yao Lee, Shu-Wen Wan, Ya-Lan Lin, Wen-Yu Su, Pei-Chun Lin, Wei-Hsun Lin, Hsi-Chang Shih, Tzong-Shiann Ho, Guan-Da Syu
Summary: This study aims to analyze the humoral immunity and cross-reactivity in dengue patients using a multiplexed protein microarray. The results show that patients with severe dengue have higher levels of IgG antibodies against multiple Flavivirus antigens. Logistic regression analysis identifies groups of markers that can effectively distinguish dengue patients from healthy controls and hospitalized patients from mild cases.
ANALYTICAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Ruixue Hou, Lewis E. Tomalin, Jessica Pintado Silva, Seunghee Kim-Schulze, Stephen S. Whitehead, Ana Fernandez-Sesma, Anna P. Durbin, Mayte Suarez-Farinas
Summary: Understanding the immune response to dengue virus is crucial for dengue vaccine development. This study showed that the tetravalent vaccine has better protective effects against DENV compared to the trivalent admixture. Additionally, differences in immune responses between Black and White participants were observed.
Article
Public, Environmental & Occupational Health
Fernando Rosso, Luis G. Parra-Lara, Olga L. Agudelo-Rojas, Diana M. Martinez-Ruiz
Summary: This study described the initial symptoms and laboratory test values of patients with dengue or COVID-19 in Cali, Colombia, and found that differences in neutrophil-lymphocyte ratio, platelet count, and absolute neutrophil count within 10 days of symptom onset could help differentiate between the two diseases. These findings may be useful in resource-limited geographical areas.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Multidisciplinary Sciences
Sutopa Talukdar, Vipa Thanachartwet, Varunee Desakorn, Supat Chamnanchanunt, Duangjai Sahassananda, Mukda Vangveeravong, Siripen Kalayanarooj, Anan Wattanathum
Summary: This study identified factors associated with plasma leakage in dengue patients, including body mass index, platelet count, and AST or ALT levels. By assigning a weighted score to each factor, plasma leakage occurrence can be predicted effectively.
Article
Public, Environmental & Occupational Health
Ikram Waheed, Samreen Khalid, Zubia Jamil
Summary: The study identified clinical parameters (such as bleeding and rash) and laboratory parameters (such as thrombocytopenia and secondary infection) as determinants of complicated dengue infection. A history of previous symptomatic dengue and positive IgG antibodies also increased the risk of severe complicated dengue.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Laura Teysseyre, Yael Levy, Amelie Renou, Charles Vidal, Mathilde Larghi, Guillaume Biland, Nicolas Ledieu, Nicolas Allou, Julien Jabot, Jerome Allyn
Summary: Dengue disease is rapidly spreading worldwide, with fulminant dengue myocarditis cases more common than previously thought. Treatment of fulminant dengue myocarditis remains challenging, especially in cases of cardiogenic shock.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Review
Public, Environmental & Occupational Health
Muhammad Bilal Khan, Zih-Syuan Yang, Chih-Yen Lin, Ming-Cheng Hsu, Aspiro Nayim Urbina, Wanchai Assavalapsakul, Wen-Hung Wang, Yen-Hsu Chen, Sheng-Fan Wang
Summary: Dengue is a disease caused by dengue virus infection, and its clinical manifestations vary. Currently, there is a lack of effective antiviral drugs and vaccines, so it is necessary to study the virus characteristics, epidemiology, and develop treatment and control strategies.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Hiroshi Koyama, Wirongrong Chierakul, Prakaykaew Charunwatthana, Natpatou Sanguanwongse, Benjaluck Phonrat, Udomsak Silachamroon, Arjen M. Dondorp
Summary: Lung ultrasound (LUS) is a more sensitive method than chest X-ray for detecting pathological pulmonary changes in dengue patients, especially for the early detection of pleural effusions and pulmonary edema signifying capillary leakage. Abnormal LUS findings, including aeration patterns, pleural effusion, and subpleural abnormalities, were observed more frequently in the critical-convalescence phase than in the febrile phase, demonstrating the potential of LUS in early detection of capillary leakage in dengue patients.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
Article
Medicine, General & Internal
Imaniar Noor Faridah, Haafizah Dania, Yen-Hsu Chen, Woro Supadmi, Barkah Djaka Purwanto, Mochammad Junaidy Heriyanto, Mahda Adil Aufa, Wei-Chiao Chang, Dyah Aryani Perwitasari
Summary: This study aimed to identify factors related to dengue hemorrhagic fever (DHF) and understand the distribution of biochemical laboratory data in dengue patients. On-admission platelet counts and hemoglobin laboratory data were found to be useful predictors of DHF. DHF patients had significantly prolonged hospitalizations compared to dengue fever patients.
Article
Multidisciplinary Sciences
Rahul Shukla, Richa Ahuja, Hemalatha Beesetti, Amit Garg, Charu Aggarwal, Shivam Chaturvedi, Kaushal Nayyar, Upasana Arora, Altaf A. Lal, Navin Khanna
Summary: Sinococuline, an active ingredient of AQCH, protects against antibody-mediated secondary-DENV infection by reducing serum viremia and tissue-viral load and inhibiting the expression of proinflammatory cytokines in vital organs.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Tehani Silva, Chandima Jeewandara, Laksiri Gomes, Chathurika Gangani, Sameera D. Mahapatuna, Thilagaraj Pathmanathan, Ananda Wijewickrama, Graham S. Ogg, Gathsaurie Neelika Malavige
Summary: The study found that levels of urinary LTE4 were significantly higher in patients who developed dengue hemorrhagic fever, while urinary histamine levels were significantly elevated in acute dengue patients. Interestingly, LTE4, histamine, and viral loads showed marked diurnal variation in both dengue fever and dengue hemorrhagic fever patients.
Article
Multidisciplinary Sciences
Layanna Freitas de Oliveira, Amanda Araujo Serrao de Andrade, Carla Pagliari, Leda Viegas de Carvalho, Taiana S. Silveira, Jedson Ferreira Cardoso, Andre Luiz Teles e Silva, Janaina Mota de Vasconcelos, Caroline Aquino Moreira-Nunes, Rommel Mario Rodriguez Burbano, Marcio Roberto Teixeira Nunes, Eduardo Jose Melo dos Santos, Joao Lidio da Silva Goncalves Vianez Junior
Summary: The study analyzed the microRNA expression profile in the liver tissue of dengue hemorrhagic fever (DHF) cases, revealing differential expression of certain microRNAs such as miR-126-5p, miR-122-5p, and miR-146a-5p. These microRNAs are involved in several crucial biological processes during DHF liver pathogenesis, including endothelial repair, vascular permeability regulation, homeostasis control, and inflammatory cytokine expression.
SCIENTIFIC REPORTS
(2021)
Article
Public, Environmental & Occupational Health
Alejandro E. Macias, Guilherme L. Werneck, Raul Castro, Cesar Mascarenas, Laurent Coudeville, David Morley, Vincent Recamier, Mariana Guergova-Kuras, Adrien Etcheto, Esteban Puentes-Rosas, Nicolas Baurin, Myew-Ling Toh
Summary: Dengue patients with comorbidities face a higher risk of death, with comorbidities significantly increasing case fatality rates. Patients with pulmonary disorders, ischemic heart disease, and renal disease/failure have significantly higher odds of in-hospital mortality. Comorbidities play a major role in increasing the risk of death from dengue.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2021)
