Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex

Entropy-Enthalpy Compensation: Role and Ramifications in Biomolecular Ligand Recognition and Design

(2013) John D. Chodera et al.   Annual Review of Biophysics

Molecular Recognition and Ligand Association

(2013) Riccardo Baron et al.   Annual Review of Physical Chemistry

Computational design, construction, and characterization of a set of specificity determining residues in protein-protein interactions

(2013) Chioko Nagao et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Impact of linker and conjugation chemistry on antigen binding, Fc receptor binding and thermal stability of model antibody-drug conjugates

(2012) Mauro Acchione et al.   mAbs

Antibody-enabled small-molecule drug discovery

(2012) Alastair D. G. Lawson   NATURE REVIEWS DRUG DISCOVERY

Computer-aided antibody design

(2012) D. Kuroda et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Biosimilar, biobetter and next generation therapeutic antibodies

(2011) Alain Beck   mAbs

The improvement of an anti-CD22 immunotoxin

(2011) Seiji Kawa et al.   mAbs

Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies

(2011) M. Muda et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Free energy perturbation approach for the rational engineering of the antibody for human hepatitis B virus

(2010) Hwangseo Park et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Fundamental Aspects of Protein−Protein Association Kinetics

(2009) G. Schreiber et al.   CHEMICAL REVIEWS

Contributions of Interfacial Residues of Human Interleukin15 to the Specificity and Affinity for Its Private α-Receptor

(2009) Sou Sakamoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Modulation of Antibody Pharmacokinetics by Chemical Polysialylation

(2008) Antony Constantinou et al.   BIOCONJUGATE CHEMISTRY

Affinity maturation of antibodies assisted byin silicomodeling

(2008) Rodrigo Barderas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA