Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Physiology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: The study reveals that Qishen Yiqi dripping pill exerts renal-protective function by inhibiting the Wnt/beta-catenin and TGF-beta/Smad2 signaling pathways in diabetic rats, as evidenced by reduced levels of serum markers and improved kidney histology and fibrosis.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jung-Il Kang, Youn Kyung Choi, Sang-Chul Han, Hyunwoo Nam, Gilwoo Lee, Ji-Hoon Kang, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee-Kyoung Kang
Summary: This study found that BDB promotes hair growth in rat models by activating the Wnt/β-catenin and autophagy pathways, while inhibiting the TGF-β pathway, thus regulating the hair cycle.
Article
Medicine, General & Internal
Lin Hu, Yuyang Wang, Yuzhou Wan, Liang Ma, Tingting Zhao, Ping Li
Summary: The study showed that Tangshen Formula can reduce the expression of myocardial fibrosis-related markers and protect cardiac fibroblasts from damage. Additionally, it regulates the TGF-beta/Smad2/3 and Wnt/beta-catenin signaling pathways to alleviate myocardial fibrosis.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang, Minghai Wang
Summary: This study found that MFAP5 regulates osteogenesis in BMSCs through the Wnt/beta-catenin and AMPK signaling pathways, and may serve as a therapeutic target for patients with osteoporosis.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jinwu Bai, Weijun Zhang, Chenwei Zhou, Guangfeng Zhao, Huiming Zhong, Kai Hang, Jianxiang Xu, Wei Zhang, Erman Chen, Jiaqi Wu, Ling Liu, Deting Xue
Summary: MFG-E8 promotes osteogenic differentiation of BMSCs by regulating the GSK3 beta/beta-catenin signaling pathway and therefore, is a potential therapeutic target. This study has important clinical significance in addressing fracture nonunion and bone defects.
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell Biology
Qing Wang, En Ma, Da Wo, Jinxiao Chen, Jia He, Jun Peng, Weidong Zhu, Dan-ni Ren
Summary: The study demonstrated that Huoxin pill (HXP) effectively protects against myocardial infarction-induced cardiac injuries, improves cardiac function, and reduces oxidative stress-induced DNA damage by inhibiting Wnt/beta-catenin signalling pathway activation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Simon Lin, Subramanya Pandruvada, Hong Yu
Summary: Treatment with S1PR2 antagonist or S1PR2 shRNA enhanced osteogenesis in BMSCs via different signaling pathways, including increased vesicle trafficking-associated proteins and activation of Wnt/Ca2+ signaling, BMP/Smad signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Genetics & Heredity
Katerina K. Yamamoto, Cathy Savage-Dunn
Summary: This article summarizes the roles of transforming growth factor-beta (TGF-beta) signaling in aging and immunity, highlighting the significance of using Caenorhabditis elegans as a research model.
FRONTIERS IN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Cuidi Xu, Hongli Shi, Xin Jiang, Yongqian Fan, Donghui Huang, Xinming Qi, Qun Cheng
Summary: ZEB1 is a key transcription factor in BMSC differentiation, playing a crucial role in maintaining bone health. Silencing ZEB1 can enhance osteogenesis and inhibit bone loss.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Mei-Jen Hsieh, Ching-Chieh Weng, Yu-Chun Lin, Chia-Chen Wu, Li-Tzong Chen, Kuang-Hung Cheng
Summary: This study revealed the importance of the Wnt/β-catenin signaling pathway in pancreatic cancer, showing that loss of LKB1 affects cystadenoma development and that the beta-catenin inhibitor FH535 can effectively suppress LKB1 loss-driven cystadenoma and slow down pancreatic cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Hao Zhang, Chuanchuan Zheng, Wei Chen, Xiaoqiang Li, Jinshu Wang, Taikun Wang, Qi Zhao, Hao Huang, Yiting Li, Chengliang Yang, Kegong Xie, Shengcai Pan, Binghao Wang, Chong Wang, Yujin Tang, Kai Li, Jia Liu, Liqiang Wang
Summary: Our study demonstrates that targeting Src with PP2 can inhibit Wnt/beta-catenin signaling and activate TGF-beta/Smad signaling, thus protecting against cartilage destruction in OA. This provides a potential therapeutic target for OA treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Fang Shen, Celiang Wu, Xiaomei Zhong, En Ma, Jun Peng, Weidong Zhu, Da Wo, Dan-ni Ren
Summary: The study aims to evaluate the cardioprotective effects of Liensinine (LSN) following myocardial infarction (MI) and its underlying mechanisms. Results showed that LSN administration effectively reduced ischemic damage and improved cardiac function. It was also found that LSN inhibits the Wnt/beta-catenin signaling pathway, leading to prevention of oxidative stress and DNA damage. These findings suggest a novel therapeutic potential of LSN or plants containing LSN in ischemic heart diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Transplantation
Milica Bozic, Juan M. Diaz-Tocados, Marcelino Bermudez-Lopez, Carles Forne, Cristina Martinez, Elvira Fernandez, Jose M. Valdivielso
Summary: The study found that SHPT and hyperphosphatemia are independently associated with CKD progression and cardiovascular event incidence in CKD patients, while hypercalcemia does not act as an effect modifier for SHPT.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Jordi Bover, Pedro Trinidad, Aquiles Jara, Jordi Soler-Majoral, Alejandro Martin-Malo, Armando Torres, Joao Frazao, Pablo Urena, Adriana Dusso, Carolt Arana, Fredzzia Graterol, Gregorio Romero, Maribel Troya, Diana Samaniego, Luis D'Marco, Jose Manuel Valdivielso, Elvira Fernandez, Maria Dolores Arenas, Vicente Torregrosa, Juan F. Navarro-Gonzalez, Maria Jesus Lloret, J. A. Ballarin, Ricardo J. Bosch, Jose L. Gorriz, Angel Luis Martin de Francisco, Orlando Gutierrez, Jordi Ara, Arnold Felsenfeld, Antonio Canalejo, Yolanda Almaden
Summary: This article reviews the research on the role of inorganic phosphates (PO43-) in secondary hyperparathyroidism in chronic kidney disease over the past 25 years. It highlights the direct effect of PO43- on parathyroid hormone synthesis and secretion, as well as the importance of PO43- overload in systemic pathogenesis.
Article
Nutrition & Dietetics
Angela Vidal, Carmen Pineda, Ana I. Raya, Rafael Rios, Azahara Espartero, Juan R. Munoz-Castaneda, Mariano Rodriguez, Escolastico Aguilera-Tejero, Ignacio Lopez
Summary: Increased dietary acid load leads to metabolic acidosis, which decreases the concentration of FGF23 in the plasma of rats, and this effect is related to the decrease in PTH.
Article
Nutrition & Dietetics
Maria Crespo-Masip, Aurora Perez-Gomez, Alicia Garcia-Carrasco, Ramiro Jover, Carla Guzman, Xavier Dolcet, Merce Ibarz, Cristina Martinez, Auria Eritja, Juan Miguel Diaz-Tocados, Jose Manuel Valdivielso
Summary: This study found that lack of vitamin D signaling increases mortality in a model of overactivation of the insulin receptor by impairing lipid metabolism. These findings highlight the importance of adequate vitamin D levels in patients with type 1 diabetes.
Article
Transplantation
Noemi Vergara, M. Victoria Pendon-Ruiz de Mier, Cristian Rodelo-Haad, Gonzalo Revilla-Gonzalez, Cristina Membrives, Juan M. Diaz-Tocados, Julio M. Martinez-Moreno, Ana Torralbo, Carmen Herencia, Maria Encarnacion Rodriguez-Ortiz, Rodrigo Lopez-Baltanas, Williams G. Richards, Arnold Felsenfeld, Yolanda Almaden, Alejandro Martin-Malo, Juan Urena, Rafael Santamaria, Sagrario Soriano, Mariano Rodriguez, Juan R. Munoz-Castaneda
Summary: This study found that high levels of FGF23 can cause a change in VSMC phenotype from contractile to synthetic by regulating the expression of miR-221/222. This change increases arterial stiffening and impairs vascular function, which may worsen cardiovascular disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Sandra Rayego-Mateos, Nuria Dolade, Alicia Garcia-Carrasco, Juan Miguel Diaz-Tocados, Merce Ibarz, Jose Manuel Valdivielso
Summary: This study found that Ca2+ can increase FGF23 levels independently of vitamin D and PTH, but the increase is lower in cells and animal models lacking VDR, and part of the increase is mediated by vitamin D signaling.
Article
Biochemistry & Molecular Biology
Rodrigo Lopez-Baltanas, Maria E. Rodriguez-Ortiz, Juan M. Diaz-Tocados, Julio M. Martinez-Moreno, Cristina Membrives, Cristian Rodelo-Haad, M. Victoria Pendon Ruiz de Mier, Mariano Rodriguez, Antonio Canalejo, Yolanda Almaden, Juan R. Munoz-Castaneda
Summary: This study evaluated whether dietary Mg supplementation could reduce vascular dysfunction in patients with concurrent MetS and CKD by modulating oxidative stress and inflammation. The results showed that dietary Mg supplementation reduced inflammation and oxidative stress, and improved vascular function.
Article
Chemistry, Physical
Fatima Guerrero, Andres Carmona, Victoria Vidal, Ana Franco, Alejandro Martin-Malo, Elena M. Sanchez-Fernandez, Carolina Carrillo-Carrion
Summary: An effective antioxidant nanoplatform, DSeU@ZIF8, was constructed by encapsulating a selenium-containing glycomimetic into zeolitic-imidazolate framework-8 nanoparticles. The nanoparticles showed remarkable antioxidant capacity and ROS-scavenging activity, and could protect endothelial cells from oxidative stress damage.
NANOSCALE HORIZONS
(2023)