Article
Biochemistry & Molecular Biology
Tasnim Arroum, Marie-Theres Borowski, Nico Marx, Frank Schmelter, Martin Scholz, Olympia Ekaterini Psathaki, Michael Hippler, Jose Antonio Enriquez, Karin B. Busch
Summary: The mitochondrial respiratory or electron transport chain (ETC) and ATP synthase collaborate in the process of oxidative phosphorylation (OXPHOS) to convert reduction power into ATP. Supramolecular assemblies known as respiratory supercomplexes (SC) are formed by three out of the four ETC complexes to adapt to changing conditions. NDUFB10, a subunit of complex I, plays a role in complex I and supercomplex assembly as well as bioenergetics function. NDUFB10 knockout results in decreased SCAF1, reduced respiration, and mitochondrial membrane potential, potentially due to loss of proton pumping.
BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jie Wang, Long-Jiang Yu, Wenda Wang, Qiujing Yan, Tingyun Kuang, Xiaochun Qin, Jian-Ren Shen
Summary: Photosystem I (PSI), a crucial component in photosynthesis, has been structurally analyzed in complex with light-harvesting complex I (LHCI) to reveal the arrangement of proteins, cofactors, and newly identified lipid molecules. The research sheds light on the mechanisms of light-energy harvesting, transfer, and supercomplex assembly.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2021)
Article
Neurosciences
Xiaoyan Zhang, Hawley E. Kunz, Kevin Gries, Corey R. Hart, Eric C. Polley, Ian R. Lanza
Summary: Healthy older adults exhibit lower cardiorespiratory fitness (V?O2peak) compared to young individuals, mainly due to changes in central hemodynamics. While total physical activity levels do not differ by age, moderate-to-vigorous physical activity is lower in older adults. Moderate-to-vigorous physical activity is associated with V?O2peak and muscle oxidative capacity, but cannot fully explain the age-related decline in fitness.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Multidisciplinary Sciences
Patricia Gonzalez-Rodriguez, Enrico Zampese, Kristen A. Stout, Jaime N. Guzman, Ema Ilijic, Ben Yang, Tatiana Tkatch, Mihaela A. Stavarache, David L. Wokosin, Lin Gao, Michael G. Kaplitt, Jose Lopez-Barneo, Paul T. Schumacker, D. James Surmeier
Summary: Loss of functional mitochondrial complex I in dopaminergic neurons can lead to a shift in metabolism in mice, causing Parkinson's disease-like symptoms. This study challenges the traditional paradigm of Parkinson's disease by showing that dysfunction of mitochondrial complex I alone is sufficient to cause progressive parkinsonism.
Letter
Genetics & Heredity
Cheng Cheng, James Cleak, Lan Weiss, Heather Cater, Michelle Stewart, Sara Wells, Rod Carlo Columbres, Alyaa Shmara, C. Alejandra Morato Torres, Faria Zafar, Birgitt Schule, Jonathan Neumann, Eli Hatchwell, Virginia Kimonis
Summary: Variants in the NUBPL gene are associated with complex I deficiency mitochondrial disease, which causes neurological symptoms. By generating a mouse model with a patient-specific Nubpl variant, researchers found that the variant might be a hypomorph allele. No significant link between aging-related behaviors and Parkinson's disease markers was found. They suggest the use of tissue-specific knockout strategy to establish a mouse model for further research.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Thomas Buttgereit, Moritz Pfeiffenberger, Stefan Frischbutter, Pierre-Louis Krauss, Yuling Chen, Marcus Maurer, Frank Buttgereit, Timo Gaber
Summary: The role of mitochondrial respiration in immune functions of human skin mast cells is important. Inhibiting mitochondrial respiration may provide potential options for controlling mast cell-driven skin symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Pin-Shiuan Chen, Ni-Chung Lee, Chieh-Ju Sung, Ya-Wen Liu, Wen-Chin Weng, Pi-Chuan Fan, Wang-Tso Lee, Yin-Hsiu Chien, Chao-Szu Wu, Yueh-Feng Sung, Ming-Chen Tsai, Yi-Chung Lee, Hsueh-Wen Hsueh, Sabrina Mai-Yi Fan, Meng-Chen Wu, Hsun Li, Huan-Yun Chen, Han- Lin, Chih-Hsin Ou-Yang, Wuh-Liang Hwuh, Chin-Hsien Lin
Summary: This study describes the clinical characteristics and functional findings in a cohort of patients with NDUFAF5 mutations, and reveals significant heterogeneity and divergent prognosis based on age at onset. This research is important for understanding the association between NDUFAF5 mutations and Leigh syndrome.
MOVEMENT DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Eugenia Trushina, Sergey Trushin, Md Fayad Hasan
Summary: Alzheimer's disease, the most common form of dementia in the elderly, has no cure. Emerging data suggest that mitochondria can initiate an integrated stress response that is beneficial for healthy aging and neuroprotection. Partial inhibition of mitochondrial complex I has been explored as a treatment strategy for various diseases, including Alzheimer's disease.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Neurosciences
Milena Pinto, Francisca Diaz, Nadee Nissanka, Chelsey S. Guastucci, Placido Illiano, Roberta Brambilla, Carlos T. Moraes
Summary: Mitochondrial dysfunctions may not be the cause of amyloid accumulation in Alzheimer's disease. Inducing mitochondrial dysfunction in adult mice neurons resulted in mild oxidative stress but decreased amyloid pathology and altered amyloid precursor protein clearance pathway.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cell Biology
Wanda van der Stel, Huan Yang, Sylvia E. le Devedec, Bob van de Water, Joost B. Beltman, Erik H. J. Danen
Summary: Cells can adjust mitochondrial morphology to adapt to stress by altering the balance between mitochondrial fission and fusion. This study used high-throughput high-content confocal microscopy to investigate the effects of different oxidative phosphorylation complex inhibitors on mitochondrial parameters. It was found that complex V inhibitors caused mitochondrial fragmentation and cleavage of the fusion protein OPA1.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Plant Sciences
Christo Schiphorst, Luuk Achterberg, Rodrigo Gomez, Rob Koehorst, Roberto Bassi, Herbert van Amerongen, Luca Dall'Osto, Emilie Wientjes
Summary: The light-harvesting antennae of photosystem I facilitate energy transfer from trimeric light-harvesting complex II to photosystem I, and the presence of LHCI significantly enhances the efficiency of energy transfer.
Article
Biochemistry & Molecular Biology
Abi S. Ghifari, Aneta Ivanova, Oliver Berkowitz, James Whelan, Monika W. Murcha
Summary: This study describes the mechanism by which the abundance of Complex I (CI) is regulated in a CI-deficient Arabidopsis thaliana mutant. The interaction between the CI subunit PSST and FTSH3 facilitates the disassembly of the CI matrix arm domain for turnover, ensuring protein quality control in the face of oxidative damage. The study reveals the molecular process by which FTSH3 recognizes CI for degradation at the amino acid level.
Article
Biochemistry & Molecular Biology
Paulina Kozakiewicz, Ludmila Grzybowska-Szatkowska, Marzanna Ciesielka, Paulina Calka, Jacek Osuchowski, Pawel Szmygin, Bozena Jarosz, Marta Ostrowska-Lesko, Jaroslaw Dudka, Angelika Tkaczyk-Wlizlo, Brygida Slaska
Summary: Mitochondria are essential organelles for oxidative phosphorylation. The interest in their role in carcinogenesis arises from the discovery of respiratory deficits in dividing cells, especially those with accelerated proliferation. This study analyzed DNA from tumor and blood samples of 30 patients with glioma grade II, III, and IV. Next-generation sequencing was conducted to investigate the possible association between specific mitochondrial DNA polymorphisms in respiratory complex I genes and brain gliomas. In silico assessments were performed to determine the impact and potential harmfulness of missense changes in the encoded protein, as well as their mitochondrial subgroup affiliation. Deleterious changes, such as A3505G, C3992T, A4024G, T4216C, G5046A, G7444A, T11253C, G12406A, and G13604C polymorphisms, were identified, indicating their involvement in carcinogenesis.
Article
Cell Biology
Meng Gao, Yuan Qin, Anqi Li, Sailei Wei, Bilin Liu, Xiangang Tian, Guohua Gong
Summary: Previous research has shown that mitoflash genesis is functionally and mechanistically integrated with mitochondrial electron transport chain energy metabolism. Blocking the complete electron flow from Complex I to IV with ETC inhibitors abolishes mitoflashes triggered by substrates in adult permeabilized cardiomyocytes. The Qo site of Complex III is critical to mitoflash generation and activity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Signorile, Domenico De Rasmo
Summary: During aging in mammals, reactive oxygen species (ROS) produced by the mitochondrial respiratory chain cause oxidative damage and dysfunction in the respiratory chain, leading to an increase in ROS production. Oxidative stress has been extensively studied in the context of aging and age-related diseases, with complex I of the mitochondrial respiratory chain being identified as a major source of ROS and associated with neurodegeneration, human diseases, and aging. Activation of the cAMP signaling pathway has been investigated as a potential treatment for age-related diseases by regulating complex I activity and reducing ROS production. This review discusses the possible connection between complex I and the cAMP pathway in the aging process.
Article
Chemistry, Physical
Katharina Braun, Alexander Pochert, Mika Linden, Mina Davoudi, Artur Schmidtchen, Randi Nordstrom, Martin Malmsten
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2016)
Article
Pharmacology & Pharmacy
Lukas Boge, Anita Umerska, Nada Matougui, Helena Bysell, Lovisa Ringstad, Mina Davoudi, Jonny Eriksson, Katarina Edwards, Martin Andersson
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2017)
Article
Chemistry, Physical
S. Malekkhaiat Haffner, L. Nystrom, R. Nordstrom, Z. P. Xu, M. Davoudi, A. Schmidtchen, M. Malmsten
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2017)
Article
Chemistry, Physical
Randi Nordstrom, Lina Nystrom, Oliver C. J. Andren, Michael Malkoch, Anita Umerska, Mina Davoudi, Artur Schmidtchen, Martin Malmsten
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Mina Davoudi, Jukka Kallijarvi, Sanna Marjavaara, Heike Kotarsky, Eva Hansson, Per Leveen, Vineta Fellman
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
Artur Schmidtchen, Mukesh Pasupuleti, Matthias Morgelin, Mina Davoudi, Jan Alenfall, Anna Chalupka, Martin Malmsten
JOURNAL OF BIOLOGICAL CHEMISTRY
(2009)
Article
Multidisciplinary Sciences
Heike Kotarsky, Matthias Keller, Mina Davoudi, Per Leveen, Riitta Karikoski, David P. Enot, Vineta Fellman
Article
Multidisciplinary Sciences
Mina Davoudi, Heike Kotarsky, Eva Hansson, Jukka Kallijarvi, Vineta Fellman
Article
Pharmacology & Pharmacy
Lukas Boge, Karin Hallstensson, Lovisa Ringstad, Jenny Johansson, Therese Andersson, Mina Davoudi, Per Tomas Larsson, Margit Mahlapuu, Joakim Hakansson, Martin Andersson
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2019)
Article
Immunology
Erik Tenland, Nitya Krishnan, Anna Ronnholin, Sadaf Kalsum, Manoj Puthia, Matthias Morgelin, Mina Davoudi, Magdalena Otrocka, Nader Alaridah, Izabela Glegola-Madejska, Erik Sturegard, Artur Schmidtchen, Maria Lerm, Brian D. Robertson, Gabriela Godaly
Article
Chemistry, Physical
Randi Nordstrom, Oliver C. J. Andren, Shalini Singh, Michael Malkoch, Mina Davoudi, Artur Schmidtchen, Martin Malmsten
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Ganna Petruk, Malin Elven, Erik Hartman, Mina Davoudi, Artur Schmidtchen, Manoj Puthia, Jitka Petrlova
Summary: ApoE exhibits antibacterial activity against Gram-negative bacteria, particularly Pseudomonas aeruginosa and Escherichia coli. Interaction between apoE and endotoxin components of Gram-negative bacteria leads to structural changes in apoE and the formation of aggregate-like complexes.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Cell Biology
Maria Jassinskaja, Kristyna Pimkova, Nejc Arh, Emil Johansson, Mina Davoudi, Carlos-Filipe Pereira, Ewa Sitnicka, Jenny Hansson
Summary: This study used mass spectrometry and functional assays to investigate the proteomic mechanisms regulating hematopoiesis, revealing distinct features and differentiation capacities between fetal and adult lympho-myeloid multipotent progenitors and granulocyte-monocyte progenitors. The results suggest a specific requirement of myosin activity for myelopoiesis in adult multipotent progenitors and an ontogenic shift in monocytic differentiation capacity of granulocyte-monocyte progenitors driven by differential expression of Irf8.
Article
Nanoscience & Nanotechnology
Shalini Singh, Aritreyee Datta, Bruno C. Borro, Mina Davoudi, Artur Schmidtchen, Anirban Bhunia, Martin Malmsten
ACS APPLIED MATERIALS & INTERFACES
(2017)