Article
Public, Environmental & Occupational Health
Cheryl Cohen, Jackie Kleynhans, Jocelyn Moyes, Meredith L. McMorrow, Florette K. Treurnicht, Orienka Hellferscee, Azwifarwi Mathunjwa, Anne von Gottberg, Nicole Wolter, Neil A. Martinson, Kathleen Kahn, Limakatso Lebina, Katlego Mothlaoleng, Floidy Wafawanaka, Francesc Xavier Gomez-Olive, Thulisa Mkhencele, Angela Mathee, Stuart Piketh, Brigitte Language, Stefano Tempia
Summary: This study evaluated the burden and transmission of influenza in rural and urban settings in South Africa, finding that children, individuals with mild symptoms, and individuals with severe symptoms were more likely to transmit influenza.
LANCET GLOBAL HEALTH
(2021)
Article
Virology
Florencia Cancela, Romina Icasuriaga, Santiago Cuevas, Valentina Hergatacorzian, Mauricio Olivera, Yanina Panzera, Ruben Perez, Julieta Lopez, Liliana Borzacconi, Elizabeth Gonzalez, Natalia Montaldo, Melissa Gaitan, Sandra Lopez-Verges, Viviana Bortagaray, Matias Victoria, Rodney Colina, Juan Arbiza, Mabel Berois, Santiago Mirazo
Summary: This study provides insights into the molecular epidemiology of zoonotic HEV in Uruguay, revealing the circulation of a new HEV-3 subtype in different epidemiological settings.
Review
Microbiology
Bo Wang, Xiang-Jin Meng
Summary: Hepatitis E virus (HEV) is an important but understudied pathogen that can cause acute viral hepatitis and, in some cases, chronic infection with other manifestations. Various strains of HEV from different animal species have been identified, with the ability to cross species barriers and infect humans through consumption of animal meat or direct contact. The discovery of animal HEV variants provides opportunities for developing useful animal models for research on HEV.
CURRENT OPINION IN MICROBIOLOGY
(2021)
Article
Microbiology
Simone Eckstein, Rosina Ehmann, Abderraouf Gritli, Mohamed Ben Rhaiem, Houcine Ben Yahia, Manuel Diehl, Roman Woelfel, Susann Handrick, Mohamed Ben Moussa, Kilian Stoecker
Summary: The rapid spread of SARS-CoV-2 has demonstrated the potential harm of zoonotic diseases to public health. Africa, with limited medical resources, underreporting, and lack of active surveillance, carries a significant burden of neglected zoonotic diseases. Recent studies have found various pathogens in Tunisian dromedary camels, which have close contact with humans and pose a high risk of transmitting zoonotic diseases.
Article
Clinical Neurology
Liying Xing, Ru Li, Suli Zhang, Dan Li, Baojing Dong, Hong Zhou, Li Jing, Yuanmeng Tian, Shuang Liu
Summary: The study revealed a high prevalence of carotid atherosclerosis, plaque, stenosis, and uncontrolled risk factors in rural northeast China, particularly among men. Factors such as age, male gender, hypertension, diabetes, smoking, and lack of exercise were associated with carotid atherosclerosis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Infectious Diseases
Huai Wang, Weixin Chen, Wenting Zhou, Feng Qiu, Wenjiao Yin, Jingyuan Cao, Pei Gao, Qianli Yuan, Min Lv, Shuang Bai, Jiang Wu
Summary: The incidence of hepatitis A virus infection is low in Beijing, China, but the risk of outbreaks still exists. It is difficult to identify possible sources of infection among sporadic cases based on a routine surveillance system. Contaminated food consumption, particularly seafood consumption, was found to be the primary potential source of infection.
BMC INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Maria Casares-Jimenez, Transito Garcia-Garcia, Jose M. Suarez-Cardenas, Ana B. Perez-Jimenez, Maria A. Martin, Javier Caballero-Gomez, Carmen Michan, Diana Corona-Mata, Maria A. Risalde, Ignacio Perez-Valero, Rafael Guerra, Ignacio Garcia-Bocanegra, Antonio Rivero, Antonio Rivero-Juarez, Juan J. Garrido
Summary: Our study longitudinally monitored the presence of HEV and RHEV in wastewater samples and evaluated their possible correlation with human cases in Cordoba, Spain. The results showed that only one sample (0.9%) tested positive for HEV, while almost all samples (94.3%) tested positive for RHEV.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Ophthalmology
Yuanyuan Liu, Baoqun Yao, Xi Chen, Xueli Yang, Yong Liu, Zhenggao Xie, Xiaofeng Chen, Zhigang Yuan, Xingrong Wang, Dan Hu, Xiang Ma, Weiqi Gao, Ruifeng Wang, Yuzhong Yang, Song Chen, Jingkai Zhang, Zuoqing Song, Junsu Wang, Jing Wang, Jinyun Pei, Weijuan Wang, Meiyan Wang, Jun Gao, Hongwen Zhang, Lian Tan, Wei Du, Xuehui Pan, Gang Liu, Xiujuan Du, Xu Hou, Xin Gao, Zhen Zhang, Zhansheng Shen, Changfu Wu, Xiaochang Yan, Shaoye Bo, Xinghuai Sun, Nai-jun Tang, Chun Zhang, Hua Yan
Summary: This study investigated the prevalence of glaucoma and associated factors in rural populations in 10 provinces in China. The results showed a high prevalence of glaucoma in rural areas, with primary angle-closure glaucoma being the most common type. Increasing age, smoking, cerebral stroke, type 2 diabetes, higher education, and higher personal income were identified as significant risk factors for glaucoma. A family history of glaucoma was also associated with the prevalence of glaucoma and blindness.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Lingxian Qiu, Sheng Liu, Minglei Zhang, Guohua Zhong, Siying Peng, Jiali Quan, Hongyan Lin, Xiaowen Hu, Kongxin Zhu, Xingcheng Huang, Junchao Peng, Yue Huang, Shoujie Huang, Ting Wu, Jinbo Xu, Zifang Dong, Qi Liang, Wei Wang, Yingying Su, Jun Zhang, Ningshao Xia
Summary: This study aimed to evaluate the epidemiology and long-term effectiveness of varicella under moderate vaccination coverage in Ganyu District, Lianyungang City, Jiangsu Province. The results indicated that the low vaccination coverage may have contributed to the increasing incidence of varicella infection, and there was a shift of varicella cases to older age groups. The effectiveness of one dose of varicella vaccine was moderate and decreased over time. Therefore, it is urgent to increase vaccine coverage to reduce the incidence of varicella and prevent any potential age shift in infection.
Article
Immunology
Jill Lea Ramassamy, Chanceline Bilounga Ndongo, Patrick Nnuka, Maelle Antunes, Margot Le Mener, Edouard Betsem A. Betsem, Richard Njouom, Olivier Cassar, Arnaud Fontanet, Antoine Gessain
Summary: This study investigated the prevalence of HTLV-1 and associated risk factors in a rural population in Cameroon. The results suggest both iatrogenic and zoonotic transmission of HTLV-1 in Cameroon. Further research is needed to assess the risk of nosocomial transmission and guide the implementation of preventive measures.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Laura M. Grajeda, John P. McCracken, Monica Berger-Gonzalez, Maria Renee Lopez, Danilo Alvarez, Salvador Mendez, Oscar Perez, Celia Cordon-Rosales, Jakob Zinsstag
Summary: Through a One-Health surveillance project in three rural communities in Guatemala, it was found that combining health facility surveillance with household visits can improve sensitivity and representativeness of surveillance, particularly for detecting acute infections and animal deaths. However, health facility surveillance alone was found to be less representative, with underrepresentation of Spanish speakers and individuals with higher economic assets.
Article
Microbiology
Florence Nicot, Chloe Dimeglio, Marion Migueres, Nicolas Jeanne, Justine Latour, Florence Abravanel, Noemie Ranger, Agnes Harter, Martine Dubois, Sonia Lameiras, Sylvain Baulande, Sabine Chapuy-Regaud, Nassim Kamar, Sebastien Lhomme, Jacques Izopet
Summary: Establishing a p-distance cut-off for defining subtypes of HEV-3 based on genome sequences could harmonize genotyping and promote molecular epidemiology research on the virus.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Tingting Li, Ruoxi Wang, Yong Zhao, Shu Su, Huan Zeng
Summary: The study revealed that participants had limited awareness and knowledge on hepatitis B and hepatitis C, especially in relation to antidiscrimination policies. Unmarried individuals, those with secondary education and above, and individuals with higher incomes tended to have a higher level of understanding about hepatitis B and hepatitis C.
Article
Clinical Neurology
Jie Bao, Jie Liu, Zhiying Li, Zhen Zhang, Xiao Su, Jiayi Sun, Jun Tu, Jinghua Wang, Jidong Li, Yijun Song, Xianjia Ning
Summary: The burden of cognitive impairment and dementia is high in low- and middle-income countries. The impact of hypertension and its classification on cognitive function is controversial. This study investigates the influence of hypertension and its classification on cognitive function in a low-income population aged over 60 in northern China.
FRONTIERS IN NEUROLOGY
(2022)
Article
Immunology
Ian D. Plumb, Prabhu P. Gounder, Leisha D. Nolen, Stephanie C. Massay, Louisa Castrodale, Joseph McLaughlin, Mary Snowball, Chriss Homan, Noele P. Nelson, Rosalyn Singleton, Michael G. Bruce, Brian J. McMahon
Summary: After assessing the impact of hepatitis A vaccine in Alaska Native persons, it was found that only 6 cases of hepatitis A were identified from 1996 to 2018, all in unvaccinated adults. The study highlights the importance of achieving sufficient vaccination coverage over time to protect populations against hepatitis A.
CLINICAL INFECTIOUS DISEASES
(2021)
Editorial Material
Immunology
Lunzhi Yuan, Ming Zhou, Jian Ma, Xuan Liu, Peiwen Chen, Huachen Zhu, Qiyi Tang, Tong Cheng, Yi Guan, Ningshao Xia
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Feixue Wei, Ningshao Xia, Rebeca Ocampo, Marc T. Goodman, Nancy A. Hessol, Beatriz Grinsztejn, Ana P. Ortiz, Fanghui Zhao, Erna M. Kojic, Rupert Kaul, Isabelle Heard, Imran O. Morhason-Bello, Anna-Barbara Moscicki, Alexandra de Pokomandy, Joel M. Palefsky, Luana L. S. Rodrigues, Racheal S. Dube Mandishora, Reshmie A. Ramautarsing, Silvia Franceschi, Sheela Godbole, Fernanda K. Tso, Lynette J. Menezes, Chunqing Lin, Gary M. Clifford
Summary: Age-specific shifts in HPV16 prevalence from cervix to anus suggest that HPV infections may persist longer, or occur later in life, in the anus than cervix. This has important implications for using cervical screening results to direct anal cancer prevention.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Feixue Wei, Marc T. Goodman, Ningshao Xia, Jun Zhang, Anna R. Giuliano, Gypsyamber D'Souza, Nancy A. Hessol, Maarten F. Schim van der Loeff, Jianghong Dai, Karin Neukam, Alexandra de Pokomandy, I. Mary Poynten, Ronald B. Geskus, Joaquin Burgos, Isabelle Etienney, Anna Barbara Moscicki, Maria Gabriella Dona, Maura L. Gillison, Alan G. Nyitray, Rebecca G. Nowak, Evy Yunihastuti, Huachun Zou, Carmen Hidalgo-Tenorio, Nittaya Phanuphak, Jean Michel Molina, Alice M. Schofield, Stephen Kerr, Song Fan, Yong Lu, Jason J. Ong, Admire T. Chikandiwa, Sirinya Teeraananchai, Nicola Squillace, Dorothy J. Wiley, Joel M. Palefsky, Damien Georges, Catharina J. Alberts, Gary M. Clifford
Summary: This study provides a comprehensive analysis of the natural history of anal high-risk HPV infection and identifies differences among different risk groups. These findings are crucial for designing effective anal cancer prevention programs.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Immunology
Wenhui Xue, Tingting Li, Ying Gu, Shaowei Li, Ningshao Xia
Summary: The global changes have led to the emergence and transmission of various biological factors, resulting in the rise of emerging and reemerging infectious diseases. The study highlights recent advancements in molecular biology, virology, and genomics that have facilitated the development of innovative molecular tools for vaccine research. The strategic application of advanced molecular engineering tools can overcome traditional vaccine limitations and enhance vaccine efficacy.
EXPERT REVIEW OF VACCINES
(2023)
Article
Computer Science, Interdisciplinary Applications
Dongxu Zhang, Yang Yan, Yulin Huang, Bowen Liu, Qingbing Zheng, Jun Zhang, Ningshao Xia
Summary: We proposed an iterative denoising and clustering method based on a deep convolutional variational autoencoder and K-means++ to improve the clustering accuracy of cryo-EM images. Experimental results showed that the proposed method can generate reliable class average images and achieve better clustering accuracy and normalized mutual information than current methods.
IEEE TRANSACTIONS ON MEDICAL IMAGING
(2023)
Review
Virology
Yang Shi, Zihan Wang, Shengxiang Ge, Ningshao Xia, Quan Yuan
Summary: The HBcAg is a highly immunogenic antigen and the anti-HBc is traditionally considered as a serological marker of HBV infections. However, recent studies have shown the predictive value of quantitative anti-HBc level in the treatment response and clinical outcome of chronic HBV infections. This review summarizes the clinical values of qAnti-HBc in differentiating CHB phases, predicting treatment response, and providing disease prognosis.
Article
Chemistry, Analytical
Yi-Quan An, Shao-Lei Huang, Bang-Chao Xi, Xiang-Lian Gong, Jun-Hao Ji, You Hu, Yi-Jie Ding, Dong-Xu Zhang, Sheng-Xiang Ge, Jun Zhang, Ning-Shao Xia
Summary: This article proposes a temperature control strategy to significantly increase the ramp rates of solution temperature by switching microfluidic chips between multiple temperature zones and increasing the temperature difference between zones and the solution. A thermocycler with ultrafast nucleic acid amplification capabilities has been designed. The results show that the ramp rates of solution temperature are linearly related to temperature differences, with larger differences resulting in faster ramp rates. The thermocycler achieves 92% reduction in nucleic acid amplification time compared to conventional methods.
Review
Microbiology
Mengling Hao, Jiabao Tang, Shengxiang Ge, Tingdong Li, Ningshao Xia
Summary: Herpesviruses are important pathogens that infect humans and animals. Bacterial artificial chromosome (BAC) technology has advanced the manipulation of herpesvirus genomes, but the efficiency still needs improvement. This review summarizes the advancements and limitations of BAC-based gene editing and its application in viral research.
Review
Immunology
Yarong Zeng, Feihong Zou, Ningshao Xia, Shaowei Li
Summary: Researchers have recognized the important role of Vaccine Adjuvant Delivery Systems (VADS) in vaccine research. This paper reviews common types of vaccine adjuvant delivery carriers, discusses current research status and future trends, and emphasizes the importance of VADS in novel vaccine research. Understanding various delivery vehicles will facilitate the development of vaccine adjuvant research.
EXPERT REVIEW OF VACCINES
(2023)
Article
Immunology
Yue Huang, Jiabao Tang, Huan Yu, Qiaoqiao Song, Mengling Hao, Han Wang, Junxian Liu, Yue Dong, Mufeng Liang, Sijie Zhuang, Caihong Li, Jiangding Wang, Caihong Liang, Yingying Su, Tingdong Li, Ting Wu, Shengxiang Ge, Jun Zhang, Ningshao Xia
Summary: This study examines the value of maternal CMV serological testing in predicting intrauterine transmission in regions with high seropositivity rates. The study found no statistical association between maternal IgM antibodies and IgG avidity during pregnancy and intrauterine transmission. The presence of CMV DNAemia indicated a higher risk of cCMV infection. However, the difference in CMV shedding rates in urine was not significant.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Letter
Biochemistry & Molecular Biology
Yizhen Wang, Feibo Song, Siling Wang, Miaolin Lan, Tingdong Li, Huilin Guo, Yali Zhang, Shengxiang Ge, Zizheng Zheng, Ningshao Xia
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemical Research Methods
Shaolei Huang, Yiquan An, Bangchao Xi, Xianglian Gong, Zhongfu Chen, Shan Shao, Shengxiang Ge, Jun Zhang, Dongxu Zhang, Ningshao Xia
Summary: Nucleic acid detection is a method that directly identifies the presence of pathogenic microorganisms and has advantages of high sensitivity, commendable specificity, and a short window period. A real-time PCR system based on multiple temperature zones was proposed to solve the time-consuming problem, enabling fast detection speed and high sensitivity under extreme conditions.
Article
Biochemical Research Methods
Zihao Chen, Nan Liu, Yang Huang, Xiaoping Min, Xiangxiang Zeng, Shengxiang Ge, Jun Zhang, Ningshao Xia
Summary: In this study, a protein docking evaluation method called PointDE is proposed, which utilizes a 3D point cloud neural network. PointDE is able to capture the geometry of the point cloud and learn the interaction information from the protein interface, showing superior performance on public datasets and an antibody-antigen dataset.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2023)
