Curcuma longa Extract Associated with White Pepper Lessens High Fat Diet-Induced Inflammation in Subcutaneous Adipose Tissue

Background Supra-nutritional doses of curcumin, derived from the spice Curcuma longa, have been proposed as a potential treatm related to obesity. The aim of the present study was to test whether Curcuma longa extract rich in curcumin and asso doses compatible with human use, could modulate systemic inflammation in diet-induced obese mice. We questioned t and gut microbiota in the effect of Curcuma-P (R) in obesity. Methodology/Principal Findings Mice were fed either a control diet (CT), a high fat (HF) diet or a HF diet containing Curcuma longa extract (0.1 % of pepper (0.01 %) for four weeks. Curcumin has been usually combined with white pepper, which contain piperine, in or combination did not significantly modify body weight gain, glycemia, insulinemia, serum lipids and intestinal inflammato curcumin accumulated in the subcutaneous adipose tissue. Importantly, the co-supplementation in curcuma extract and pro-inflammatory cytokines expression in the subcutaneous adipose tissue, an effect independent of adiposity, immune of gut bacteria controlling inflammation. Conclusions/Significance These findings support that nutritional doses of Curcuma longa, associated with white pepper, is able to decrease infl tissue and this effect could be rather linked to a direct effect of bioactive metabolites reaching the adipose tissue, than composition.