Article
Cell Biology
Chathurika Henpita, Rajesh Vyas, Chastity L. Healy, Tra L. Kieu, Aditi U. Gurkar, Matthew J. Yousefzadeh, Yuxiang Cui, Aiping Lu, Luise A. Angelini, Ryan D. O'Kelly, Sara J. McGowan, Sanjay Chandrasekhar, Rebecca R. Vanderpool, Danielle Hennessy-Wack, Mark A. Ross, Timothy N. Bachman, Charles McTiernan, Smitha P. S. Pillai, Warren Ladiges, Mitra Lavasani, Johnny Huard, Donna Beer-Stolz, Claudette M. St. Croix, Simon C. Watkins, Paul D. Robbins, Ana L. Mora, Eric E. Kelley, Yinsheng Wang, Timothy D. O'Connell, Laura J. Niedernhofer
Summary: Cardiomyopathy is a progressive disease of the myocardium leading to impaired contractility. This study shows that endogenous genotoxic stress contributes to the development of cardiomyopathy by activating the p53 pathway and increasing oxidative stress, leading to cardiac myocyte apoptosis, dilated cardiomyopathy, and sudden death.
Review
Environmental Sciences
Yu Mou, Wenhao Liao, Yun Liang, Yuchen Li, Mei Zhao, Yaoyao Guo, Qin Sun, Jianyuan Tang, Zhilei Wang
Summary: Environmental pollution is changing with economic development. Most pollutants have stable chemical properties, strong migratory abilities, potential toxicity, and multiple exposure routes. Excessive discharge of harmful substances and emergence of unknown compounds in the food chain are exacerbating the severe issues of environmental pollution.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Food Science & Technology
Kasra Jahankhani, Niloofar Taghipour, Mohammad Mashhadi Rafiee, Maryam Nikoonezhad, Mahshid Mehdizadeh, Nariman Mosaffa
Summary: Trace elements and other micronutrients have a crucial role in growth, health, and immune system function. Estimating the serum levels of trace elements in hematologic malignancy patients can determine the severity of the tumor. In addition to conventional medicine, the use of dietary supplements, such as trace minerals, can enhance recovery and reduce inflammation in diseases like multiple myeloma.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ausra Nemeikaite-Ceniene, Per Haberkant, Dalius Kuciauskas, Frank Stein, Narimantas Cenas
Summary: This study reveals that heteroaromatic N-oxides exhibit antitumor, antibacterial, and antiprotozoal activities by enzymatic single-electron reduction, which initiates prooxidant processes. The main mechanism of their cytotoxicity under aerobic conditions is oxidative stress, rather than intranuclear oxidative stress as a main factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Christopher D. Pascoe, Neilloy Roy, Emily Turner-Brannen, Alexander Schultz, Jignesh Vaghasiya, Amir Ravandi, Andrew J. Halayko, Adrian R. West
Summary: Oxidative stress induced by OxPCs impairs epithelial cell function and barrier integrity, contributing to the pathological features of asthma. Mitochondrial dysfunction, lipid peroxidation, and reactive oxygen species generation are involved in a self-propagating cycle of pathological lipid metabolism. Antioxidant N-acetyl cysteine can partially restore cell function.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Article
Engineering, Multidisciplinary
Pan Diao, Fangping Jia, Xiaojing Wang, Xiao Hu, Takefumi Kimura, Takero Nakajima, Toshifumi Aoyama, Kyoji Moriya, Kazuhiko Koike, Naoki Tanaka
Summary: This study summarizes the findings from mouse models transgenic for the HCV genome, with a focus on the HCV core gene transgenic mice, elucidating the impact of the HCV core protein on HCC development, as well as the regulatory role of dietary habits on steatosis and hepatocarcinogenesis.
Article
Pharmacology & Pharmacy
Qiqi Xin, Weili Shi, Yan Wang, Rong Yuan, Yu Miao, Keji Chen, Weihong Cong
Summary: The study demonstrates that Pantao Pill (PTP) significantly improves cognitive impairment by regulating autophagy, apoptosis, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Samson M. Gichuki, Yavuz S. Yalcin, LaDonna Wyatt, William Ghann, Jamal Uddin, Hyeonggon Kang, Viji Sitther
Summary: The study shows that nZVIs-induced oxidative stress increases ROS levels in F. diplosiphon, resulting in significant enzyme responses and lipid peroxidation levels in the strains. Further research is needed to investigate the transduction mechanisms that lead to metabolic and epigenetic changes in response to nZVIs in F. diplosiphon.
Review
Neurosciences
Nur Musfirah Mahmud, Luminita Paraoan, Nurliza Khaliddin, Tengku Ain Kamalden
Summary: Thymoquinone, a naturally occurring compound with antioxidant, antibacterial, anti-inflammatory, and neuroprotective properties, has shown potential as a treatment for neurodegenerative diseases. Studies suggest that its anti-inflammatory and antioxidant properties may be the main mechanisms for its neuroprotective effects. This review aims to summarize and critically analyze the evidence of thymoquinone's effects and potential neuroprotective actions in ocular neurodegenerations.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Ines Sturmlechner, Chance C. Sine, Karthik B. Jeganathan, Cheng Zhang, Raul O. Fierro Velasco, Darren J. Baker, Hu Li, Jan M. van Deursen
Summary: Super-enhancers regulate genes that are important for specific cell functions or defining cell identity. Senescent cells have survival mechanisms that involve inhibiting p53-mediated apoptosis through multiple mechanisms, including binding to ribonucleases.
NATURE COMMUNICATIONS
(2022)
Article
Environmental Sciences
Yong Huang, Ziqin Wang, Yuyang Peng, Rong Xu, Jiajie Yan, Cong Xiong, Jinze Ma, Keyuan Zhong, Huiqiang Lu
Summary: Carboxin exhibits developmental and cardiotoxicity in zebrafish embryos, causing structural changes in the heart and disruption of heart developmental gene expression. Additionally, Carboxin induces oxidative stress and accumulation of reactive oxygen species (ROS) in zebrafish embryos, leading to mitochondrial damage and decreased ATPase activities. Carboxin also inhibits myocardial cell proliferation and decreases the number of blood cells in the heart, resulting in embryo death.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Infectious Diseases
Tawanny K. B. Aguiar, Felipe P. Mesquita, Nilton A. S. Neto, Francisco I. R. Gomes, Cleverson D. T. Freitas, Romulo F. Carneiro, Celso S. Nagano, Luciana M. R. Alencar, Ralph Santos-Oliveira, Jose T. A. Oliveira, Pedro F. N. Souza
Summary: Mo-CBP3-PepII, a synthetic peptide, exhibits potent activity against multidrug-resistant Cryptococcus neoformans. It targets the cells through multiple mechanisms including induction of reactive oxygen species (ROS), inhibition of enzyme activities, disruption of energy metabolism and DNA/RNA metabolism, as well as impact on protein metabolism, cytoskeleton, and cell wall organization. These findings suggest that Mo-CBP3-PepII could be a promising molecule for the development of new drugs against C. neoformans infections.
Article
Public, Environmental & Occupational Health
Jianhao Peng, Siyuan Wang, Yunlong Wang, Wanchao Yu, Yejun Zha, Shuxin Gao
Summary: Ozone pollution is a significant environmental concern and exposure to ozone increases the risk of metabolic liver disease. However, there is limited research on the mechanisms underlying the effects of ozone exposure on liver oxidative damage and lipid metabolism. In this study, human hepatocellular carcinoma cells were exposed to 200 ppb ozone for various durations. The results showed elevated levels of oxidative stress and disrupted lipid metabolism in the cells, leading to intracellular lipid accumulation.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Neurosciences
Musa O. Iliyasu, Sunday A. Musa, Sunday B. Oladele, Abdullahi I. Iliya
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by tau pathology and accumulation of amyloid-beta (Aβ). Aβ aggregation leads to oxidative stress, inflammatory cascade, and caspase activation, causing hyperphosphorylation of tau protein and formation of neurofibrillary tangles (NFTs). Acetylcholine degradation is accelerated, resulting in neurotransmitter deficiency and cognitive impairment. AD research is necessary to identify novel compounds for treatment and prevention, including those targeting Aβ, tau, neurotransmitter modulation, neuroinflammation, neuroprotection, and cognition enhancement.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Arya Iranmehr, Tsering Stobdan, Dan Zhou, Huiwen Zhao, Sergey Kryazhimskiy, Vineet Bafna, Gabriel G. Haddad
Summary: Using experimental evolution with fruit flies to analyze adaptation to extreme oxygen conditions, researchers found surprising synchronicity in selective sweeps, de novo mutations, and adaptive recombination events.
NATURE COMMUNICATIONS
(2021)
Review
Microbiology
Mikhail V. Golikov, Birke Bartosch, Olga A. Smirnova, Olga N. Ivanova, Alexander V. Ivanov
Summary: Viral infections have gained increased attention due to the emergence of novel zoonotic coronaviruses and the monkeypox virus. Research on viruses heavily relies on mammalian cell lines, but the traditional culture media used for these cells may have significant impacts on cell growth, phenotype, and metabolism. Recently, new culture media resembling human blood plasma have been developed in the field of biochemistry and metabolomics, and their potential role in viral replication and pathogenesis should be explored.
Article
Oncology
Stefan Petkov, Athina Kilpelaeinen, Ekaterina Bayurova, Anastasia Latanova, Dzeina Mezale, Ilse Fridrihsone, Elizaveta Starodubova, Juris Jansons, Alesja Dudorova, Ilya Gordeychuk, Britta Wahren, Maria Isaguliants
Summary: In this study, DNA immunization with drug-resistant HIV-1 protease (DR PR) was used to prevent the evolution of HIV-1 towards drug resistance. A consensus gene of PR of HIV-1 clade A FSU_A strain was designed and characterized. It was demonstrated that DNA immunization with DR PR protected mice against the growth and metastatic activity of tumor cells expressing the respective DR PR variant.
Article
Oncology
Olga A. Smirnova, Olga N. Ivanova, Irina T. Fedyakina, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev, Dmitry V. Yanvarev, Olga I. Kechko, Vladimir A. Mitkevich, Pavel O. Vorobyev, Vyacheslav S. Fedorov, Birke Bartosch, Vladimir T. Valuev-Elliston, Anastasiya L. Lipatova, Alexander V. Ivanov
Summary: This study found that the novel coronavirus can infect liver cancer cells and certain types of brain tumor cells, but not normal liver cells. Additionally, the study found that viral infection may lead to a decrease in the differentiation level of liver cells. Overall, these results suggest that liver dysfunction during COVID-19 is not caused by SARS-CoV-2 infection, and tumors may potentially serve as reservoirs for the virus during infection.
Article
Pharmacology & Pharmacy
Sergey Brezgin, Anastasiya Kostyusheva, Natalia Ponomareva, Ekaterina Bayurova, Alla Kondrashova, Anastasia Frolova, Olga Slatinskaya, Landysh Fatkhutdinova, Georgy Maksimov, Mikhail Zyuzin, Ilya Gordeychuk, Alexander Lukashev, Sergey Makarov, Alexander Ivanov, Andrey A. Zamyatnin Jr, Vladimir Chulanov, Alessandro Parodi, Dmitry Kostyushev
Summary: Biological nanoparticles, such as extracellular vesicles (EVs) and extracellular vesicle-mimetic nanovesicles (EMNVs), have been extensively studied as drug delivery vehicles in medical applications. This study investigated the properties and drug delivery abilities of EVs and EMNVs, and analyzed their use for delivering the chemotherapeutic drug doxorubicin. EMNVs were found to be more effectively internalized, while EVs showed higher intracellular release of doxorubicin.
Article
Biochemistry & Molecular Biology
Elena Matyugina, Ivan Petushkov, Sergei Surzhikov, Vasily Kezin, Anna Maslova, Olga Ivanova, Olga Smirnova, Ilya Kirillov, Irina Fedyakina, Andrey Kulbachinskiy, Sergey Kochetkov, Anastasia Khandazhinskaya
Summary: The SARS-CoV-2 pandemic has caused more than 6.5 million deaths and remains a significant global public health concern despite the availability of COVID-19 vaccines. The development of specific drugs for treating this disease is still an urgent task.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Olga N. Ivanova, George S. Krasnov, Anastasiya V. Snezhkina, Anna V. Kudryavtseva, Vyacheslav S. Fedorov, Natalia F. Zakirova, Michail V. Golikov, Sergey N. Kochetkov, Birke Bartosch, Vladimir T. Valuev-Elliston, Alexander V. Ivanov
Summary: ROS play a major role in cell regulation, and their increase is associated with the development of various pathologies. This study analyzed gene expression of redox systems and related metabolic processes in hepatoma cells and liver progenitor cell lines, shedding light on the redox biology of viral hepatitis and the influence of laboratory models.
Article
Biochemistry & Molecular Biology
Olga A. Smirnova, Olga N. Ivanova, Furkat Mukhtarov, Vladimir T. Valuev-Elliston, Artemy P. Fedulov, Petr M. Rubtsov, Natalia F. Zakirova, Sergey N. Kochetkov, Birke Bartosch, Alexander V. Ivanov
Summary: Hepatitis delta virus (HDV) enhances oxidative and ER stress induced by hepatitis B virus (HBV), aggravating HBV-associated pathologies.
Article
Microbiology
Andris Dishlers, Ivars Petrovskis, Dace Skrastina, Ieva Zarina, Ilva Lieknina, Juris Jansons, Inara Akopjana, Jelena Zakova, Velta Ose, Irina Sominskaya
Summary: The currently available HBV vaccines based on HBV surface protein manufacturing by yeasts are effective in preventing but not treating chronic HBV infection. This study utilized different HBV core proteins to create modified virus-like particles (VLPs) with high expression and immunogenicity. The incorporation of oligonucleotide ODN 1668 in the modified VLPs was also demonstrated.
Article
Microbiology
Karen K. Kyuregyan, Juris Jansons, Maria Isaguliants
Article
Gastroenterology & Hepatology
Sarah Duponchel, Lea Monnier, Jennifer Molle, Nadia Bendridi, Muhammad Rizwan Alam, Ahmed Gaballah, Boyan Grigorov, Alexander Ivanov, Marcel Schmiel, Margarete Odenthal, Michel Ovize, Jennifer Rieusset, Fabien Zoulim, Birke Bartosch
Summary: Chronic HCV infection causes cellular stress, fibrosis, and predisposes to hepatocarcinogenesis. Mitochondria play key roles in orchestrating stress responses. The study revealed that HCV proteins associate with mitochondria and alter the composition of mitochondrial subdomains, which are crucial for efficient viral replication.
Article
Biochemistry & Molecular Biology
Anastasia Khandazhinskaya, Barbara Eletskaya, Anton Mironov, Irina Konstantinova, Olga Efremenkova, Sofya Andreevskaya, Tatiana Smirnova, Larisa Chernousova, Evgenia Kondrashova, Alexander Chizhov, Katherine Seley-Radtke, Sergey Kochetkov, Elena Matyugina
Summary: A variety of flexible derivatives of 8-aza-7-deazahypoxanthine were synthesized and screened for antibacterial activity. Some of the compounds showed significant inhibition against the growth of Mycobacterium tuberculosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Liba Sokolovska, Maria Isaguliants, Franco M. Buonaguro
Summary: The international online conference VAC & VAC 2022 addressed various aspects of COVID-19 vaccine research and development, including mass vaccination strategies, vaccine compliance and hesitancy, acceptance of novel vaccine approaches, and preclinical and animal models. The conference attracted nearly 150 participants from 14 countries and featured renowned experts from leading research institutions worldwide. This report summarizes the conference presentations and discussions.