期刊
PLOS ONE
卷 8, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0076362
关键词
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资金
- Horticulture Australia Limited
- Australian Mushroom Growers Association
- Australian Government
- CSIRO Preventative Health National Research Flagship
Vitamin D deficiency is widespread, affecting over 30% of adult Australians, and increasing up to 80% for at-risk groups including the elderly (age>65). The role for Vitamin D in development of the central nervous system is supported by the association between Vitamin D deficiency and incidence of neurological and psychiatric disorders including Alzheimer's disease (AD). A reported positive relationship between Vitamin D status and cognitive performance suggests that restoring Vitamin D status might provide a cognitive benefit to those with Vitamin D deficiency. Mushrooms are a rich source of ergosterol, which can be converted to Vitamin D-2 by treatment with UV light, presenting a new and convenient dietary source of Vitamin D-2. We hypothesised that Vitamin D-2-enriched mushrooms (VDM) could prevent the cognitive and pathological abnormalities associated with dementia. Two month old wild type (B6C3) and AD transgenic (APP(Swe)/PS1dE9) mice were fed a diet either deficient in Vitamin D-2 or a diet which was supplemented with VDM, containing 1 +/- 0.2 mu g/kg (similar to 54 IU/kg) vitamin D-2, for 7 months. Effects of the dietary intervention on memory were assessed pre- and post-feeding. Brain sections were evaluated for amyloid beta (A beta) plaque loads and inflammation biomarkers using immuno-histochemical methods. Plasma vitamin D metabolites, A beta 40, A beta 42, calcium, protein and cholesterol were measured using biochemical assays. Compared with mice on the control diet, VDM-fed wild type and AD transgenic mice displayed improved learning and memory, had significantly reduced amyloid plaque load and glial fibrillary acidic protein, and elevated interleukin-10 in the brain. The results suggest that VDM might provide a dietary source of Vitamin D-2 and other bioactives for preventing memory-impairment in dementia. This study supports the need for a randomised clinical trial to determine whether or not VDM consumption can benefit cognitive performance in the wider population.
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