Article
Multidisciplinary Sciences
Moritoshi Hirono, Masanori Nakata
Summary: A study found that the appetite-stimulating peptide ghrelin enhances GABAergic transmission between neurons in the cerebellum, affecting its activity. This effect may be mediated by the GHS-R1a receptor and the TRPC1 and KCNQ ion channels.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Shu-Min Chou, Ke-Xin Li, Ming-Yueh Huang, Chao Chen, Yuan-Hung Lin King, Grant Guangnan Li, Wei Zhou, Chin Fen Teo, Yuh Nung Jan, Lily Yeh Jan, Shi-Bing Yang
Summary: The study elucidates the important role of the Kv1.1 potassium channel in regulating the proliferation of postnatal neural progenitor cells in the mouse hippocampus. Loss of Kv1.1 channel activity leads to depolarization of neural progenitor cells and promotes their proliferation.
Article
Chemistry, Medicinal
Mirjana Antonijevic, Despoina Charou, Isbaal Ramos, Maria Valcarcel, Achille Gravanis, Patricia Villace, Noelle Callizot, Marc Since, Patrick Dallemagne, Ioannis Charalampopoulos, Christophe Rochais
Summary: Numerous studies have investigated the role of BDNF and its receptor TrkB in neurodegenerative diseases. BDNF activates the TrkB receptor, promoting neuronal survival and differentiation. In this study, a small data set of compounds was designed and synthesized based on the structure of a previously published activator of TrkB. The compounds were evaluated for their ADME and toxicity profiles, as well as their biological properties and affinity to promote neurite differentiation through the TrkB receptor.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Jeongyeon Seo, Christina Lanara, Ji Yu Choi, Jungnam Kim, Hyeoncheol Cho, Young-Tae Chang, Kyungtae Kang, Emmanuel Stratakis, Insung S. Choi
Summary: This study investigates the migratory behaviors of primary hippocampal neurons on a silicon microcone array, revealing a correlation between neuronal migration and the morphology dictated by the pitch and shape of underlying SiMC structures. Real-time imaging on the topographical substrate also unveils new modes of neuronal migration not observed on conventional flat culture plates.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Endocrinology & Metabolism
Dominique Ameroso, Alice Meng, Stella Chen, Jennifer Felsted, Chris G. Dulla, Maribel Rios
Summary: This study reveals the role of astrocytic brain-derived neurotrophic factor (BDNF) in regulating energy and glucose homeostasis through TrkB.T1 receptor signaling. Depletion of BDNF in ventromedial hypothalamus astrocytes affects neuronal activity and synaptic glutamate clearance, leading to changes in response to energy status and metabolic regulators.
Article
Biochemistry & Molecular Biology
Ramon Martinez-Marmol, YeJin Chai, Jacinta N. Conroy, Zahra Khan, Seong-Min Hong, Seon Beom Kim, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Elizabeth J. Coulson, Mi Kyeong Lee, Sun Yeou Kim, Frederic A. Meunier
Summary: The traditional medicinal mushroom Hericium erinaceus enhances peripheral nerve regeneration through neurotrophic activity. We identified N-de phenylethyl isohericerin (NDPIH) and hericene A as biologically active compounds from this mushroom that promote neurite outgrowth in hippocampal neurons. NDPIH acts through a neurotrophic pathway independent of TrkB with ERK1/2 activation, while hericene A acts through a novel pan-neurotrophic signaling pathway, leading to improved cognitive performance in mice.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biology
Wenqin Luo, Guan Ning Lin, Weichen Song, Yu Zhang, Huadong Lai, Man Zhang, Juju Miao, Xiaomu Cheng, Yongjie Wang, Wang Li, Wenxiang Wei, Wei-Qiang Gao, Ru Yang, Jia Wang
Summary: This study used single-cell spatial transcriptomics analysis to reveal the similarities and differences between developing cerebellar granule cells and medulloblastoma cells. The research identified different states of developing granule cells and found that transformed granule cells in medulloblastoma closely resemble developing granule neurons but exhibit less tendency to differentiate. This provides direct evidence for the similarities and discrepancies between normal cerebellar development and tumorigenesis.
Article
Psychology, Biological
Jian-Feng Fan, Zeng-Hui Tang, Shi-Yi Wang, Si Lei, Bo Zhang, Shao-Wen Tian
Summary: In addition to its antidepressant properties, ketamine has been found to influence memory acquisition, consolidation, and reconsolidation. Administering ketamine immediately after reactivation significantly improves memory reconsolidation, while administering it 6 hours later is not effective. ANA-12, a BDNF TrkB receptor antagonist, reduces the ketamine-induced improvement in memory reconsolidation, although it has no significant effect on hippocampal BDNF levels.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Cell Biology
Pei-Yi Lin, Z. Zack Ma, Melissa Mahgoub, Ege T. Kavalali, Lisa M. Monteggia
Summary: Ketamine's rapid antidepressant action is dependent on BDNF-TrkB signaling in CA1 neurons and a specific synaptic locus, suggesting the importance of synaptic potentiation in the hippocampus for its therapeutic effects.
Article
Neurosciences
Jinyu Zhang, Kaiyan Wei, Wenzheng Qu, Mengxuan Wang, Qiang Zhu, Xiaoxue Dong, Xiaoli Huang, Wen Yi, Shunliang Xu, Xuekun Li
Summary: Previous studies have demonstrated the important roles of O-GlcNAc transferase (Ogt) and O-GlcNAcylation in neuronal development, function, and neurologic diseases. However, the functions of Ogt and O-GlcNAcylation in the adult cerebellum have not been well understood. This study revealed that the cerebellum of adult male mice has the highest level of O-GlcNAcylation compared to the cortex and hippocampus. Deletion of Ogt specifically in granule neuron precursors (GNPs) resulted in abnormal cerebellar morphology, impaired motor coordination, and learning and memory abilities in adult male mice.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Rafael Zuniga, Daniel Mancilla, Tamara Rojas, Fernando Vergara, Wendy Gonzalez, Marcelo A. Catalan, Leandro Zuniga
Summary: Two pore domain potassium channels play an important role in excitability in the nervous system. These channels produce background K+ currents and are associated with lipid rafts, but their functional activity is independent of cholesterol membrane organization.
Article
Biology
Chong Guo, Stephanie Rudolph, Morgan E. Neuwirth, Wade G. Regehr
Summary: In the cerebellar cortex, Purkinje cells selectively inhibit unipolar brush cells expressing mGluR1, thus regulating balance and eye movement. GABA receptor-mediated inhibition on unipolar brush cells can influence the input-output transformations of the cerebellar cortex in diverse ways.
Article
Neurosciences
C. H. H. Hor, J. C. W. Lo, A. L. S. Cham, W. Y. Leong, E. L. K. Goh
Summary: The study showed that conditional knock-out of the Shh pathway repressor Rab23 in mice resulted in mis-patterning of the cerebellum and increased GCP proliferation. Despite no prevalent occurrence of medulloblastoma in adulthood, Rab23-depleted GCPs exhibited upregulated Shh pathway activities and abnormal ciliogenesis.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Environmental Sciences
Churaibhon Wisessaowapak, Apichaya Niyomchan, Daranee Visitnonthachai, Naphada Leelaprachakul, Piyajit Watcharasit, Jutamaad Satayavivad
Summary: Arsenic can lead to insulin and IGF-1 resistance in human neuroblastoma cells, disrupting cellular signaling and potentially affecting growth and neurite formation by inhibiting tyrosine kinase activity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Clinical Neurology
Seong Su Kang, Zhourui Wu, Xia Liu, Laura Edgington-Mitchell, Keqiang Ye
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor disorders. Stimulation of deficient BDNF/TrkB signalings and blockade of delta-secretase show promising therapeutic effects in PD, and their combination enhances the restorative efficacy. This study is significant for the discovery of potential therapeutic agents for PD.
Review
Clinical Neurology
Shogo Tanabe, Toshihide Yamashita
Article
Cell Biology
Toru Nakanishi, Yuki Fujita, Toshihide Yamashita
CELL DEATH & DISEASE
(2019)
Article
Neurosciences
Toru Nakanishi, Yuki Fujita, Takashi Tanaka, Toshihide Yamashita
NEUROSCIENCE LETTERS
(2019)
Article
Multidisciplinary Sciences
Yuki Nakazato, Yuki Fujita, Masamitsu Nakazato, Toshihide Yamashita
SCIENTIFIC REPORTS
(2020)
Article
Cell Biology
Naoki Sada, Yuki Fujita, Nanano Mizuta, Masaki Ueno, Takahisa Furukawa, Toshihide Yamashita
CELL DEATH & DISEASE
(2020)
Review
Biochemistry & Molecular Biology
Yuki Fujita, Toshihide Yamashita
Summary: Microglia, as the resident immune cells of the central nervous system, not only play important roles in pathophysiological conditions but also interact dynamically with neurons in physiological conditions, influencing their structure and function. These immune cells contact neurons at various points and support developmental functions such as neuronal survival, axon elongation, and synaptic circuit maturation. Recent findings on the functions and signaling pathways involved in the reciprocal interactions between microglia and neurons are reviewed, along with discussions on the altered interactions in disease conditions and the potential role of microglia in developmental brain disorders.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Oluwaseun Fatoba, Takahide Itokazu, Toshihide Yamashita
Summary: The complement system, essential for normal brain development and function, can lead to neuroinflammatory responses, neurodegenerative processes, and cognitive impairment when its components are expressed and activated abnormally in the brain. Complement-mediated neuroinflammatory responses and complement-driven neurodegeneration are increasingly implicated in a wide range of CNS disorders as pathologic insults trigger these processes.
Article
Cell Biology
Wakana Oda, Yuki Fujita, Kousuke Baba, Hideki Mochizuki, Hitoshi Niwa, Toshihide Yamashita
Summary: Inhibiting RGMa can attenuate neuronal loss and inflammation in a mouse model of Parkinson's disease, suggesting that RGMa antibodies could be a potential therapeutic option.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Yuka Honjo, Yuki Fujita, Hitoshi Niwa, Toshihide Yamashita
Summary: Neuropathic pain is a type of pain caused by lesions or diseases of the somatosensory nervous system, and in the maxillofacial region, it can be induced by Netrin-4 and Unc5B.
Article
Cell Biology
Hisao Miyajima, Takahide Itokazu, Shogo Tanabe, Toshihide Yamashita
Summary: Ependymal cells have the potential to enhance regeneration processes by secreting neurotrophic factors, with IL-17A negatively regulating this effect. Conditional knockout of IL-17RA in ependymal cells leads to enhanced axonal growth and functional recovery after spinal cord injury. Manipulation of ependymal cells at a molecular level could be a promising strategy for improving functional recovery.
CELL DEATH & DISEASE
(2021)
Article
Clinical Neurology
Nao Shibuya, Takahide Itokazu, Tsubasa Ueda, Toshihide Yamashita
Summary: In this study, the behavior of recruited neutrophils in the peri-infarct area after stroke was investigated using intravital imaging. Colchicine and an anti-P-selectin antibody were found to be effective in inhibiting neutrophil attachment and infiltration, with colchicine showing potential as a therapeutic strategy for acute ischemic stroke.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Multidisciplinary Sciences
Mario R. Calderon, Megumi Mori, Grant Kauwe, Jill Farnsworth, Suzana Ulian-Benitez, Elie Maksoud, Jordan Shore, A. Pejmun Haghighi
Summary: This study reveals that Delta/Notch signaling in subperineurial glia plays an essential role in controlling the expression of matrix metalloproteinase 1 (Mmp1), which is crucial for the extracellular matrix (ECM). In the absence of this signaling, enhanced Mmp1 activity disrupts septate junctions and glial ensheathment, leading to compromised neurotransmitter release.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Masahiro Sawada, Kimika Yoshino-Saito, Taihei Ninomiya, Takao Oishi, Toshihide Yamashita, Hirotaka Onoe, Masahiko Takada, Yukio Nishimura, Tadashi Isa
Summary: This study investigates the morphologic changes in the corticospinal tract (CST) after injury, and reveals that multiple reorganizations of the corticospinal projections to spinal segments contribute to the recovery of hand function after spinal cord injury.
Article
Neurosciences
Toke Jost Isaksen, Toshihide Yamashita
NEUROSCIENCE INSIGHTS
(2020)
Article
Medicine, Research & Experimental
Shin-ichiro Hiraga, Takahide Itokazu, Maki Hoshiko, Hironobu Takaya, Mariko Nishibe, Toshihide Yamashita