Article
Acoustics
Xiaowei Huang, Lili Niu, Long Meng, Zhengrong Lin, Wei Zhou, Xiufang Liu, Jiqing Huang, Derek Abbott, Hairong Zheng
Summary: Autophagy, the process of cellular self-digestion, plays a crucial role in eliminating abnormal proteins in mammalian cells. Studies have shown that low-intensity pulsed ultrasound (LIPUS) stimulation can enhance neuronal autophagy, indicating its potential as a safe and effective tool for activating autophagy in neurons.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2021)
Article
Immunology
Simone Schilling, Bruno Chausse, Hasan Onur Dikmen, Fadi Almouhanna, Jan-Oliver Hollnagel, Andrea Lewen, Oliver Kann
Summary: Activation of microglia by Toll-like receptors can lead to varying levels of neuronal network dysfunction, with severe dysfunction primarily caused by reactive oxygen and nitrogen species rather than proinflammatory cytokines.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Yuan-Shen Chen, Wei-Chu Chuang, Hsiu-Ni Kung, Ching-Yuan Cheng, Duen-Yi Huang, Ponarulselvam Sekar, Wan-Wan Lin
Summary: In addition to inducing apoptosis, caspase inhibition can also contribute to necroptosis and/or autophagy depending on the cell type and context. This study investigated the signaling pathways and mechanisms of cell death induced by co-treatment with Toll-like receptor (TLR) ligands and a caspase inhibitor in macrophages. The results showed that necrostatin-1 and autophagy inhibitor 3-methyladenine could inhibit cell death in bone marrow-derived macrophages (BMDMs) induced by the TLR ligands and caspase inhibitor. The study also revealed the involvement of different molecular pathways and factors in the cell death process.
MOLECULES AND CELLS
(2022)
Article
Biochemistry & Molecular Biology
Tsukasa Tominari, Miyuki Akita, Chiho Matsumoto, Michiko Hirata, Shosei Yoshinouchi, Yuki Tanaka, Kento Karouji, Yoshifumi Itoh, Takayuki Maruyama, Chisato Miyaura, Yukihiro Numabe, Masaki Inada
Summary: TLR3 signaling plays a crucial role in periodontal bone resorption by controlling the production of PGE2 and inducing the differentiation and survival of mature osteoclasts.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Hagos Amare Gebreyesus, Girmatsion Fisseha Abreha, Sintayehu Degu Besherae, Merhawit Atsbha Abera, Abraha Hailu Weldegerima, Aregawi Haileslassie Gidey, Afework Mulugeta Bezabih, Tefera Belachew Lemma, Tsinuel Girma Nigatu
Summary: The study found that in Northern Ethiopia, T2DM patients with high AIP levels and poor glycemic control are at increased risk for coronary heart disease. Healthy eating behavior and taking metformin are associated with better glycemic outcomes.
Article
Neurosciences
Alma S. Halgren, Zarek Siegel, Ryan Golden, Maxim Bazhenov
Summary: Cortical stimulation is a useful tool for research and treatment of neuro-psychiatric conditions, but the lack of predictive models makes it difficult to control the induced physiological patterns. This study uses a hybrid model to understand how cortical surface stimulation can induce traveling waves through asymmetrical activation of inhibitory interneurons. The results show that asymmetric electrical stimulation can easily facilitate traveling waves by relying on the activation of different types of inhibitory interneurons.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Pedro Lobos, Alex Cordova, Ignacio Vega-Vasquez, Omar A. Ramirez, Tatiana Adasme, Jorge Toledo, Mauricio Cerda, Steffen Hartel, Andrea Paula-Lima, Cecilia Hidalgo
Summary: In the hippocampus, the expression of genes involved in learning and memory processes is influenced by Ca2+ signals, which are propagated to the nucleus through Ca2+ release mediated by the ryanodine receptor. This mechanism contributes to CREB phosphorylation, Npas4, and RyR2 expression, playing a crucial role in hippocampal synaptic plasticity and memory processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Veronica Elizabeth Burns, Tom Klaus Kerppola
Summary: Keap1 binds to cytokine genes upon virus infection and moderates their induction by recruiting NF-kappa B p50 and G9a-GLP. This suggests a feedback circuit between Keap1, NF-kappa B, and G9a-GLP that helps moderate viral induction of cytokine transcription.
JOURNAL OF IMMUNOLOGY
(2021)
Letter
Immunology
Stephanie Haack, Sarah Baiker, Jan Schlegel, Markus Sauer, Tim Sparwasser, Daniela Langenhorst, Niklas Beyersdorf
Summary: Research shows that mouse Th1 cells, similar to human Th1 cells, secrete IFN-gamma in response to stimulation with a superagonistic anti-CD28 monoclonal antibody. Crosslinking of the CD28-SA via FcR and CD40-CD40L interactions significantly enhances IFN-gamma release, highlighting the mouse as a useful model organism for studying immune responses in humans.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ryota Araki, Shoji Nishida, Yuki Nakajima, Arimi Iwakumo, Hayato Tachioka, Ayami Kita, Takeshi Yabe
Summary: Low folate conditions affect the expression and epigenetic modifications of genes involved in neuronal differentiation and maturation in primary mouse neural stem/progenitor cells, leading to neural immaturity.
Article
Virology
Marlies Boeren, Elise Van Breedam, Tamariche Buyle-Huybrecht, Marielle Lebrun, Pieter Meysman, Catherine Sadzot-Delvaux, Viggo F. Van Tendeloo, Geert Mortier, Kris Laukens, Benson Ogunjimi, Peter Ponsaerts, Peter Delputte
Summary: This study developed a compartmentalized hiPSC-derived neuronal culture model to mimic natural VZV infection route. The study found that hiPSC-neurons do not mount an effective antiviral response following VZV infection, unlike Sendai virus infection. The cells do not upregulate interferon-stimulated genes and do not produce interferon-alpha. However, exogenous interferon-alpha effectively limits VZV spread in the neuronal cells and promotes upregulation of ISGs.
Article
Immunology
J. J. Rosales, M. Nieto Farias, M. Burucua, M. S. Marin, S. E. Perez
Summary: This study investigated the antiviral response of IFN-lambda 3 in bovine alphaherpesvirus (BoHV-1 and BoHV-5) infections. The results showed that there is a strong IFN-lambda 3 response early after BoHV-1 infection in undifferentiated neuroblastoma cells. However, low levels of IFN-lambda 3 expression were detected in the brain during acute infections, facilitating virus spread. There were also significant differences in IFN-lambda 3 transcriptional levels in the trigeminal ganglion, particularly in BoHV-1 acutely and latently infected calves. During reactivation, IFN-lambda 3 expression was down-regulated, possibly to promote virus replication and spread.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Haiyan Wang, Amy Zheng, Edward B. Arias, Gregory D. Cartee
Summary: AICAR treatment can increase γ3-AMPK activity and reduce membrane cholesterol content, leading to enhanced glucose uptake in aged skeletal muscles. This study provides insights into potential mechanisms for improving glucose metabolism in older individuals.
Article
Cell Biology
Jose Rodrigues Neto, Arthur Wilson Florencio da Costa, Yarlla Loyane Lira Braga, Fernanda Helia Lucio, Ana Luisa Monteiro dos Santos Martins, Marlene Antonia dos Reis, Flavia Aparecida de Oliveira, Mara Rubia Nunes Celes, Marcos Vinicius da Silva, Milton Adriano Pelli Oliveira, Juliana Reis Machado
Summary: This study aimed to evaluate the histopathological changes caused by infection with the Colombian strain of Trypanosoma cruzi in acute and chronic phases. Results showed that the infection led to weight loss, intestinal inflammatory infiltrates, increased levels of interferon gamma and tumor necrosis factor-alpha, as well as elevated interleukin-10 in the early chronic phase.
MEDIATORS OF INFLAMMATION
(2022)
Article
Clinical Neurology
Anthony Yuan, Catherine Claussen, Zachary Jones, Bin Tang, Nachum Dafny
Summary: Methylphenidate increases dopamine, norepinephrine, and serotonin levels in the brain, affecting neurocognitive function. This study recorded neuronal activity in different brain regions of rats and found that chronic methylphenidate administration led to either behavioral sensitization or tolerance. The dorsal raphe nucleus showed the most significant response to methylphenidate compared to other brain areas.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Geriatrics & Gerontology
Danut-Adrian Dumbrava, Roxana Surugiu, Verena Boerger, Mihai Ruscu, Tobias Tertel, Bernd Giebel, Dirk M. Hermann, Aurel Popa-Wagner
Summary: The study found that MSC-sEVs can improve neurological recovery and brain tissue remodeling in aged rats post-stroke by promoting angiogenesis and neurogenesis to alleviate the inflammatory environment after stroke.
Article
Neurosciences
Nilay Ates, Aysun Caglayan, Zeynep Balcikanli, Elif Sertel, Mustafa Caglar Beker, Pelin Dilsiz, Ahmet Burak Caglayan, Suleyman Celik, Muhammed Furkan Dasdelen, Berrak Caglayan, Turkan Yigitbasi, Hanefi Ozbek, Thorsten Roland Doeppner, Dirk Matthias Hermann, Ertugrul Kilic
Summary: Lithium has neuroprotective effects after ischemic stroke, which involves modulation of the PI3K/Akt pathway but not the MEK/ERK pathway. High doses of lithium decrease brain perfusion and lead to animal death, while moderate doses improve brain tissue survival and reverse blood-brain barrier leakage, hemodynamic impairment, and apoptosis.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Egor Dzyubenko, Daniel Manrique-Castano, Matthias Pillath-Eilers, Paraskevi Vasileiadou, Jacqueline Reinhard, Andreas Faissner, Dirk M. Hermann
Summary: Cellular responses in glia play a key role in regulating brain remodeling post-stroke. Excessive glial reactivity impedes neuroplasticity and hampers neurological recovery. We found that tenascin-C (TnC) plays a central role in restraining astrogliosis and regulating astrocyte-microglial interactions.
Article
Clinical Neurology
Anne-Carina Scharf, Janine Gronewold, Olga Todica, Christoph Moenninghoff, Thorsten R. Doeppner, Bianca de Haan, Claudio L. A. Bassetti, Dirk M. Hermann
Summary: This study prospectively evaluated the cognitive deficits in patients with acute thalamic stroke and found that the deficits varied depending on the location of the stroke lesions.
Editorial Material
Neurosciences
Dirk M. Hermann, Aurel Popa-Wagner, Luca Peruzzotti-Jametti, Matthias Gunzer
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Dirk M. Hermann
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Ahmet Burak Caglayan, Mustafa Caglar Beker, Elif Sertel Evren, Berrak Caglayan, Ulkan Kilic, Nilay Ates, Aysun Caglayan, Muhammed Furkan Dasdelen, Thorsten Roland Doeppner, Mart Saarma, Dirk Matthias Hermann, Ertugrul Kilic
Summary: CDNF and MANF, when administered after stroke, can promote neurological recovery and increase neuronal survival. They also reduce brain atrophy and glial scar formation. CDNF has the additional effect of increasing endogenous neurogenesis and promoting axonal growth.
TRANSLATIONAL STROKE RESEARCH
(2023)
Review
Geriatrics & Gerontology
Leonard Radu Pinosanu, Bogdan Capitanescu, Daniela Glavan, Sanziana Godeanu, Israel Fernaundez Cadenas, Thorsten R. Doeppner, Dirk M. Hermann, Adrian-Tudor Balseanu, Catalin Bogdan, Aurel Popa-Wagner
Summary: The functions and activities of astroglia cells in brain development, aging, and neurodegenerative diseases differ. Comparing the transcriptomic activity of astroglia cells in these processes may provide new therapeutic strategies to protect the aging brain and improve clinical outcomes.
Article
Cell Biology
Egor Dzyubenko, Katrin I. Willig, Dongpei Yin, Maryam Sardari, Erdin Tokmak, Patrick Labus, Ben Schmermund, Dirk M. Hermann
Summary: The study found that perineuronal nets (PNNs) undergo structural changes after ischemic stroke and these changes are associated with the recovery of motor coordination. The study also revealed that activated microglia/macrophages preferentially contact neurons coated with PNNs. These findings provide new insights into the mechanisms underlying neuroplasticity after stroke.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Daniela Colita, Cezar-Ivan Colita, Dirk Hermann, Eugen Colita, Thorsten Doeppner, Ion Udristoiu, Aurel Popa-Wagner
Summary: The evidence suggests that affective disorders increase the risk for cognitive decline and dementia in aging individuals. Cognitive decline is a central feature of aging and impacts quality of life. Motor deficits are common after brain injuries and stroke, affecting subjective well-being and quality of life.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Cell Biology
Thorsten R. Doeppner, Cristin Coman, Daiana Burdusel, Diana-Larisa Ancuta, Ulf Brockmeier, Daniel Nicolae Pirici, Kuang Yaoyun, Dirk M. Hermann, Aurel Popa-Wagner
Summary: Chloroquine treatment extends the lifespan of middle-aged NMRI mice through an increase in autophagosome accumulation and inhibition of proteasome activity.
Meeting Abstract
Geriatrics & Gerontology
A. Maiworm, R. Langner, S. Wilm, D. M. Hermann, H. Frohnhofen, J. Gronewold
ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE
(2022)
Review
Medicine, Research & Experimental
Dirk M. Hermann, Wenqiang Xin, Mathias Baehr, Bernd Giebel, Thorsten R. Doeppner
Summary: This review discusses the recent evidence on EV-associated ncRNAs in hypoxic cancer, myocardial infarction and stroke, emphasizing their roles in intercellular communication and disease development, and proposing that ncRNAs synergistically respond to hypoxia to modify disease responses.
Meeting Abstract
Endocrinology & Metabolism
Toru Yamashita, Thorsten R. Doeppner, Cesar Borlongan, Kuniyasu Niizuma, Stefano Pluchino, Dirk M. Hermann
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Meeting Abstract
Cell & Tissue Engineering
Y. Mouloud, N. Labusek, C. Wang, H. Hanenberg, D. Hermann, J. Herz, B. Giebel