Article
Multidisciplinary Sciences
Kaue Machado Costa, Daniela Schenkel, Jochen Roeper
Summary: Heterozygous mice expressing Cre-recombinase under the dopamine transporter promoter exhibit sex-dependent behavioral and molecular differences, with female KI mice displaying opposing behaviors compared to male KIs. These differences are accompanied by disparities in striatal DAT expression.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma O'Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan W. Logan, Jill R. Glausier, Kenneth N. Fish, David A. Lewis, J. Timothy Greenamyre, Brian D. McCabe, Claire E. J. Cheetham, Thomas S. Hnasko, Zachary Freyberg
Summary: The study revealed the impact of age and sex differences on dopamine neuron vulnerability, with males exhibiting greater decreases in neuron number and locomotion during aging, and dynamic changes in VGLUT expression in dopamine neurons possibly serving as a compensatory mechanism. Female fruit flies were found to possess higher levels of VGLUT expression in dopamine neurons compared to males, and diminishing VGLUT expression eliminated their greater resilience to neuron loss. Optimal control over VGLUT expression in dopamine neurons was identified as essential for neuron survival and a potential therapeutic target for age- and PD-related neurodegeneration.
Article
Agriculture, Dairy & Animal Science
Milena Santariova, Adela Polonyiova, Ivona Svobodova, Radka Prochazkova, Helena Chaloupkova
Summary: Detection dogs trained to search for various odorous substances are an effective tool in the fight against crime. Due to the high costs of training and maintaining these dogs, it is necessary to preselect suitable individuals for this purpose. One of the selection criteria is the dog breed. Unfortunately, there is a lack of studies that compare dog breeds for their suitability as detection dogs.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Medicine, General & Internal
David Devos, Julien Labreuche, Olivier Rascol, Jean-Christophe Corvol, Alain Duhamel, P. Guyon Delannoy, Werner Poewe, Yaroslau Compta, Nicola Pavese, Evzen Ruzicka, Petr Dusek, Bart Post, Bastiaan R. Bloem, Daniela Berg, Walter Maetzler, Markus Otto, Marie-Odile Habert, Stephane Lehericy, Joaquim Ferreira, Richard Dodel, Christine Tranchant, Alexandre Eusebio, Stephane Thobois, Ana-Raquel Marques, Wassilios G. Meissner, Fabienne Ory-Magne, Uwe Walter, Rob M. A. de Bie, Miguel Gago, Dolores Vilas, Jaime Kulisevsky, Cristina Januario, Miguel V. S. Coelho, Stefanie Behnke, Paul Worth, Klaus Seppi, Thavarak Ouk, Camille Potey, Celine Leclercq, Romain Viard, Gregory Kuchcinski, Renaud Lopes, Jean-Pierre Pruvo, Pascal Pigny, Guillaume Garcon, Ophelie Simonin, Jessica Carpentier, Anne-Sophie Rolland, Dag Nyholm, Christoph Scherfler, Jean-Francois Mangin, Marie Chupin, Regis Bordet, David T. Dexter, Caroline Fradette, Michael Spino, Fernando Tricta, Scott Ayton, Ashley I. Bush, Jean-Christophe Devedjian, James A. Duce, Ioav Cabantchik, Luc Defebvre, Dominique Deplanque, Caroline Moreau
Summary: In a 36-week trial involving participants with early Parkinson's disease who had not received levodopa, treatment with the iron chelator deferiprone led to worse scores in measures of parkinsonism compared to placebo.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Veterinary Sciences
Yangfeng Xu, Kathelijne Peremans, Sofie Salden, Kurt Audenaert, Andre Dobbeleir, Ann Van Eeckhaut, Dimitri De Bundel, Jimmy H. H. Saunders, Chris Baeken
Summary: This study investigated the direct and delayed effects of five sessions of aHF-rTMS on the dopamine transporter and dopamine metabolites in cerebrospinal fluid. The results showed that active aHF-rTMS significantly reduced striatal dopamine transporter binding index at 1 day and 1 month post-stimulation, indicating immediate and delayed effects on the brain dopaminergic system.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maria Ptukha, Zoia Fesenko, Anastasia Belskaya, Arina Gromova, Arseniy Pelevin, Natalia Kurzina, Raul R. Gainetdinov, Anna Volnova
Summary: This study evaluated the effect of atomoxetine on the behavior and brain activity of dopamine transporter knockout (DAT-KO) rats, which exhibit ADHD-like behavior. Atomoxetine improved PPI and reduced repetitive behaviors in DAT-KO rats and also influenced the behavior of wild-type rats. Furthermore, it led to significant changes in power spectra and coherence of both DAT-KO and wild type rats.
Article
Biochemistry & Molecular Biology
Shima Kouhnavardi, Alev Ecevitoglu, Vladimir Dragacevic, Fabrizio Sanna, Edgar Arias-Sandoval, Predrag Kalaba, Michael Kirchhofer, Jana Lubec, Marco Niello, Marion Holy, Martin Zehl, Matthias Pillwein, Judith Wackerlig, Rita Murau, Andrea Mohrmann, Kathryn R. Beard, Harald H. Sitte, Ernst Urban, Claudia Sagheddu, Marco Pistis, Roberto Plasenzotti, John D. Salamone, Thierry Langer, Gert Lubec, Francisco J. Monje
Summary: Dopamine and DAT signaling dysfunctions are associated with various neuropsychiatric disorders and progressive brain diseases, leading to devastating personal and familial concerns and high socioeconomic costs worldwide.
Review
Behavioral Sciences
Gabriella E. DiCarlo, Mark T. Wallace
Summary: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and restricted interests/repetitive behaviors. Over 1000 genes and 2000 copy number variants have been implicated in ASD. It is believed that there is not a single genetic cause or neurobiological basis for ASD, but rather multiple subtypes with different genetic and neurobiological perturbations. Dopamine dysfunction may be one potential subtype associated with ASD. This research provides a framework for subcategorizing ASD based on genetic changes, neurobiological differences, and behavioral features.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Cell Biology
Adithya Gopinath, Phillip M. Mackie, Leah T. Phan, Rosa Mirabel, Aidan R. Smith, Emily Miller, Stephen Franks, Ohee Syed, Tabish Riaz, Brian K. Law, Nikhil Urs, Habibeh Khoshbouei
Summary: The dopamine transporter (DAT) is not only expressed in the central nervous system and involved in neurological and neuropsychiatric diseases, but also in peripheral immune cells where it regulates immune responses. Blocking DAT activity enhances immune stimulation in macrophages, leading to increased inflammatory response and altered T and B cell populations.
Article
Biochemistry & Molecular Biology
Willian Goulart Salgueiro, Marcell Valandro Soares, Cassiano Fiad Martins, Favero Reisdorfer Paula, Rafaela Maria Rios-Anjos, Thiago Carrazoni, Marcelo A. Mori, Roman-Ulrich Mueller, Michael Aschner, Chariston Andre Dal Belo, Daiana Silva Avila
Summary: Quercetin has been found to restore neuronal function in disease models, especially in diseases related to impaired dopaminergic neurotransmission. This study suggests that quercetin may act as a dopaminergic modulator by interacting with the dopamine transporter, thus altering the behavior of the nematode.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Pharmacology & Pharmacy
Ole Jensen, Johannes Matthaei, Henry G. Klemp, Marleen J. Meyer, Jurgen Brockmoller, Mladen V. Tzvetkov
Summary: This study confirmed IBC as an endogenous biomarker of OCT1 activity in humans, with OCT1 potentially regulating cellular concentrations of specific regulators or co-substrates in lipid and energy metabolism. Unlike in mice, OCT1 in humans may not directly mediate the efflux of IBC, suggesting a different mechanism for the association between blood concentrations of carnitine derivatives and OCT1 genotype in humans.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Marzieh Eslami Rasekh, Yozen Hernandez, Samantha D. Drinan, Juan I. Fuxman Bass, Gary Benson
Summary: VNTRs are tandem repeat loci that vary in copy number across a population. Commonly polymorphic VNTR loci, enriched in genomic regions with regulatory function, can be used for population ancestry classification and show correlation with gene expression differences.
NUCLEIC ACIDS RESEARCH
(2021)
Review
Neurosciences
Mengfei Bu, Matthew J. Farrer, Habibeh Khoshbouei
Summary: The dopamine transporter (DAT) plays a crucial role in regulating dopamine neurotransmission and is implicated in neurodegenerative diseases like Parkinson's. Surface expression of DAT is dynamically regulated through endocytic trafficking, impacting dopamine signaling. Research shows that dysregulation of DAT trafficking is linked to neurodegenerative diseases.
NPJ PARKINSONS DISEASE
(2021)
Article
Medicine, Research & Experimental
Silvia Cerantola, Sofia Faggin, Valentina Caputi, Annalisa Bosi, Davide Banfi, Anna Rambaldo, Andrea Porzionato, Rosa Di Liddo, Raffaele De Caro, Edoardo Savarino, Cristina Giaroni, Maria Cecilia Giron
Summary: This study aims to evaluate the impact of ileitis on enteric dopaminergic pathways, and finds that ileitis mainly affects D1 receptor-mediated dopaminergic neurotransmission.
Article
Biochemistry & Molecular Biology
Kinga Huminska-Lisowska, Krzysztof Chmielowiec, Aleksandra Stronska-Pluta, Jolanta Chmielowiec, Aleksandra Suchanecka, Jolanta Masiak, Monika Michalowska-Sawczyn, Agnieszka Boron, Pawel Cieszczyk, Anna Grzywacz
Summary: This study investigated the association between methylation in the promoter region of the DAT1 gene and personality traits in athletes. Results showed that athletes scored significantly higher in extraversion and conscientiousness compared to non-athletes. Total methylation and the number of methylated islands in the DAT1 gene were higher in athletes. Correlations were found between methylation levels and extraversion and agreeability traits. This study provides new insights into the biological mechanisms of dopamine release and personality traits in athletes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)