Article
Cell Biology
Xin Fang, Nan Ni, Xiaofang Wang, Yanan Tian, Ivan Ivanov, Monique Rijnkels, Kayla J. Bayless, John P. Lydon, Qinglei Li
Summary: EZH2 has dual roles in the development of endometrial cancer, functioning as an oncogene in the early stages but also leading to unfavorable outcomes during disease progression, characterized by exacerbated epithelial stratification and heightened inflammatory response.
Article
Multidisciplinary Sciences
Ye He, Joshua Rivera, Miklos Diossy, Haohui Duan, Christian Bowman-Colin, Rachel Reed, Rebecca Jennings, Jesse Novak, Stevenson Tran, Elizabeth F. Cohen, David Szuts, Anita Giobbie-Hurder, Roderick T. Bronson, Adam J. Bass, Sabina Signoretti, Zoltan Szallasi, David M. Livingston, Shailja Pathania
Summary: BRCA1 heterozygous cells with unresolved replication stress have been shown to drive esophageal tumorigenesis, using 4NQO as an RS-inducing agent, resulting in higher tumor formation rates and genome mutation rates in Brca1 heterozygous mice compared to wild-type mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Christopher B. Morse, Valentin Voillet, Breanna M. Bates, Edison Y. Chiu, Nicolas M. Garcia, Raphael Gottardo, Philip D. Greenberg, Kristin G. Anderson
Summary: The study established a mouse model of ovarian cancer that predictably represents micro-metastatic disease, benefiting from surgical cytoreduction to remove bulky disease and prolong survival. Results showed that metastatic sites developed following orthotopic injection were similar to metastatic human ovarian cancer sites, and surgical cytoreduction was beneficial in removing substantial disease burden.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemical Research Methods
Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee
Summary: A new method for establishing orthotopic xenograft of gastric cancer was developed, allowing for the insertion of soft tissue fragments or minced tissues into the stomach submucosa layer of immunodeficient mice. This surgical procedure demonstrated high reproducibility with a success rate of 96% and tumor formation rate of 93% in generating mouse models.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Oncology
Juan Morote, Angel Borque-Fernando, Marina Triquell, Miriam Campistol, Anna Celma, Lucas Regis, Jose M. Abascal, Pol Servian, Jacques Planas, Olga Mendez, Luis M. Esteban, Enrique Trilla
Summary: By using a risk-organized model, initial screening of PCa suspicion can reduce the demand for mpMRI while maintaining an acceptable level of accuracy in detecting clinically significant prostate cancer (csPCa).
Article
Medicine, Research & Experimental
Ruobing Hu, Xiuling Li, Xiaomin Zhou, Songze Ding
Summary: The predictive nomogram based on a competing risk model for time-specific mortality in patients with rectal cancer has high accuracy and can assist physicians in making clinical decisions and follow-up strategies.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Emergency Medicine
Stephen GyungWon Lee, Sang Do Shin, Hui Jai Lee, Gil Joon Suh, Do Joong Park
Summary: The study aimed to develop a prediction model for clinically important outcomes of AD in the ED, to aid clinical decision making. Analysis of potential risk factors resulted in a model with good discrimination and calibration power for predicting CIOs in AD patients visiting the ED.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Oncology
Floor Piqeur, Britt J. P. Hupkens, Stefi Nordkamp, Marnix G. Witte, Philip Meijnen, Heleen M. Ceha, Maaike Berbee, Margriet Dieters, Sofia Heyman, Alexander Valdman, Martin P. Nilsson, Joost Nederend, Harm J. T. Rutten, Jacobus W. A. Burger, Corrie A. M. Marijnen, Heike M. U. Peulen
Summary: This study presents the first consensus-based delineation guideline for locally recurrent rectal cancer (LRRC). Multidisciplinary evaluation is beneficial in determining target volumes. Further analysis of re-recurrences is needed to optimize the delineation guidelines.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Medical Laboratory Technology
Yu-Shen Yang, Chu-Yun Liu, Dan Wen, Da-Zhi Gao, Shu Lin, He-Fan He, Xue-Feng Zhao
Summary: Despite progress in prevention and treatment, colorectal cancer remains a common malignancy worldwide. Various mouse models, including transplant mouse models, have been established to study the characteristics of colorectal cancer and its clinical behavior and therapeutic progress.
TRANSLATIONAL RESEARCH
(2022)
Correction
Biochemical Research Methods
Wonyoung Kang, Leigh Maher, Michael Michaud, Seong-Woo Bae, Seongyeong Kim, Hye Seung Lee, Seock-Ah Im, Han-Kwang Yang, Charles Lee
Summary: An amendment to the paper has been published and can be accessed through the original article.
BIOLOGICAL PROCEDURES ONLINE
(2021)
Article
Oncology
Xiaolin Pang, Liang Huang, Yan Ma, Zhanzhen Liu, Peiyi Xie, Hailing Liu, Xiangbo Wan, Shuai Liu, Jian Zheng
Summary: The study compared the efficacy of three neoadjuvant therapeutic regimens for LLNs metastasis of locally advanced rectal cancer and found that radiation dose boost is effective in increasing response rate and decreasing recurrence rates. A short axis of LLNs in restaging MRI is an independent risk factor for prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Robert Glynne-Jones, Stuart Glynne-Jones
Summary: There is a lack of universally accepted instrument for predicting overall survival in rectal cancer trials using chemoradiotherapy, with the neoadjuvant rectal score proposed as a potential solution to categorize response and downstaging and predict overall survival outcomes. The score has been conceptually validated, but its statistical validation remains incomplete, and the absence of significant survival benefits in preoperative phase 3 trials poses a challenge for its widespread acceptance as a surrogate endpoint.
Review
Oncology
Gyu Sang Yoo, Hee Chul Park, Jeong Il Yu
Summary: Rectal cancer is a common malignancy worldwide. While total mesorectal excision (TME) and neoadjuvant chemoradiation (NCRT) have improved intrapelvic local control, lateral pelvic recurrence remains problematic, especially in patients with clinically suspicious lateral pelvic lymph node (LPLN). The optimal management strategy for patients with rectal cancer with suspicious LPLN metastasis has not been determined.
FRONTIERS IN ONCOLOGY
(2022)
Article
Orthopedics
B. Bodic, M. A. Boutet, C. Boyer, B. Metayer, C. Vignes, J. Lesoeur, J. Veziers, V. Daguin, F. Haspot, Y. Maugars, F. Djouad, J. Guicheux, C. Vinatier
Summary: This study demonstrated the feasibility of inducing osteoarthritis (OA) in immunologically humanized mice by destabilization of the medial meniscus (DMM). The developed OA model could serve as a useful tool for bridging the gap between preclinical and clinical evaluation of immune interacting disease-modifying osteoarthritis drugs (DMOADs) and cell-based therapies.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Neurosciences
Ping Hu, Dan Wu, Yan-Yu Zang, Yan Wang, Ya-Ping Zhou, Fengchang Qiao, Xiao-Yu Teng, Jiang Chen, Qing-Qing Li, Jia-Hui Sun, TingTing Liu, Hao-Yang Feng, Qi-Gang Zhou, Yun Stone Shi, Zhengfeng Xu
Summary: In this study, a novel LGI1 mutation was identified in a Chinese family with ADLTE, and a precise knock-in mouse model was generated to mimic the epileptic symptoms of human patients. The knock-in mice exhibited spontaneous recurrent generalized seizures and premature death, providing insights into the pathomechanism of the mutation and potential therapies for epilepsy.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)