Article
Medicine, Research & Experimental
Seyyed Mohammad Reza Hashemnia, Reza Meshkani, Fahimeh Zamani-Garmsiri, Maryam Shabani, Maryam Tajabadi-Ebrahimi, Iraj Ragerdi Kashani, Seyed Davar Siadat, Samaneh Mohassel Azadi, Solaleh Emamgholipour
Summary: New evidence suggests that B. coagulans can be a promising alternative for treating metabolic disorders. However, its effects on obesity-induced adipose tissue inflammation are still unknown.
Article
Hematology
Mark Colin Gissler, Nathaly Anto-Michel, Jan Pennig, Philipp Scherrer, Xiaowei Li, Timoteo Marchini, Katharina Pfeiffer, Carmen Haerdtner, Tijani Abogunloko, Timothy Mwinyella, Lucia Sol Mitre, Lisa Spiga, Christoph Koentges, Christian Smolka, Dominik von Elverfeldt, Natalie Hoppe, Peter Stachon, Bianca Dufner, Timo Heidt, Sven Piepenburg, Ingo Hilgendorf, Jan-Inge Bjune, Simon N. Dankel, Gunnar Mellgren, Gabriel Seifert, Steffen U. Eisenhardt, Heiko Bugger, Constantin von zur Muhlen, Christoph Bode, Andreas Zirlik, Dennis Wolf, Florian Willecke
Summary: Genetic deficiency of TRAF5 exacerbates diet-induced obesity and metabolic dysregulation by promoting a proinflammatory response in adipocytes, indicating a potential role of TRAF5 in anti-inflammatory and obesity-preventing signaling events in adipose tissue.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Cell Biology
Ajeeth K. Pingili, Mehdi Chaib, Laura M. Sipe, Emily J. Miller, Bin Teng, Rahul Sharma, Johnathan R. Yarbro, Sarah Asemota, Qusai Al Abdallah, Tahliyah S. Mims, Tony N. Marion, Deidre Daria, Radhika Sekhri, Alina M. Hamilton, Melissa A. Troester, Heejoon Jo, Hyo Young Choi, D. Neil Hayes, Katherine L. Cook, Ramesh Narayanan, Joseph F. Pierre, Liza Makowski
Summary: Obesity may enhance the efficacy of immune checkpoint therapies in breast cancer, leading to differential responses to anti-PD-1 treatment in lean and obese mice.
Review
Food Science & Technology
William T. Festuccia
Summary: Evidence suggests that lipotoxicity and inflammation are key factors linking adipose tissue dysfunction to metabolic diseases, with mTOR playing a crucial role in regulating adipocyte and macrophage function. Studies reviewed here show that optimal levels of mTORC1 activity are necessary for lipogenic actions in adipocytes, while mTORC1 also regulates polarization in macrophages. On the other hand, mTORC2 promotes glucose uptake and lipogenesis in adipocytes while dampening macrophage inflammatory response.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sabrina Folie, Bernhard Radlinger, Georg Goebel, Karin Salzmann, Gabriele Staudacher, Claudia Ress, Herbert Tilg, Susanne Kaser
Summary: The study suggests that switching from a metabolically harmful Western diet to a balanced standard diet can improve adipose tissue inflammation, while long-term consumption of a Western diet negatively impacts the thermogenic capacity of brown adipose tissue and inhibits beiging of white adipose tissue.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yea-Jin Park, Tae-Young Gil, Bo-Ram Jin, Yun-Yeop Cha, Hyo-Jin An
Summary: This study aimed to investigate the effect of APO on the reduction of weight gain and obesity-induced adipose tissue inflammation. The results showed that APO-treated mice had a significantly lower white adipose tissue mass index compared to orlistat-treated mice. APO also reduced the expression of inflammatory markers and improved local inflammatory response in adipose tissue. These findings provide a foundation for further research on the use of APO as a therapeutic agent for obesity-induced inflammatory diseases.
PHYTOTHERAPY RESEARCH
(2023)
Article
Nutrition & Dietetics
So-Won Heo, Kyung-Sook Chung, Young-Seo Yoon, Soo-Yeon Kim, Hye-Shin Ahn, Yu-Kyong Shin, Sun-Hee Lee, Kyung-Tae Lee
Summary: Obesity is a global threat to public health, leading to diseases such as type 2 diabetes and non-alcoholic fatty liver disease. In this study, we found that a herbal extract called EECM has anti-obesity effects by inhibiting adipogenesis and lipogenesis and regulating adipogenic hormones. EECM was also effective in reducing body weight gain, body fat accumulation, and adipocyte and lipid accumulation in mice. It induced thermogenic factors in brown adipose tissue and restored gut microbiome composition. EECM may serve as a promising therapeutic agent for preventing obesity.
Article
Biochemistry & Molecular Biology
Zenan Yang, Xiaofang Li, Dianwei Li, Cheng Wang, Yuanqi Song, Jingnan Ren, Kaikai Li, Hao Chen
Summary: Purple leafed rice (SPLR) seedlings, characterized by high amounts of anthocyanins and polyphenols, have shown potential in preventing obesity and related complications by alleviating obesity and suppressing pro-inflammatory cytokines and macrophage infiltration.
Article
Genetics & Heredity
Zhe Wang, Ming Zhu, Meng Wang, Yihui Gao, Cong Zhang, Shangyun Liu, Shen Qu, Zhongmin Liu, Chao Zhang
Summary: Histone modifications can activate or suppress genes related to lipogenesis, energy metabolism, and inflammation. Certain genes activated under high-fat diet conditions may be associated with inflammation and energy metabolism.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Angelo Di Vincenzo, Marnie Granzotto, Marika Crescenzi, Vincenzo Vindigni, Roberto Vettor, Marco Rossato
Summary: In this study, the effects of sex steroids on the expression of inflammatory mediators in human-derived adipocytes were evaluated. The results showed that non-aromatizable androgen DHT and the aromatase inhibitor anastrozole in combination with testosterone significantly enhanced the expression of inflammatory cytokines induced by LPS. These results confirm the involvement of sex hormones in adipose tissue inflammation and suggest a specific role for non-aromatizable androgens as amplificatory sex hormones of the inflammatory response.
Article
Biochemistry & Molecular Biology
Amanda J. Croft, Conagh Kelly, Dongqing Chen, Tatt Jhong Haw, Aaron L. Sverdlov, Doan T. M. Ngo
Summary: Obesity is associated with various metabolic disorders and cardiovascular diseases, causing increased hospitalizations, morbidity, and mortality. Dysfunction of adipose tissue due to chronic nutrient stress can lead to oxidative stress, mitochondrial dysfunction, inflammation, hypoxia, and insulin resistance. This study aimed to reduce adipose tissue oxidative stress by overexpressing the antioxidant mitochondrial catalase (mCAT) in adipose tissue to improve systemic metabolic function. The results showed that the AdipoQ-mCAT mice were protected from further metabolic impairment under obesogenic dietary conditions compared to obese wild-type mice, highlighting the critical role of physiological H2O2 signaling in metabolism and adipose tissue function.
Review
Biochemistry & Molecular Biology
Pei-Chi Chan, Po-Shiuan Hsieh
Summary: This review focuses on the role and regulatory mechanism of BAT in DIT and whether these mechanisms are applicable to human health and diseases. BAT is considered an important organ in the process of counter-regulating energy intake and lipid accumulation through DIT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Jessica Latorre, Jordi Mayneris-Perxachs, Nuria Oliveras-Canellas, Francisco Ortega, Ferran Comas, Jose Manuel Fernandez-Real, Jose Maria Moreno-Navarrete
Summary: This study investigated the role of CDO1 gene expression in adipose tissue and found that higher CDO1 expression was associated with improved metabolic profiles, decreased fasting triglycerides and blood HbA1c levels, as well as gene expression markers of adipocyte function and inflammation in both visceral and subcutaneous adipose tissue.
Review
Biochemistry & Molecular Biology
Byung Chul Jung, Sona Kang
Summary: Obesity is strongly associated with insulin resistance, and chronic low-grade tissue inflammation and systemic inflammation are proposed as major mechanisms. Adipose tissue serves as a crucial link between inflammation and metabolism, while epigenetic modifications play a key role in gene regulation in response to environmental changes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Article
Food Science & Technology
Jasmine F. Plows, Mark H. Vickers, Thashma P. Ganapathy, Pania E. Bridge-Comer, Joanna L. Stanley, Clare M. Reynolds
Summary: The knockout of IL1R1 does not protect nulliparous or pregnant females from glucose intolerance induced by a high-fat diet. Postpartum, IL1R1(-/-) mice still have impaired glucose tolerance compared to control mice. These effects are associated with adipocyte hypertrophy, hyperleptinemia, and increased expression of inflammatory genes in adipose tissue.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Endocrinology & Metabolism
Tomohito Gohda, Yuji Nishizaki, Maki Murakoshi, Shuko Nojiri, Naotake Yanagisawa, Terumi Shibata, Mami Yamashita, Kanako Tanaka, Yoshinori Yamashita, Yusuke Suzuki, Nozomu Kamei
DIABETES RESEARCH AND CLINICAL PRACTICE
(2018)
Article
Immunology
Youngjo Kim, Princess Wendy Bayona, Miri Kim, Jiyeon Chang, Sunmin Hong, Yoona Park, Andrea Budiman, Yong-Jin Kim, Chang Yong Choi, Woo Seok Kim, Jongsoon Lee, Kae Won Cho
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Nozomu Kamei, Mami Yamashita, Yuji Nishizaki, Naotake Yanagisawa, Shuko Nojiri, Kanako Tanaka, Yoshinori Yamashita, Terumi Shibata, Maki Murakoshi, Yusuke Suzuki, Tomohito Gohda
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Mitsuhide Naruse, Yasuhiro Koike, Nozomu Kamei, Ryuichi Sakamoto, Yuko Yambe, Michinori Arimitsu
Article
Immunology
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, Hye Jin Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, Chang Joo Oh, Eun Kyung Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, Daehee Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, Keun-Gyu Park, Ajay Chawla, Jongsoon Lee, Robert A. Harris, In-Kyu Lee
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Endocrinology & Metabolism
Tomohito Gohda, Nozomu Kamei, Takeo Koshida, Mitsunobu Kubota, Kanako Tanaka, Yoshinori Yamashita, Eri Adachi, Saki Ichikawa, Maki Murakoshi, Seiji Ueda, Yusuke Suzuki
JOURNAL OF DIABETES INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Gotaro Toda, Kotaro Soeda, Yukiko Okazaki, Naoki Kobayashi, Yukari Masuda, Naoko Arakawa, Hirotsugu Suwanai, Yosuke Masamoto, Yoshihiko Izumida, Nozomu Kamei, Takayoshi Sasako, Ryo Suzuki, Tetsuya Kubota, Naoto Kubota, Mineo Kurokawa, Kazuyuki Tobe, Tetsuo Noda, Kenya Honda, Domenico Accili, Toshimasa Yamauchi, Takashi Kadowaki, Kohjiro Ueki
Article
Endocrinology & Metabolism
Tomohito Gohda, Nozomu Kamei, Mitsunobu Kubota, Kanako Tanaka, Yoshinori Yamashita, Hiroko Sakuma, Chiaki Kishida, Eri Adachi, Takeo Koshida, Maki Murakoshi, Shinji Hagiwara, Kazuhiko Funabiki, Seiji Ueda, Yusuke Suzuki
Summary: Increased concentrations of serum TNFRs are positively associated with ACR and negatively associated with eGFR in patients with type 2 diabetes. The study shows that serum TNFRs are more strongly correlated with kidney measures, while urinary TNFRs are primarily associated with ACR.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Hitoshi Ishii, Hiroki Nakajima, Nozomu Kamei, Tetsuji Niiya, Toru Hiyoshi, Yuko Hiramori, Shigeyuki Ohtsu, Takashi Noto, Dai Shimono
Article
Endocrinology & Metabolism
Hitoshi Ishii, Hiroki Nakajima, Nozomu Kamei, Daigaku Uchida, Daisuke Suzuki, Yasuhiro Ono, Yasunori Sato, Dai Shimono
Summary: This study compared the effects of patient-led and physician-led insulin titration in Japanese insulin-naive T2DM patients. It found no significant difference in emotional distress and treatment satisfaction between the two groups, but higher self-efficacy scores in the patient-led group. In terms of glycemic control, the patient-led group showed significantly larger decreases in HbA1c and fasting plasma glucose levels.
Article
Endocrinology & Metabolism
Maki Murakoshi, Tomohito Gohda, Hiroko Sakuma, Terumi Shibata, Eri Adachi, Chiaki Kishida, Saki Ichikawa, Takeo Koshida, Nozomu Kamei, Yusuke Suzuki
Summary: High levels of PGRN and TNFR1 are associated with poor renal prognosis in patients with type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Tsuguka Matsuda, Natsumi Himeno, Akira Nakashima, Naoya Nakagawa, Toshihiko Kohashi, Dan Kawamori, Nozomu Kamei
Summary: Residual pancreatic endocrine function is crucial for metabolic status after pancreatectomy. This study investigated the changes in pancreatic glucagon secretion and found that fasting plasma glucagon levels decreased after pancreatectomy, while postprandial glucagon responses were maintained. The difference in postprandial glucagon response between pancreaticoduodenectomy and distal pancreatectomy suggests its involvement in postoperative nutritional status.
Article
Endocrinology & Metabolism
Jieun Kim, Jongsoon Lee
Summary: The creatine/phosphocreatine system has diverse functions in various tissues. A new study reveals its role in regulating obesity-induced inflammation in white adipocytes.
Review
Endocrinology & Metabolism
Jieun Kim, Jongsoon Lee
Summary: Obesity-induced chronic inflammation is closely linked to the development of type 2 diabetes, primarily regulated by adipose tissue-resident immune cells. Research areas include factors inducing adipose tissue macrophage inflammation, effector functions promoting insulin resistance by adipose tissue immune cells, and the potential targeting of early immunological events to halt the progression of insulin resistance.
ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Fumio Sawano, Nozomu Kamei, Mitsue Miyahara, Kyoko Kobuke, Shuhei Nakanishi, Chihiro Nagano, Hideki Nojima, Shusaku Maeda, Hiroshi Watanabe, Rui Kishimoto, Mami Yamashita, Aya Hamaoka, Kana Mukai, Tomoko Tsuboi, Hisayoshi Mochizuki, Reiko Nakashima, Yu Sakashita, Hisaaki Morishita, Tadahiro Kitamura
Summary: The study comprehensively investigated the effects of ipragliflozin in different conditioned type 2 diabetes patients, showing significant improvements in glycemic control and metabolic changes. Ipragliflozin demonstrated contrastive effects on various clinical parameters compared to DPP-4i, with better clinical outcomes when co-administered with a DPP-4i.
DIABETOLOGY INTERNATIONAL
(2021)