Article
Geriatrics & Gerontology
Alexander P. Young, Jiequan Zhu, Amina M. Bagher, Eileen M. Denovan-Wright, Susan E. Howlett, Melanie E. M. Kelly
Summary: The study revealed that aged rats have higher myogenic tone in cerebral arteries, a loss of ETB receptor activity, and an increase in ETA receptor expression, compared to young rats. This suggests that in aging vasculature, there is a shift towards ETA receptors in regulating cerebral blood flow, highlighting potential clinical implications for treating conditions with reduced cerebral perfusion in older adults.
Article
Plant Sciences
Marcelo Augusto Altieri, Luis Manuel Sarmiento-Machado, Guilherme Ribeiro Romualdo, Nelci Antunes de Moura, Luis Fernando Barbisan
Summary: The study found that dietary capsaicin can reduce the development of urothelial lesions in rats, demonstrating a protective effect.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Toxicology
Barbara G. Schmitt, Joseph Tobin, Debra A. McNett, Jaeshin Kim, Jeremy Durham, Kathleen P. Plotzke
Summary: Octamethylcyclotetrasiloxane (D4) is a high production volume chemical that has been thoroughly studied for its toxicological properties. This study compared the pharmacokinetic behavior of D4 in Fischer and Sprague Dawley CD rats and identified strain-specific differences.
TOXICOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Veronica Arreaza-Gil, Hector Palacios-Jordan, Maria del Mar Romero, Cristina Torres-Fuentes, Miguel A. A. Rodriguez, Xavier Remesar, Jose-Antonio Fernandez-Lopez, Anna Arola-Arnal
Summary: This study aimed to investigate the influence of timing, sex, and diet on the effects of proanthocyanidins (PAs) on the metabolome. The results showed that the effects of PAs on metabolites were sex and diet-dependent, and were also modulated by the timing of consumption.
Article
Environmental Sciences
Solomon Owumi, Taofeek Bello, K. Adegboyega Oyelere
Summary: NAC has a protective effect on hepatorenal function toxicity induced by PFOA, reducing the increase of toxic biomarkers and restoring antioxidant status, while alleviating the increase of inflammatory mediators. NAC can effectively alleviate the severity of kidney and liver tissue damage caused by PFOA.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Abdulrazaq Yusuf, Ochai Emmanuel Odeh, Solomon Oguche Alhassan, Sunday Ene-Ojo Atawodi
Summary: The study evaluated the preventive effect of Hyphaene thebaica fruit on colon carcinogenesis in rats. The fruit protected against lipid peroxidation and early biomarkers of colon carcinogenesis. It also prevented severe inflammations and damage to the MLH1 gene. The results validate the use of H. thebaica fruit for the management of colorectal disorders.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Substance Abuse
Shadab Forouzan, Steven J. Nieto, Therese A. Kosten
Summary: Chronic cocaine exposure has differential neural effects in Fischer 344 (F344) vs Lewis inbred rats, with prior exposure leading to persistence of responding during extinction in F344 but not Lewis rats. This suggests that genetic factors may play a role in relapse-like behaviors.
AMERICAN JOURNAL ON ADDICTIONS
(2021)
Article
Multidisciplinary Sciences
Baki Vijaya Bhaskar, Aluru Rammohan, Tirumalasetty Munichandra Babu, Gui Yu Zheng, Weibin Chen, Wudayagiri Rajendra, Grigory Zyryanov, Wei Gu
Summary: This study analyzed thirty dietary compounds on nine drug targets through in silico studies and found that compounds like silibinin and flavopiridol showed the highest binding energy with targets such as PI3K-alpha and PKC-eta, demonstrating broad spectrum anticancer activity. Pharmacophore modeling and database screening identified potential lead compounds, contributing to the development of novel anticancer agents.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Afrah F. Alkhuriji, Seham G. Alsaiari, Suliman Y. Alomar, Alaa A. Alnafjan, Hussah Alobaid, Manal F. El-Khadragy
Summary: Through experiments on a rat model of colorectal cancer, it was found that bone marrow stem cells have anti-inflammatory and anti-tumor effects, improving the histopathological picture of tumors, reducing the number of inflammatory cells, and modulating cellular redox status, which may have therapeutic value for colon cancer treatment.
BIOSCIENCE REPORTS
(2021)
Article
Immunology
Maria Amparo Assis, David Diaz, Rosa Ferrado, Carmelo Antonio Avila-Zarza, Eduardo Weruaga, Emilio Ambrosio
Summary: Peripheral immune system, particularly CD4(+) T cells, play a significant role in drug addiction and relapse, impacting vulnerability and resilience mechanisms. Understanding individual susceptibility and resistance can lead to personalized treatment strategies to prevent relapse.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Agriculture, Dairy & Animal Science
Amir Mosayyeb Zadeh, Seyyed Ali Mirghelenj, Mohsen Daneshyar, Mohsen Eslami, Mohammad Amir Karimi Torshizi, Mahdi Zhandi
Summary: This study investigated the effects of dietary supplementation of tomato pomace (TP) and L-arginine (L-Arg) on sperm characteristics, reproductive performance, and semen biochemical components of aged commercial male broiler breeders. The results showed that 15% TP supplementation resulted in increased semen volume and sperm concentration, as well as improved sperm viability, motility, and fertility rate. Additionally, supplementation of L-Arg above the recommended level negatively affected these parameters. Overall, 15% dietary TPS is recommended to improve the reproductive performance of aged commercial male broiler breeders.
Article
Nutrition & Dietetics
Mohammed Al-Zharani, Mohammed Mubarak, Hassan Ahmed Rudayni, Amin A. Al-Doaiss, Mahmoud M. Abd-Elwahab, Mohammed S. Al-Eissa
Summary: This study aims to evaluate the effect of quercetin on lead toxicity. The results show that quercetin can improve the hematological and biochemical parameters in animals exposed to lead, reducing the oxidative stress induced by lead toxicity.
Article
Biochemistry & Molecular Biology
Fen Sun, Jin-Yang Zhang, Lu-Ping Zhao, Qi Jin, Chao Jin, Qiu-Xiang Wang, Jun-Tao Xu, Meng-Jia Yin
Summary: The study investigates the differential effects of salt intake on young and aged male rats, revealing age-dependent physiological effects. The findings indicate that salt consumption affects survival rates, body weight, blood parameters, blood pressure, heart rate, and cognition, with significant age differences.
Article
Multidisciplinary Sciences
Hany Salah Mahmoud, Amani A. Almallah, Heba Nageh Gad El-Hak, Tahany Saleh Aldayel, Heba M. A. Abdelrazek, Howayda E. Khaled
Summary: The experiment demonstrated that Nigella sativa seeds exhibit immunostimulatory function through their antioxidant potential, induction of cytokine production, promotion of CD8 expression, and reduction of splenic apoptosis.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Ahmed Mahmoud Ismail, Eman Said Elshewy, Sherif Mohamed El-Ganainy, Donato Magista, Ahlam Farouk Hamouda, Khalid A. Alhudaib, Weaam Ebrahim, Mustafa I. Almaghasla
Summary: This study aimed to explore the cytotoxicity and genotoxicity of mycotoxins produced by pathogenic A. alternata from tomatoes. The mycotoxins ALT, AOH, TeA, and AS exhibited cytotoxic and genotoxic effects on human oral epithelial cells, lung fibroblast cells, and male albino rats. The pathogenic potentiality and mycotoxin production ability of A. alternata were also investigated.
Article
Radiology, Nuclear Medicine & Medical Imaging
Sangeeta Ray Banerjee, Il Minn, Vivek Kumar, Anders Josefsson, Ala Lisok, Mary Brummet, Jian Chen, Ana P. Kiess, Kwamena Baidoo, Cory Brayton, Ronnie C. Mease, Martin Brechbiel, George Sgouros, Robert F. Hobbs, Martin G. Pomper
JOURNAL OF NUCLEAR MEDICINE
(2020)
Article
Immunology
Dilini C. Gunasekera, Jinxia Ma, Vimvara Vacharathit, Palak Shah, Amritha Ramakrishnan, Priyanka Uprety, Zeli Shen, Alexander Sheh, Cory F. Brayton, Mark T. Whary, James G. Fox, Jay H. Bream
MUCOSAL IMMUNOLOGY
(2020)
Article
Nutrition & Dietetics
Kirstie Canene-Adams, Lisa Spence, Lore W. Kolberg, Kavita Karnik, DeAnn Liska, Eunice Mah
Summary: The study aimed to determine the available energy of dietary non-digestible fibers fermented by intestinal microbes and metabolized to short chain fatty acids. Results showed that the available energy of soluble fiber products was roughly equivalent, at approximately 0.2 kcal per gram.
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2021)
Article
Endocrinology & Metabolism
Matthias Van Hul, Kavita Karnik, Kirstie Canene-Adams, Mervyn De Souza, Pieter Van den Abbeele, Massimo Marzorati, Nathalie M. Delzenne, Amandine Everard, Patrice D. Cani
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander S. Pasciak, Sasicha Manupipatpong, Ferdinand K. Hui, Larry Gainsburg, Rebecca Krimins, M. Christine Zink, Cory F. Brayton, Meaghan Morris, Jaime Sage, Danielle R. Donahue, Matthew R. Dreher, Dara L. Kraitchman, Clifford R. Weiss
Article
Pathology
Mark James Hoenerhoff, David K. Meyerholz, Cory Brayton, Amanda P. Beck
Summary: Animal models play crucial roles in biomedical research, with veterinary pathologists being essential in understanding and characterizing the models. Veterinary pathologists are vital in interpreting pathology data, ensuring research rigor, and reproducibility.
VETERINARY PATHOLOGY
(2021)
Review
Veterinary Sciences
Kristi L. Helke, David K. Meyerholz, Amanda P. Beck, Eric R. Burrough, Rachel J. Derscheid, Christiane Lohr, Elizabeth F. McInnes, Cheryl L. Scudamore, Cory F. Brayton
Summary: Animal models are valuable tools for biomedical researchers, but careful consideration of various features and background factors is necessary for accurate interpretation of results. Different species, breeds/stocks, sex, age, diseases, and other factors can all impact study outcomes.
Letter
Nutrition & Dietetics
Kirstie Canene-Adams, Lisa Spence, Lore W. Kolberg, Kavita Karnik, DeAnn Liska, Eunice Mah
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
(2021)
Article
Clinical Neurology
Aysel Cetinkaya-Fisgin, Jing Zhu, Xinghua Luan, Jun-Soon Kim, Byoungchol Oh, Cory Brayton, Jesse Alt, Rana Rais, Barbara Slusher, Ahmet Hoke
Summary: EQ-6 is a neuroprotective drug that shows potential in preventing CIPN by preventing axon degeneration and influencing the metabolic pathways related to nerve protection.
Article
Pathology
Kathleen R. Mulka, Sarah E. Beck, Clarisse Solis, Andrew L. Johanson, Suzanne E. Queen, Megan E. McCarron, Morgan R. Richardson, Ruifeng Zhou, Paula Marinho, Anne Jedlicka, Selena Guerrero-Martin, Erin N. Shirk, Alicia M. Braxton, Jacqueline Brockhurst, Patrick S. Creisher, Santosh Dhakal, Cory F. Brayton, Rebecca T. Veenhuis, Kelly A. Metcalf Pate, Petros C. Karakousis, Cynthia A. Zahnow, Sabra L. Klein, Sanjay K. Jain, Patrick M. Tarwater, Andrew S. Pekosz, Jason S. Villano, Joseph L. Mankowski
Summary: The progression of SARS-CoV-2 in a Syrian hamster model provides valuable insights for the development of therapeutic and preventive interventions for COVID-19.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Nutrition & Dietetics
Kirstie Canene-Adams, Ieva Laurie, Kavita Karnik, Brian Flynn, William Goodwin, Sandrine Pigat
Summary: This study uses statistical modeling to evaluate the impact of fiber enrichment in food on consumer diet and health. The results show that fiber fortification can help with weight reduction, decrease cardiovascular disease risk, and reduce the risk of type 2 diabetes. The study provides an overview of the potential public health benefits of reformulating food products.
BRITISH JOURNAL OF NUTRITION
(2022)
Review
Veterinary Sciences
Liza Bau-Gaudreault, Tara Arndt, Anne Provencher, Cory F. Brayton
Summary: Clinical pathology testing is a distinct specialty in investigative or biomedical research, as well as in preclinical toxicity and safety assessments for laboratory animals, requiring a thorough understanding of species-specific variables. This review aims to be a useful resource for researchers, veterinary specialists, toxicologists, and clinical or anatomic pathologists.
Review
Veterinary Sciences
Timothy K. Cooper, David K. Meyerholz, Amanda P. Beck, Martha A. Delaney, Alessandra Piersigilli, Teresa L. Southard, Cory F. Brayton
Summary: Animals are valuable resources in biomedical research, helping us understand biological processes and disease pathogenesis. Interpreting data from animals requires knowledge of the processes or diseases being studied, as well as recognition of other conditions that may influence the study results. This article provides a pathology resource for researchers, pathologists, and veterinary personnel.
Review
Veterinary Sciences
Lewis B. Kinter, Robert C. Dysko, Barbara Natterson-Horowitz, Cory F. Brayton
Summary: ILAR, established in 1953 as part of the National Academies, has played a significant role in advancing necessary research using animals for the benefit of humans, animals, and the environment. In 2022, it will be restructured into BAHSCR within the National Academies, continuing its mission of promoting animal health sciences, conservation, and research.
Review
Veterinary Sciences
Cory F. Brayton
Summary: Laboratory registration codes play a critical role in standardized laboratory animal and genetic nomenclature, ensuring accurate scientific communication and research reproducibility. These codes are assigned by the International Laboratory Code Registry and maintained by ILAR. Continued recognition of the importance of genetic backgrounds and variants in research highlights the need for broader adoption of standardized animal naming conventions.