Article
Nanoscience & Nanotechnology
Md Wazedur Rahman, Seyedamin Firouzeh, Sandipan Pramanik
Summary: Functionalizing carbon nanotubes with DNA strands in a helical manner can polarize carrier spins through the CISS effect. The conduction mechanism is strongly localized due to DNA functionalization, and the observed magnetoresistance arises from interference effects between different hopping paths. CISS-induced spin polarization increases carrier localization length significantly in the low temperature range, impacting magnetoresistance in a non-trivial way not seen in conventional systems.
Article
Energy & Fuels
Suleiman Sani, Xin Liu, Lee Stevens, Haomin Wang, Chenggong Sun
Summary: In this work, novel solid amine adsorbents were prepared by impregnating polyethyleneimine (PEI) on mesoporous carbons. The adsorbents exhibited excellent CO2 adsorption capacity and thermo-stability, making them ideal candidates for post-combustion CO2 capture.
Article
Chemistry, Physical
Praveen Kumar Singh, Prashant Dubey, Ravindra Dhar, Roman Dabrowski
Summary: The dispersion of functionalized and non-functionalized multi walled carbon nanotubes has an effect on the thermodynamic, dielectric, optical, and electro-optical properties of 40octyl-4-cyanobiphenyl, a nematic host. The transition temperature and associated enthalpy increase in the thermodynamic study. The dielectric anisotropy increases in both dispersed nano-composites compared to the pure sample. The conductivity of non-functionalized multi walled carbon nanotubes increases by 2 orders of magnitude. The optical band gap decreases in both dispersed nanocomposites, as shown by the ultraviolet-visible spectroscopy study. The electro-optical parameters vary for functionalized and non-functionalized multi walled carbon nanotubes dispersed nanocomposites.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Biochemistry & Molecular Biology
Gaku Yamanaka, Fuyuko Takata, Yasufumi Kataoka, Kanako Kanou, Shinichiro Morichi, Shinya Dohgu, Hisashi Kawashima
Summary: Pericytes are crucial for maintaining the integrity of the blood-brain barrier and have been implicated in neuroinflammation associated with epilepsy. Clinical and experimental studies have shown that pericytes undergo morphological changes and redistribution in response to proinflammatory cytokines, potentially contributing to epilepsy pathogenesis and BBB permeability. Furthermore, pericytes may act as sensors of the inflammatory response and have potential as a therapeutic target for seizure disorders.
Article
Engineering, Environmental
Yufeng Zhao, Heqing Tang, Dongfang Wang, Myung-Hee Song, Chul-Woong Cho, Yeoung-Sang Yun
Summary: This study experimentally investigated the adsorption affinities of micropollutants onto multi-walled carbon nanotubes (MWCNTs) with different functional groups. The results showed that functionalized MWCNTs exhibited different adsorption affinities for charged compounds, and the adsorption affinity could be accurately predicted using LFER models. The models also provided insights into the adsorption mechanism and contribution of individual intermolecular interactions.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Petr Rozhin, Simone Adorinni, Daniel Iglesias, Tino Mackiol, Slavko Kralj, Matteo Bisetto, Michela Abrami, Mario Grassi, Manuela Bevilacqua, Paolo Fornasiero, Silvia Marchesan
Summary: Carbon nanostructures are modified to improve their dispersibility in aqueous conditions and favor the formation of hydrogels. The morphology and functionalization effects of the nanostructures are studied to understand their impact on the self-healing ability of the hydrogel and peptide fibrillation in aqueous buffer.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Materials Science, Textiles
Mohammad Farsi, Fatemeh Maashi Sani, Masoud Ebadi, Majid Shahbabaei
Summary: This study proposes a strategy to enhance the performance of wood-plastic composites (WPCs) using functionalized carbon nanotubes (CNTs). The results show that increasing the content of raw CNTs and Maleic Anhydride grafted Polyethylene (MAPE) can improve the mechanical and physical properties of the composite.
FIBERS AND POLYMERS
(2023)
Article
Nanoscience & Nanotechnology
Helena Uceta, Andrea Cabrera-Espinoza, Myriam Barrejon, Josei G. Sanchez, Edgar Gutierrez-Fernandez, Ivet Kosta, Jaime Martin, Silvia Collavini, Eugenia Martinez-Ferrero, Fernando Langa, Juan Luis Delgado
Summary: This study reports for the first time the incorporation of p-type functionalized carbon nanohorns (CNHs) in perovskite solar cells (PSCs) and compares them with p-type functionalized single- and double-walled carbon nanotubes (SWCNTs and DWCNTs). The p-type functionalized carbon nanomaterial (CNM) derivatives were successfully synthesized and incorporated into the hole transport layer (HTL) to evaluate their impact on PSCs. The results show that all p-type functionalized CNMs significantly improve the power conversion efficiency (PCE) by enhancing the short-circuit current density (J(sc)) and fill factor (FF). The incorporation of CNHs derivatives showed slightly better PCE compared to SWCNTs and DWCNTs derivatives. Moreover, the incorporation of p-type functionalized CNMs improves device stability by enhancing the hydrophobicity of the layer and hole transport across the interface.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Polymer Science
Vijay Patel, Unnati Joshi, Anand Joshi, Tarun Kumar Upadhyay, Lamya Ahmed Al-Keridis, Mohd Saeed
Summary: In this research, a unique three-dimensional mixing technique was used to incorporate MWCNTs into PMMA. The cytotoxicity, apoptosis detection, and cell viability of the composite were analyzed using the KB cell line. The results showed that the CNT increased lymphocyte-mediated cytotoxicity against KB cell lines and could potentially be used to treat certain types of cancer.
Article
Materials Science, Composites
Saddiqa Begum, Hameed Ullah, Irfan Ahmed, Yiqiang Zhan, Ayesha Kausar, Muhammad Adeel Aleem, Saeed Ahmad
Summary: Oxidized and grafted multi-walled carbon nanotubes in PVDF matrix showed improved dispersion and enhanced electrical properties, making them suitable for various energy applications. The nanocomposites exhibited well crystalline structure and uniform distribution of nanotubes, leading to the formation of beta-phase and improved electrical conductivity.
COMPOSITES SCIENCE AND TECHNOLOGY
(2021)
Article
Polymer Science
Weibing Liang, Ming Chen, Lin Li, Liqiang Yan, Xiuli Wang, Xiongzhi Wu, Chenghong Lei
Summary: In this study, polyethyleneimine was used to functionalize carbon nanotubes and activated carbon for loading antimycotic enzyme lyticase. The research showed that polyethyleneimine not only enhanced the antimycotic activity of loaded lyticase, but also exhibited its own antimycotic activity. This study provides a new antimycotic protection for medicine, food industry, and other biochemical processes.
Article
Chemistry, Multidisciplinary
Claudio Ferrari, Giovanni Attolini, Matteo Bosi, Cesare Frigeri, Paola Frigeri, Enos Gombia, Laura Lazzarini, Francesca Rossi, Luca Seravalli, Giovanna Trevisi, Riccardo Lolli, Lucrezia Aversa, Roberto Verucchi, Nahida Musayeva, Muhammad Alizade, Sevinj Quluzade, Teimur Orujov, Francesco Sansone, Laura Baldini, Francesco Rispoli
Summary: In this study, amino-functionalized carbon nanotubes were used to produce resistive sensors for detecting nitroaromatic explosives through their interaction with vapor. The sensors demonstrated simple construction, low power consumption, and potential for portable device preparation.
Article
Materials Science, Multidisciplinary
Indrani Gupta, Samar Azizighannad, Edgardo T. Farinas, Somenath Mitra
Summary: The study found that various nanocarbons possess antiviral properties, with higher concentrations leading to better efficacy. Functionalized CNT-phenol and CNT-Ag showed the highest virus removal efficiencies, while GO and rGO had lower efficiency individually but significantly improved when combined with CNTs.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Construction & Building Technology
Jeison Vasquez, Marcelo Gonzalez, Paulina Vergara, Jose F. Munoz, Juan Arellano, Nestor Escalona Burgos
Summary: This study investigates the impact of incorporating carbon nanotubes into a cementitious matrix with high levels of sulfate. Results show that carbon nanotubes can significantly improve compressive strength and reduce expansion. This research is novel as it explores the application of carbon nanotubes in alkaline pastes with high sulfate content.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Environmental Sciences
Shikha Gulati, Harish Neela B. Lingam, Sanjay Kumar, Kartika Goyal, Aryan Arora, Rajender S. Varma
Summary: This article introduces the method and advantages of using carbon nanotubes as adsorbents to purify the air, including the synthesis, functionalization, and purification methods of carbon nanotubes, as well as their applications in removing pollutants and detecting harmful gases.
Article
Neurosciences
Francesca Zummo, Pietro Esposito, Huilei Hou, Cecilia Wetzl, Gemma Rius, Raphaela Tkatchenko, Anton Guimera, Philippe Godignon, Maurizio Prato, Elisabet Prats-Alfonso, Alejandro Criado, Denis Scaini
Summary: In recent years, there has been an increasing demand for surface modifications to enhance neuronal cell interactions and modulation. Graphene-based nanomaterials, characterized by their cytocompatibility and chemical functionalization, have become increasingly appealing for these purposes. The study demonstrated that both pristine and functionalized graphene substrates can intrinsically promote or depress neuronal activity.
FRONTIERS IN NEUROSCIENCE
(2022)
Editorial Material
Chemistry, Multidisciplinary
Giuseppe Bardi, Monica Neagu
Article
Engineering, Biomedical
Paul S. Sharp, Maria Stylianou, Luis M. Arellano, Juliana C. Neves, Alfredo M. Gravagnuolo, Abbie Dodd, Katharine Barr, Neus Lozano, Thomas Kisby, Kostas Kostarelos
Summary: Graphene-based 2D nanomaterials have unique physicochemical characteristics that can be used in various biomedical applications, such as drug delivery and treatment. This study investigates the distribution of thin graphene oxide (GO) nanosheets in GBM mouse models and designs a novel nano-chemotherapeutic approach using GO sheets as platforms for drug complexation. The results demonstrate enhanced cytotoxic effects of the GO-BTZ complex in vivo.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Chen-Xia Hu, Oliver Read, Yuyoung Shin, Yingxian Chen, Jingjing Wang, Matthew Boyes, Niting Zeng, Adyasha Panigrahi, Kostas Kostarelos, Igor Larrosa, Sandra Vranic, Cinzia Casiraghi
Summary: In this study, we used liquid cascade centrifugation to obtain fractions of nanosheets with different lateral size distributions from highly concentrated graphene dispersions. The concentration, stability, size, thickness, and cytotoxicity profile were studied as a function of the initial stabilizer concentration for each fraction. Our results reveal the critical importance of the initial stabilizer concentration in determining the concentration, stability, and biocompatibility of the dispersions, regardless of the lateral size of the flakes.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Giuseppe Di Mauro, Roberta Amoriello, Neus Lozano, Alberto Carnasciali, Daniele Guasti, Maurizio Becucci, Giada Cellot, Kostas Kostarelos, Clara Ballerini, Laura Ballerini
Summary: In neuroinflammation, astrocytes respond to pro-inflammatory cytokines (CKs) through Ca2+ signaling and play important roles in disease progression. Graphene oxide (GO) nanoparticles offer a promising approach to target astrocytes and regulate their reactivity. This study investigates the effects of CKs on astrocytic Ca2+ signaling and demonstrates the potential of GO to reverse the dysregulated cellular changes in astrocytes. The findings suggest that GO-based therapeutics may be effective in treating immune-mediated neuroinflammatory diseases.
Article
Pharmacology & Pharmacy
Yue Qin, Adam A. Walters, Khuloud T. Al-Jamal
Summary: This study compared the transfection efficiency and cytotoxicity of three non-viral vectors (PEI, LPF, and SNALPs) for delivering pDNA expressing immunostimulatory molecules. PEI and LPF showed high transfection efficiency but upregulated PD-L1 expression and induced cytotoxicity. SNALPs, on the other hand, had lower transfection efficiency but did not upregulate PD-L1 expression or induce cytotoxicity, making them a viable non-viral vector for pDNA delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Nanoscience & Nanotechnology
Guotao Peng, Hanna M. Sinkko, Harri Alenius, Neus Lozano, Kostas Kostarelos, Lars Brautigam, Bengt Fadeel
Summary: The presence of graphene oxide in the diet alters the composition of the gut microbiome in adult zebrafish, with differences seen between wild-type and ahr2-deficient animals. Furthermore, oral exposure to graphene oxide in combination with butyrate induces AhR-dependent expression of cyp1a and homing of lck(+) cells to the gut in germ-free zebrafish. Single-cell RNA sequencing studies reveal the presence of innate lymphoid cell (ILC)-like cells in germ-free zebrafish, and a "corona" of microbial butyrate triggered by graphene oxide leads to the induction of ILC2-like cells with regulatory properties.
NATURE NANOTECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Adam A. Walters, Abrar Ali, Julie Tzu-Wen Wang, Khuloud T. Al-Jamal
Summary: This study aimed to investigate the effects of intratumoral injection of immunoadjuvants on antibody response and the ability of serum obtained from in situ vaccinated mice to neutralize circulating tumor cells. The results showed that in situ vaccination can modify the isotype of anti-tumor antibodies, but it is not sufficient to neutralize circulating cancer cells.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Engineering, Biomedical
Daniela De Luca, Sara Moccia, Leonardo Lupori, Raffaele Mazziotti, Tommaso Pizzorusso, Silvestro Micera
Summary: This study aims to develop an algorithm that can automatically associate a cortical activation pattern with the visual stimulus that generated it. By conducting experiments on three mice using wide-field calcium imaging, a convolutional neural network (CNN) was trained to classify different visual stimuli. The results show that this method can be used to classify cortical responses to simple visual stimuli, offering a potential alternative to existing decoding methodologies.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Andrea Poli, Aurelia Viglione, Raffaele Mazziotti, Valentino Totaro, Silvia Morea, Riccardo Melani, Davide Silingardi, Elena Putignano, Nicoletta Berardi, Tommaso Pizzorusso
Summary: The ability to store, retrieve, and extinguish memories of adverse experiences is essential for animal survival. Recent studies suggest that the aggregation of CSPGs into PNNs regulates the boundaries of the critical period for fear extinction. The presence of PNNs in the adult brain may be responsible for the appearance of persistent fear memories.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Thomas Loret, Luis Augusto Visani de Luna, Matteo Andrea Lucherelli, Alexander Fordham, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Cyrill Bussy
Summary: The study investigates the biological response, distribution, and bio-persistence of four different graphene-based materials (GBMs) in mouse lungs. The size, carbon to oxygen ratio, and thickness of the GBMs do not induce a strong pulmonary immune response. Neutrophils internalize and degrade small GBMs faster than macrophages, revealing their crucial role in the elimination of these materials. Large GBMs, on the other hand, have hindered degradation and long-term persistence in macrophages, leading to more damages. These findings are important for the design of safer GBMs for biomedical applications.
Editorial Material
Biotechnology & Applied Microbiology
Giuseppe Bardi, Donato Zipeto, Monica Neagu, Dragana Nikitovic
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Lorenza Tortella, Irene Santini, Neus Lozano, Kostas Kostarelos, Giada Cellot, Laura Ballerini
Summary: Small graphene oxide nanosheets can reversibly downregulate excitatory synapses in the central nervous system and have potential applications as therapeutic tools for neuro-disorders. This study demonstrates that the delivery of s-GO can improve neuronal survival during oxygen-glucose deprivation and protect neuronal integrity under exogenous glutamate application.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Helene Cazier, Carole Malgorn, Dominique Georgin, Nathalie Fresneau, Fabrice Beau, Kostas Kostarelos, Cyrill Bussy, Stephane Campidelli, Mathieu Pinault, Martine Mayne-L'Hermite, Frederic Taran, Christophe Junot, Francois Fenaille, Antoine Sallustrau, Benoit Colsch
Summary: Research on graphene based nanomaterials has expanded in recent years due to their unique properties and potential socio-economic impact. This study proposes a novel approach combining radioimaging and mass spectrometry imaging for detecting Graphene Oxide (GO) labeled with carbon-14 in mice. The results demonstrate the advantages of this correlative imaging technique for the pre-clinical development of graphene-based biomedical applications.
Article
Chemistry, Multidisciplinary
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Neus Lozano, Kostas Kostarelos, Giada Cellot, Laura Ballerini
Summary: Graphene oxide nanosheets have the potential to alter neurobiological processes and regulate glutamatergic synapses, making them a promising candidate for future neurotherapeutic developments. In a rat model of post-traumatic stress disorder (PTSD), it was found that a single injection of graphene oxide to the lateral amygdala could induce behavior remission and reduce dendritic spine densities associated with PTSD. Mechanistically, graphene oxide was found to affect the probability of release, thus modulating synaptic plasticity in the amygdala.
