Article
Clinical Neurology
Alex Hatzimanolis, Stefania Foteli, Pentagiotissa Stefanatou, Angeliki-Aikaterini Ntigrintaki, Irene Ralli, Konstantinos Kollias, Chrysoula Nikolaou, Maria Gazouli, Nikos C. Stefanis
Summary: This study found that individuals with first-episode psychosis have lower expression levels of the CSMD1 gene compared to mentally healthy volunteers, further confirming the positive correlation between C4A and CSMD1 gene expression levels in healthy individuals but not in patients with first-episode psychosis. Additionally, copy number variants in the C4 gene previously associated with schizophrenia risk were correlated with higher C4A gene expression levels in patients with first-episode psychosis, confirming the regulatory effect of C4 structural variants on gene expression. Furthermore, significantly higher C4A serum concentrations were observed in patients with first-episode psychosis.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2022)
Review
Genetics & Heredity
Esra Ermis Akyuz, Sandra M. Bell
Summary: CSMD1, a tumor suppressor gene, plays important roles in various biological processes including development, complement system, neurodevelopment, and cancer progression. Its association with schizophrenia, Parkinson's disease, and different cancers contributes to the development of new diagnosis and treatment methods.
Review
Psychiatry
Jintao Zhou, Jingfangzhou Li, Qi Zhao, Peixin Ou, Wan Zhao
Summary: This study reviews recent research from both behavioral and neuroimaging perspectives to summarize the working memory deficits of children with schizophrenia and discusses pathogenic factors such as genetic susceptibility. Additionally, this study proposes practical interventions to improve cognitive symptoms of schizophrenia from psychological and neural perspectives.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Chemistry, Multidisciplinary
Qian Wang, Meng-wei Wang, Yan-yun Sun, Xiao-yan Hu, Pan-pan Geng, Hui Shu, Xiao-na Wang, Hao Wang, Jun-fang Zhang, Hong-qiang Cheng, Wei Wang, Xin-chun Jin
Summary: Increasing evidence suggests that chronic nicotine treatment can alleviate MK-801-induced schizophrenia-like symptoms and cognitive impairment in mice. This study found that nicotine treatment reversed the increased expression levels of PDZ and LIM domain 5 (Pdlim5) and prevented the decrease in CREB-regulated transcription coactivator 1 (CRTC1) in the prefrontal cortex (PFC), resulting in improved cognition in mice.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Biochemistry & Molecular Biology
Maximiliano Rapanelli, Jamal B. Williams, Kaijie Ma, Fengwei Yang, Ping Zhong, Rajvi Patel, Manasa Kumar, Luye Qin, Benjamin Rein, Zi-Jun Wang, Bibi Kassim, Behnam Javidfar, Lizette Couto, Schahram Akbarian, Zhen Yan
Summary: Large-scale genetic studies have shown that chromatin regulators playing a role in histone methylation/demethylation are disrupted in autism. This study found a significant decrease in histone lysine 4 dimethylation (H3K4me2), a histone mark linked to gene activation, in the prefrontal cortex of autistic patients and mutant mice with the deficiency of top-ranking autism risk factor Shank3 or Cul3. The study further demonstrated that inhibition of the H3K4me2 demethylase LSD1 can rescue core symptoms of autism, restore receptor function, and regulate gene expression relevant to synaptic signaling and developmental processes.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Kyna-Anne Conn, Suzy Alexander, Thomas H. J. Burne, James P. Kesby
Summary: This study examines the role of D1 and D2 receptors in learning induced by amphetamine. The results suggest that overall D1 receptor availability is crucial for learning, while modifying D2 receptor function can ameliorate learning deficits in a state of elevated dopamine.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Cell Biology
Meng Ye, Jingqiu Huang, Qianxue Mou, Jing Luo, Yuanyuan Hu, Xiaotong Lou, Ke Yao, Bowen Zhao, Qiming Duan, Xing Li, Hong Zhang, Yin Zhao
Summary: The study demonstrates that CD82 plays a neuroprotective role in glaucoma treatment, offering potential therapeutic strategies for the disease by promoting optic nerve regeneration and ameliorating axon degeneration.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Xianjun Chen, Nan-Xin Huang, Yong-Jie Cheng, Qi-Yan Cai, Yan-Ping Tian, Xing-Shu Chen, Lan Xiao
Summary: This research indicates that DNA hypermethylation in oligodendroglial cells contributes to anxious behavior, impaired sociability, and sensorimotor gating deficits in mice. It also leads to dysregulation of oligodendroglia-specific transcription factors and reduction of oligodendroglial lineage cells and myelin integrity in the frontal white matter. These findings suggest that DNA hypermethylation may play a role in the pathogenesis of schizophrenia-like behaviors in mice and provide insights into potential therapeutic strategies for white matter pathology in schizophrenia.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Roderick P. P. W. M. Maas, Sven Killaars, Bart P. C. van de Warrenburg, Dennis J. L. G. Schutter
Summary: The CCAS-S is effective in identifying cognitive deficits in SCA3 patients, showing a high discriminative ability and correlating with disease severity measures.
JOURNAL OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lanxiang Tian, Yukai Luo, Aisheng Zhan, Jie Ren, Huafeng Qin, Yongxin Pan
Summary: This study demonstrates that long-term exposure to hypomagnetic field (HMF) leads to cognitive impairments, which may be caused by high levels of ROS and hippocampal oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Marco Canevelli, Lindsay M. K. Wallace, Giuseppe Bruno, Matteo Cesari, Kenneth Rockwood, David D. Ward
Summary: Frailty is associated with cognitive expression of neuropsychological deficits in older adults, as found in the analysis of data from three large cohort studies. Among participants with higher frailty levels, there was a stronger negative association between neuropsychological deficits and cognitive performance.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anika Pupak, Ankita Singh, Anna Sancho-Balsells, Rafael Alcala-Vida, Marc Espina, Albert Giralt, Eulalia Marti, Ulf Andersson Vang Orom, Silvia Gines, Veronica Brito
Summary: This study investigated the m6A methylation pattern in the hippocampus of Huntington's disease (HD) mice and its role in HD cognitive symptoms. The study found that m6A was hypermethylated in certain genes in the hippocampus of HD mice. Conversely, m6A was aberrantly regulated in the HD hippocampus, leading to demethylation of important components of synapse organization. Inhibition of FTO expression in the hippocampus restored memory disturbances in symptomatic HD mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Qian He, Adam N. Bennett, Jundong Liu, Beifang Fan, Xue Han, Lu Cheng, Yan Chen, Xia Yang, Kei Hang Katie Chan
Summary: There is a genetic overlap between schizophrenia and cardiometabolic traits, with shared variants influencing both conditions. Novel genetic variants and genes have been discovered that potentially play a role in the comorbidity between schizophrenia and body mass index.
Article
Genetics & Heredity
Xianglai Liu, Hailing Xie, Zejuan Fu, Qiankun Yao, Tianming Han, Dafei Zhan, Zhan Lin, Hong Zhu
Summary: The study revealed a correlation between MAD1L1 and TSNARE genetic polymorphisms and susceptibility to schizophrenia, suggesting a protective role. Replication experiments in cohorts with larger sample sizes are needed to confirm these findings.
BMC MEDICAL GENOMICS
(2021)
Article
Neurosciences
Taesun Yoo, Shambhu Joshi, Sanjaya Prajapati, Yi Sul Cho, Jinkyeong Kim, Pil-Hoon Park, Yong Chul Bae, Eunjoon Kim, Soo Young Kim
Summary: Loss of function of the DLG2/PSD-93 gene is associated with an increased risk for schizophrenia, intellectual disability, and autism spectrum disorders. Mice lacking exon 14 of the Dlg2 gene display autistic-like behaviors and aberrant synaptic activity in the striatum. DLG2/PSD-93 deficiency results in striatal dysfunction.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Ibrahim A. Akkouh, Silje Skrede, Asbjorn Holmgren, Kari M. Ersland, Lars Hansson, Shahram Bahrami, Ole A. Andreassen, Vidar M. Steen, Srdjan Djurovic, Timothy Hughes
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Gastroenterology & Hepatology
Chirag Nepal, Bin Zhu, Colm J. O'Rourke, Deepak Kumar Bhatt, Donghyuk Lee, Lei Song, Difei Wang, Alison L. Van Dyke, Hyoyoung Choo-Wosoba, Zhiwei Liu, Allan Hildesheim, Alisa M. Goldstein, Michael Dean, Juan LaFuente-Barquero, Scott Lawrence, Karun Mutreja, Mary E. Olanich, Justo Lorenzo Bermejo, Catterina Ferreccio, Juan Carlos Roa, Asif Rashid, Ann W. Hsing, Yu-Tang Gao, Stephen J. Chanock, Juan Carlos Araya, Jesper B. Andersen, Jill Koshiol
Summary: This study characterized gallbladder cancer by analyzing the mutational landscape, molecular subtypes, and survival-associated genes. The findings suggest a crucial role of tumor microenvironment and immune profiles in gallbladder carcinogenesis.
JOURNAL OF HEPATOLOGY
(2021)
Letter
Medicine, General & Internal
Trond Traetteberg Serkland, Silje Skrede, Jon Andsnes Berg
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Psychology, Clinical
Dimitrios Andreou, Nils Eiel Steen, Kjetil Nordbo Jorgensen, Runar Elle Smelror, Kirsten Wedervang-Resell, Stener Nerland, Lars T. Westlye, Terje Naerland, Anne Margrethe Myhre, Inge Joa, Solveig Merete Klaebo Reitan, Arne Vaaler, Gunnar Morken, Erlend Boen, Torbjorn Elvsashagen, Birgitte Boye, Ulrik Fredrik Malt, Pal Aukrust, Silje Skrede, Rune Andreas Kroken, Erik Johnsen, Srdjan Djurovic, Ole A. Andreassen, Thor Ueland, Ingrid Agartz
Summary: The study found lower levels of NSE in adult and adolescent patients with SMI compared to healthy controls. Among adults, both patients with schizophrenia spectrum disorders and bipolar spectrum disorders had lower NSE levels, which were associated with increased symptom severity. Females also had lower NSE concentrations than males, suggesting a potential role of gender in the pathogenesis of SMI.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Nutrition & Dietetics
Sayani Mukherjee, Silje Skrede, Edward Milbank, Ramaroson Andriantsitohaina, Miguel Lopez, Johan Ferno
Summary: Antipsychotic drugs play a crucial role in the treatment of schizophrenia and other psychoses. However, many of these drugs have side effects such as increased appetite, weight gain, and increased risk for diabetes and cardiovascular disease. Understanding the molecular mechanisms behind drug-induced hyperphagia is important for the development of new drugs and advancing our knowledge of appetite regulation.
FRONTIERS IN NUTRITION
(2022)
Article
Genetics & Heredity
Damir Baranasic, Matthias Hortenhuber, Piotr J. Balwierz, Tobias Zehnder, Abdul Kadir Mukarram, Chirag Nepal, Csilla Varnai, Yavor Hadzhiev, Ada Jimenez-Gonzalez, Nan Li, Joseph Wragg, Fabio M. D'Orazio, Dorde Relic, Mikhail Pachkov, Noelia Diaz, Benjamin Hernandez-Rodriguez, Zelin Chen, Marcus Stoiber, Michael Dong, Irene Stevens, Samuel E. Ross, Anne Eagle, Ryan Martin, Oluwapelumi Obasaju, Sepand Rastegar, Alison C. McGarvey, Wolfgang Kopp, Emily Chambers, Dennis Wang, Hyejeong R. Kim, Rafael D. Acemel, Silvia Naranjo, Maciej Lapinski, Vanessa Chong, Sinnakaruppan Mathavan, Bernard Peers, Tatjana Sauka-Spengler, Martin Vingron, Piero Carninci, Uwe Ohler, Scott Allen Lacadie, Shawn M. Burgess, Cecilia Winata, Freek van Eeden, Juan M. Vaquerizas, Jose Luis Gomez-Skarmeta, Daria Onichtchouk, Ben James Brown, Ozren Bogdanovic, Erik van Nimwegen, Monte Westerfield, Fiona C. Wardle, Carsten O. Daub, Boris Lenhard, Ferenc Muller
Summary: Zebrafish, an important model organism for studying embryonic development and human diseases, lacks a systematic functional annotation program. The international DANIO-CODE consortium addressed this issue by creating a central repository to store and process zebrafish developmental functional genomic data. They improved existing annotations and identified over 140,000 cis-regulatory elements throughout development. They also compared regulatory elements and epigenomic landscapes between zebrafish and mouse, predicting functional relationships between them. This study extends the utility of zebrafish developmental genomics to mammals.
Review
Endocrinology & Metabolism
Katerina Horska, Jana Ruda-Kucerova, Silje Skrede
Summary: Antipsychotics (APDs) are core treatments for severe mental disorders but do not improve cognitive impairment. Adverse metabolic effects are common during APD treatment. Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1 RAs) have potential in reversing APD-induced metabolic adverse effects and promoting cognition.
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Psychiatry
Gunnhild E. Hoprekstad, Eirik Kjelby, Rolf Gjestad, Farivar Fathian, Tor K. Larsen, Solveig K. Reitan, Maria Rettenbacher, Anja Torsvik, Silje Skrede, Erik Johnsen, Rune A. Kroken
Summary: Depression is common in all phases of schizophrenia spectrum disorders, and immune system activity is altered in both depression and schizophrenia. In this study, we aimed to identify different depressive trajectories in a sample of 144 adult individuals with schizophrenia spectrum disorders and investigate possible cytokine profile differences.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Multidisciplinary Sciences
Chirag Nepal, Jesper B. Andersen
Summary: The study investigates the regulatory mechanisms of alternative promoters in hepatocellular carcinoma and provides insights into their sequence and epigenetics landscape. The authors identify 4083 alternative promoters in 2926 multi-promoter genes, which are rarely detected in normal livers. These alternative promoters play a role in oncogenic processes and are associated with overall survival. The findings reveal the unique characteristics of alternative promoters, such as their narrow nucleosome depleted regions and enrichment of tissue-specific transcription factors.
NATURE COMMUNICATIONS
(2023)
Review
Psychiatry
Malene Kalsnes Tyssedal, Erik Johnsen, Aurora Bronstad, Silje Skrede
Summary: This systematic review examined the effect of dog-assisted interventions as a supplementary treatment for individuals diagnosed with schizophrenia and related disorders. The included studies indicated potential benefits in improving various outcome measures, but the interpretation of results was complicated due to the low number of participants, heterogeneity, and risk of bias.
FRONTIERS IN PSYCHIATRY
(2023)
Meeting Abstract
Pharmacology & Pharmacy
Jon Andsnes Berg, Silje Skrede, Joakim Hansen, Kristian Avlesbug, Trond Traetteberg Serkland
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Medical Laboratory Technology
Erik I. Hallin, Trond Traetteberg Serkland, Kjell-Morten Myhr, Oivind Grytten Torkildsen, Silje Skrede
Summary: This study established and validated an LC-MS/MS-based quantitation method for ocrelizumab, showing that it can provide results within the same day. Serum concentrations of ocrelizumab in three MS patients treated with the drug were measured, with the results indicating expected values for Cmax and drug half-life over the sampled time period.
JOURNAL OF MASS SPECTROMETRY AND ADVANCES IN THE CLINICAL LAB
(2022)
Article
Psychiatry
Erik Johnsen, Rune A. Kroken, Else-Marie Loberg, Maria Rettenbacher, Inge Joa, Tor Ketil Larsen, Solveig Klaebo Reitan, Berit Walla, Renata Alisauskiene, Liss Goril Anda, Christoffer Bartz-Johannessen, Jan Oystein Berle, Jill Bjarke, Farivar Fathian, Kenneth Hugdahl, Eirik Kjelby, Igne Sinkeviciute, Silje Skrede, Lena Stabell, Vidar M. Steen, W. Wolfgang Fleischhacker
Meeting Abstract
Psychiatry
Gunnhild Hoprekstad, Rolf Gjestad, Eirik Kjelby, Silje Skrede, Erik Johnsen, Rune A. Kroken
SCHIZOPHRENIA BULLETIN
(2020)
Article
Multidisciplinary Sciences
Chirag Nepal, Andrzej Taranta, Yavor Hadzhiev, Sachin Pundhir, Piotr Mydel, Boris Lenhard, Ferenc Muller, Jesper B. Andersen