Review
Pharmacology & Pharmacy
Xue Hu, Qiang Zhang, Wanying Xing, Wan Wang
Summary: This mini-review discusses the modulation of the Wnt/beta-catenin signaling pathway in triple-negative breast cancer, focusing on the involvement of lncRNAs and miRNAs in its regulation and their impact on breast cancer pathogenesis, proliferation, migration, and malignancy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Shuyan Han, Huifeng Hao, Haibo Han, Dong Xue, Yanna Jiao, Yuntao Xie, Ye Xu, Longtao Huangfu, Jialei Fu, Shan Wang, Hong Sun, Pingping Li, Qun Zhou
Summary: CUEDC2 plays a crucial role in the hyperactivation of Wnt signaling and tumorigenesis in triple-negative breast cancer (TNBC). It enhances Wnt signaling by directly binding to β-catenin and promoting its nuclear translocation. Targeting the interaction between CUEDC2 and β-catenin may be a promising strategy for combating TNBC.
Article
Engineering, Biomedical
Xianquan Feng, Jialiang Zhang, Lina Wu, Wanjing Lin, Zhihong Liu, Xin Zhou, Yang Qi, Zhenzhen Chen, Lingjun Zeng, Changqing Zheng, Xiaomu Hu, Qian Zhang, Hongtao Song
Summary: This study evaluates the role of drug self-delivery nanocubes (ATO/PpIX-SMN) combined with anti-PD-L1 in TNBC treatment. The nanocubes enhance photodynamic therapy-induced immunogenic cell death and downregulate tumor signaling. Combined with anti-PD-L1, they promote dendritic cell maturation, increase CTL infiltration, reduce regulatory T cells, and activate the host immune system, effectively treating primary and distal tumors.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Qi Zhou, Xiaoyan Ren, Michelle K. Oberoi, Meiwand Bedar, Rachel M. Caprini, Marley J. Dewey, Vasiliki Kolliopoulos, Dean T. Yamaguchi, Brendan A. C. Harley, Justine C. Lee
Summary: The nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffold promotes skull regeneration in vivo without exogenous growth factors or progenitor cells. Modulation of MC-GAG stiffness affects the expression of primary human bone marrow-derived mesenchymal stem cells (hMSCs) and canonical Wnt (cWnt) signaling. Stiffness-induced activation of the Wnt and mechanotransduction pathways promotes osteogenesis on MC-GAG, while activated beta-catenin serves as a limiting agent and a potential target for optimal modulation of stiffness in skeletal regenerative materials.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Oncology
Siqi Li, Haoming Wu, Xinjian Huang, Yunting Jian, Lingzhi Kong, Hongyi Xu, Ying Ouyang, Xiangfu Chen, Geyan Wu, Liang Yu, Xi Wang
Summary: BOP1 plays a crucial role in chemoresistance of TNBC, and its overexpression is associated with poor prognosis in patients, indicating it may serve as a therapeutic target.
JOURNAL OF PATHOLOGY
(2021)
Article
Oncology
Zhi Li, Hai-Yan Yang, Xiao-Lan Zhang, Xu Zhang, Yu-Zhou Huang, Xin-Yuan Dai, Liang Shi, Guo-Ren Zhou, Ji-Fu Wei, Qiang Ding
Summary: This study revealed that KIF23 is up-regulated in TNBC and is associated with poor prognosis. KIF23 promotes TNBC proliferation, migration, and invasion by activating the Wnt/beta-catenin pathway and inducing epithelial-mesenchymal transition (EMT). The WDR5/FOXM1/KIF23/Wnt/beta-catenin axis may serve as a promising therapeutic target for TNBC treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xiao Ma, Xiaoling Hu, Yijia Zhu, Huixian Jin, Guifen Hu, Linchao Ding, Shilong Ning
Summary: Sesamol inhibits proliferation, migration, and invasion of triple negative breast cancer (TNBC) cells by attenuating PCNA, CyclinD1 expression and reverting epithelial-mesenchymal transition (EMT). It also inactivates the Wnt/beta-catenin signaling pathway and induces the expression of Wnt inhibitory factor 1 (WIF1), which leads to the inhibition of TNBC growth and metastasis.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Oncology
Liang Zhang, Qin Liu, Ke-wei Liu, Zhong-yi Qin, Guang-xi Zhu, Li-ting Shen, Ni Zhang, Bi-ying Liu, Lin-rong Che, Jin-yang Li, Tao Wang, Liang-zhi Wen, Kai-jun Liu, Yan Guo, Xin-ru Yin, Xing-wei Wang, Zhi-hua Zhou, Hua-liang Xiao, You-hong Cui, Xiu-wu Bian, Chun-hui Lan, Dongfeng Chen, Bin Wang
Summary: SHARPIN interacts with beta-catenin to stabilize its protein, competing with the E3 ubiquitin ligase beta-Trcp1 to reduce beta-catenin ubiquitination levels and prevent its degradation. SHARPIN is essential for the invasiveness and malignant growth of gastric cancer cells, dependent on its binding partner beta-catenin. Elevated SHARPIN expression in gastric cancer tissues is associated with disease malignancy and correlates with beta-catenin expression levels.
Article
Oncology
Wei Xie, Huijie Zhao, Fengxian Wang, Yiyun Wang, Yuan He, Tong Wang, Kunchi Zhang, Hao Yang, Zhaoli Zhou, Haibin Shi, Jin Wang, Gang Huang
Summary: A novel humanized antibody targeting Fzd7, named SHH002-hu1, was developed and demonstrated potential anti-tumor activity. It showed high affinity with Fzd7, specifically targeted Fzd7(+) cells and tumor tissues, and enhanced the anti-TNBC capacity of Bevacizumab through inhibiting Wnt/beta-catenin signaling. SHH002-hu1 could be a promising candidate for synergistic therapy with Bevacizumab in preventing TNBC recurrence.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hongjiao Li, Chenglian Xie, Yurong Lu, Kaijing Chang, Feng Guan, Xiang Li
Summary: This study reveals that plasma exosomal miR92a is significantly upregulated in MDS/AML patients and can interfere with cell resistance to Ara-C by regulating the PTEN and Wnt/β-catenin signaling pathway.
Article
Biochemistry & Molecular Biology
Zhaobo Cheng, Renjie Yu, Li Li, Junhao Mu, Yijia Gong, Fan Wu, Yujia Liu, Xiangyi Zhou, Xiaohua Zeng, Yongzhong Wu, Ran Sun, Tingxiu Xiang
Summary: In our research, we identified ZNF334 as a novel tumor suppressor of triple-negative breast cancer (TNBC). ZNF334 expression was usually reduced in breast cancer tissues and TNBC cell lines, likely due to promoter hypermethylation. Ectopic expression of ZNF334 suppressed the growth and metastatic capacity of TNBC cell lines, induced cell cycle arrest at S phase and apoptosis. Additionally, re-expression of ZNF334 restored the Epithelial-Mesenchymal Transition (EMT) process and inhibited stemness by up-regulating SFRP1.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Duanyang Zhai, Mengmeng Zhang, Yuying Li, Jiong Bi, Xiaying Kuang, Zhen Shan, Nan Shao, Ying Lin
Summary: LINC01194 promotes the malignant progression of TNBC by recruiting NUMA1 to stabilize UBE2C mRNA. These findings may provide a more effective therapeutic strategy for TNBC patients.
Article
Oncology
H. Wan, Z. Li, H. Wang, F. Cai, L. Wang
Summary: The study found that upregulation of ST8SIA1 is associated with chemoresistance in TNBC, and inhibition of ST8SIA1 can enhance the efficacy of chemotherapy by suppressing the FAK/Akt/mTOR and Wnt/beta-catenin signaling pathways.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Parnaz Merikhian, Mohammad Reza Eisavand, Leila Farahmand
Summary: Triple-negative breast cancer presents challenges in treatment strategies due to its complexity and heterogeneity, with research showing the pivotal role of Wnt/beta-catenin signaling in resistance development.
CANCER CELL INTERNATIONAL
(2021)
Article
Biology
Duo Tian, Laifu Luo, Tao Wang, Jian Qiao
Summary: miR-296-3p is downregulated in TNBC tissues and cells, its overexpression suppresses TNBC cell proliferation, migration, invasion, and CSC-like properties, by binding to SOX4 and negatively regulating SOX4 expression, it inhibits the Wnt/beta-catenin pathway.
JOURNAL OF BIOSCIENCES
(2021)
Article
Hematology
Vikas A. Gupta, Benjamin G. Barwick, Shannon M. Matulis, Ryosuke Shirasaki, David L. Jaye, Jonathan J. Keats, Benjamin Oberlton, Nisha S. Joseph, Craig C. Hofmeister, Leonard T. Heffner, Madhav Dhodapkar, Ajay K. Nooka, Sagar Lonial, Constantine S. Mitsiades, Jonathan L. Kaufman, Lawrence H. Boise
Summary: This study found that Venetoclax sensitivity is closely associated with the expression of B-cell genes and genomic features identified in transposase-accessible chromatin sequencing, and there are potential novel biomarkers associated with Venetoclax sensitivity.
Meeting Abstract
Hematology
Serges P. Tsofack, Danielle C. Croucher, Benjamin G. Barwick, Zhihua Li, Ahmed Aman, Dennis Tao, Ellennong Wei, Laura Garcia Prat, Aaron D. Schimmer, Suzanne Trudel
Meeting Abstract
Hematology
Seth Welsh, Daniel Riggs, Erin Meermeier, Chang-Xin Shi, Victoria Garbitt, Meaghen E. Sharik, Megan Du, Kennedi Todd, Zachary Hammond, Sochilt Brown, Caleb K. Stein, Paola Neri, Nizar J. Bahlis, Benjamin G. Barwick, Larry H. Boise, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Meeting Abstract
Hematology
Olga Dashevsky, Ricardo De Matos Simoes, Benjamin G. Barwick, Sara Gandolfi, Ryosuke Shirasaki, Michal Sheffer, Aedin Culhane, Richard Wj Groen, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Meeting Abstract
Hematology
Theodora Alese, Benjamin G. Barwick, Vikas A. Gupta, Nisha Joseph, Craig C. Hofmeister, Mala Shanmugam, Jonathan L. Kaufman, Madhav V. Dhodapkar, Sagar Lonial, Ajay K. Nooka, Lawrence H. Boise
Meeting Abstract
Hematology
Ricardo De Matos Simoes, Benjamin G. Barwick, Ryosuke Shirasaki, Olga Dashevsky, Sara Gandolfi, Huihui Tang, Brian Glassner, Richard W. J. Groen, Daniel Auclair, Aedin Culhane, Aviad Tsherniak, Francisca Vazquez, Jonathan D. Licht, Lawrence H. Boise, Constantine S. Mitsiades
Meeting Abstract
Hematology
Aditi Sharma, Abhinav Achreja, Remya Nair, Pulkit Gupta, Claudia L. Edgar, Olamide Animasahun, Anjali Mitta, Bhakti Dwivedi, Manoj Bhasin, Vikas A. Gupta, Benjamin G. Barwick, Shannon M. Matulis, Sagar Lonial, Lawrence H. Boise, David L. Jaye, Arun P. Wiita, Ajay K. Nooka, Deepak Nagrath, Mala Shanmugam
Letter
Hematology
Remya Nair, Vimal Subramaniam, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Sagar Lonial, Lawrence H. Boise, Ajay K. Nooka, Kuzhali Muthumalaiappan, Mala Shanmugam
Article
Oncology
Tyler Moser-Katz, Catherine M. Gavile, Benjamin G. Barwick, Kelvin P. Lee, Lawrence H. Boise
Summary: Despite advances in multiple myeloma treatment, the disease remains incurable. This study reveals the role of CD86 cytoplasmic tail in trafficking CD86 to the cell surface and identifies SCRIB and DLG1 as important proteins for myeloma cell growth and survival.
MOLECULAR CANCER RESEARCH
(2022)
Article
Oncology
Olayinka O. Adebayo, Eric B. Dammer, Courtney D. Dill, Adeyinka O. Adebayo, Saheed O. Oseni, Ti'ara L. Griffen, Adaugo Q. Ohandjo, Fengxia Yan, Sanjay Jain, Benjamin G. Barwick, Rajesh Singh, Lawrence H. Boise, James W. Lillard
Summary: This study investigates the molecular mechanisms underlying treatment failures in multiple myeloma using bioinformatic tools. Through gene co-expression network analysis, modules of genes associated with disease survival status were identified and crucial genes within these modules were further studied. The findings reveal the biological functions related to the risk of death in multiple myeloma, providing insights for improving treatment strategies for the disease.
Letter
Oncology
Vikas A. Gupta, Shannon M. Matulis, Benjamin G. Barwick, R. Devin Bog, Conrad W. Shebelut, Mala Shanmugam, Paola Neri, Nizar J. Bahlis, Madhav V. Dhodapkar, Leonard T. Heffner, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Jonathan L. Kaufman, David L. Jaye, Ajay K. Nooka, Lawrence H. Boise
BLOOD CANCER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Lei Zhu, Yi Zhao, Tongrui Liu, Minglong Chen, Wei Ping Qian, Binghua Jiang, Benjamin G. Barwick, Lumeng Zhang, Toncred M. Styblo, Xiaoxian Li, Lily Yang
Summary: This study developed a bioactive and CD44 targeted hyaluronic acid nanoparticle encapsulated with an NOX inhibitor, GKT831 (HANP/GKT831), resulting in increased sensitivity of breast cancer cells to radiotherapy. By downregulating DNA repair function and oncogenic signal pathways, HANP/GKT831 primed tumor cells for radiation-induced DNA damage and cell death.
Article
Multidisciplinary Sciences
Aditi Sharma, Remya Nair, Abhinav Achreja, Anjali Mittal, Pulkit Gupta, Kamakshi Balakrishnan, Claudia L. Edgar, Olamide Animasahun, Bhakti Dwivedi, Benjamin G. Barwick, Vikas A. Gupta, Shannon M. Matulis, Manoj Bhasin, Sagar Lonial, Ajay K. Nooka, Arun P. Wiita, Lawrence H. Boise, Deepak Nagrath, Mala Shanmugam
Summary: This study reveals the link between metabolic state and therapy resistance in multiple myeloma. Suppression of the electron transport chain increases resistance to proteasome inhibitors. Mitochondrial stress-induced resistance can be alleviated by specific drugs.
Meeting Abstract
Hematology
Seth J. Welsh, Benjamin G. Barwick, Erin Meermeier, Daniel Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E. Sharik, Megan T. Du, Victoria Marie Garbitt, Caleb K. Stein, Joachim L. Petit, Nathalie Meurice, Rodrigo Fonseca, Kennedi Todd, Sochilt Brown, Yuliza Tafoya Alvarado, Zachary Hammond, Nicklus Cuc, Courtney Wittenberg, Camille Herzog, Lawrence H. Boise, Nizar J. Bahlis, Paola Neri, W. Michael Kuehl, Marta Chesi, P. Leif Bergsagel
Article
Immunology
Nataliya Prokhnevska, Maria A. Cardenas, Rajesh M. Valanparambil, Ewelina Sobierajska, Benjamin G. Barwick, Caroline Jansen, Adriana Reyes Moon, Petra Gregorova, Luke delBalzo, Rachel Greenwald, Mehmet Asim Bilen, Mehrdad Alemozaffar, Shreyas Joshi, Cara Cimmino, Christian Larsen, Viraj Master, Martin Sanda, Haydn Kissick
Summary: Improvements in tumor immunotherapies rely on understanding the T cell response to tumors. By studying tumor-draining lymph nodes (TDLNs), it was discovered that activated CD8+ T cells in TDLNs shared characteristics with stem-like cells in tumors. These TDLN cells were revealed to be precursors of tumor-resident stem-like CD8+ T cells. Murine tumor models showed that tumor-specific CD8+ T cells were activated in TDLNs and later differentiated into effector cells in the tumor with co-stimulation.