Article
Immunology
Barakat Alrashdi, Bassel Dawod, Sabine Tacke, Stefanie Kuerten, Patrice D. Cote, Jean S. Marshall
Summary: Nav1.6 plays a crucial role in EAE, and reducing Nav1.6 levels improves motor capacity and reduces inflammatory responses, demonstrating its impact on innate immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Evgenii N. Tcyganov, Shino Hanabuchi, Ayumi Hashimoto, David Campbell, Gozde Kar, Timothy W. F. Slidel, Corinne Cayatte, Aimee Landry, Fernanda Pilataxi, Susana Hayes, Brian Dougherty, Kristin C. Hicks, Kathy Mulgrew, Chih-Hang Anthony Tang, Chih-Chi Andrew Hu, Wei Guo, Sergei Grivennikov, Mohammed-Alkhatim A. Ali, Jean-Christophe Beltra, E. John Wherry, Yulia Nefedova, Dmitry Gabrilovich
Summary: MDSCs play important roles in regulating immune responses in cancer and chronic infections, with different mechanisms controlling the activity of MDSCs in these conditions. Cancer-associated PMN-MDSCs acquire immune-suppressive activity through the IRE1 alpha and ATF6 pathways of the ER stress response, while M-MDSCs in cancer and LCMV infection do not rely on the ER stress response for suppressive activity. The immune-suppressive activity of M-MDSCs in spleens is mediated by IFN-gamma signaling, while IL-6 in tumor tissues retains the suppressive activity of M-MDSCs.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Immunology
David E. Ochayon, Stephen N. Waggoner
Summary: This article discusses the important role of cytokines in regulating immune responses, particularly the impact of mixed types of cytokines on immune responses, and their significance in disease pathogenesis and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Zou, Fang-jun Chen, Li-rong Deng, Qian Han, Chang-yin Huang, Shi-shi Shen, Brian Tomlinson, Yan-hong Li
Summary: Anemoside B4 (AB4) demonstrated significant preventive and therapeutic effects on experimental autoimmune encephalomyelitis (EAE) by modulating inflammatory responses and the gut microbiota, indicating its potential as a therapeutic agent for treating multiple sclerosis (MS).
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Deming Sun, Nymph Chan, Hui Shao, Willi K. Born, Henry J. Kaplan
Summary: Gamma delta T cells play a significant role in immune regulation, and their activation status and pathway impact their functions. In this study, it was shown that activated gamma delta T cells under different inflammatory conditions differ in functions.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biology
Thomas P. Burke, Patrik Engstrom, Cuong J. Tran, Ingeborg M. Langohr, Dustin R. Glasner, Diego A. Espinosa, Eva Harris, Matthew D. Welch
Summary: Mice lacking both interferon receptors provide a tractable model for investigating rickettsiosis, virulence factors, and immunity. The study shows that the actin-based motility factor Sca2 is required for dissemination from the skin to internal organs, and the outer membrane protein OmpB contributes to eschar formation, revealing potential live-attenuated vaccine candidates. Differences in interferon signaling may underlie the discrepancies in susceptibility to rickettsial pathogens between mice and humans.
Article
Microbiology
Jeremy D. Ward, Caleb Cornaby, John L. Schmitz
Summary: Severely ill COVID-19 patients show reduced IFN-γ levels and T cells unable to produce IFN-γ when stimulated with PHA, along with elevated IL-6 levels.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Immunology
Avik Chattopadhyay, Joel P. Joseph, Sirisha Jagdish, Somak Chaudhuri, Nikita S. Ramteke, Aagosh Kishore Karhale, Uchenna Waturuocha, Deepak Kumar Saini, Dipankar Nandi
Summary: This study identified novel non-steroidal small molecule inhibitors of interferon gamma (IFN-γ)-induced nitric oxide (NO) production through screening on a mouse hepatoma cell line. The most potent compounds were pentamidine and auranofin, which showed significant protection in the models of ulcerative colitis and sepsis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Virology
Fernanda Bellaniza Caminha de Oliveira, Vanessa Paola Alves Sampaio de Sa Freire, Sharton Vinicius Antunes Coelho, Lana Monteiro Meuren, Julys da Fonseca Palmeira, Ana Luisa Cardoso, Francisco de Assis Rocha Neves, Bergmann Morais Ribeiro, Gustavo Adolfo Arganaraz, Luciana Barros de Arruda, Enrique Roberto Arganaraz
Summary: In this study, the researchers compared the effects of two strains of the Zika Virus (ZIKV), derived from African and Asian lineages, on BV2 microglia cells. They found that both strains were able to infect the cells, but the strain from the Asian lineage had higher infectivity and replicative capacity. The Asian strain also induced a stronger inflammatory response and lower expression of anti-viral factors compared to the African strain. These findings provide insight into the mechanisms involved in the pathogenesis of ZIKV-associated diseases.
Review
Immunology
Forrest C. Walker, Pratyush R. Sridhar, Megan T. Baldridge
Summary: Interferons play specific roles in limiting local and systemic infection, showing synergistic activities and a spectrum of protective and detrimental effects during the infection response.
TRENDS IN IMMUNOLOGY
(2021)
Article
Microbiology
Chaitanya Kurhade, Soowon Kang, Scott B. Biering, Seungmin Hwang, Glenn Randall
Summary: This study reveals the collaborative action of autophagy and interferon in inhibiting viral replication. It also uncovers the mechanism by which autophagy proteins target viral replication complexes and the role of interferon-inducible GTPases in disrupting these complexes. This research provides a new understanding of the recognition and inhibition of viral replication complexes by the autophagy machinery.
Article
Immunology
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mocsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke
Summary: Siglec-H regulates TLR-9-dependent inflammatory responses after virus infections, but not TLR-7 dependent responses. Lack of Siglec-H in pDCs leads to impaired Hck expression and downregulation of chemokine receptor CCR9, affecting pDC function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Medicinal
Filippos Stavropoulos, Elena Georgiou, Irene Sargiannidou, Kleopas A. Kleopa
Summary: Deficiency in oligodendrocyte gap junction protein Cx47 leads to a more severe course of experimental autoimmune encephalomyelitis (EAE) in mice, with earlier onset and increased disease severity accompanied by dysregulated pro-inflammatory responses. Analysis of cytokine expression in Cx47 KO EAE mice show alterations before, during, and after EAE onset, alongside more severe blood-spinal cord barrier disruption and enhanced astroglial activation. Further investigation into the role of oligodendrocyte Cx47 in EAE and multiple sclerosis pathology is warranted.
Article
Biochemistry & Molecular Biology
Tomohiro Watanabe, Kosuke Minaga, Hajime Honjo, Masatoshi Kudo
Summary: The liver showed hypo-responsiveness to antigens and high doses of orally-administered ovalbumin (OVA) generated unique CD4+ T cells and tolerogenic dendritic cells that can suppress Th1 responses. OVA administration at high doses inhibited hepatitis development in mice with OVA-specific CD4+ T cells, and this was associated with downregulation of Th1 responses. The results suggest that high-dose oral antigen administration can suppress Th1-mediated hepatitis in an antigen-non-specific manner.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Mohammad Reza Madanipour, Mortaza Fatehi-Zardalou, Nastaran Rahimi, Sara Hemmati, Mojgan Alaeddini, Shahroo Etemad-Moghadam, Maryam Shayan, Sasan Dabiri, Ahmad Reza Dehpour
Summary: This study found that dapsone has anti-inflammatory effects on allergic rhinitis in mice, significantly reducing nasal symptoms caused by inflammation and showing improvement in histopathological analysis.
Article
Virology
Sivabalan Manivannan, Victoria K. Baxter, Kimberly L. W. Schultz, Barbara S. Slusher, Diane E. Griffin
JOURNAL OF VIROLOGY
(2016)
Article
Virology
Kimberly L. W. Schultz, Justin A. Wetter, Diccon C. Fiore, Paul D. Friesen
JOURNAL OF VIROLOGY
(2009)
Article
Virology
Kimberly L. W. Schultz, Paul D. Friesen
JOURNAL OF VIROLOGY
(2009)
Article
Virology
Ronald L. Knight, Kimberly L. W. Schultz, Rebekah J. Kent, Meera Venkatesan, Diane E. Griffin
JOURNAL OF VIROLOGY
(2009)
Article
Virology
Rupak Shivakoti, Martina Siwek, Debra Hauer, Kimberly L. W. Schultz, Diane E. Griffin
JOURNAL OF VIROLOGY
(2013)
Article
Virology
Jonathan E. Snyder, Kirsten A. Kulcsar, Kimberly L. W. Schultz, Catherine P. Riley, Jacob T. Neary, Scott Marr, Joyce Jose, Diane E. Griffin, Richard J. Kuhn
JOURNAL OF VIROLOGY
(2013)
Article
Virology
Hal P. Bogerd, Rebecca L. Skalsky, Edward M. Kennedy, Yuki Furuse, Adam W. Whisnant, Omar Flores, Kimberly L. W. Schultz, Nicole Putnam, Nicholas J. Barrows, Barbara Sherry, Frank Scholle, Mariano A. Garcia-Blanco, Diane E. Griffin, Bryan R. Cullen
JOURNAL OF VIROLOGY
(2014)
Article
Virology
Kimberly L. W. Schultz, Patty S. Vernon, Diane E. Griffin
JOURNAL OF VIROLOGY
(2015)