Article
Oncology
Hossein Sendi, Mostafa Yazdimamaghani, Mengying Hu, Nikhila Sultanpuram, Jie Wang, Amber S. Moody, Ellie McCabe, Jiajie Zhang, Amanda Graboski, Liantao Li, Juan D. Rojas, Paul A. Dayton, Leaf Huang, Andrew Z. Wang
Summary: Efficient delivery of miR-122 to hepatocytes using a nanomedicine-based formulation has the potential to prevent and treat colorectal cancer liver metastasis. Mechanistically, it downregulates key genes involved in metastatic and cancer inflammation pathways, increases CD8(+)/CD4(+) T-cell ratio, and decreases immunosuppressive cell infiltration, making the liver more conducive to antitumor immune response.
Article
Biochemistry & Molecular Biology
Tian Jiang, Yaojuan Yang, Chunping Wu, Chunsheng Qu, Jie-Guang Chen, Huateng Cao
Summary: Neuronal migration and morphogenesis are crucial for cortical development, and their dysregulation can lead to neural circuit abnormalities and neuropsychiatric disorders. While various proteins have been studied in regulating these processes, the involvement of non-coding RNAs in cortical development remains largely unexplored. This study identifies miR-218 as a layer V-specific microRNA in mouse brains and reveals its elevated expression in patients with autism spectrum disorder (ASD) and schizophrenia. Overexpression of miR-218 in developing mouse cortex impairs radial migration, morphogenesis, and spatial distribution of cortical neurons, likely through repression of the upper-layer marker Satb2. These findings shed light on the potential role of miR-218 and the interplay between layer-specific non-coding RNAs and proteins in neuropsychiatric disorders and cortical development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Beibei Cao, Kailun Zhang, Changjie Pan, Yifei Dong, Feng Lu
Summary: Radiotherapy and chemotherapy are the main treatment methods for colorectal cancer, but their effectiveness is limited. Understanding the molecular mechanisms of colorectal cancer progression could lead to the development of new therapies. NEK8 positively regulates CRC progression by phosphorylating c-MYC protein at serine 405, enhancing its stability through polyubiquitination. This study highlights the role of NEK8/MYC signaling as a potential target for colorectal cancer treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Chonnapat Naktubtim, Witchuda Payuhakrit, Tamonwan Uttarawichien, Artchaya Hassametto, Prasit Suwannalert
Summary: The progression of colorectal cancer (CRC) is affected by the tumor microenvironment (TME), where cancer-associated fibroblasts (CAFs) play a significant role. This study investigated the role of YAP in CAF transformation and its potential as a target for inhibiting CRC growth and progression. The results showed that conditioned media from CRC cells induced CAF marker expression and rearrangement of F-actin in colon fibroblasts, leading to upregulation and nuclear translocation of YAP. Additionally, the conditioned media promoted proliferation, migration, invasion, and angiogenesis of CRC cells. Interestingly, a YAP inhibitor, Verteporfin, inhibited CAF conversion and the aforementioned effects in CRC cells. Furthermore, bioinformatics analysis suggested that YAP could serve as a prognostic marker in CRC patients. In conclusion, YAP-related F-actin rearrangement may be a potential target for combination therapy in CRC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Liu Yang, Da-wei Ma, Yue-peng Cao, Dong-zheng Li, Xin Zhou, Ji-feng Feng, Jun Bao
Summary: PRMT5 interacts with EZH2 to epigenetically regulate CDKN2B expression and promote CRC progression, suggesting a potential combinational therapy strategy for CRC involving PRMT5 and EZH2 inhibitors.
Article
Biochemistry & Molecular Biology
Zilong Fang, Xinran Tong, Guangzheng Shi, Wendong Chen, Qun Li
Summary: Vascular endothelial cell apoptosis is the fundamental cause of pulmonary arterial hypertension. MiR-31 is a novel target for hypertension treatment. This study aims to determine the role and mechanism of miR-31 in VEC apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Shiki Fujino, Norikatsu Miyoshi, Aya Ito, Masayoshi Yasui, Chu Matsuda, Masayuki Ohue, Mamoru Uemura, Tsunekazu Mizushima, Yuichiro Doki, Hidetoshi Eguchi
Summary: HNF1A, a CRC-specific gene downstream of POU5F1, plays a crucial role in regulating cell growth, apoptosis, and drug sensitivity in colorectal cancer. High expression of HNF1A is associated with poor prognosis in CRC patients, while its inhibition can improve sensitivity to anticancer drugs.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Ning Zhang, Xianyu Hu, Yinan Du, Juan Du
Summary: Colorectal cancer is the third most common and fourth most deadly cancer worldwide, with microRNAs playing essential roles in CRC and serving as potential targets for therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Xuguang Zhao, Xiao Song, Yanxia Zhao
Summary: This study aims to investigate the potential impact of circNBPF10 on the malignant progression of lung cancer. The findings show that circNBPF10 is highly expressed in lung cancer tissues and cells, and its expression is associated with lymphatic and distant metastasis. circNBPF10 promotes the proliferation, migration, and invasion of lung cancer cells through the regulation of miR-224 and PBX3.
JOURNAL OF ONCOLOGY
(2022)
Article
Plant Sciences
Shuai Sun, Xiaotian Wang, Zhiqiang Liu, Jingwei Bai, Jia Song, Ren Li, Xia Cui
Summary: Inflorescence architecture directly impacts yield potential in most crops. This study investigates the genetic regulatory network of inflorescence architecture in tomato and discovers a regulator called TARGET OF EAT1 (SlTOE1), which is primarily expressed in the floral meristem and represses the transcription of key genes involved in inflorescence development. The study also finds that SlTOE1 and ENHANCER OF JOINTLESS 2 (EJ2) act additively to regulate inflorescence branching in tomato.
Article
Cell Biology
Laura Pezze, Erna Marija Meskyte, Mattia Forcato, Stefano Pontalti, Kalina Aleksandra Badowska, Dario Rizzotto, Ira-Ida Skvortsova, Silvio Bicciato, Yari Ciribilli
Summary: The study revealed a new role for ETV7 in promoting plasticity and resistance in breast cancer stem-like cells. By reprogramming gene expression, ETV7 influenced the proliferation and treatment sensitivity of breast cancer stem cells.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Qihua Chen, Na Deng, Ke Lu, Qiao Liao, Xiaoyan Long, Deming Gou, Fangfang Bi, Jinxia Zhou
Summary: Elevated levels of miR-133b and miR-221-3p showed high sensitivity and specificity in distinguishing early-stage PD patients from controls, suggesting their potential as biomarkers for early PD. Additionally, miR-4454 demonstrated the ability to differentiate between PD and MSA. These findings highlight the potential of miRNAs as non-invasive biomarkers for PD diagnosis.
SCIENTIFIC REPORTS
(2021)
Article
Hematology
Yoshitaka Sunami, Takashi Yokoyama, Seiko Yoshino, Tomoko Takahara, Yukari Yamazaki, Hironori Harada, Takuro Nakamura
Summary: The transcriptional repressor BCL11A is involved in the development of acute myeloid leukemia (AML) by cooperating with Trib1. BCL11A promotes the proliferation and engraftment of AML cells by repressing the expression of PU.1 target genes. These findings reveal the role of BCL11A and its molecular mechanism in myeloid leukemia.
Article
Oncology
Yujin Wu, Longling Cong, Wenjian Chen, Xuechuan Wang, Fanghua Qiu
Summary: In this study, elevated expression of LINC00963 was found in CRC tissues and cell lines, leading to inhibition of CRC cell proliferation, migration, and invasion by regulating the miR-10b/FGF13 pathway. These findings suggest a potential lncRNA-based diagnostic or therapeutic target for CRC.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Medical Laboratory Technology
Ying Tang, Wenjing Fan, Bu Zou, Wei Yan, Yangfeng Hou, Oware Kwabena Agyare, Zhisheng Jiang, Shunlin Qu
Summary: Research indicates that dysregulation of the TGF-beta signaling pathway and miRNAs may be associated with the development of AAA, making them potential therapeutic targets.
CLINICA CHIMICA ACTA
(2021)