MuSK Myasthenia Gravis IgG4 Disrupts the Interaction of LRP4 with MuSK but Both IgG4 and IgG1-3 Can Disperse Preformed Agrin-Independent AChR Clusters

Long-term benefit of rituximab in MuSK autoantibody myasthenia gravis patients: Table 1

(2013) Benison Keung et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

CD20 Antibody Primes B Lymphocytes for Type I Interferon Production

(2013) Dongsheng Xu et al.   PLoS One

The Role of MuSK in Synapse Formation and Neuromuscular Disease

(2013) S. J. Burden et al.   Cold Spring Harbor Perspectives in Biology

The search for new antigenic targets in myasthenia gravis

(2012) Judith Cossins et al.   Annals of the New York Academy of Sciences

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice

(2012) Rinse Klooster et al.   BRAIN

Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases

(2012) Anna Rostedt Punga et al.   CURRENT OPINION IN PHARMACOLOGY

Initiation of synapse formation by Wnt-induced MuSK endocytosis

(2012) L. R. Gordon et al.   DEVELOPMENT

Passive and active immunization models of MuSK-Ab positive myasthenia: Electrophysiological evidence for pre and postsynaptic defects

(2012) Stuart Viegas et al.   EXPERIMENTAL NEUROLOGY

The spectrum of mutations that underlie the neuromuscular junction synaptopathy in DOK7 congenital myasthenic syndrome

(2012) Judith Cossins et al.   HUMAN MOLECULAR GENETICS

Role of type I interferons in the activation of autoreactive B cells

(2012) Kerstin Kiefer et al.   IMMUNOLOGY AND CELL BIOLOGY

Antibodies against Wnt receptor of muscle-specific tyrosine kinase in myasthenia gravis

(2012) Masaharu Takamori et al.   JOURNAL OF NEUROIMMUNOLOGY

Long-lasting treatment effect of rituximab in MuSK myasthenia

(2012) J. Diaz-Manera et al.   NEUROLOGY

Myasthenia gravis

(2012) J. Spillane et al.   BMJ-British Medical Journal

Wnt proteins regulate acetylcholine receptor clustering in muscle cells

(2012) Bin Zhang et al.   Molecular Brain

Antibodies against Muscle-Specific Kinase Impair Both Presynaptic and Postsynaptic Functions in a Murine Model of Myasthenia Gravis

(2011) Shuuichi Mori et al.   AMERICAN JOURNAL OF PATHOLOGY

MuSK levels differ between adult skeletal muscles and influence postsynaptic plasticity

(2011) Anna R. Punga et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Agrin Binds to the N-terminal Region of Lrp4 Protein and Stimulates Association between Lrp4 and the First Immunoglobulin-like Domain in Muscle-specific Kinase (MuSK)

(2011) Wei Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Complement Consumption in MuSK-Antibody-Positive Myasthenia Gravis Patients

(2011) Erdem Tüzün et al.   MEDICAL PRINCIPLES AND PRACTICE

Rituximab for the Treatment of IgG4-Related Disease

(2011) Arezou Khosroshahi et al.   MEDICINE

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis

(2010) Osamu Higuchi et al.   ANNALS OF NEUROLOGY

Rituximab therapy leads to rapid decline of serum IgG4 levels and prompt clinical improvement in IgG4-related systemic disease

(2010) Arezou Khosroshahi et al.   ARTHRITIS AND RHEUMATISM

Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice

(2010) Samira Saadoun et al.   BRAIN

What is IgG4? A review of the biology of a unique immunoglobulin subtype

(2010) Ajay Nirula et al.   CURRENT OPINION IN RHEUMATOLOGY

Muscle Specific Kinase: Organiser of synaptic membrane domains

(2010) Nazanin Ghazanfari et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice

(2010) R. N. Cole et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Effect of Plasma From Muscle-Specific Tyrosine Kinase Myasthenia Patients on Regenerating Endplates

(2009) W. Pascale ter Beek et al.   AMERICAN JOURNAL OF PATHOLOGY

Immunoglobulin G4: an odd antibody

(2009) R. C. Aalberse et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Dok-7 Activates the Muscle Receptor Kinase MuSK and Shapes Synapse Formation

(2009) A. Inoue et al.   Science Signaling

Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction

(2008) Rebecca N. Cole et al.   ANNALS OF NEUROLOGY

IgG1 antibodies to acetylcholine receptors in ‘seronegative’ myasthenia gravis†

(2008) Maria Isabel Leite et al.   BRAIN

Lrp4 Is a Receptor for Agrin and Forms a Complex with MuSK

(2008) Natalie Kim et al.   CELL

Clinical fluctuations in MuSK myasthenia gravis are related to antigen-specific IgG4 instead of IgG1

(2008) E.H. Niks et al.   JOURNAL OF NEUROIMMUNOLOGY

LRP4 Serves as a Coreceptor of Agrin

(2008) Bin Zhang et al.   NEURON