Article
Oncology
Hakim Bouamar, Larry Esteban Broome, Kate Ida Lathrop, Ismail Jatoi, Andrew Jacob Brenner, Alia Nazarullah, Karla Moncada Gorena, Michael Garcia, Yidong Chen, Virginia Kaklamani, Lu-Zhe Sun
Summary: This study demonstrates the efficacy of rapamycin in reducing mammary stem/progenitor cell activity and malignant progression markers, particularly in postmenopausal patients.
BREAST CANCER RESEARCH
(2023)
Article
Oncology
Angela Alonso-Diez, Sara Caceres, Laura Pena, Belen Crespo, Juan Carlos Illera
Summary: Inflammatory breast cancer is an aggressive type of breast cancer associated with exacerbated angiogenesis, lymphangiogenesis, and lymphangiotropism. Current antiangiogenic therapies have limited effects on the overall survival of IBC patients. Steroid hormones play a significant role in tumor development, angiogenesis regulation, and metastasis. Sex steroid hormones can influence the production of angiogenic factors and may offer insights into developing personalized therapeutic strategies to manage IBC.
Article
Oncology
Maria Rosaria Ambrosio, Giusy Mosca, Teresa Migliaccio, Domenico Liguoro, Gisella Nele, Fabrizio Schonauer, Francesco D'Andrea, Federica Liotti, Nella Prevete, Rosa Marina Melillo, Carla Reale, Concetta Ambrosino, Claudia Miele, Francesco Beguinot, Vittoria D'Esposito, Pietro Formisano
Summary: This study demonstrates that high glucose levels enhance the aggressiveness of breast cancer cells and promote a pro-tumorigenic phenotype in mammary adipose tissue-derived mesenchymal stromal/stem cells (MAT-MSCs). The findings suggest that metabolic control may be important for reducing cancer outgrowth and preserving the functions of the adipose microenvironment.
Review
Oncology
Caroline J. J. Campbell, Brian W. W. Booth
Summary: The tumor microenvironment plays a critical role in tumor initiation, progression, and metastasis of various cancers, including breast cancer. The complex interaction between tumor cells and the microenvironment affects tumor behavior and patient response to therapies. This review highlights the importance of the normal mammary microenvironment in redirecting tumorigenic cells to assume a non-tumorigenic phenotype.
Review
Biochemistry & Molecular Biology
Marcela Valko-Rokytovska, Peter Ocenas, Aneta Salayova, Zuzana Kostecka
Summary: Metabolomics is a promising analytical method for the diagnosis and prognosis of breast cancer, offering a comprehensive non-invasive approach. Targeted metabolomics of steroid hormones play a crucial role in the classification and development of breast cancer, with high potential for effective diagnosis and monitoring of disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Weizhen Chen, Wei Wei, Liya Yu, Xin Zhang, Fujing Huang, Qiping Zheng, Lingli Wang, Cheguo Cai
Summary: Baicalin, extracted from Scutellaria roots, has diverse biological activities and affects mammary gland development, immune response, and cell cycle control. It accelerates duct elongation, promotes alveolar development and milk secretion, and enhances self-renewal of MaSCs. In tumor models, baicalin affects tumor growth by inducing protein C receptor expression and inhibiting estrogen receptor expression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Svetlana Soboleva, Ryo Kurita, Fredrik Ek, Hugo Akerstrand, Rita Silverio-Alves, Roger Olsson, Yukio Nakamura, Kenichi Miharada
Summary: In an imaging-based screen of >3,300 compounds, Soboleva et al identify HDAC inhibitors as mediators of erythroid cell enucleation. They further show that the erythroid-specific cell membrane protein, SPTA1, is downregulated in HDAC inhibited cells and that restoration of SPTA1 expression using CRISPR-activation partially rescues the fragility of cells, improving enucleation efficiency.
COMMUNICATIONS BIOLOGY
(2021)
Article
Veterinary Sciences
Paloma Jimena de Andres, Sara Caceres, Juan Carlos Illera, Belen Crespo, Gema Silvan, Felisbina Luisa Queiroga, Maria Jose Illera, Maria Dolores Perez-Alenza, Laura Pena
Summary: This study compares the hormonal aspects of breast cancer samples and canine mammary tumors, validating the canine species as a model for studying human breast cancer. There is a close similarity between the hormonal receptors in both species, with increased hormone levels in tumors compared to normal samples. This research supports the use of canine mammary cancer as a spontaneous model for studying human breast cancer and provides insight into the hormonal pathogenesis of breast/mammary cancer in each species.
VETERINARY SCIENCES
(2022)
Article
Multidisciplinary Sciences
Hyun Ju Lee, Jae Kyung Myung, Hye Sung Kim, Dong Hui Lee, Hyun Su Go, Jae Hyuck Choi, Hyun Min Koh, Su-Jae Lee, Bogun Jang
Summary: Lineage tracing in mice has shown that LGR5 is an adult stem cell marker in various organs, and this study aimed to investigate its expression in human breast tissue. LGR5 expression was found in regenerative tissues, ductal carcinoma in situ, and ducts surrounded by invasive cancer cells, with a higher prevalence in triple-negative breast cancer cases. The study also revealed positive correlations with higher histologic grades and T stages, but negative associations with estrogen and progesterone receptor expression. Further research is needed to understand the functional and prognostic implications of LGR5 in triple-negative breast cancer.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Aurelie Dos Santos, Ning Lyu, Alis Balayan, Rob Knight, Katherine Sun Zhuo, Yuzhao Sun, Jianjiang Xu, Martha L. Funderburgh, James L. Funderburgh, Sophie X. Deng
Summary: This study successfully established immortalized CSSC lines by overexpressing SV40T, which can sustain proliferation while retaining similar characteristics and anti-inflammatory properties. These immortalized CSSCs provide a potential large-scale source for regenerative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Li Liu, Lilong Zhang, Chunlei Li, Zhendong Qiu, Tianrui Kuang, Zhongkai Wu, Wenhong Deng
Summary: This review summarizes recent progress in the identification of hormones associated with intestinal stem cells, which can promote or prevent their development. Several hormones, such as thyroid hormone, glucagon-like peptide-2, androgens, insulin, leptin, growth hormone, corticotropin-releasing hormone, and progastrin, promote the development of intestinal stem cells, while somatostatin and melatonin prevent their proliferation. This provides potential new therapeutic targets for the diagnosis and treatment of intestinal illnesses.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Multidisciplinary Sciences
Alecia-Jane Twigger, Lisa K. Engelbrecht, Karsten Bach, Isabel Schultz-Pernice, Sara Pensa, Jack Stenning, Stefania Petricca, Christina H. Scheel, Walid T. Khaled
Summary: This study characterizes cells in human milk and identifies epithelial cells similar to luminal progenitors and immune cells. The findings contribute to understanding the remodelling of human mammary tissue during pregnancy and lactation, and provide insights into the interplay between pregnancy, lactation, and breast cancer.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Yun Chang, Ramizah Syahirah, Stephanie N. Oprescu, Xuepeng Wang, Juhyung Jung, Scott H. Cooper, Sandra Torregrosa-Allen, Bennett D. Elzey, Alan Y. Hsu, Lauren N. Randolph, Yufei Sun, Shihuan Kuang, Hal E. Broxmeyer, Qing Deng, Xiaojun Lian, Xiaoping Bao
Summary: This study demonstrates the successful generation of AGM-like hematopoietic system from human pluripotent stem cells through temporal manipulation of Wnt signaling. The generated hematopoietic progenitor cells resemble primary cord blood HSCs at the transcriptional level and exhibit lymphoid and myeloid potential in vitro. The cells also show the ability to home to a definitive hematopoietic site, rescue bloodless zebrafish, and engraft and repopulate in mouse recipients.
Article
Environmental Sciences
Junxia Shi, Chenyu Liu, Mingyue Chen, Jinhui Yan, Chonggang Wang, Zhenghong Zuo, Chengyong He
Summary: The study demonstrates that exposure to environmentally relevant levels of BPA can disrupt steroid hormone synthesis in human ovarian granulosa cells, leading to decreased gene expression in hormone synthesis and inhibition of the FSHR/GS/AC signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Cell Biology
Joseph Hiatt, Devin A. Cavero, Michael J. McGregor, Weihao Zheng, Jonathan M. Budzik, Theodore L. Roth, Kelsey M. Haas, David Wu, Ujjwal Rathore, Anke Meyer-Franke, Mohamed S. Bouzidi, Eric Shifrut, Youjin Lee, Vigneshwari Easwar Kumar, Eric Dang, David E. Gordon, Jason A. Wojcechowskyj, Judd F. Hultquist, Krystal A. Fontaine, Satish K. Pillai, Jeffery S. Cox, Joel D. Ernst, Nevan J. Krogan, Alexander Marson
Summary: A method for delivering CRISPR-Cas9 ribonucleoprotein complexes via nucleofection into human monocytes has been developed for precise gene knockout and differentiation into macrophages or dendritic cells. This system shows promise for genetic studies of human myeloid cells in various areas such as immune signaling, inflammation, cancer immunology, host-pathogen interactions, and beyond.
Article
Cell Biology
Charlotte Lepleux, Aurelie Marie-Brasset, Mihaela Temelie, Marion Boulanger, Emilie Brotin, Mary B. Goldring, Christophe Hirtz, Guillaume Vares, Tetsuo Nakajima, Yannick Saintigny, Diana Savu, Francois Chevalier
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2019)
Article
Oncology
Anne-Sophie Wozny, Guillaume Vares, Gersende Alphonse, Alexandra Lauret, Caterina Monini, Nicolas Magne, Charlotte Cuerq, Akira Fujimori, Jean-Claude Monboisse, Michael Beuve, Tetsuo Nakajima, Claire Rodriguez-Lafrasse
Article
Oncology
Ju Yeon Oh, Eun Ho Kim, Yeon-Joo Lee, Sei Sai, Sun Ha Lim, Jang Woo Park, Hye Kyung Chung, Joon Kim, Guillaume Vares, Akihisa Takahashi, Youn Kyoung Jeong, Mi-Sook Kim, Chang-Bae Kong
Article
Oncology
Eun Ho Kim, Mi-Sook Kim, Akihisa Takahashi, Masao Suzuki, Guillaume Vares, Akiko Uzawa, Akira Fujimori, Tatsuya Ohno, Sei Sai
Correction
Oncology
Ju Yeon Oh, Eun Ho Kim, Yeon-Joo Lee, Sei Sai, Sun Ha Lim, Jang Woo Park, Hye Kyung Chung, Joon Kim, Guillaume Vares, Akihisa Takahashi, Youn Kyoung Jeong, Mi-Sook Kim, Chang-Bae Kong
Article
Nanoscience & Nanotechnology
Guillaume Vares, Vincent Jallet, Yoshitaka Matsumoto, Cedric Rentier, Kentaro Takayama, Toshio Sasaki, Yoshio Hayashi, Hiroaki Kumada, Hirotaka Sugawara
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Cuihua Liu, Kaoru Tanaka, Takanori Katsube, Guillaume Vares, Kouichi Maruyama, Yasuharu Ninomiya, Zeenath Fardous, Chao Sun, Akira Fujimori, Stephanie G. Moreno, Mitsuru Nenoi, Bing Wang
Article
Oncology
Guillaume Vares, Vidhula Ahire, Shigeaki Sunada, Eun Ho Kim, Sei Sai, Francois Chevalier, Paul-Henri Romeo, Tadashi Yamamoto, Tetsuo Nakajima, Yannick Saintigny
RADIOTHERAPY AND ONCOLOGY
(2020)
Article
Biology
Bing Wang, Takanori Katsube, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Seiji Kito, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
Summary: This study found that chronic restraint-induced psychological stress can enhance the deleterious effects of high-LET radiation on hematopoietic toxicity, especially at low doses.
Article
Biotechnology & Applied Microbiology
Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Qiang Liu, Masahiro Murakami, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
Summary: This study compared the genotoxic effects of high atomic number and energy (HZE) particles and low linear energy transfer (LET) photons on mice. The results showed that only X-rays induced clonal expansions of cells with chromosomal aberrations (CAs), while Fe-particles did not. Both types of radiation increased the frequencies of stable-type CAs, but the mice exposed to X-rays had a higher frequency. The frequencies of unstable-type CAs induced by both X-rays and Fe-particles were similar and decreased over time. Additionally, Fe-particle exposure resulted in a relatively higher frequency of insertions, which can be used as indicators of past exposure to high-LET particle radiation.
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
(2022)
Article
Biology
Takanori Katsube, Bing Wang, Kaoru Tanaka, Yasuharu Ninomiya, Hirokazu Hirakawa, Cuihua Liu, Kouichi Maruyama, Guillaume Vares, Qiang Liu, Seiji Kito, Tetsuo Nakajima, Akira Fujimori, Mitsuru Nenoi
Summary: Astronauts can develop psychological stress and radiation exposure during space flights, which can cause detrimental effects in humans.
RADIATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Bing Wang, Kaoru Tanaka, Takanori Katsube, Kouichi Maruyama, Yasuharu Ninomiya, Guillaume Vares, Cuihua Liu, Hirokazu Hirakawa, Masahiro Murakami, Zeenath Fardous, Nahida Sultana, Kazuko Fujita, Akira Fujimori, Tetsuo Nakajima, Mitsuru Nenoi
Summary: Radioadaptive response (RAR) reduces the detrimental effects of high-dose ionizing radiation (IR) by priming with low-dose IR, while the combination of RAR and mild dietary restriction (MDR) shows even more efficient reduction of radiogenotoxic damage. This indicates a potential strategy of combining adaptive responses with dietary interventions to increase treatment efficacy and prevent radiation risks in humans.
Article
Oncology
Eun Ho Kim, Jeong Yub Kim, Mi-Sook Kim, Guillaume Vares, Tatsuya Ohno, Akihisa Takahashi, Akiko Uzawa, Seung-Jun Seo, Sei Sai
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Article
Oncology
Sei Sai, Eun Ho Kim, Guillaume Vares, Masao Suzuki, Dong Yu, Yoshiya Horimoto, Mitsuhiro Hayashi
AMERICAN JOURNAL OF CANCER RESEARCH
(2020)
Article
Oncology
Francois Chevalier, Dounia Houria Hamdi, Charlotte Lepleux, Mihaela Temelie, Anais Nicol, Jean Baptiste Austry, Paul Lesueur, Guillaume Vares, Diana Savu, Tetsuo Nakajima, Yannick Saintigny
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2019)