Article
Health Care Sciences & Services
Hyemi Hwang, Yeonjae Han, Geun-Young Park, Soohwan Lee, Hae-Yeon Park, Sun Im
Summary: This study investigated the effects of tDCS on swallowing function in individuals with different COMT gene polymorphisms. The results showed that individuals with COMT Val/Val polymorphism experienced improvement in swallowing motor function after tDCS, while those with COMT Met carrier group did not show significant changes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jin-Hee Kim, Jimin Lee, Hyesoo Jeong, Mi Seo Bang, Jin-Hyun Jeong, Minsun Chang
Summary: The study investigated the novel biological activities of NDGA in relation to COMT and how COMT inhibition by NDGA affects 4-OHE2-induced cyto- and genotoxicity in MCF-7 human breast cancer cells. The results showed that NDGA both inhibits COMT-mediated formation of 4-MeOE2 and increases 4-OHE2-induced DNA damage and cytotoxicity, potentially increasing catechol estrogen-induced genotoxicities in mammary tissues.
Article
Neurosciences
L. Bonetti, S. E. P. Bruzzone, N. A. Sedghi, N. T. Haumann, T. Paunio, K. Kantojarvi, M. Kliuchko, P. Vuust, E. Brattico
Summary: This study explores the influence of different COMT gene variants on auditory prediction processes, demonstrating that catecholamine levels determined by genetics can affect the brain's mechanisms for detecting deviant events.
Article
Neurosciences
Mi Su, Yongyan Song
Summary: This meta-analysis did not find a significant association between COMT Val158Met polymorphism and PTSD. The Hardy-Weinberg equilibrium status of genotype distributions may influence the relationship between the two factors. Further large-scale population-based studies are needed to evaluate the impact of COMT Val158Met polymorphism on the risk of PTSD.
NEUROPSYCHOBIOLOGY
(2022)
Article
Geriatrics & Gerontology
Min Zhong, Chenglin Li, Hongquan Lu, Donghui Xue, Yaxi Wang, Yinyin Jiang, Sha Zhu, Ruxin Gu, Xu Jiang, Bo Shen, Jun Zhu, Wenbin Zhang, Yang Pan, Jun Yan, Li Zhang
Summary: This study aims to investigate the pathogenesis of minor hallucination in Parkinson's disease and identify brain regions associated with structural and functional abnormalities that may contribute to the generation of hallucinations in PD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Olga A. Korczeniewska, Fengshen Kuo, Ching-Yu Huang, Cibele Nasri-Heir, Junad Khan, Rafael Benoliel, Craig Hirschberg, Eli Eliav, Scott R. Diehl
Summary: This study investigated the impact of the COMT gene on pain sensitivity and found that the low pain sensitivity haplotype is influenced by genetic variation in gene expression, rather than SNP rs4680. The results suggest that the frequency of the COMT low pain sensitivity haplotype varies widely among global populations.
JOURNAL OF GENE MEDICINE
(2021)
Article
Behavioral Sciences
Gerly Tamm, Kairi Kreegipuu, Jaanus Harro
Summary: This study aimed to describe the interaction between platelet MAO activity and COMT Val158Met genotype in visual working memory updating. The results suggest that the effect of COMT Val158Met on updating efficiency depends on the level of platelet MAO activity.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Dong-Fang Zhao, Yu-Fan Fan, Fang-Yuan Wang, Fan-Bin Hou, Frank J. Gonzalez, Shi-Yang Li, Ping Wang, Yang-Liu Xia, Guang-Bo Ge, Ling Yang
Summary: The study identified Scutellariae radix as the most potent inhibitor of hCOMT among 53 herbal products. Specific chemicals like scutellarein, baicalein, and oroxylin A from the extract were found to be potent COMT inhibitors. These findings suggest the potential for developing more effective non-nitrocatechol COMT inhibitors for biomedical applications.
Article
Medicine, General & Internal
Zhonggui Xiong, Jiong Yan, Shuhua Shi
Summary: This study found that Val158Met polymorphisms of the COMT gene and serum concentrations of catecholaminergic neurotransmitters are associated with ADHD children and adolescents, with significant differences between the two groups.
Article
Chemistry, Medicinal
Dong-Fang Zhao, Yu-Fan Fan, Hao-Nan Yu, Fan-bin Hou, Yan-Wei Xiang, Ping Wang, Guang-Bo Ge, Ling Yang, Jian-Guang Xu
Summary: The study revealed that the flavonoids in vine tea exhibit strong inhibition against human catechol-Omethyltransferase, with myricetin being the most potent compound. This finding not only has implications for the drug exposure of catechol drugs, but also provides a promising lead compound for developing more effective hCOMT inhibitors.
Article
Agriculture, Multidisciplinary
Seul Hoo Lee, Bongsang Kim, Kyung-Jin Kim
Summary: The study reported the biochemical and structural analysis of COMT enzyme from Niastella koreensis, revealing that its activity is mainly influenced by magnesium ion, but also shows significant activity with copper and zinc ions. Structural analysis showed that the region near the SAM binding site undergoes conformational changes upon binding of the cosubstrate and the metal ion. Additionally, by developing variants, the activity and selectivity of NkCOMT can be enhanced.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wataru Kadowaki, Ryo Miyata, Misa Fujinami, Yoshizumi Sato, Shigenori Kumazawa
Summary: The study found that Calendula officinalis leaves contain 10 compounds with inhibitory activities against neurotransmitter-related diseases, particularly Parkinson's disease and depression.
Article
Clinical Neurology
Joe Yamamoto, Tomohiro Omura, Sachiko Kasamo, Shota Yamamoto, Masayoshi Kawata, Atsushi Yonezawa, Yosuke Taruno, Hisako Endo, Hitoshi Aizawa, Nobukatsu Sawamoto, Kazuo Matsubara, Ryosuke Takahashi, Yoshikazu Tasaki
Summary: In the pharmacotherapy of patients with Parkinson's disease, entacapone can reduce the metabolism of l-dopa, increase its concentration in the body, and improve the treatment. The COMT Val158Met polymorphism affects the response to this treatment, with differences in patients with different genotypes. Concurrent administration of l-dopa with entacapone can suppress the increase in 3-OMD levels, suggesting the polymorphism may be useful for personalized dose adjustment of COMT inhibitors in PD treatment.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Medicine, Research & Experimental
Andrea Polli, Jolien Hendrix, Kelly Ickmans, Jelena Bakusic, Manosij Ghosh, Dora Monteyne, Brigitte Velkeniers, Bram Bekaert, Jo Nijs, Lode Godderis
Summary: The study found associations between COMT haplotypes and DNA methylation, cytokine expression, and symptoms in patients with CFS/FM, but not specific to one condition. Significant differences were observed in increased DNA methylation in the MB-COMT promoter and decreased IFN-gamma expression in patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Medicinal
A. Katherine Hatstat, Grace M. Kennedy, Trevor R. Squires, Gisela Xhafkollari, C. Skyler Cochrane, Mauricio Cafiero, Larryn W. Peterson
Summary: L-DOPA, a dopamine precursor, is commonly used in Parkinson's disease treatment. Inhibiting COMT can prolong the effects of L-DOPA and dopamine, increasing the efficiency of the treatment. Nitrile derivatives with a nitro substituent show the most promise as COMT inhibitors.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Feng Liu, Jiayuan Xu, Lining Guo, Wen Qin, Meng Liang, Gunter Schumann, Chunshui Yu
Summary: Individual differences in human brain structure, function, and behavior can be explained by genetic variations, environmental exposures, and their interactions. While genetic variants associated with brain imaging phenotypes have been identified, the environmental exposures related to these phenotypes are largely unknown. This study proposes that research in environmental neuroscience should focus on understanding the associations between lifetime environmental exposures and brain imaging phenotypes, as well as identifying cumulative environmental effects and their vulnerable age windows.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Yuxin Zhao, Meng Wang, Ke Hu, Qi Wang, Jing Lou, Lingzhong Fan, Bing Liu
Summary: The study reveals the developmental patterns and underlying molecular mechanisms of the functional hierarchy in the human cerebral cortex, shedding light on the potential pathobiology of neurodevelopmental disorders.
Article
Neurosciences
Weiyang Shi, Lingzhong Fan, Haiyan Wang, Bing Liu, Wen Li, Jin Li, Luqi Cheng, Congying Chu, Ming Song, Jing Sui, Na Luo, Yue Cui, Zhenwei Dong, Yuheng Lu, Yawei Ma, Liang Ma, Kaixin Li, Jun Chen, Yunchun Chen, Hua Guo, Peng Li, Lin Lu, Luxian Lv, Ping Wan, Huaning Wang, Huiling Wang, Hao Yan, Jun Yan, Yongfeng Yang, Hongxing Zhang, Dai Zhang, Tianzi Jiang
Summary: By utilizing a large-scale multisite SCZ dataset, this study identified and validated two neuroanatomical subtypes of schizophrenia with individual-level abnormal patterns. The study revealed the heterogeneity in neuroanatomical patterns among SCZ patients with different clinical symptoms and identified potential underlying biological factors.
Article
Neurosciences
Jingchun Liu, Caihong Wang, Wen Qin, Hao Ding, Yanmin Peng, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical ischemic stroke can cause long-lasting changes in the cerebral cortex. This study investigated the relationship between cortical structural changes, motor recovery, lesion location, and early impairment of specific subsets of fibers in the corticospinal tract (CST) in patients with subcortical stroke. The findings revealed different patterns of cortical structural changes in patients with partial and complete recovery, which were associated with lesion location and impairment of specific CST fiber subsets.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Shao-Zhi Zhao, Yu-Xin Zhao, Xiao-Hua Liao, Ran Huo, Hao Li, Yu-Ming Jiao, Jian-Cong Weng, Jie Wang, Bing Liu, Yong Cao
Summary: In this study, the brain regions responsible for seizures in patients with unruptured bAVMs were investigated. VLSM and LNM analyses were performed to identify the seizure-susceptible brain regions and determine their involvement in a distributed brain network. The study also revealed the impact of resting-state networks on bAVM-related seizures.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Psychiatry
Yuqing Sun, Yuxin Zhao, Ke Hu, Meng Wang, Yong Liu, Bing Liu
Summary: We investigated the relationship between amyloid deposition and Alzheimer's disease (AD) profiles in cognitively normal (CN) individuals and those with mild cognitive impairment (MCI). Using amyloid-PET data, we identified and validated two subtypes with distinct regional patterns of progression, genetic, clinical, and biomarker characteristics. Our findings suggest that the spatiotemporal variants of amyloid deposition are closely associated with disease trajectories, providing insight into disease monitoring and therapeutic trials in AD.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Neurosciences
Huaigui Liu, Wei Li, Nana Liu, Jie Tang, Lixin Sun, Jiayuan Xu, Yuan Ji, Yingying Xie, Hao Ding, Zhaoxiang Ye, Chunshui Yu, Wen Qin
Summary: Evidence suggests that dysregulation of the dopamine (DA) system and dysfunction of the prefrontal cortex (PFC) may contribute to the development of schizophrenia. However, the relationship between DA genes, PFC morphology, and schizophrenia is still not fully understood. In this study, we analyzed brain gene expression data and structural magnetic resonance imaging data to identify specific PFC subregions that are associated with the expression profiles of DA genes. We found that some PFC subregions showed abnormal increases in gray matter volume covariance with other brain regions in schizophrenia patients. Furthermore, our analysis of postmortem expression data revealed reduced coexpression of DA genes between the middle frontal gyrus and hippocampus in schizophrenia patients, with these genes being implicated in brain functions related to working memory, reward processing, speech production, and episodic memory.
Article
Neurosciences
Wenshuang Zhu, Feng Liu, Jilian Fu, Wen Qin, Kaizhong Xue, Jie Tang, Yong Zhang, Chunshui Yu
Summary: This study identified 903 clinically sensitive genes and 633 clinically insensitive genes associated with ALFF alterations in MDD. The sensitive genes were enriched for cell differentiation and development, while the insensitive genes were enriched for ion transport and synaptic signaling.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Xiaofeng Deng, Meng Wang, Yan Zhang, Shuo Wang, Yong Cao, Xiaolin Chen, Fangrong Zong, Bo Wang, Bing Liu, Jizong Zhao
Summary: This study evaluated resting-state functional alterations and investigated the language reorganization mechanism in patients with brain arteriovenous malformations (AVMs) involving language areas. The results showed that language network reorganization occurs in AVM patients to maintain normal language abilities, and these reorganization patterns vary according to the location of the lesion.
HUMAN BRAIN MAPPING
(2023)
Article
Endocrinology & Metabolism
Jingchun Liu, Caihong Wang, Wen Qin, Jun Guo, Tong Han, Jingliang Cheng, Chunshui Yu
Summary: Subcortical stroke leads to structural changes in multiple areas of the cerebral cortex. The location of the lesion affects the pattern of cortical thickness changes. Motor outcomes and impairment of the corticospinal tract are correlated with cortical thickness in specific gyri. The longitudinal dataset shows gradual changes in cortical thickness and area in regions with structural reorganization.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neuroimaging
Ling Wang, Yi Ji, Hao Ding, Qin Tian, Ke Fan, Dapeng Shi, Chunshui Yu, Wen Qin
Summary: The study used arterial spin labeling (ASL) to investigate abnormal cerebral blood flow (CBF) in patients with Leber's hereditary optic neuropathy (LHON) and its associations with disease duration and neuro-ophthalmological impairment. The results showed differences in brain regions of LHON patients, including the left sensorimotor and bilateral visual areas. LHON patients had lower CBF in the bilateral calcarine compared to healthy controls. Chronic LHON patients also showed lower CBF in the left middle frontal gyrus, sensorimotor cortex, and temporal-partial junction. Disease duration and neuro-ophthalmological impairments were found to affect the metabolism of non-visual areas.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Psychiatry
Jing Lou, Kai Liu, Junyan Wen, Yini He, Yuqing Sun, Xiaohan Tian, Ke Hu, Yanjia Deng, Bing Liu, Ge Wen
Summary: By studying MDD patients and healthy controls in two datasets, we found a stable ACC functional dysconnectivity pattern of MDD and established the association between miR-134 target genes and brain functional dysconnectivity and behavior. Individual exosomal miR-134 expression levels impact individual clinical symptoms of MDD by modulating ACC-related functional dysconnectivity.
PSYCHIATRY RESEARCH
(2023)