Evodiamine Inhibits Insulin-Stimulated mTOR-S6K Activation and IRS1 Serine Phosphorylation in Adipocytes and Improves Glucose Tolerance in Obese/Diabetic Mice

Yes, even human brown fat is on fire!

(2012) Barbara Cannon et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2012) Li-Chieh Ching et al.   MOLECULAR MEDICINE

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes

(2011) Kumiko Saito et al.   ANALYTICAL BIOCHEMISTRY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity

(2009) M. Saito et al.   DIABETES

Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes

(2009) E J Bak et al.   INTERNATIONAL JOURNAL OF OBESITY

Evodiamine and rutaecarpine inhibit migration by LIGHT via suppression of NADPH oxidase activation

(2009) Sook-Kyoung Heo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evodiamine Improves Diet-Induced Obesity in a Uncoupling Protein-1-Independent Manner: Involvement of Antiadipogenic Mechanism and Extracellularly Regulated Kinase/Mitogen-Activated Protein Kinase Signaling

(2007) Ting Wang et al.   ENDOCRINOLOGY