Article
Multidisciplinary Sciences
Laura A. Shaw, Tianda Z. Deng, Kyla D. Omilusik, Kennidy K. Takehara, Quynh P. Nguyen, Ananda W. Goldrath
Summary: CD4(+) T cells are important in vaccine development, but the existence of multiple helper subsets complicates the identification of memory precursor cells. Recent research has found that the expression of Id3 can identify a subset of CD4(+) T cells with memory potential, which exhibit significant re-expansion in response to secondary infection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Sarah L. Bevington, Remi Fiancette, Dominika W. Gajdasik, Peter Keane, Jake K. Soley, Claire M. Willis, Daniel J. L. Coleman, David R. Withers, Peter N. Cockerill
Summary: Research reveals that T cell immunological memory is established within 7 days post-infection, with epigenetic programs playing a crucial role in Th differentiation and memory T cell formation. Memory T cell-specific regulatory elements contribute to enhanced inducible responses during secondary antigen exposures.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Rui Xu, Ming Wu, Shuna Liu, Wenwen Shang, Rong Li, Juan Xu, Lei Huang, Fang Wang
Summary: Immunotherapy is expected to be a promising treatment for ovarian cancer due to its immunogenicity. However, immunosuppression in the tumor microenvironment poses challenges. Studies have shown that the metabolism pathways of Tregs in the cancer environment may contribute to immunosuppression, and TLR8 can reverse the inhibitory function of Tregs. Activation of TLR8 signaling results in decreased glucose metabolism in Tregs and promotes proliferation of naive T cells in the ovarian cancer microenvironment.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Laura Perucho, Laura Icardi, Elisabetta Di Simone, Veronica Basso, Alessandra Agresti, Amaia Vilas Zornoza, Teresa Lozano, Felipe Prosper, Juan Jose Lasarte, Anna Mondino
Summary: Sin3A plays a crucial role in regulating the differentiation of Th17 cells and the development of lymphocytes.
Article
Fisheries
Belen Alvarez, Concepcion Revilla, Sara Moreno, Angeles Jimenez-Marin, Elena Ramos, Paloma Martinez de la Riva, Teresa Poderoso, Juan J. Garrido, Angel Ezquerra, Javier Dominguez
Summary: This report describes a new monoclonal antibody, 4H5CR4, against porcine CD9, which together with other antibodies can distinguish at least five CD4(+) T cell subsets. The analysis of CD45RA, CD27, CD29, CD95, CCR7, and SLA-DR markers on these subsets reveals a progressive model of CD4(+) T cell development.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Letter
Immunology
Damaris C. S. C. Fonseca, Mirtes C. B. Rocha, Lucca A. Pereira, Leticia P. Botega, Susanne C. P. F. Cutrim, Fabiano Silva, Flavio D. Batista, Adriana S. Rego, Angela Falcai, Lidio G. Lima-Neto, Ana Paula S. A. Santos, Rafael C. Carvalho, Eduardo M. Sousa
Summary: The frequency of central memory T cells was found to decrease in individuals who were vaccinated following COVID-19 infection, emphasizing the importance of T cell responses in addition to antibody induction by vaccines.
CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Alexandra Berger, Sarah J. Colpitts, Morgan Zych, Christopher J. Paige
Summary: We explored the use of IL-21 cell-based anti-leukemia treatment in a mouse model of acute lymphoblastic leukemia. Injection of IL-21-secreting 70Z/3 leukemia cells induced a strong anti-leukemia response and led to 100% survival rate. IL-21 secretion correlated with improved survival and the expansion of IL-21-secreting cells. The delivery of IL-21 showed the potential to induce a potent immune response and long-term immunity, making it an attractive candidate for cancer immunotherapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Ezgi Sengun, Tim G. A. M. Wolfs, Valery L. E. van Bruggen, Bram van Cranenbroek, Elles R. Simonetti, Daan Ophelders, Marien I. de Jonge, Irma Joosten, Renate G. van der Molen
Summary: Inflammation is a physiological state where immune cells respond to harmful insults. Human mesenchymal stem cells (hMSC) have immunomodulatory effects and regenerative capacity, making them a promising therapeutic option for inflammation. However, the regulatory effects of hMSC on T cells, particularly in CD4(+) T cell memory formation and responsiveness, are not fully understood. Our study investigated the effects of umbilical cord mesenchymal stem cells (UC-MSC) on CD4(+) T cells and found that cell-cell contact and paracrine factors are necessary for the immunomodulatory effects.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Marco Kunzli, David Masopust
Summary: This review provides updates on our understanding of the biology of memory CD4(+) T cells as well as key technological advances that facilitate their characterization.
Article
Immunology
Gurupreet S. Sethi, Donald Gracias, Michael Croft
Summary: This study investigated the role of circulatory T cells in asthma relapse and the population of lung Trm cells. They found that circulatory cells contribute to the accumulation and expansion of Trm phenotype cells, but are not required to maintain this population once lung-localized Trm cells develop. However, circulatory cells still contribute to the overall asthmatic lung inflammatory response.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Nianbin Song, Robin A. Welsh, Scheherazade Sadegh-Nasseri
Summary: The absence of HLA-DO protein alters the presentation of foreign antigens and impacts the development of memory cells. This finding provides new insights for vaccine design and improves immune memory responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Daniel S. Shin, Sneha Ratnapriya, Creel Ng Cashin, Lucy F. Kuhn, Rod A. Rahimi, Robert M. Anthony, James J. Moon
Summary: Self-antigen-specific T cells are regulated through tolerance mechanisms, but tissue injury can disrupt this regulation and trigger autoimmunity. Using mouse models of lung injury, we found that acute injury leads to the expansion of CD4+ regulatory T cells (Tregs) that specifically recognize self-antigen. Conventional CD4+ T cells with the same self-antigen specificity remained unresponsive even after Treg ablation. Therefore, the self-antigen-specific CD4+ T cell repertoire plays a regulatory role in limiting tissue damage and autoimmunity during acute injury.
Article
Immunology
Jin Wu, Tianyi Zhang, Haofeng Xiong, Liujun Zeng, Zijia Wang, Ying Peng, Weijun Chen, Xin Hu, Tong Su
Summary: This study aimed to screen immune cells and genes related to the prognosis of oral squamous cell carcinoma (OSCC). Through the analysis of data from the TCGA database, CD4(+) central memory T cells were identified as the only independent immune cell associated with the prognosis of OSCC. A prognostic prediction model based on the abundance of CD4(+) T cells was established. In addition, 34 prognostic genes related to the infiltration of CD4(+) central memory T cells were screened, and DEFB1 was found to potentially regulate the abundance of these cells and improve the prognosis of OSCC.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Cell Biology
Erica C. Lorenzo, Blake L. Torrance, Spencer R. Keilich, Iman Al-Naggar, Andrew Harrison, Ming Xu, Jenna M. Bartley, Laura Haynes
Summary: The differentiation of CD4 T helper cells during influenza infection is affected by aging, with an increase in regulatory T cells (Treg) and higher levels of TGF-beta in the lungs of aged mice. Treatment with senolytic drugs in aged mice prior to infection can restore Th cell differentiation and promote a return to homeostasis by reducing the percentage of Treg cells and inducing a healing Type 2 phenotype. Senescent cells play a significant role in impacting Th cell differentiation through production of cytokines like TGF-beta.
Article
Cardiac & Cardiovascular Systems
Aini Xie, Hui Yan, Jinfei Fu, Adam He, Xiang Xiao, Xian C. Li, Wenhao Chen
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2020)
Review
Cell Biology
Preston R. Arnold, Andrew D. Wells, Xian C. Li
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2020)
Article
Surgery
Shuqiu Chen, Lei Zhang, Yuanlin Ying, Yixuan Wang, Preston R. Arnold, Guangchuan Wang, Junhui Li, Rafik M. Ghobrial, Wenhao Chen, Xiang Xiao, Xian C. Li
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Immunology
Lei Zhang, Yuanlin Ying, Shuqiu Chen, Preston R. Arnold, Fafa Tian, Laurie J. Minze, Xiang Xiao, Xian C. Li
Summary: This study found that RelB plays a critical role in restraining ILC2s in vivo by primarily suppressing Bcl11b activity, consequently inhibiting the development of type 2 lung pathology.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Junji Xing, Ao Zhang, Yong Du, Mingli Fang, Laurie J. Minze, Yong-Jun Liu, Xian Chang Li, Zhiqiang Zhang
Summary: In this study, the authors highlight the role of PARP9 in detecting viral RNA and inducing the IFN pathway via the PI3K/AKT3 pathway.
NATURE COMMUNICATIONS
(2021)
Article
Surgery
Stephen L. Jones, Linda W. Moore, Xian C. Li, Constance M. Mobley, Paul A. Fields, Edward A. Graviss, Duc T. Nguyen, Joy Nolte Fong, Ashish Saharia, Mark J. Hobeika, Robert R. McMillan, David W. Victor, Laurie J. Minze, A. Osama Gaber, R. Mark Ghobrial
Summary: This study found that pre-transplant T-cell clonality can predict the occurrence of sepsis after liver transplant, providing a new biomarker for early monitoring and management of sepsis. Adequate treatment for sepsis can reduce mortality after liver transplant.
Article
Medicine, Research & Experimental
Mou Wen, Yuanlin Ying, Xiang Xiao, Preston R. Arnold, Guangchuan Wang, Xiufeng Chu, Rafik M. Ghobrial, Xian C. Li
Summary: This study reveals an unexpected role of BRD4 in regulating skin follicle stem cells and skin inflammation, providing important clues for further investigation into skin diseases and cell fate determination.
Article
Surgery
Krupa R. Mysore, Sunil Kannanganat, Jeremy M. Schraw, Philip J. Lupo, John A. Goss, Kenneth D. R. Setchell, Farrah Kheradmand, Xian C. Li, Benjamin L. Shneider
Summary: This study found that children with advanced liver diseases undergoing liver transplantation (LT) exhibited phenotypic and functional alterations in circulating monocyte and dendritic cells. Children with severe ALD demonstrated immune dysfunction and had an increased incidence of infections before and after LT. Identifying at-risk patients may reduce the occurrence of infection-related complications.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Jesus Paez-Mayorga, Jocelyn Nikita Campa-Carranza, Simone Capuani, Nathanael Hernandez, Hsuan-Chen Liu, Corrine Ying Xuan Chua, Fernanda Paola Pons-Faudoa, Gulsah Malgir, Bella Alvarez, Jean A. Niles, Lissenya B. Argueta, Kathryn A. Shelton, Sarah Kezar, Pramod N. Nehete, Dora M. Berman, Melissa A. Willman, Xian C. Li, Camillo Ricordi, Joan E. Nichols, A. Osama Gaber, Norma S. Kenyon, Alessandro Grattoni
Summary: By using the Neovascularized Implantable Cell Homing and Encapsulation (NICHE) device, pancreatic islet transplantation for type 1 diabetes can achieve long-term reversal without the need for systemic immunosuppression, making it a promising approach for effective treatment.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Surgery
Wenhao Chen, Xian C. Li
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Editorial Material
Surgery
Jiannan Wang, Xian C. Li
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Cell Biology
Xiufeng Chu, Xiang Xiao, Guangchuan Wang, Ahmed Uosef, Xiaohua Lou, Preston Arnold, Yixuan Wang, Gangcheng Kong, Mou Wen, Laurie J. Minze, Xian C. C. Li
Summary: This study shows that the cytolytic activity of Gasdermin D N-terminal pore-forming domain (GD-NT) is negatively regulated by AMP-activated protein kinase (AMPK). AMPK phosphorylates GD-NT at serine 46, which alters its oligomerization and inhibits its pore-forming ability. The negative regulation of GD-NT by AMPK impacts its anti-tumor activity and promotes aggressive tumor growth.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Xiaohua Lou, Binbin Ma, Yuan Zhuang, Xiang Xiao, Laurie J. Minze, Junji Xing, Zhiqiang Zhang, Xian C. Li
Summary: Protein ubiquitination is crucial for controlling protein degradation and cell signaling pathways. This study elucidated the crystal structure of TRIM75, a member of the RING E3 ligase family, revealing its tetrameric structure and function.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Immunology
Guangchuan Wang, Xiang Xiao, Yixuan Wang, Xiufeng Chu, Yaling Dou, Laurie J. Minze, Rafik M. Ghobrial, Zhiqiang Zhang, Xian C. Li
Summary: The RNA helicase DHX15 plays a key role in regulating NK-cell activities by modulating IL-15 signaling pathway, affecting NK-cell phenotype and function.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)