Article
Biochemistry & Molecular Biology
Shuqiang An, Yang Li, Xiaojing Jia, Yaqin Yang, Xiaojuan Jia, Xiaozhao Jia, Wujun Xue
Summary: The study demonstrated that ponicidin has therapeutic potential in ameliorating diabetic nephropathy by reducing oxidative stress, inflammation, and renal injury. Its benefits include weight reduction, improved blood glucose control, and modulation of lipid metabolism.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Nada H. Eisa, Ahmed E. Khodir, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Eman Said
Summary: PEITC showed renal protective effects against DN in rats induced by STZ, improving kidney and liver functions, histopathological features, tissue fibrosis, macrophage infiltration, and blood glucose levels. The mechanisms involved modulation of glycation, oxidative stress, and inflammatory response, including activation of GLO1 and Nrf2 pathways and suppression of NLRP3 inflammasome activation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Sang Hyun Song, Dawool Han, Kyeonghui Park, Jo Eun Um, Seonghun Kim, Minhee Ku, Jaemoon Yang, Tae-Hyun Yoo, Jong In Yook, Nam Hee Kim, Hyun Sil Kim
Summary: Diabetic nephropathy is a common complication of diabetes. The newly discovered cell death mechanism called ferroptosis, induced by TGF-beta, is involved in kidney damage in diabetic nephropathy. BMP7, a known antagonist of TGF-beta, can inhibit TGF-beta-induced fibrosis and play a role in the regeneration of pancreatic beta cells in diabetic animal models.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wenjuan Wang, Caiyun Deng, Fang Chen, Li Zhang, Yi Hu, Qin Lu, Aihua Zhang
Summary: This study found that methylmercury exposure leads to damage to synaptogenesis and impairs learning and memory capacity in the hippocampus. Resveratrol mitigates the neurotoxic effects of methylmercury by regulating the expression of the miR-9-5p/FOXP2 axis and improving synaptic plasticity. These findings reveal the neurotoxicity of methylmercury and its protective measures.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Plant Sciences
Miao-miao Chen, Jin-hao Jia, Yu-jun Tan, Yu-shan Ren, Jun-lin Lv, Ting Chu, Xin-yue Cao, Ru Ma, De-fang Li, Qiu-sheng Zheng, Zhong Liu, Jie Li
Summary: This study aimed to explore the therapeutic effect of Shen-Qi-Jiang-Tang granule (SQJTG) on diabetic nephropathy (DN) through bioinformatics analysis and in vivo experiments. The results showed that SQJTG exerts a kidney protective effect in DN mice by modulating the TNF signaling pathway, suggesting its potential application for the treatment of DN.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Gao-shu Zheng, Yan-min Tan, Yuan-yuan Shang, Ya-peng Liu, Bo-ang Hu, Di Wang, Lu Han, Zhi-hao Wang, Wei Zhang, Yun Ti, Ming Zhong
Summary: CIDEC gene silencing can improve metabolic disorder and insulin resistance in type 2 diabetic rat model, alleviate renal hypertrophy and renal function damage, decrease glomerular and tubular apoptosis, increase autophagy, and inhibit renal fibrosis.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Chemistry, Medicinal
Xia Zhu, Zongli Deng, Yanjuan Cao, Zihui Zhou, Wen Sun, Chang Liu, Siwen Fan, Xiao-Xing Yin
Summary: The role of PDE4D in diabetic nephropathy (DN) was explored and it was investigated whether resveratrol protects against DN through inhibiting PDE4D. The results showed that resveratrol attenuates the development of DN by preventing mitochondrial fission through inhibiting PDE4D.
PHYTOTHERAPY RESEARCH
(2023)
Article
Food Science & Technology
Ge Chenxu, Zhong Shaoyu, Lai Lili, Xianling Dai, Qin Kuang, Li Qiang, Hu Linfeng, Lou Deshuai, Tan Jun, Xu Minxuan
Summary: The study showed that plant-derived betacyanins (BCN) could alleviate diabetic nephropathy (DN) by reducing fibrosis and oxidative stress, mainly through improving the Nrf2 signaling pathway, subsequently improving renal function.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Cell Biology
Mei Xue, Ting Fang, Hongxi Sun, Ying Cheng, Ting Li, Chaofei Xu, Chao Tang, Xiaohuan Liu, Bei Sun, Liming Chen
Summary: The study revealed the crucial role of PACS-2 in the development of diabetic renal tubular injury by stabilizing MAM and protecting cells in diabetic kidneys.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Tingli Sun, Jizhang Liu, Changying Xie, Jun Yang, Lijie Zhao, Jingbo Yang
Summary: This study found that metformin could reduce kidney damage caused by diabetic nephropathy (DN) by activating the AMPK-mTOR-autophagy axis, resulting in decreased oxidative damage, fibrosis, and inflammatory response. This suggests that metformin may be considered as a potential target in the treatment of DN.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Genetics & Heredity
Ke-Xue Li, Miao-Jin Ji, Hai-Jian Sun
Summary: Phytochemicals, including resveratrol, have emerged as alternative therapies with therapeutic effects on various pathologies, including diabetic kidney disease. Resveratrol has been found to have a broad spectrum of health benefits, particularly in ameliorating chronic or acute kidney injury in the renal system. Further research is needed to overcome limitations, such as poor bioavailability, and improve the efficacy of resveratrol in diabetic nephropathy therapy.
Review
Immunology
Qi Jin, Tongtong Liu, Yuan Qiao, Donghai Liu, Liping Yang, Huimin Mao, Fang Ma, Yuyang Wang, Liang Peng, Yongli Zhan
Summary: Diabetic nephropathy (DN) can cause end-stage renal disease. Oxidative stress plays a crucial role in the development of DN, leading to various pathological processes and promoting inflammation. Polyphenols, such as quercetin, resveratrol, curcumin, and phenolic acid, have shown antioxidant and anti-inflammatory effects by targeting Nrf2, SIRT1, HMGB1, NF-κB, and NLRP3. However, further research is needed to fully understand the molecular mechanisms and clinical applications of polyphenols in DN.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Qunwei Huang, Hongbo Chen, Kai Yin, Yilan Shen, Kanghong Lin, Xieyi Guo, Xiang Zhang, Niansong Wang, Wenfeng Xin, Youhua Xu, Dingkun Gui
Summary: Formononetin (FMN) may alleviate renal tubular injury and mitochondrial damage in diabetic nephropathy (DN) partly by regulating the Sirt1/PGC-1 alpha pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mona K. Tawfik, Mohammed M. Keshawy, Samy Makary
Summary: The study demonstrates that the intervention of valsartan in diabetic nephropathy shows renoprotective effects in both early and late stages, reducing the expression of various related factors, improving pathological indicators, and slowing down the progression of renal damage.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Pharmacology & Pharmacy
Wenmin Dong, Chenglin Jia, Ji Li, Yi Zhou, Yun Luo, Jibo Liu, Zhiguo Zhao, Jiaqi Zhang, Shan Lin, Ying Chen
Summary: This study finds that fisetin can alleviate high glucose-induced podocyte injury and STZ-induced DN by restoring autophagy-mediated CDKN1B/P70S6K pathway and inhibiting NLRP3 inflammasome.
FRONTIERS IN PHARMACOLOGY
(2022)