Article
Medicine, General & Internal
Tong Su, Jiejun Hou, Tonghua Liu, Pei Dai, LingLing Qin, Lei Ding, Yan Hu, Xiangyu Guo
Summary: This study identified miR-34a-5p and miR-452-5p as novel regulators of pancreatic endocrine dysfunction, with miR-34a-5p negatively regulating pancreatic β-cell proliferation through the Wnt signaling pathway, and miR-452-5p affecting mitochondrial function in pancreatic β-cells through the branched chain amino acid metabolism pathway. These miRNAs have the potential to be utilized as new predictive biomarkers for the diagnosis and treatment targets for Type 2 diabetes.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jiung-Pang Huang, Chih-Chun Chang, Chao-Yu Kuo, Kuang-Jing Huang, Etienne M. Sokal, Kuan-Hsing Chen, Li-Man Hung
Summary: EXO-miRNAs have the potential to be used as biomarkers for diabetic HFpEF. The study found that miR-30d-5p and miR-126a-5p were associated with HFpEF, and may be important for the development of diagnostic tools for diabetic HFpEF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Wei Kang, Jinglin Zhang, Tingting Huang, Yuhang Zhou, Chi Chun Wong, Ronald C. K. Chan, Yujuan Dong, Feng Wu, Bin Zhang, William K. K. Wu, Michael W. Y. Chan, Alfred S. L. Cheng, Jun Yu, Nathalie Wong, Kwok Wai Lo, Ka Fai To
Summary: Aberrant activation of NOTCH3 has been linked to poor clinical outcomes in gastric cancer, partially attributed to the silencing of tumor suppressor miRNAs miR-491-5p and miR-875-5p. PHLDB2 was identified as a functional downstream modulator of NOTCH3 in gastric carcinogenesis, with positive correlation with NOTCH3 and negative correlation with miR-491-5p. The NOTCH3-PHLDB2-Akt cascade acts oncogenically in gastric carcinogenesis and may serve as a potential therapeutic target.
Article
Endocrinology & Metabolism
Qiyao Zhang, Jinfeng Su, Wei Kong, Zhou Fang, Yan Li, Ziqiang Huang, Ji Wen, Yue Wang
Summary: This study reveals that miR-103a-3p or miR-10a-5p negatively influence oocyte maturation by regulating BDNF expression in human follicular fluid. The expression levels of miR-103a-3p or miR-10a-5p in follicular fluid may predict the outcomes of IVF, assisting in improving embryo selection and increasing the IVF success rate in clinical practice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
L. C. Ye, L. F. Qian, L. Liang, U. Jiang, Z. Y. Che, Y. H. Guo
Summary: miR-195-5p enhances osteogenic differentiation by targeting SMURF1 and activating the BMP-2/SMAD/Akt/RUNX2 pathway, thus relieving the progression of osteoporosis.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2021)
Article
Oncology
Rui-ji Liu, Zhi-Peng Xu, Shu-Ying Li, Jun-Jie Yu, Ning-han Feng, Bin Xu, Ming Chen
Summary: This study found that in BAP1-deficient ccRCC, NEAT1 competitively binds to miR-10a-5p, indirectly upregulating SERPINE1 expression to promote kidney cancer cell proliferation, and NEAT1/miR-10a-5p/SERPINE1 are independent prognostic factors of ccRCC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qing Xu, Yong Wang, Xin Li, Yu Du, Yanyan Li, Jiangjiang Zhu, Yaqiu Lin
Summary: In this study, miR-10a-5p was found to inhibit the differentiation of goat intramuscular preadipocytes by targeting KLF8, thus suppressing the accumulation of lipid droplets. This provides a new target for fat deposition and improvement of meat quality.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Multidisciplinary Sciences
Haijun Zhu, Mengshi Kang, Xinping Bai
Summary: The study confirmed that miR-10a-5p had lower expression in melanoma cells and high expression suppressed the proliferation, migration, and invasion abilities. It was also found that miR-10a-5p targeted LIN28B mRNA and decreased LIN28B protein expression. TCF21 upregulation led to decreased LIN28B expression and increased miR-10a-5p expression, revealing a potential regulatory relationship between TCF21 and miR-10a-5p in melanoma.
Article
Oncology
Shiyuan Li, Ming Zeng, Lin Yang, Jianshao Tan, Jianqi Yang, Hongye Guan, Manyuan Kuang, Jiaying Li
Summary: The study found that lnc-SELPLG-2:1 is associated with the progression of osteosarcoma and can promote the proliferation and invasion of osteosarcoma cells by regulating the hsa-miR-10a-5p /BTRC cascade.
Article
Oncology
Dan Yin, Zhi-Qiang Hu, Chu-Bin Luo, Xiao-Yi Wang, Hao-Yang Xin, Rong-Qi Sun, Peng-Cheng Wang, Jia Li, Jia Fan, Zheng-Jun Zhou, Jian Zhou, Shao-Lai Zhou
Summary: In hepatocellular carcinoma (HCC), genomic copy numbers of LINC01133 are increased and positively correlated with its expression. Higher copy number of LINC01133 predicts a poor prognosis in HCC patients. LINC01133 promotes HCC progression by sponging miR-199a-5p and interacting with ANXA2.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Jiacui Zheng, Meirong Tian, Lanlan Liu, Xueqin Jia, Meiling Sun, Yongjing Lai
Summary: This study found that magnesium sulfate can reduce the apoptosis of vascular endothelial cells (VECs) in rats with preeclampsia (PE) through the miR-218-5p/HMGB1 pathway, providing a new strategy for the treatment of preeclampsia.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Medicine, Research & Experimental
Fang Wang, Meixia Zhang
Summary: The study found that circ_001209 promotes diabetic retinal vascular dysfunction by regulating the expression of miR-15b-5p and COL12A1. This provides a potential treatment strategy for diabetic retinopathy.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Peng Peng, Juan Jin, Guoliang Zou, Yanbo Sui, Yubo Han, Dapeng Zhao, Li Liu
Summary: The study demonstrated that hesperidin has a preventive effect against type 2 diabetes and insulin resistance by improving insulin sensitivity and regulating hepatic glucose metabolism pathways.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Runhui Wang, Jia Wang, Yuanyu Wang, Liang Yang
Summary: In this study, it was discovered that TUSC7 acts as a tumor suppressor gene in human gliomas by inhibiting cell proliferation and migration through the negative modulation of miR-10a-5p and the inhibition of the BDNF/ERK pathway.
Article
Oncology
Lei Yang, Hong-Fang Sun, Lin-Qing Guo, Hai-Bing Cao
Summary: This study demonstrates that miR-10a-5p is upregulated in bladder cancer tissues and is closely associated with advanced clinicopathological features, poor survival outcomes, and can serve as a crucial diagnostic and prognostic biomarker for bladder cancer patients. Over-expression of miR-10a-5p promotes bladder cancer cell proliferation, migration, and invasion capabilities.
CANCER MANAGEMENT AND RESEARCH
(2021)
Review
Education, Scientific Disciplines
Liyun He, Na Yang, Lingling Xu, Fan Ping, Wei Li, Qi Sun, Yuxiu Li, Huijuan Zhu, Huabing Zhang
Summary: This study found that synchronous distance education was not significantly different from traditional education in terms of knowledge acquisition, but had higher satisfaction ratings. Additionally, the analysis showed that there were no factors significantly impacting the pooled results of knowledge acquisition.
Article
Oncology
Chifa Ma, Yiwen Liu, Shuli He, Jingbo Zeng, Pingping Li, Chunxiao Ma, Fan Ping, Huabing Zhang, Lingling Xu, Wei Li, Yuxiu Li
Summary: Research on individuals with normal glucose tolerance has shown that glucose fluctuation may increase inflammation and oxidative stress markers, leading to a decrease in islet beta-cell function.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiaojing Wang, Sin Man Lam, Mingjun Cao, Tong Wang, Zhixin Wang, Miao Yu, Bowen Li, Huabing Zhang, Fan Ping, Guangyao Song, Kai Feng, Qian Zhang, Jianping Xu, Liyuan Zhou, Mingqun Deng, Xiao Zhai, Xinhua Xiao, Guanghou Shui
Summary: GCK-MODY is a rare genetic disorder caused by mutations in the GCK gene, with low incidence of vascular complications, making it a model for studying molecular mechanisms promoting vascular health under prolonged hyperglycemia. Analysis of serum lipids in GCK-MODY patients revealed specific lipid abnormalities that can aid in diagnosis and treatment. The study also showed enhanced regulation of lipid metabolism and potential protective effects on the vasculature in GCK-MODY patients compared to T2D.
Article
Oncology
Yiwen Liu, Jie Yu, Chifa Ma, Shuli He, Fan Ping, Huabing Zhang, Wei Li, Lingling Xu, Xinhua Xiao, Yuxiu Li
Summary: In adults with T1D, the relationship between triglyceride levels and time below range may be influenced by HbA1c levels, suggesting that individuals with HbA1c<7.0% and lower triglyceride levels may need less intensive glycemic targets to reduce the risk of hypoglycemia.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Lee-Shing Chang, Shervin Malmasi, Naoshi Hosomura, Huabing Zhang, C. Justin Brown, Victor J. Lei, Alexa Rubin, Clara Ting, Kimhouy Tong, Maria Shubina, Alexander Turchin
Summary: The study aimed to investigate if patients who discussed bariatric surgery with their providers were more likely to undergo the procedure and lose weight. Results showed that patients who had such discussions were more likely to experience weight loss and undergo bariatric surgery.
Article
Endocrinology & Metabolism
Liyun He, Na Yang, Jialu Wang, Jingyue Huang, Wei Li, Lingling Xu, Fan Ping, Yuxiu Li, Huabing Zhang
Summary: The study systematically evaluated the association between triceps skinfold thickness, mid-arm muscle circumference, mid-upper arm circumference, and all-cause mortality. Results revealed an inverse association between mid-arm muscle and subcutaneous fat with all-cause mortality, independent of BMI, extending beyond the elderly population. Both mid-arm muscle and subcutaneous fat made comparable contributions and had positive joint effects on all-cause mortality.
Article
Endocrinology & Metabolism
Lu Lyu, Jie Yu, Yiwen Liu, Shuli He, Yuan Zhao, Mengya Qi, Fan Ping, Lingling Xu, Wei Li, Huabing Zhang, Yuxiu Li
Summary: The study found a negative correlation between hemoglobin glycation index (HGI) and aging biomarkers, and the inflammation marker TNFα mediated the relationship between HGI and telomere length (LTL).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Jie Yu, Yan-Chuan Shi, Fan Ping, Wei Li, Hua-Bing Zhang, Shu-Li He, Yuan Zhao, Ling-Ling Xu, Yu-Xiu Li
Summary: This study found that the bone loss in T1D mice is mainly due to increased osteoclastogenesis and upregulated expression of Trem2. Liraglutide provides protective effects on bone loss in T1D mice by suppressing osteoclastogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuan Zhao, Ying Zhang, Mengya Qi, Fan Ping, Huabing Zhang, Lingling Xu, Wei Li, Yuxiu Li
Summary: This study analyzed the clinical characteristics and long-term changes of fasting plasma C-peptide in patients with mitochondrial diabetes (MD), and found that increased plasma lactate during exercise and delayed recovery could contribute to the diagnosis of MD. The fasting plasma C-peptide levels in MD patients decreased exponentially with disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Danning Wu, Shi Chen, Yuelun Zhang, Huabing Zhang, Qing Wang, Jianqiang Li, Yibo Fu, Shirui Wang, Hongbo Yang, Hanze Du, Huijuan Zhu, Hui Pan, Zhen Shen
Summary: This study summarized and quantitatively analyzed the performance of AI technology in diagnosing heterogeneous diseases based on facial features for the first time. The results showed that the facial recognition intensity (FRI) had a significant impact on diagnostic accuracy, and increasing training size and utilizing deep learning models could improve accuracy for diseases with low FRI.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, General & Internal
Liyun He, Jialu Wang, Fan Ping, Na Yang, Jingyue Huang, Yuxiu Li, Lingling Xu, Wei Li, Huabing Zhang
Summary: This systematic review and meta-analysis of RCTs found that the use of GLP-1 RAs is associated with an increased risk of gallbladder or biliary diseases, especially at higher doses, for longer durations, and for weight loss.
JAMA INTERNAL MEDICINE
(2022)
Article
Genetics & Heredity
Yuan Zhao, Jie Yu, Yiwen Liu, Lu Lyu, Fan Ping, Lingling Xu, Wei Li, Ou Wang, Qiang Xu, Wenming Wu, Huabing Zhang, Yuxiu Li
Summary: The study found that patients with MEN1-related insulinoma and high serum calcium levels may have altered insulin secretion. Postoperative recurrence rates and long-term complications were significantly different in these patients.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Review
Medicine, General & Internal
Liyun He, Jialu Wang, Fan Ping, Na Yang, Jingyue Huang, Wei Li, Lingling Xu, Huabing Zhang, Yuxiu Li
Summary: This study aimed to examine the association between dipeptidyl peptidase-4 inhibitors and gallbladder or biliary diseases, finding a significant increase in the risk of cholecystitis associated with these drugs.
BMJ-BRITISH MEDICAL JOURNAL
(2022)
Letter
Medicine, General & Internal
Farid Salih, Andreas Greinacher, Matthias Endres
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Lingling Xu, Jie Yu, Ou Wang, Yanfang Hou, Wei Li, Huabing Zhang, Fan Ping, Qun Xu, Yuxiu Li, Weibo Xia
Summary: Evidence of compromised bone microarchitecture in Asian type 1 diabetes (T1D) patients was lacking. This study found differences in cortical and trabecular microarchitecture between adult-onset and juvenile-onset T1D patients.