Article
Oncology
Chantal L. Duurland, Saskia J. Santegoets, Ziena Abdulrahman, Nikki M. Loof, Gregor Sturm, Tom H. Wesselink, Ramon Arens, Sanne Boekestijn, Ilina Ehsan, Mariette I. E. van Poelgeest, Francesca Finotello, Hubert Hackl, Zlatko Trajanoski, Peter Ten Dijke, Veronique M. Braud, Marij J. P. Welters, Sjoerd H. van der Burg
Summary: The expression of CD4+CD161+ effector memory T cells is associated with improved survival in HPV16+ oropharyngeal squamous cell carcinoma. Therapeutic vaccination activates and expands CD4+CD161+ effector T cells. CD161 functions dynamically and is regulated by cell intrinsic and extrinsic factors. CD161 expressing CD4+ T cells respond more vigorously to suboptimal antigen stimulation and may amplify TCR signals.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Clinical Neurology
Elena Contaldi, Luca Magistrelli, Alessia Furgiuele, Silvia Gallo, Cristoforo Comi
Summary: Dysregulation of CD4 + T cell compartment occurs in Parkinson's Disease (PD), but its relationship with dopamine transporter (DAT) SPECT denervation patterns is unknown.
JOURNAL OF NEUROLOGY
(2023)
Article
Nutrition & Dietetics
Konstantinos Efthymakis, Giuseppina Bologna, Pasquale Simeone, Laura Pierdomenico, Giulia Catitti, Simone Vespa, Angelo Milano, Domenico De Bellis, Francesco Laterza, Assunta Pandolfi, Caterina Pipino, Michele Sallese, Marco Marchisio, Sebastiano Miscia, Matteo Neri, Paola Lanuti
Summary: Extracellular vesicles (EVs) play important roles in intercellular communication, homeostasis maintenance, and diseases. This study aimed to assess and characterize circulating EVs in celiac disease patients and patients on a gluten-free diet (GFD) using a novel flow cytometry technique. The results showed significantly increased total EV counts in both newly diagnosed celiac disease patients and patients on GFD, while endothelial-derived and epithelial-derived EV counts were significantly decreased in subjects on gluten exclusion. These findings indicate that EVs could serve as potential disease-specific biomarkers in celiac disease.
Article
Endocrinology & Metabolism
Xia Deng, Zhensheng Cai, Yanyan Li, Xunan Wu, Li Zhao, Haoxiang Li, Ke Chen, Panpan Zhang, Chenxi Wang, Zhicong Zhao, Ling Yang, Guoyue Yuan
Summary: This study found that serum EDA levels were significantly higher in newly diagnosed type 2 diabetes mellitus patients, and positively correlated with various metabolic indexes such as body mass index and fasting plasma glucose. Additionally, EDA levels were independently associated with T2DM.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Oncology
Weiqin Yao, Haifei Yang, Hongying You, Jingjing Shang, Yingying Zhai, Zhi Yan, Shuang Yan, Xiaolan Shi, Ying Yao, Jing Wang, Panfeng Wang, Yun Xu, Song Jin, Lingzhi Yan, Depei Wu, Chengcheng Fu
Summary: This study retrospectively analyzed the prognostic value of circulating plasma cells (cPCs) quantified by 10-color flow cytometry in newly diagnosed multiple myeloma (MM) cases. The study found that a high ratio of cPCs is a reliable indicator for predicting a poorer prognosis in MM patients. Incorporating the Revised International Staging System (R-ISS) and cytogenetic risk factors alongside cPC levels enhances the accuracy of prognostic predictions for MM patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Juan-Jose Garces, Maria-Teresa Cedena, Noemi Puig, Leire Burgos, Jose J. Perez, Lourdes Cordon, Juan Flores-Montero, Luzalba Sanoja-Flores, Maria-Jose Calasanz, Albert Ortiol, Maria-Jesus Blanchard, Rafael Rios, Jesus Martin, Rafael Martinez-Martinez, Joan Bargay, Anna Sureda, Javier de la Rubia, Miguel-Teodoro Hernandez, Paula Rodriguez-Otero, Javier de la Cruz, Alberto Orfao, Maria-Victoria Mateos, Joaquin Martinez-Lopez, Juan-Jose Lahuerta, Laura Rosinol, Joan Blade, Jesus F. San-Miguel, Bruno Paiva
Summary: In patients with newly diagnosed MM, CTCs were detected in 92% of cases and showed a modest correlation with BM PCs. Increasing percentages of CTCs were associated with inferior PFS, with a cutoff of 0.01% CTCs showing independent prognostic value.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Niels W. C. J. van de Donk
Summary: The evaluation of circulating plasma cells in newly diagnosed multiple myeloma patients is essential to differentiate between MM and pPCL. A new study challenges the current threshold of >= 5% circulating plasma cells and suggests that a threshold of 2% circulating tumor cells may identify a subset of ultra-high-risk MM patients with comparable prognosis as pPCL. This finding has implications for treatment decisions and clinical trial enrollment.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Elizabeth Oluwatoyin Abe, Akinyele Olumuyiwa Adisa, Bukola Folasade Adeyemi, Olutosin Alaba Awolude, Foluso John Owotade
Summary: The research found a significant association between oral melanotic hyperpigmentation (OMH) and severe immunosuppression in newly diagnosed HIV-seropositive patients, with over half of the participants experiencing severe immunosuppression. However, serum cytokine levels did not vary significantly between the cases and control subjects.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2022)
Article
Multidisciplinary Sciences
Tiia Koivula, Salla Lempiainen, Petteri Rinne, Jenna H. Rannikko, Maija Hollmen, Carl Johan Sundberg, Helene Rundqvist, Heikki Minn, Ilkka Heinonen
Summary: The role of exercise in cancer prevention and control is being recognized, especially regarding the mobilization of leukocytes. A study on newly diagnosed breast cancer patients showed that a 10-min acute exercise increased the counts of various immune cells, such as CD8(+) T cells, CD19(+) B cells, and CD56(+)CD16(+) NK cells. The mobilization of these cells correlated positively with exercise intensity measures, suggesting a direct relationship between leukocyte mobilization and exercise intensity.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Patrizia Mondello, Angelo Fama, Melissa C. Larson, Andrew L. Feldman, Jose C. Villasboas, Zhi-Zhang Yang, Ilia Galkin, Viktor Svelolkin, Ekaterina Postovalova, Alexander Bagaev, Pavel Ovcharov, Arina Varlamova, Sarah Huet, Bruno Tesson, Kaitlyn R. McGrath, Susan Slager, Brian K. Link, Sergei Syrbu, Anne J. Novak, Thomas M. Habermann, Thomas E. Witzig, Grzegorz S. Nowakowski, Gilles Salles, James R. Cerhan, Stephen M. Ansell
Summary: Lack of intrafollicular CD4 expression is identified as a predictor of early failure in follicular lymphoma patients, and its combination with FLIPI can improve the identification of high-risk patients.
BLOOD CANCER JOURNAL
(2021)
Article
Immunology
Roham Parsa, Mariya London, Tiago Bruno Rezende de Castro, Bernardo Reis, Julian Buissant des Amorie, Jason G. Smith, Daniel Mucida
Summary: The intestinal epithelium is the largest surface in the body that is exposed to viruses and houses a large population of intraepithelial T lymphocytes. This study found that newly recruited CD4(+) T cells accumulate in the intestine after infection with certain viruses, and they provide protection against enteric adenovirus. These findings reveal a potential protective role of intraepithelial Ly6A(+)CCR9(+)CD4(+) T cells against enteric adenovirus.
Article
Pharmacology & Pharmacy
Hong-Qing Niu, Chenrui Yuan, Chenglan Yan, Na Li, Yuan-Sheng Lei, Xuxu Li, Jinli Ru, Xiao-Feng Li
Summary: In patients with seropositive undifferentiated arthritis (SUA), the early and preclinical stage of rheumatoid arthritis, a significant decrease in circulating regulatory T (Treg) cells was observed, along with abnormally increased Th17/Treg cell ratios. Female SUA patients showed lower proportions and absolute counts of Treg cells compared to males, which also correlated with higher disease activity scores.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Article
Oncology
Fei Wang, Sahara J. Cathcart, Dominick J. DiMaio, Nan Zhao, Jie Chen, Michele R. Aizenberg, Nicole A. Shonka, Chi Lin, Chi Zhang
Summary: This study elucidates that TILs and TAM are more abundant in recurrent GBM compared to newly diagnosed GBM, and tend to accumulate in the perivascular region.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Sung Min Choi, Hi Jung Park, Eun A. Choi, Kyeong Cheon Jung, Jae Il Lee
Summary: The study identified a diverse subset of circulating DP cells, including naive cells and various subpopulations with multiple potential functions such as CD4 CTL-, Eomes(+) Tr1-, Th2-, Th17-, Tfh-, Treg-, CD8 CTL-, and innate-like cells. In addition, flow cytometry analysis showed that a substantial number of naive DP T cells express CD8 alpha beta and CD8 alpha alpha, while subsets with high levels of CD4 co-receptor express helper and regulatory functions. Conversely, subsets with high CD8 co-receptor expression in the CD4(lo)CD8(hi) population display characteristics of CD8 CTL- and innate-like properties.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Georgios K. Vasileiadis, Anna-Carin Lundell, Yuan Zhang, Kerstin Andersson, Inger Gjertsson, Anna Rudin, Cristina Maglio
Summary: The study found a positive association between total adiponectin and pro-inflammatory chemokines, as well as markers of inflammation in patients with untreated newly diagnosed RA. However, high-molecular weight adiponectin was only associated with specific chemokines. Leptin and resistin showed no association with plasma chemokines, markers of inflammation, or disease activity scores.
Letter
Rheumatology
Kornelis S. M. van der Geest, Bhaskar Dasgupta
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
William F. Jiemy, Anqi Zhang, Annemieke M. H. Boots, Peter Heeringa, Maria Sandovici, Arjan Diepstra, Sandra Hein, Bhaskar Dasgupta, Elisabeth Brouwer, Kornelis S. M. van der Geest
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Francois Jamar, J. van der Laken, Emmanouil Panagiotidis, Maarten M. Steinz, Kornelis S. M. van der Geest, Richard N. J. Graham, Olivier Gheysens
Summary: Arthritis and other rheumatic disorders are common and burdensome conditions. Clinical evaluation alone may not be sufficient, and additional imaging techniques can provide better assessment, prognostic information, treatment evaluation, and diagnosis. Radiological techniques, functional and molecular imaging, including FDG-PET/CT, are valuable tools for these purposes. Alternative tracers are also being developed and applied in clinical trials. It is worth mentioning that 18F-fluoride is more effective than FDG in AS.
SEMINARS IN NUCLEAR MEDICINE
(2023)
Article
Rheumatology
Christian Dejaco, Cristina Ponte, Sara Monti, Davide Rozza, Carlo Alberto Scire, Lene Terslev, George A. W. Bruyn, Dennis Boumans, Wolfgang Hartung, Alojzija Hocevar, Marcin Milchert, Uffe Moller Dohn, Chetan B. Mukhtyar, Markus Aschwanden, Philipp Bosch, Dario Camellino, Stavros Chrysidis, Giovanni Ciancio, Maria Antonietta D'Agostino, Thomas Daikeler, Bhaskar Dasgupta, Eugenio De Miguel, Andreas P. Diamantopoulos, Christina Duftner, Ana Agueda, Ulrich Fredberg, Petra Hanova, Ib Tonder Hansen, Ellen-Margrethe Hauge, Annamaria Iagnocco, Nevsun Inanc, Aaron Juche, Rositsa Karalilova, Toshio Kawamoto, Kresten Krarup Keller, Helen Isobel Keen, Tanaz A. Kermani, Minna J. Kohler, Matthew Koster, Raashid Ahmed Luqmani, Pierluigi Macchioni, Sarah Louise Mackie, Esperanza Naredo, Berit Dalsgaard Nielsen, Michihiro Ogasawara, Carlos Pineda, Valentin Sebastian Schafer, Luca Seitz, Alessandro Tomelleri, Karina D. Torralba, Kornelis S. M. van der Geest, Kenneth J. Warrington, Wolfgang A. Schmidt
Summary: This study aimed to develop an OMERACT ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. The study followed the OMERACT Instrument Selection Algorithm and conducted Delphi rounds and online reliability exercise. The results showed that the OGUS had good reliability and sensitivity in assessing disease activity in GCA and could be used in clinical trials.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Multidisciplinary Sciences
Mariana Freitas de Aguiar, Heron Torquato, Bruno Ramos Salu, Ana Cecilia Diniz Oliveira, Maria Luiza Vilela Oliva, Edgar Julian Paredes-Gamero, Wayel H. Abdulahad, Elisabeth Brouwer, Alexandre W. S. de Souza
Summary: This study found that individuals with Takayasu arteritis (TAK) showed abnormal levels of monocyte subsets and related chemokines. Active TAK patients had higher monocyte counts, while glucocorticoid treatment affected the proportion of monocyte subsets. CCL22 was found to have the strongest association with disease activity in TAK.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Joanna Sophia J. Vinke, Dania H. A. Altulea, Michele F. F. Eisenga, Renate L. L. Jagersma, Tessa M. M. Niekolaas, Debbie van Baarle, Marieke van Der Heiden, Maurice Steenhuis, Theo Rispens, Wayel H. H. Abdulahad, Jan-Stephan F. Sanders, Martin H. H. De Borst
Summary: This study aimed to investigate whether iron supplementation improves immune response after SARS-CoV-2 vaccination in iron-deficient kidney transplant recipients. The results showed that iron supplementation efficiently restored iron status but did not improve humoral or cellular immune response against SARS-CoV-2.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Kornelis S. M. van der Geest, Berend G. C. Slijkhuis, Alessandro Tomelleri, Olivier Gheysens, William F. Jiemy, Costanza Piccolo, Pieter Nienhuis, Maria Sandovici, Elisabeth Brouwer, Andor W. J. M. Glaudemans, Douwe J. Mulder, Riemer H. J. A. Slart
Summary: FDG-PET/CT is a valuable diagnostic tool for identifying inflammation in large and medium-sized blood vessels in patients with systemic vasculitides. It can complement other vascular imaging techniques such as ultrasound, CTA, and MRA. In addition, FDG-PET/CT plays an important role in monitoring the treatment of vasculitis patients. The introduction of new immune-cell targeted radiotracers may enable direct visualization of inflammatory cell infiltrates in the vasculature of vasculitis patients.
CARDIOLOGY CLINICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Riemer H. J. A. Slart, Pieter H. Nienhuis, Andor W. J. M. Glaudemans, Elisabeth Brouwer, Olivier Gheysens, Kornelis S. M. van der Geest
Summary: This article discusses the role of 18F-FDG PET/CT in systemic vasculitides, including LVV, medium-sized vessel vasculitis, and PMR. It provides up-to-date guidance for the diagnosis and treatment of these autoimmune diseases.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Rheumatology
Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Munoz-Elias, Eric J. Tarcha, Shawn P. Iadonato, Abraham Rutgers, Peter Heeringa, Wayel H. Abdulahad
Summary: This study aimed to provide a new treatment strategy for GPA by modulating the activity of CD4(+)T(EM) cells using the specific peptide inhibitor, ShK-186. The results showed that ShK-186 reduced the expression levels of IFN gamma, TNF alpha, IL-4, IL-17, and IL-21 in CD4(+)T(H) cells from patients with GPA.
Article
Medicine, General & Internal
Joanna S. J. Vinke, Michele F. Eisenga, Jan-Stephan F. Sanders, Stefan P. Berger, Jacoba M. Spikman, Wayel H. Abdulahad, Stephan J. L. Bakker, Carlo A. J. M. Gaillard, Arjan D. van Zuilen, P. van der Meer, Martin H. de Borst
Summary: This article presents a clinical trial aimed at investigating the effect of intravenous iron on exercise tolerance in iron-deficient kidney transplant recipients. The study will include 158 participants who will be randomly assigned to receive either iron or placebo treatment. The primary outcome measure is the change in exercise capacity as measured by the 6-minute walk test, and secondary measures include hemoglobin levels, quality of life, among others.
Article
Immunology
Rienk Gerben van der Meer, Anneke Spoorenberg, Elisabeth Brouwer, Berber van der Meer, Annemieke M. H. Boots, Suzanne Arends, Wayel H. Abdulahad
Summary: This study reveals the changes in the number and phenotype of CD8+ mucosal-associated invariant T-cells (MAIT) in peripheral blood of patients with spondyloarthritis. Additionally, the study suggests that the inflammatory function of these cells is also affected, which might be implicated in the pathogenesis of axial diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Marieke van Nieuwland, Idil Esen, Rosanne D. Reitsema, Wayel H. Abdulahad, Yannick van Sleen, William F. Jiemy, Maria Sandovici, Elisabeth Brouwer, Lenny van Bon
Summary: The study investigates the activity of interferon type I (IFN-I) in CD8+ T cells of giant cell arteritis (GCA) patients. The results indicate increased expression of pSTAT1 in CD8+ T cells of GCA patients, while pSTAT3 and pSTAT5 expression did not differ. Additionally, MxA and CD8+ T cells were found to co-localize in artery tissues and biopsy samples of GCA patients. These findings suggest the potential of IFN-I induced biomarkers and novel therapeutic options in GCA.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Rheumatology
Suzanne Arends, Kornelis S. M. van der Geest, Maria Sandovici
LANCET RHEUMATOLOGY
(2023)
Article
Immunology
Jacoba C. Graver, William F. Jiemy, Dania H. A. Altulea, Yannick van Sleen, Shuang Xu, Kornelis S. M. van der Geest, Gwenny M. P. J. Verstappen, Peter Heeringa, Wayel H. Abdulahad, Elisabeth Brouwer, Annemieke M. H. Boots, Maria Sandovici
Summary: In patients with giant cell arteritis (GCA), B cells in the inflamed arteries are capable of producing cytokines and steering macrophages towards a pro-inflammatory phenotype. This study provides evidence for a cytokine-mediated role of B cells in GCA and suggests the potential of B-cell targeted therapy.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Immunology
Ana Merino-Vico, Jan Piet van Hamburg, Paul Tuijnenburg, Giulia Frazzei, Aram Al-Soudi, Carlo G. Bonasia, Boy Helder, Abraham Rutgers, Wayel H. Abdulahad, Coen A. Stegeman, Jan-Stephan Sanders, Laura Bergamaschi, Paul A. Lyons, Theo Bijma, Laura van Keep, Kirsten Wesenhagen, Aldo Jongejan, Henric Olsson, Niek de Vries, Taco W. Kuijpers, Peter Heeringa, Sander W. Tas
Summary: B lineage cells play a critical role in ANCA-associated vasculitis (AAV), and the transcription factor NF-kappa B may be a potential therapeutic target for AAV and other autoimmune diseases with prominent B cell involvement.
JOURNAL OF AUTOIMMUNITY
(2024)