Article
Multidisciplinary Sciences
Anish Mitra, Marcus E. Raichle, Andrew D. Geoly, Ian H. Kratter, Nolan R. Williams
Summary: This study investigates the relationship between directed brain activity, major depressive disorder (MDD), and the response to neurostimulation therapy. The findings suggest that directed signaling patterns in the anterior cingulate cortex (ACC) are potential biomarkers of MDD, as changes in ACC signaling predict improvement in depression symptoms and treatment response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Neurosciences
Abderrahim Laaziz, Hicham El Mostafi, Aboubaker Elhessni, Tarik Touil, Hanane Doumar, Abdelhalem Mesfioui
Summary: The study showed that chronic administration of DEX can lead to a range of depression-related behavioral traits, including anhedonia, despair, weight loss, anxiety-like behavior, and cognitive impairments, which fulfill the face validity criterion. The behavioral changes induced by DEX may result from the massive production of oxidative stress agents.
IBRO NEUROSCIENCE REPORTS
(2022)
Article
Psychology, Clinical
Marcelo T. Berlim, Stephane Richard-Devantoy, Nicole Rodrigues dos Santos, Gustavo Turecki
Summary: The study found that the psychopathological network structure of major depressive disorder changed after 8 weeks of antidepressant treatment, showing increased interconnectedness. Throughout the treatment process, the core symptoms of major depressive disorder include depressed mood, fatigue, and cognitive/psychomotor disturbance.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Immunology
Chao Huang, Ting Ye, Bingran Chen, Zhuo Chen, Ying Ye, Huijun Liu
Summary: Intranasal administration of low dose lipopolysaccharide (LPS) rapidly reversed depression-like behavior in mice under chronic unpredictable stress (CUS). The antidepressant effect lasted for at least 10 days and was dependent on microglial activation. This study suggests that stimulating microglia-mediated innate immune response through intranasal LPS administration can produce rapid and sustained antidepressant effects in animals with chronic stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Ofelia Limon-Morales, Kenia Morales-Quintero, Marcela Arteaga-Silva, Tania Molina-Jimenez, Marco Cerbon, Herlinda Bonilla-Jaime
Summary: Depressive illness is associated with cognitive impairment, reduced levels of neurotrophins, and dysfunctions in the serotonergic system. The study found that neonatal treatment with clomipramine caused molecular changes in brain regions related to learning and memory.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Chemistry, Medicinal
Slawomir Murawiec, Marek Krzystanek
Summary: Despite the limited effectiveness of antidepressants, rational selection based on matching mechanisms of action to symptomatic profiles may improve treatment outcomes for individuals with depression. The effectiveness of drug-targeted symptom cluster-matching treatment (SCMT) was demonstrated in this pilot study, offering a personalized approach to antidepressant selection. Further validation in clinical trials could make SCMT a valuable tool for managing treatment-resistant depression.
Article
Biochemistry & Molecular Biology
Karin N. Westlund, Marena A. Montera, Aleyah E. Goins, Sascha R. A. Alles, Nikita Suri, Sabrina L. McIlwrath, Robyn Bartel, Ravi V. Durvasula, Adinarayana Kunamneni
Summary: Non-opioid engineered scFv antibodies targeting the P2X4R receptor show potential as biotherapeutic interventions for chronic pain, with enhanced binding affinity and tissue penetrability leading to persistent pain relief in animal models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Andreas Hostmaelingen, Helene Amundsen Nissen-Lie, Bruce Wampold, Pal G. Ulvenes
Summary: Patients seeking psychotherapy often experience unknown effects during waitlist time, which may lead to worse outcomes compared to those who are not placed on a waitlist and may forego alternative non-psychotherapeutic assistance. The impact of antidepressant medication on symptom change during waitlist period remains unexplored in the literature.
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2023)
Article
Clinical Neurology
Hannah N. Ziobrowski, Lucinda B. Leung, Robert M. Bossarte, Corey Bryant, Janelle N. Keusch, Howard Liu, Victor Puac-Polanco, Wilfred R. Pigeon, David W. Oslin, Edward P. Post, Alan M. Zaslavsky, Jose R. Zubizarreta, Ronald C. Kessler
Summary: The study found that depression severity and comorbidities have independent and significant associations with role impairments in Veterans. The impact of depression severity on role impairments is greater than that of comorbidities.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Evelien Snippe, Bennard Doornbos, Robert A. Schoevers, Klaas J. Wardenaar, Marieke Wichers
Summary: The study found that there is significant variation in the order in which depressive symptoms improve among different patients. Improvement in core depressive symptoms is more likely to occur before improvements in non-core symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Endocrinology & Metabolism
Andrea Maglione, Bruna P. P. do Nascimento, Miriam O. Ribeiro, Talytha J. L. de Souza, Renata E. C. da Silva, Monica A. Sato, Carlos A. A. Penatti, Luiz R. G. Britto, Janaina S. de Souza, Rui M. B. Maciel, Rodrigo Rodrigues da Conceicao, Roberto Laureano-Melo, Gisele Giannocco
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive and behavioral impairments. Thyroid hormones (TH) have shown an inverse association with AD symptoms and progression. In this study, T3 treatment was found to improve depression-like behavior in an AD mouse model, possibly through the modulation of serotonergic related genes.
METABOLIC BRAIN DISEASE
(2022)
Article
Obstetrics & Gynecology
C. Hellberg, M. Osterberg, A. K. Jonsson, S. Fundell, F. Tronnberg, M. Jonsson, A. Skalkidou
Summary: The study aimed to develop a Core Outcome Set for the treatment of perinatal depression through a systematic literature review and consensus development study, resulting in a COS of nine outcomes. This COS is expected to improve the consistency and uniformity of outcome selection and reporting in future clinical trials.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Urology & Nephrology
Kendra E. Wulczyn, Sophia H. Zhao, Eugene P. Rhee, Sahir Kalim, Tariq Shafi
Summary: This study found an association between decline in kidney function and worsening of uremic symptom severity in patients with chronic kidney disease. However, the magnitude of these changes is small and of uncertain clinical significance.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Neurosciences
Kelly H. Forest, Ruth Taketa, Komal Arora, Cedomir Todorovic, Robert A. Nichols
Summary: The N-Aβ core can reverse impaired synaptic plasticity in hippocampal slices from 5xFAD APP/PS1 model mice, including effects on LTP and LTD, correlating with alleviation of downregulation of hippocampal AMPA-type glutamate receptors in preparations from 5xFAD mice. The action of the N-Aβ core depends on a critical di-histidine sequence and involves the phosphoinositide-3 (PI3) kinase pathway via mTOR (mammalian target of rapamycin).
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Amy M. Rapp, Denise A. Chavira, Catherine A. Sugar, Joan R. Asarnow
Summary: This study found that high perceived parental criticism is significantly associated with more severe depression outcomes in youth over an 18-month period. The study suggests that the brief measure used in this research can be feasibly integrated into clinical assessments to help clinicians optimize treatment benefits.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Kang Huang, Qin Yang, Yaning Han, Yulin Zhang, Zhiyi Wang, Liping Wang, Pengfei Wei
Summary: Measuring eye movement is important in cognitive science, and this study introduces a novel system that combines hardware and algorithms to analyze complex and dynamic eye-tracking data in freely-moving animals. This system provides a feasible approach to understanding the neural substrates of cognitive function.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Chuanliang Han, Mingrou Guo, Xiaoyin Ke, Lanting Zeng, Meijia Li, Naem Haihambo, Jianping Lu, Liping Wang, Pengfei Wei
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that has deficits in social and cognitive functioning. It is diagnosed subjectively, and objective criteria for early diagnosis are still being researched. A recent animal study found that the defensive response to looming stimuli was impaired in mice with ASD, but whether this effect exists in humans and can serve as a reliable clinical neural biomarker is uncertain. This study recorded electroencephalogram responses in children with ASD and typical developed children and found that alpha-band activity in the posterior brain region remained unchanged in the ASD group after looming stimuli, while it was suppressed in the TD group. This method could be a novel, objective way to detect ASD earlier.
COGNITIVE NEURODYNAMICS
(2023)
Article
Neurosciences
Xulin Li, Gaoyang Zhao, Hongren Huang, Jialin Ye, Junfeng Xu, Yuan Zhou, Xiaojuan Zhu, Liping Wang, Feng Wang
Summary: Age-related characteristics in female brain functions show variations in different brain regions, and the expressions of certain genes are also influenced by age. The expression of CB1 receptor increases in some brain regions but decreases in others with age. These findings suggest the need for further investigation into age-related characteristics of female brain functions.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Letter
Neurosciences
Yu-Ting Tseng, Lisha Liang, Binghao Zhao, Jialin Ye, Liping Wang
NEUROSCIENCE BULLETIN
(2023)
Article
Neurosciences
Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Gao
Summary: Studies have shown that protein phosphorylation is important in morphine abuse, but the role of protein phosphatase 2A (PP2A) in the morphine-priming process is unclear. In this study, conditional knockout mice were used to investigate the role of hippocampal PP2A in morphine priming. The results suggest that hippocampal PP2A may be involved in morphine priming through the PP2A/HDAC4/Rack1 pathway.
Article
Multidisciplinary Sciences
Jing Chen, Yitao Jiang, Keen Yang, Xiuqin Ye, Chen Cui, Siyuan Shi, Huaiyu Wu, Hongtian Tian, Di Song, Jincao Yao, Liping Wang, Sijing Huang, Jinfeng Xu, Dong Xu, Fajin Dong
Summary: This research explores the method of using artificial intelligence to capture complementary responsible frames from breast ultrasound screening in AI-assisted breast diagnosis. The AI model based on FEBrNet-recommended frames outperforms other frame set based AI models, as well as ultrasound and mammography physicians, indicating the level of FEBrNet reaching medical specialists.
Article
Immunology
Ling Shuai, Jiajie She, Ruiying Diao, Huihui Zhao, Xuemin Liu, Qingyu Hu, Dongdong Li, Danna Su, Xiaofeng Ye, Yan Guo, Mei Zhong, Liping Wang
Summary: This study investigated the effect of hydroxychloroquine (HCQ) on ovarian function in mice with premature ovarian insufficiency (POI). The results showed that HCQ restored ovarian function, increased estradiol levels, and decreased follicle stimulating hormone levels. HCQ also inhibited the activation of the TLR7 signaling pathway, preventing inflammation and the differentiation of CD4(+) T cells into Th17 cells. These findings suggest that HCQ may be a promising therapeutic method for patients with POI.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Psychiatry
Yu-Ting Tseng, Binghao Zhao, Hui Ding, Lisha Liang, Bernhard Schaefke, Liping Wang
Summary: Investigation into neurobiology of depression requires animal models that mimic specific aspects of the human disorder. However, commonly used paradigms have gender biases when applied to female mice. This study shows that predator stress effectively induces depression-like behaviors in both male and female mice, and machine learning-based analysis can predict depression status from behavioral patterns. The study highlights the importance of unbiased evaluation and provides a holistic approach for studying neuropsychiatric disorders.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Behavioral Sciences
Xue-Fei Hou, Ya-Bo Zhao, Yue-Xiong Yang, Jing Zhu, Li-Su Zhu, Lin Xu, Qi-Xin Zhou
Summary: In this study, a simple and effective experimental model was designed to investigate the generalization memory of morphine reward. By replacing the conditioning CPP box, it was found that mice still showed a clear preference for generalized information. The establishment of this study provides a new tool for studying generalization memory in substance use disorders.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Wei Ren, Kang Huang, Yumo Li, Qin Yang, Liping Wang, Kun Guo, Pengfei Wei, Yong Q. Zhang
Summary: This study developed a pupilometer for dogs and used it to measure real-time pupillary responses. The researchers found that gene-edited dogs carrying mutations in Shank3 showed altered pupillary responses to light, loud noise, and high reward food. The Shank3 mutant dogs also exhibited impaired pupillary synchrony during dog-human interaction. These findings suggest that the pupilometer can be used to study the underlying neural mechanisms of autism spectrum disorder and other psychiatric disorders.
MOLECULAR PSYCHIATRY
(2023)
Review
Neurosciences
Yu-Ting Tseng, Bernhard Schaefke, Pengfei Wei, Liping Wang
Summary: Animals need to balance defensive responses against predators with other adaptive behaviors. Accumulating evidence suggests that endocrine, immune, gastrointestinal, and reproductive systems play important roles in modulating behavioral responses to threat. Understanding the interconnected network between the brain and body is crucial for appropriate defensive responses to threats.
NATURE REVIEWS NEUROSCIENCE
(2023)
Article
Neurosciences
Moxuan Luo, Qingqing Liu, Liping Wang, Rosa H. M. Chan
Summary: This article introduces DLATA, a deep learning-assisted transformation alignment method that can automatically identify feature points in brain slice images and perform geometric transformations for alignment using a local weighted mean method. It achieves higher efficiency and better results compared to other semi-automated alignment methods.
NEUROSCIENCE LETTERS
(2023)
Article
Multidisciplinary Sciences
Lei Gao, Xinyu Zhang, Jinlong Zhu, Songbai Han, Hao Zhang, Liping Wang, Ruo Zhao, Song Gao, Shuai Li, Yonggang Wang, Dubin Huang, Yusheng Zhao, Ruqiang Zou
Summary: The lattice manipulation method of replacing [Li2OH]+ clusters with potassium ions in antiperovskite solid-state electrolyte leads to an increase in ionic conductivity. The method stabilizes the cubic phase and causes lattice contraction, resulting in improved lithium ion transport properties. The electrolyte shows potential application prospects in all-solid-state lithium batteries.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Xiaoyuan Jing, Feng Hong, Yinfang Xie, Yutong Xie, Feng Shi, Ruoxi Wang, Liping Wang, Zuxin Chen, Xin-an Liu
Summary: The high risk of anxiety and depression among individuals with stress has become a global concern. This study found that cordycepin, a Chinese herbal medicine, can alleviate stress-induced mental disorders and metabolic dysfunction. A dosage of 12.5 mg/kg cordycepin significantly reduced anxiety and depression-like behaviors, while a dosage of 25 mg/kg restored the weight and cell size of adipose tissues.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Zoology
Ting-Ting Pan, Chao Liu, De-Min Li, Bin-Bin Nie, Tian-Hao Zhang, Wei Zhang, Shi-Lun Zhao, Qi-Xin Zhou, Hua Liu, Gao-Hong Zhu, Lin Xu, Bao-Ci Shan
ZOOLOGICAL RESEARCH
(2022)