Article
Oncology
Jie Li, Jianguo Wang, Zhikun Liu, Haijun Guo, Xuyong Wei, Qiang Wei, Shusen Zheng, Xiao Xu
Summary: The expression of MFAP4 is significantly downregulated in hepatocellular carcinoma (HCC), and it can serve as a molecular marker for diagnosis and prognosis of HCC. Additionally, MFAP4 acts as an important tumor suppressor in HCC by inducing S phase arrest, promoting apoptosis, cell migration, and invasion.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Physics, Multidisciplinary
Mark A. Novotny, G. Inkoom, Tomas Novotny
Summary: We demonstrate that quantum systems with disordered Hamiltonians can exhibit order in commonly measured quantities. We use a conventional tight binding model to study two-dimensional nanoribbons with various boundary conditions, and analyze electron transport using the non-equilibrium Green's function methodology. Our study focuses on quantum dragon nanodevices that show order in both bond currents and local density of states (LDOS) of the propagating electrons.
Article
Immunology
Daniella M. Schwartz, Philip Parel, Haiou Li, Alexander V. Sorokin, Alexander R. Berg, Marcus Chen, Amit Dey, Christin G. Hong, Martin Playford, McKella Sylvester, Heather Teague, Evan Siegel, Nehal N. Mehta
Summary: In this study, we comprehensively phenotyped a cohort of PsA patients to investigate the potential contributors to cardiovascular disease. We found that inflammation and metabolic dysfunction, including adipose inflammation, were associated with subclinical coronary artery disease in PsA patients. These findings suggest novel targets for the prevention and treatment of cardiovascular disease in PsA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rashmi Rekha Boruah, Trishna Konwar, Pranab Kumar Nath, Sumita Acharjee, Bidyut Kumar Sarmah
Summary: The activity of a green tissue-specific promoter of the Rubisco small subunit gene from Arabidopsis (AraSSU) was studied in transgenic chickpea lines. The AraSSU promoter was shown to drive high-level expression of the cry2Aa gene in all green tissues, while the CaMV35S promoter only resulted in low-level expression. Immunolocalization confirmed expression of the cry2Aa gene in the mesophyll cells of both AraSSU and CaMV35 chickpea lines, with accumulation of the Cry2Aa protein also observed in vascular tissues. However, expression was not observed in the roots of AraSSU lines. RT-PCR further confirmed the activity of the AraSSU promoter in above-ground tissues of the chickpea plant.
Article
Microbiology
Yuri Ikeda, Mana Kishimoto, Masaki Shintani, Nobuyuki Yoshida
Summary: This study elucidates the regulatory mechanism of gene expression of aldA and mnoA in Rhodococcus erythropolis N9T-4 under oligotrophic conditions. The findings are important for the production of useful compounds in oligotrophic microbial processes.
Article
Endocrinology & Metabolism
Li Wang, Nie Hu, Zhongjun Jiang, Ping Luo, Nian Yi, Yanhua Chen, Ning Zhou, Longfei Liu
Summary: The study revealed a significant association between serum HE4 levels and cardiovascular events in obese breast cancer patients, indicating a good predictive value for cardiovascular events. Serum HE4 may serve as a valuable indicator for the early detection of cardiovascular complications in obese patients with breast cancer.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Agnieszka Miklosz, Bartlomiej Lukaszuk, Adrian Chabowski, Jan Gorski
Summary: This study found that even a single bout of exercise could induce changes in the mRNA and protein levels of EL, with a clearer pattern observed for the former. The protein content of EL in the muscles varied with the intensity and/or duration of the run. The differences in EL expression in vascular beds of muscles may indicate a muscle-specific role of the lipase.
Article
Cardiac & Cardiovascular Systems
Xiaoling Gao, Yanjuan Jia, Hui Xu, Yonghong Li, Qing Zhu, Chaojun Wei, Jinxia Hou, Dehong Li, Wanxia Wang, Zhenhao Li, Rui Guo, Jing Jia, Yu Wu, Zhenhong Wei, Xiaoming Qi, Yuanting Li
Summary: Serum pepsinogens are non-linearly correlated with ASCVD, with PGR potentially serving as a reliable biomarker for ASCVD among all PGs.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, General & Internal
Dong-Yuan Chang, Jin-Wei Wang, Min Chen, Lu-Xia Zhang, Ming-Hui Zhao
Summary: The study indicated that there is a differential association between SUA levels and mortality by sex, showing a U-shaped relationship between SUA levels and all-cause and CVD mortalities among men in China.
CHINESE MEDICAL JOURNAL
(2021)
Article
Environmental Sciences
Tomoko Takahashi, Akifumi Eguchi, Masahiro Watanabe, Emiko Todaka, Kenichi Sakurai, Chisato Mori
Summary: Environmental exposure to persistent organic pollutants during pregnancy can have adverse health effects on the fetus. This study found that fetal exposure to polychlorinated biphenyls (PCBs) affects the telomere length of the umbilical cord.
Article
Cardiac & Cardiovascular Systems
Hongyu Li, Yating Wang, Yiping Xu, Kefei Wu, Xiaohui Lu, Yagui Qiu, Xiao Yang, Qinghua Liu, Haiping Mao
Summary: This study found that lower serum chloride levels were associated with increased all-cause and cardiovascular disease mortality in continuous ambulatory peritoneal dialysis (CAPD) patients, especially in patients over the age of 50 or with a history of diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, Research & Experimental
Chun Zhou, Yuanyuan Zhang, Jianghua Chen, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Jianwei Tian, Ziliang Ye, Qimeng Wu, Xianhui Qin, Jianping Jiang, Fan Fan Hou
Summary: This study aimed to assess the correlation of serum advanced oxidation protein products (AOPP) levels with the risk of all-cause mortality in hemodialysis (HD) patients in China. The results showed that elevated serum AOPP levels were associated with a higher risk of all-cause mortality in Chinese maintenance HD patients, particularly in those with AOPP levels >=87 mu mol/L.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Acoustics
Thanh-Cao Le, Duc-Duy Ho, Thanh-Canh Huynh, Van-Sy Bach
Summary: The modal strain energy method is developed for damage detection in plate-like structures, using finite element analysis and damage index to verify the feasibility of the method.
SHOCK AND VIBRATION
(2021)
Article
Multidisciplinary Sciences
Xin-zheng Hou, En-qi Liu, Si-qi Liu, Hao Lv, Hua-feng Cui, Jing Han
Summary: This study aimed to assess the correlation between serum albumin levels and coronary heart disease (CHD) risk in adults aged over 45 years. Multiple logistic regression and smooth curve fitting analysis were performed using the non-institutionalized US population from NHANES 2011-2018. The results showed an inverse association between serum albumin levels and CHD risk, with lower levels of serum albumin associated with a higher risk of CHD. Subgroup analysis indicated that this correlation was statistically significant in female patients over 60 years with hypertension but without diabetes.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui
Summary: Oxysterols are believed to contribute to the development of cardiovascular diseases, and their serum levels are positively associated with cholesterol absorption and synthesis. However, the regulation of different oxysterols in the body is largely unknown. This study aimed to investigate the relationship between clinical factors and cholesterol metabolism markers, as well as identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease.
Article
Critical Care Medicine
Tessa M. Kole, Elise Vanden Berghe, Monica Kraft, Judith M. Vonk, Martijn C. Nawijn, Salman Siddiqui, Kai Sun, Leonardo M. Fabbri, Klaus F. Rabe, Kian Fan Chung, Gabriele Nicolini, Alberto Papi, Chris Brightling, Dave Singh, Thys van der Molen, Sven-Erik Dahlen, Alvar Agusti, Rosa Faner, Jadwiga A. Wedzicha, Gavin C. Donaldson, Ian M. Adcock, Lies Lahousse, Huib A. M. Kerstjens, Maarten van den Berge
Summary: This post-hoc analysis investigates the determinants, clinical implications, and outcome of persistent airflow limitation (PAL) in patients with asthma. The study reveals that PAL is not only present in severe asthma, but also in a considerable proportion of patients with milder disease. In patients with mild asthma, PAL is associated with eosinophilic inflammation and a higher risk of exacerbations, suggesting the need for increased treatment intensity.
LANCET RESPIRATORY MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Rikke Sogaard, Axel Diederichsen, Jes Lindholt
EUROPEAN HEART JOURNAL
(2023)
Article
Hematology
Thorsten Brodersen, Klaus Rostgaard, Cathrine Juel Lau, Knud Juel, Christian Erikstrup, Kasper Rene Nielsen, Sisse Rye Ostrowski, Kjell Titlestad, Susanne G. Saekmose, Ole B. Pedersen, Henrik Hjalgrim
Summary: This study found that blood donors were more likely to participate in health surveys, indicating the presence of the healthy donor effect. Furthermore, blood donation was associated with better self-reported health and healthier lifestyles.
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Review
Cardiac & Cardiovascular Systems
Katrine Lawaetz Larsen, Egle Kavaliunaite, Lars Melholt Rasmussen, Jesper Hallas, Axel Diederichsen, Flemming Hald Steffensen, Martin Busk, Lars Frost, Grazina Urbonaviciene, Jess Lambrechtsen, Kenneth Egstrup, Jes Sanddal Lindholt
Summary: A paradoxical protective effect of diabetes on the development and progression of abdominal aortic aneurysms (AAA) has been investigated through a cross-sectional study, systematic review, and meta-analysis. The results suggest a potential change in the association between diabetes and AAA over time.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Zhaojie Meng, Shuya Zhang, Wei Li, Yunzhe Wang, Minjie Wang, Xin Liu, Cong-Lin Liu, Sha Liao, Tianxiao Liu, Chongzhe Yang, Jes S. Lindholt, Lars M. Rasmussen, Lasse M. Obel, Jane Stubbe, Axel C. Diederichsen, Yong Sun, Yabing Chen, Paul B. Yu, Peter Libby, Guo-Ping Shi, Junli Guo
Summary: In this study, it was found that blood eosinophil count and eosinophil cationic protein (ECP) concentration are risk factors for cardiovascular diseases. Eosinophils and ECP were shown to contribute to vascular calcification and atherogenesis through the BMPR-1A/1B-Smad-1/5/8-Runx2 signaling pathway.
EUROPEAN HEART JOURNAL
(2023)
Article
Health Care Sciences & Services
Marie Dahl, Susanne F. Sondergaard, Rafel Salman Al-Allaq, Axel Diederichsen, Jes S. Lindholt
Summary: This study explores the perceptions of Arabic-speaking male immigrants on preventive initiatives, particularly for cardiovascular diseases. The findings reveal that preventive initiatives are ethically and culturally acceptable, and are considered important for the participants' health and self-determination. However, Arabic-speaking men may face barriers in engaging in prevention due to their basic assumptions and limited capabilities. Therefore, a person-centred approach and efforts to improve health literacy can help address inequality in accessibility and acceptability of preventive measures.
HEALTH EXPECTATIONS
(2023)
Review
Hematology
William McIntyre
Summary: Atrial fibrillation is a common cause of stroke. Timely diagnosis and treatment with oral anticoagulation can prevent many AF-related strokes. However, the impact of population-based ECG screening on stroke is uncertain as current RCTs lack sufficient power.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Lea A. N. Christoffersen, Dorte Helenius, Michael Schwinn, Christian Erikstrup, Henrik Hjalgrim, Janna Nissen, Karina Banasik, Kaspar Nielsen, Kathrine A. Kaspersen, Khoa M. Dinh, Mie T. Bruun, Sisse R. Ostrowski, Susanne Saekmose, Thomas F. Hansen, Thomas Werge, Maria Didriksen, Ole Birger Pedersen
Summary: This cross-sectional cohort study examined the level of loneliness during the COVID-19 pandemic in Denmark and identified associated behavioral patterns and demographic factors. The findings showed an increase in experienced loneliness during the pandemic, particularly affecting individuals with low well-being, women, and younger individuals.
Article
Oncology
Mikail Gogenur, Lukas Balsevicius, Mustafa Bulut, Nesibe Colak, Tobias Freyberg Justesen, Anne-Marie Kanstrup Fiehn, Marianne Bogevang Jensen, Kathrine Host-Rasmussen, Britt Cappelen, Shruti Gaggar, Asma Tajik, Jawad Ahmad Zahid, Astrid Louise Bjorn Bennedsen, Tommaso Del Buono D'Ondes, Hans Raskov, Susanne Gjorup Saekmose, Lasse Bremholm Hansen, Ali Salanti, Susanne Brix, Ismail Gogenur
Summary: A clinical trial was conducted to investigate the safety and efficacy of intratumoral influenza vaccine in patients with non-metastasizing sigmoid or rectal cancer. The results showed that the vaccine was safe and feasible, and induced infiltration of CD8+T cells and upregulation of PD-L1 in proficient mismatch repair tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Letter
Cardiac & Cardiovascular Systems
Selma Hasific, Lars Melholt Rasmussen, Jordi S. Dahl, Axel C. P. Diederichsen
Article
Oncology
Agon Olloni, Carsten Brink, Ebbe L. Lorenzen, Stefan S. Jeppesen, Lone Hoffmann, Charlotte Kristiansen, Marianne M. Knap, Ditte S. Moller, Lotte Nygard, Gitte F. Persson, Rune S. Thing, Hella MB. Sand, Axel Diederichsen, Tine Schytte
Summary: This study investigated the role of coronary artery calcium score (CACs) as a prognostic marker in locally advanced non-small cell lung cancer (LA-NSCLC) patients. The results showed that CACs did not significantly impact the overall survival of the patients, highlighting the priority of lung cancer treatment.
RADIOTHERAPY AND ONCOLOGY
(2023)
Letter
Hematology
Lasse M. Obel, Jes S. Lindholt, Axel C. Diederichsen, Christian Kring, Lars M. Rasmussen, Anne B. Alnor, Pernille J. Vinholt
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, General & Internal
Selma Hasific, Kristian A. Ovrehus, Susanne Hosbond, Jess Lambrechtsen, Preman Kumarathurai, Anna Mejldal, Emil Johannes Ravn, Lars Melholt Rasmussen, Oke Gerke, Hans Mickley, Axel Diederichsen
Summary: This study aims to investigate the effects of vitamin K2 and D3 supplementation on severe coronary artery calcification. The findings suggest that supplementation with these vitamins can slow down the calcification process and have a protective role in predicting acute myocardial infarction and cardiovascular mortality.
