Article
Cardiac & Cardiovascular Systems
Nian Huang, Chengyao Tang, Shiyang Li, Wenzhi Ma, Xiaobing Zhai, Keyang Liu, Haytham A. Sheerah, Jinhong Cao
Summary: The study found that decreased lung function is associated with a higher risk of cardiovascular diseases and all-cause mortality in people with diabetes. Specifically, lower levels of FEV1 and FVC were associated with a higher risk of the mentioned diseases, and lung function tests can provide predictive and prognostic information for the management of patients with diabetes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Makoto Saegusa, Yumi Matsuda, Tsuneo Konta, Takafumi Saitoh, Kaori Sakurada, Midori Furuse, Chisaki Uno, Takamasa Kayama, Yoshiyuki Ueno
Summary: This study found that serum cholinesterase (ChE) levels are independent predictors of all-cause mortality in a community-based population, while serum albumin (Alb) levels do not have this effect.
ANNALS OF NUTRITION AND METABOLISM
(2022)
Article
Environmental Sciences
Chih-Wen Wang, Szu-Chia Chen, Da-Wei Wu, Huang-Chi Chen, Hung-Hsun Lin, Hung Su, Jen-taie Shiea, Wen-Yi Lin, Chih-Hsing Hung, Chao-Hung Kuo
Summary: This study found that dermal phthalate levels were significantly associated with decreases in lung function tests, particularly with FVC and FEV1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Clinical Neurology
Gang Peng, Yujing Xin, Xiaojing Cao, Yi Chen, Yi Yang, Xinyuan Zhang, Xiang Zhou
Summary: This study investigated the association between depressive symptoms and lung function in US adults and found a correlation, especially among non-Hispanic White individuals.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, General & Internal
Mariana B. Cartuliares, Flemming S. Rosenvinge, Christian B. Mogensen, Thor A. Skovsted, Steen L. Andersen, Andreas K. Pedersen, Helene Skjot-Arkil
Summary: This study compared the effects of tracheal suction and expiratory technique on the quality of sputum samples in patients hospitalized with suspected LRTI. The findings showed that tracheal suction obtained higher quality sputum samples, while patients in the expiratory technique group had a better experience.
Article
Environmental Sciences
Chin-Chung Shu, Jia-Kun Chen, Po-Chin Huang, Jing-Shiang Hwang, Ta-Chen Su
Summary: The study found a negative association between urinary manganese level and pulmonary function in young adults, even when the level was within normal range. Additionally, women may be more susceptible to manganese compared to men. Further investigation is urgently needed to confirm the respiratory hazardous effects of manganese.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Respiratory System
Yong Suk Jo, Ji-Yong Moon, Yong Bum Park, Yee Hyung Kim, Soo-Jung Um, Woo Jin Kim, Hyoung Kyu Yoon, Kwang Ha Yoo, Ki-Suck Jung, Chin Kook Rhee
Summary: This study investigated the longitudinal changes in lung function in eosinophilic COPD patients and the effects of inhaled corticosteroid (ICS) therapy. The results showed that eosinophilic COPD had a more favorable annual rate of decline in forced expiratory volume in 1 s (FEV1) compared to non-eosinophilic COPD, and ICS therapy did not have any beneficial effects on the changes in FEV1.
BMC PULMONARY MEDICINE
(2022)
Article
Endocrinology & Metabolism
Zobida Islam, Shamima Akter, Yosuke Inoue, Huan Hu, Keisuke Kuwahara, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Hiroko Okazaki, Toshiaki Miyamoto, Takayuki Ogasawara, Naoko Sasaki, Akihiko Uehara, Makoto Yamamoto, Takeshi Kochi, Masafumi Eguchi, Taiki Shirasaka, Makiko Shimizu, Satsue Nagahama, Ai Hori, Teppei Imai, Akiko Nishihara, Kentaro Tomita, Tomofumi Sone, Maki Konishi, Isamu Kabe, Tetsuya Mizoue, Seitaro Dohi
Summary: Prediabetes defined according to the American Diabetes Association criteria is associated with increased risk of all-cause and cancer deaths, but not cardiovascular disease deaths. In a cohort of Japanese workers, prediabetes defined by FPG and HbA(1c) according to ADA or WHO/IEC criteria is significantly linked to higher mortality risk.
Article
Allergy
So-Hee Lee, Kyung-Min Ahn, Suh-Young Lee, Sun-Sin Kim, Heung-Woo Park
Summary: This study found that in healthy individuals, blood eosinophil count (BEC) is associated with a decline in lung function, and consistently high BEC is an independent risk factor for accelerated decline in FEV1. Using BEC may help identify healthy individuals at high risk for developing chronic lung disease and enable tailored preventive strategies.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Environmental Sciences
Chih-Wen Wang, Da-Wei Wu, Szu-Chia Chen, Huang-Chi Chen, Hung-Hsun Lin, Hung Su, Jen-taie Shiea, Wen-Yi Lin, Chih-Hsing Hung, Chao-Hung Kuo
Summary: Phthalate concentrations in dust are related to respiratory disease. Dermal DEP level is positively associated with changes in lung function test values and is mediated by absolute eosinophil count.
ENVIRONMENTAL RESEARCH
(2021)
Article
Anesthesiology
Douglas A. Colquhoun, Aleda M. Leis, Amy M. Shanks, Michael R. Mathis, Bhiken I. Naik, Marcel E. Durieux, Sachin Kheterpal, Nathan L. Pace, Wanda M. Popescu, Robert B. Schonberger, Benjamin D. Kozower, Dustin M. Walters, Justin D. Blasberg, Andrew C. Chang, Michael F. Aziz, Izumi Harukuni, Brandon H. Tieu, Randal S. Blank
Summary: The study did not find an independent association between a low tidal volume lung-protective ventilation regimen and a composite of postoperative pulmonary complications in patients undergoing one-lung ventilation during thoracic surgery.
Article
Engineering, Multidisciplinary
Walter Boscheri, Giacomo Dimarco, Maurizio Tavelli
Summary: This study presents a numerical method for the compressible Navier-Stokes equation that is second-order accurate in both time and space, applicable to high and low Mach numbers. The method is stable for time steps independent of pressure wave speeds and diffusive terms, and allows for efficient three-dimensional simulations of all Mach problems.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Koji Inagaki, Naoto Tawada, Masahiro Takanashi, Toshiyuki Akahori
Summary: In Japanese patients initiating hemodialysis, higher BMI at 2 weeks after initiation was associated with lower mortality, while lower BMI at the first hemodialysis session was associated with higher mortality.
Article
Physiology
Gwen S. Skloot, Kieley L. O'Connor-Chapman, Clyde B. Schechter, Daniel J. Markley, Jason H. T. Bates
Summary: Forced expiratory time (FET) is believed to reflect lung function but its physiological basis is not clear. Research suggests that FET is negatively correlated with FEV1/FVC, negatively correlated with FEV1 in obstructed patients, and positively correlated with FVC in normal and restricted patients.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Physiology
Ningfang Lian, Sijiao Wang, Lijuan Hu, Liping Xue, Ying Gong, Li Li, Yanjie Yang, Lei Zhu
Summary: This study found that a 500 m simulated saturation dive caused damage to lung function, specifically affecting small airway and diffusion function. This injury may be associated with small airway and diffusion membrane lesions.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kei Mizuno, Hiroaki Haga, Kazuo Okumoto, Kyoko Hoshikawa, Tomohiro Katsumi, Taketo Nishina, Takafumi Saito, Hideki Katagiri, Yoshiyuki Ueno
Summary: Autonomic nerve fibers in the liver play a crucial role in regulating blood flow, bile secretion, and hepatic metabolism to maintain systemic homeostasis. Chronic hepatitis, especially viral hepatitis, and advanced liver fibrosis were associated with significantly lower nerve fiber ratios in the liver. However, antiviral treatment for HCV showed recovery of nerve fiber ratios along with improvement of liver fibrosis.
Article
Gastroenterology & Hepatology
Hitoshi Yoshiji, Yoshiyuki Ueno, Masayuki Kurosaki, Takuji Torimura, Etsuro Hatano, Hiroshi Yatsuhashi, Koichiro Yamakado
Summary: Thrombocytopenia is common in patients with chronic liver disease, who often require invasive procedures with a risk of bleeding. Platelet transfusion and thrombopoietin receptor agonists (TPORAs) are two options to increase platelet counts in these patients. Treatment algorithms in different countries vary, with the choice of treatment mainly dependent on the physician's judgment and experience. A more guidance-oriented treatment algorithm is needed for optimal decision making in selecting TPORA therapy or platelet transfusion based on the latest evidence and clinical practice.
HEPATOLOGY RESEARCH
(2021)
Article
Endocrinology & Metabolism
Makoto Saegusa, Yumi Matsuda, Tsuneo Konta, Takafumi Saitoh, Kaori Sakurada, Midori Furuse, Chisaki Uno, Takamasa Kayama, Yoshiyuki Ueno
Summary: This study found that serum cholinesterase (ChE) levels are independent predictors of all-cause mortality in a community-based population, while serum albumin (Alb) levels do not have this effect.
ANNALS OF NUTRITION AND METABOLISM
(2022)
Review
Gastroenterology & Hepatology
Tomohiro Katsumi, Yoshiyuki Ueno
Summary: Autoimmune hepatitis (AIH) is a chronic liver disease that mainly affects hepatocytes. Recent epidemiological studies in Asia have revealed regional characteristics of AIH, with type 1 being predominant in East Asia and type 2 being as frequent as in Europe and the USA in South Asia. The prevalence of AIH is increasing worldwide, and early diagnosis and treatment can improve the situation in Asia.
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Tetsuya Ishizawa, Naohiko Makino, Yasuharu Kakizaki, Akiko Matsuda, Yoshihide Toyokawa, Shun Ooyama, Masaru Tanaka, Yoshiyuki Ueno
Summary: This study demonstrated the biosafety of PMEA-CSEMS in normal porcine bile ducts, showing no significant inflammatory response and resistance to sludge. Additionally, no abnormalities were observed in serological and histological analyses.
Article
Medicine, General & Internal
Hideto Kawaratani, Yasuteru Kondo, Ryoji Tatsumi, Naoto Kawabe, Norikazu Tanabe, Akira Sakamaki, Kazuo Okumoto, Yoshihito Uchida, Kei Endo, Takumi Kawaguchi, Tsunekazu Oikawa, Yoji Ishizu, Shuhei Hige, Taro Takami, Shuji Terai, Yoshiyuki Ueno, Satoshi Mochida, Yasuhiro Takikawa, Takuji Torimura, Tomokazu Matsuura, Masatoshi Ishigami, Kazuhiko Koike, Hitoshi Yoshiji
Summary: This study found that long-term treatment with rifaximin is effective and safe for patients with hepatic encephalopathy. Ammonia levels significantly improved after 3 months of treatment and remained improved until 12 months. There were no serious adverse events reported, and the incidence of overt hepatic encephalopathy was low.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ayumi Tamura, Masaya Murabayashi, Yuki Nishiya, Satoru Mizushiri, Kiho Hamaura, Ryoma Ito, Shoma Ono, Akihide Terada, Hiroshi Murakami, Jutaro Tanabe, Miyuki Yanagimachi, Itoyo Tokuda, Kaori Sawada, Kazushige Ihara, Makoto Daimon
Summary: This study aimed to investigate the influence of nutrient composition on the association between gut microbiota and type 2 diabetes. The results showed differences in gut microbiota composition between diabetic and non-diabetic subjects and its correlation with energy, carbohydrates, and fiber consumed. Cluster analysis revealed a negative association between a Blautia-dominant gut microbiota and diabetes, while a Bifidobacterium-dominant gut microbiota was positively associated with diabetes, suggesting the involvement of nutrient factors in the gut microbiota-diabetes association.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Y. Sasaki, Y. Abe, S. Nishise, Y. Ueno
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Kaori Sakurada, Tsuneo Konta, Narumi Murakami, Naoko Kosugi, Takafumi Saito, Masafumi Watanabe, Kenichi Ishizawa, Yoshiyuki Ueno, Takamasa Kayama
Summary: This study found that lack of sexual interest may be a risk factor for all-cause mortality in Japanese males over 40 years old.
Article
Medicine, General & Internal
Shoma Ono, Satoru Mizushiri, Yuki Nishiya, Ayumi Tamura, Kiho Hamaura, Ryoma Ito, Akihide Terada, Jutaro Tanabe, Miyuki Yanagimachi, Kyi Mar Wai, Kaori Sawada, Kazushige Ihara, Makoto Daimon
Summary: The association between serum adiponectin concentration (S-Adipo) and type 2 diabetes (T2D) may be influenced by the extent of kidney damage. The adiponectin relative excess index is a superior marker for this relationship.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Ryoma Ito, Satoru Mizushiri, Yuki Nishiya, Shoma Ono, Ayumi Tamura, Kiho Hamaura, Akihide Terada, Jutaro Tanabe, Miyuki Yanagimachi, Kyi Mar Wai, Yutaro Kudo, Kazushige Ihara, Yoshiko Takahashi, Makoto Daimon
Summary: Recent attempts to classify adult-onset diabetes into different clusters showed that it can be categorized into five clusters, with four corresponding to type 2 diabetes (T2DM). This study aimed to identify risk clusters for incident T2DM among nondiabetic individuals. The analysis found two clusters, one labeled as obese insulin resistant with sufficient compensatory insulin secretion and the other as low insulin secretion, were at higher risk of developing diabetes during the 5-year follow-up period. Assessing an individual's risk of diabetes can be done more effectively based on their cluster membership.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Shinobu Takayasu, Kazunori Kageyama, Makoto Daimon
Summary: Cushing's disease is caused by autonomous secretion of adrenocorticotropic hormone (ACTH) from corticotroph pituitary neuroendocrine tumors, leading to excess cortisol production. It presents with a variety of clinical features, from overt to subtle, caused by hormonal activities. Understanding the molecular and genetic causes of Cushing's disease is essential for its treatment. This review discusses recent advances in molecular insights and targeted therapy for Cushing's disease.
Review
Medicine, General & Internal
Yu Sasaki, Yasuhiko Abe, Naoko Mizumoto, Eiki Nomura, Yoshiyuki Ueno
Summary: Eosinophilic gastroenteritis (EoGE) is a rare digestive disorder characterized by eosinophilic infiltration in the stomach and intestines. The endoscopic findings of EoGE in the small intestine are not well understood, but this literature review identified common findings such as redness, villous atrophy, erosion, ulceration, edema, and stenosis. These findings contribute to the development of EoGE practice.
Review
Medicine, General & Internal
Yasuhiko Abe, Yu Sasaki, Makoto Yagi, Naoko Mizumoto, Yusuke Onozato, Matsuki Umehara, Yoshiyuki Ueno
Summary: Eosinophilic esophagitis is a chronic immune-mediated inflammatory disease characterized by esophageal dysfunction and intense eosinophil infiltration. The recognition of characteristic endoscopic features and subsequent biopsy are crucial for early diagnosis and treatment, but the diagnostic consistency among endoscopists is still inadequate. Image-enhanced endoscopy holds promise for improving diagnostic efficiency.
Article
Biochemistry & Molecular Biology
Shinpei Sugahara, Hiroaki Haga, Chisaki Ikeda, Naohiko Makino, Akiko Matsuda, Yasuharu Kakizaki, Kyoko Hoshikawa, Tomohiro Katsumi, Tetsuya Ishizawa, Toshikazu Kobayashi, Keita Maki, Fumiya Suzuki, Ryoko Murakami, Hidenori Sato, Yoshiyuki Ueno
Summary: Despite extensive study on liver regeneration, the impact of bile-derived extracellular vesicles (bile EVs) on hepatocytes remains unclear. Using a rat model of partial hepatectomy (PH), this study found that bile EVs released 12 hours after PH significantly promoted hepatocyte proliferation. Transcriptome analysis revealed an upregulation of genes promoting cell cycle progression in hepatocytes treated with PH24-EVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)