Article
Immunology
Ze-Hui Liu, Hui-Ling Xu, Guang-Wei Han, Li-Na Tao, Ying Lu, Su-Ya Zheng, Wei-Huan Fang, Fang He
Summary: This study developed a novel vaccine strategy to display CSFV E2 glycoprotein on self-assembling NPs, resulting in significant immunogenic effects in pigs, including enhanced antigen uptake and up-regulated production of immunostimulatory cytokines in antigen presenting cells (APCs).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Muhammad Naveed Anwar, Chunying Jiang, Di Di, Junjie Zhang, Shuang Guo, Xin Wang, Muddassar Hameed, Abdul Wahaab, Donghua Shao, Zongjie Li, Ke Liu, Beibei Li, Yafeng Qiu, Zhiyong Ma, Jianchao Wei
Summary: VLP-JEVe was constructed by inserting six JEV envelope protein epitopes into PPV VP2 and demonstrated high efficacy in protecting mice and guinea pigs against JEV challenge, inducing neutralizing antibodies and providing 100% protection. The vaccine also induced protective immunity against PPV challenge in guinea pigs, suggesting its potential as a candidate for vaccine development.
Article
Veterinary Sciences
Pinghua Li, Shulun Huang, Jingjing Zha, Pun Sun, Dong Li, Huifang Bao, Yimei Cao, Xingwen Bai, Yuanfang Fu, Xueqing Ma, Kun Li, Hong Yuan, Jing Zhang, Zhixun Zhao, Jian Wang, Keqiang Zhang, Yingli Chen, Qiang Zhang, Shuyun Qi, Zaixin Liu, Zengjun Lu
Summary: This study aimed to develop a promising vaccine candidate strain against serotype O foot-and-mouth disease (FMD) in China. Two chimeric FMD viruses were constructed and evaluated, and one of them (rHN/TURVP1) showed a protective immune response to the field isolate of the Cathay lineage at 28 days post-vaccination.
VETERINARY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
H. Lalzampuia, Subhadra Elango, Jitendra K. Biswal, Narayanan Krishnaswamy, R. P. Tamil Selvan, P. Saravanan, Priyanka Mahadappa, V. Umapathi, G. R. Reddy, V. Bhanuprakash, Aniket Sanyal, H. J. Dechamma
Summary: Deletion mutant viruses of FMDV Asia1, developed by PCR-mediated mutagenesis of NSP 3A and 3B1, were genetically stable. The growth kinetics and antigenic relatedness of the mutant viruses were comparable with that of the wild-type virus. Vaccination of guinea pigs with the deletion mutant viruses conferred complete protection upon challenge with the homologous virus.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
B. S. Ananda Kumar, Sivasankar Panickan, Suresh Bindu, Vimal Kumar, Saravanan Ramakrishnan, Sonal Saxena, Sameer Shrivastava, Satyabrata Dandapat
Summary: An immunization experiment using PLGA nanoparticles encapsulating inactivated NDV vaccine was conducted in specific pathogen-free chickens. The results showed that the nano-NDV vaccine induced high levels of antibodies and cell-mediated immune responses, providing 100% protection against NDV challenge. This study provides insights for developing PLGA nanoparticle-based vaccines against avian diseases.
Article
Multidisciplinary Sciences
Myriam Arevalo-Herrera, Xiomara Gaitan, Michelle Larmat-Delgado, Maria Alejandra Caicedo, Sonia M. Herrera, Juliana Henao-Giraldo, Angelica Castellanos, Jean-Christophe Devaud, Andre Pannatier, Jose Onate, Giampietro Corradin, Socrates Herrera
Summary: In this randomized, double-blind, controlled vaccine clinical trial, the authors evaluate the protective efficacy of a Plasmodium vivax circumsporozoite (CS) protein vaccine in both naive and semi-immune individuals and explore the antibody and IFN-gamma response to the vaccine.
NATURE COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Ning Li, Qi-long Qiao, Hui-fang Guo, Bai-yu Wang, Qing Huang, Zeng Wang, Yong-tao Li, Jun Zhao
Summary: Senecavirus A (SVA) is an emerging virus associated with porcine idiopathic vesicular disease (PIVD), and there are currently no vaccines available for prevention and control. This study isolated a new strain of SVA and proposed a mouse model for evaluating the immunogenicity and protective efficacy of the vaccine.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Immunology
Rania Bouzeyen, Saurabh Chugh, Tannu Priya Gosain, Mohamed-Ridha Barbouche, Meriam Haoues, Kanury V. S. Rao, Makram Essafi, Ramandeep Singh
Summary: This study demonstrates that enhancing the protective efficacy of M. bovis BCG in mice and guinea pig infection models by inhibiting Akt inhibitor MK-2206 promotes FOXO3 activation and BCG-induced immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lucila Garcia-Contreras, Vasu Sethuraman, Masha Kazantseva, Anthony Hickey
Summary: The study found that the combination of rifampicin liposomes (RLs) and rifampicin microparticles (RMs) with liposomes can enhance the permeation of rifampicin into granulomas. RLs delivered via the pulmonary route showed more significant reduction in lung bacterial burden and spleen weight in TB-infected guinea pigs compared to other treatment groups.
Article
Multidisciplinary Sciences
Pragya D. Yadav, Raches Ella, Sanjay Kumar, Dilip R. Patil, Sreelekshmy Mohandas, Anita M. Shete, Krishna M. Vadrevu, Gaurav Bhati, Gajanan Sapkal, Himanshu Kaushal, Savita Patil, Rajlaxmi Jain, Gururaj Deshpande, Nivedita Gupta, Kshitij Agarwal, Mangesh Gokhale, Basavaraj Mathapati, Siddhanath Metkari, Chandrashekhar Mote, Dimpal Nyayanit, Deepak Y. Patil, B. S. Sai Prasad, Annasaheb Suryawanshi, Manoj Kadam, Abhimanyu Kumar, Sachin Daigude, Sanjay Gopale, Triparna Majumdar, Deepak Mali, Prasad Sarkale, Shreekant Baradkar, Pranita Gawande, Yash Joshi, Sidharam Fulari, Hitesh Dighe, Sharda Sharma, Rashmi Gunjikar, Abhinendra Kumar, Kaumudi Kalele, Vellimedu K. Srinivas, Raman R. Gangakhedkar, Krishna M. Ella, Priya Abraham, Samiran Panda, Balram Bhargava
Summary: This study demonstrates the protective efficacy and immunogenicity of the inactivated SARS-CoV-2 vaccine BBV152 in rhesus macaques, indicating that the vaccine candidate is in clinical development.
NATURE COMMUNICATIONS
(2021)
Article
Parasitology
Debora Azevedo Borges, Yara Peluso Cid, Viviane de Sousa Magalhaes, Melina Cardilo Campos Alves, Thais Paes Ferreira, Isabelle Vilela Bonfim, Emily Andressa Santos Lima, Juliana Pereira de Freitas, Fabio Barbour Scott
Summary: The study aimed to determine an effective fluazuron (FLU) dose to control A. sculptum larvae in capybaras. The results showed that FLU caused significant morphological and behavioral changes in the larvae, and the efficacy reached 100% for all treated groups.
PARASITES & VECTORS
(2022)
Article
Biotechnology & Applied Microbiology
Cory J. Knudson, Pedro Alves-Peixoto, Hiromi Muramatsu, Colby Stotesbury, Lingjuan Tang, Paulo J. C. Lin, Ying K. Tam, Drew Weissman, Norbert Pardi, Luis J. Sigal
Summary: Different doses of modified mRNA vaccines can induce strong CD8 T cell responses, providing protective immunity and increasing the memory CD8 T cell pool, which can be used to create CD8 T cell-based vaccines against viral infections.
Article
Biotechnology & Applied Microbiology
Huildore Bommanna Ranjitha, Valiya Valappil Dhanesh, Madhusudan Hosamani, B. P. Sreenivasa, Uzma Jabeen, Jitendra Kumar Biswal, P. Saravanan, Aniket Sanyal, Veerakyathappa Bhanuprakash, Suresh H. Basagoudanavar
Summary: Foot-and-mouth disease (FMD) is a contagious viral disease that affects cloven-hoofed animals. Preventive vaccination using inactivated virus is common practice, but the presence of antibodies to non-structural proteins is needed for differentiation of infected from vaccinated animals (DIVA). To address this, a thermostable and negative marker vaccine strain for FMDV serotype O was developed, along with a cELISA for detecting the deleted 3A region, to enhance FMD control in enzootic countries.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Review
Anatomy & Morphology
Stephan Maxeiner, Selina Gebhardt, Frederick Schweizer, Agnes E. Venghaus, Gabriela Krasteva-Christ
Summary: This article discusses the differences between the human genome and the mouse genome, particularly the issues in generating gene research models, pointing out the absence of some genes in mice and rats.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Immunology
Hong-chao Sun, Pu-ming Deng, Yuan Fu, Jin-hua Deng, Rong-hui Xie, Jing Huang, Meng Qi, Tuan-yuan Shi
Summary: In this study, PLGA nanoparticles were used as a delivery system for T. gondii GRA12 and GRA7 antigens. Mice immunized with PLGA+GRA12 showed higher levels of IgG antibodies, increased lymphocyte proliferation, and a predominant Th1 immune response. Immunization with PLGA+GRA12 vaccine resulted in significantly reduced parasite loads and longer survival times compared to other vaccinated groups. However, PLGA was ineffective in enhancing the immune response induced by T. gondii GRA7.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Junjie Wang, Tianping Ying, Jun Deng, Cuiying Pei, Tongxu Yu, Xu Chen, Yimin Wan, Mingzhang Yang, Weiyi Dai, Dongliang Yang, Yanchun Li, Shiyan Li, Soshi Iimura, Shixuan Du, Hideo Hosono, Yanpeng Qi, Jian-gang Guo
Summary: Searching for functional square lattices in layered superconductor systems provides a clue to modify electron behavior and find exotic properties. Structural transformation of trigonal SnAs3 to square SnAs4 under pressure enables the realization of a functional As square lattice in Li0.6Sn2As2 and NaSnAs, resulting in record-high Tc values. The transfer of the conductive channel from out-of-plane to in-plane orbitals facilitates electron hopping within the 2D lattice and enhances superconductivity. Reorienting p-orbitals through a local structure transformation offers an effective strategy for modifying layered superconducting systems.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biotechnology & Applied Microbiology
Zhixun Zhao, Caiyun Huang, Xueliang Zhu, Zheng Qi, Yimei Cao, Pinghua Li, Huifang Bao, Pu Sun, Xingwen Bai, Yuanfang Fu, Kun Li, Jing Zhang, Xueqing Ma, Jian Wang, Hong Yuan, Dong Li, Zaixin Liu, Qiang Zhang, Zengjun Lu
Summary: In this study, a dual live vector vaccine against Foot-and-mouth disease (FMD) and Peste des petits ruminant disease (PPR) was constructed using the MVA-GFP recombinant virus skeleton. The recombinant virus successfully expressed the target proteins and the empty capsid of FMDV. This study laid the foundation for the successful construction of a live vector vaccine against FMD and PPR.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Physics, Multidisciplinary
Shien Li, Zefeng Lin, Wei Hu, Dayu Yan, Fucong Chen, Xinbo Bai, Beiyi Zhu, Jie Yuan, Youguo Shi, Kui Jin, Hongming Weng, Haizhong Guo
Summary: In this study, TaAs films were grown on different substrates using pulsed laser deposition (PLD) method. It was found that partial As ions from the GaAs substrate are likely to diffuse into the TaAs films during growth, leading to improved As content and the achievement of the TaAs phase. This work presents an effective method for the fabrication of TaAs films using PLD.
Article
Physics, Multidisciplinary
Akihiko Sumiyama, Takumi Nagaeki, Akira Yamaguchi, Ke Jia, Jie Yang, Youguo Shi, Guo-qing Zheng
Summary: We measured the DC magnetic susceptibility of single crystals of the quasi-one-dimensional superconductor Cs2Cr3As3. Diamagnetism appears below 1.2 and 2 K for magnetic fields parallel and perpendicular to the c-axis, respectively, whereas the Meissner effect emerges at 1.2 K in both directions, suggesting that, between 1.2 and 2 K, superconductivity is filamentary along the c-axis.
JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN
(2023)
Article
Physics, Multidisciplinary
Miao Xu, Changwei Zou, Benchao Gong, Ke Jia, Shusen Ye, Zhenqi Hao, Kai Liu, Youguo Shi, Zhong-Yi Lu, Peng Cai, Yayu Wang
Summary: We use scanning tunneling microscopy to investigate the atomic scale electronic structure of spin-orbit-coupling assisted Mott insulator Sr3Ir2O7. We find that the tunneling spectra exhibit a homogeneous Mott gap in defect-free regions, but near the oxygen vacancy in the rotated IrO2 plane the local Mott gap size is significantly enhanced. This enhancement is attributed to the locally reduced hopping integral between the 5d electrons of neighboring Ir sites via the bridging planar oxygen p orbitals.
CHINESE PHYSICS LETTERS
(2023)
Article
Physics, Condensed Matter
Jing-Jing Xiao, Cui-Xiang Wang, Da-Yu Yan, Yong Li, Hai L. Feng, Lai-Jun Liu, You-Guo Shi
Summary: Single crystals of LnRu(2)Ga(8) and LnCo(2)Al(8) (Ln = La and Pr) were grown using a Ga/Al self-flux method. The orthorhombic CaCo2Al8-type structure with space group Pbam (No.55) was identified by x-ray diffraction. LaRu2Ga8 and LaCo2Al8 are Pauli paramagnetic down to 2 K, while PrRu2Ga8 and PrCo2Al8 show antiferromagnetic (AFM) order at 2.5 and 5 K, respectively. Strong magnetic anisotropy in PrRu2Ga8 and PrCo2Al8 single crystals was observed, with field-induced FM state for H||c and robust AFM state for H perpendicular to c.
JOURNAL OF PHYSICS-CONDENSED MATTER
(2023)
Article
Physics, Multidisciplinary
Qi Wang, Xiao-Le Qiu, Cuiying Pei, Ben-Chao Gong, Lingling Gao, Yi Zhao, Weizheng Cao, Changhua Li, Shihao Zhu, Mingxin Zhang, Yulin Chen, Kai Liu, Yanpeng Qi
Summary: Researchers have discovered superconductivity in Pd3P2S8, a van der Waals material consisting of Pd kagome lattice, under pressure. The superconductivity in Pd3P2S8 is observed when the resistivity shows a metallic temperature dependence instead of a semiconducting-like one. The transition temperature of the superconductivity increases gradually with pressure, reaching 6.83 K at 79.5 GPa. High-pressure x-ray diffraction, Raman spectroscopy, and theoretical calculations suggest that the observed superconductivity in Pd3P2S8 is closely linked to the formation of an amorphous phase resulting from the enhanced coupling between interlayer Pd and S atoms upon compression.
NEW JOURNAL OF PHYSICS
(2023)
Article
Multidisciplinary Sciences
Yigui Zhong, Shaozhi Li, Hongxiong Liu, Yuyang Dong, Kohei Aido, Yosuke Arai, Haoxiang Li, Weilu Zhang, Youguo Shi, Ziqiang Wang, Shik Shin, H. N. Lee, H. Miao, Takeshi Kondo, Kozo Okazaki
Summary: In the study, it was found that the new kagome metal CsV3Sb5 may have superconductivity that intertwines with time-reversal and spatial symmetry-breaking orders, suggesting an unconventional pairing mechanism. Through angle-resolved photoemission spectroscopy and Eliashberg function analysis, an EPC strength of lambda=0.45-0.6 for both Sb 5p and V 3d electronic bands was determined, supporting the conventional superconducting transition temperature in CsV3Sb5. Additionally, the EPC on the V 3d-band was enhanced to lambda~0.75 as the superconducting transition temperature elevated to 4.4 K in Cs(V0.93Nb0.07)(3)Sb-5. These results provide important insights into the pairing mechanism in the kagome superconductor CsV3Sb5.
NATURE COMMUNICATIONS
(2023)
Review
Multidisciplinary Sciences
Cuiying Pei, Jianfeng Zhang, Qi Wang, Yi Zhao, Lingling Gao, Chunsheng Gong, Shangjie Tian, Ruitao Luo, Mingtao Li, Wenge Yang, Zhong-Yi Lu, Hechang Lei, Kai Liu, Yanpeng Qi
Summary: The discovery of superconductivity up to 32K in MoB2 under pressure is reported, highlighting the roles of transitional metals in high-Tc superconductors. Despite the exploration of approximately 100 binary borides, only a few of them exhibit relatively low Tc superconductivity. The high Tc of 32K in MoB2 is well explained by theoretical calculations based on electron-phonon coupling, with the coupling between Mo's d electrons and out-of-plane Mo-phonon modes being the main driving force. This study provides insights into the exploration of high-Tc superconductors in transition metal borides.
NATIONAL SCIENCE REVIEW
(2023)
Article
Multidisciplinary Sciences
Jianlei Shen, Jiacheng Gao, Changjiang Yi, Meng Li, Shen Zhang, Jinying Yang, Binbin Wang, Min Zhou, Rongjin Huang, Hongxiang Wei, Haitao Yang, Youguo Shi, Xiaohong Xu, Hong -Jun Gao, Baogen Shen, Geng Li, Zhijun Wang, Enke Liu
Summary: By applying a magnetic field through induced non-collinear magnetism in EuB6, the modulation of topological electronic state and the emergence of a magneto-transport phenomenon were observed. A giant unconventional anomalous Hall effect (UAHE) was found during the magnetization reorientation, with a peak around 5 kOe. The field-dependent scanning tunneling microscopy/spectroscopy (STM/S) revealed the folding of bands and the excited UAHE by external magnetic fields.
Article
Materials Science, Multidisciplinary
Minhao Zhao, Zhongbo Yan, Yunkun Yang, Nesta Benno Joseph, Pengliang Leng, Mykhaylo Ozerov, Zhongchen Xu, Youguo Shi, Awadhesh Narayan, Faxian Xiu
Summary: This study reports the evolutionary process of the energy dispersion of the zeroth Landau level under increasing magnetic fields in TaP and elucidates the relationship between the chiral Landau level and the Fermi level via magneto-optical measurements. Comparing the spectra under Voigt and Faraday geometries, it is found that the chiral nature of the Landau level becomes stronger when the magnetic field is above 13 T. The state transition of the zeroth Landau level can be explained by the strength of the field-induced chiral anomaly effect and the position of the Fermi level. These magneto-optical results unveil the chiral Landau-level transitions in TaP, serving as an ideal material platform to analyze the chiral anomaly effect.
Article
Materials Science, Multidisciplinary
Xiaohu Zheng, Ke Jia, Junhai Ren, Chongli Yang, Xingjun Wu, Youguo Shi, Katsumi Tanigaki, Rui-Rui Du
Summary: By constructing heterostructures with graphite, electron tunneling measurements were performed on few-layer alpha-RuCl3 using scanning tunneling microscopy/spectroscopy. In-gap states in the Mott gap regime were observed in single-layer alpha-RuCl3 in direct contact with graphite. These states were found to be sensitive to interfacial coupling and act as a charge reservoir for weakly doping the alpha-RuCl3 upper layers, leading to a considerable decrease in the Mott gap within those layers. This work demonstrates the potential of the heterostructure for studying doping physics in alpha-RuCl3 and investigating otherwise insulating spin liquid candidates.
Article
Materials Science, Multidisciplinary
Yi Li, Maoyuan Wang, Yong Li, Siwei Xue, Jiade Li, Zhiyu Tao, Xin Han, Jianhui Zhou, Youguo Shi, Jiandong Guo, Xuetao Zhu
Summary: We systematically investigate the nodal-line plasmons of prototypical nodal-line semimetals ZrSiX (X = S, Se, Te) by high-resolution electron energy loss spectroscopy and first-principles calculations. Plasmons induced by intraband and interband correlations of surface states related to the nodal-line electrons are universally observed in the ZrSiX family. The bulk plasmon is observed in ZrSiS but is indiscernible in ZrSiSe and ZrSiTe due to stronger screening effect and larger interlayer distance.
Article
Materials Science, Multidisciplinary
Chunyao Song, Lulu Liu, Shengtao Cui, Jingjing Gao, Pengbo Song, Lei Jin, Wenjuan Zhao, Zhe Sun, Xiaoming Zhang, Lin Zhao, Xuan Luo, Yuping Sun, Youguo Shi, Haijun Zhang, Guodong Liu, X. J. Zhou
Summary: By using angle-resolved photoemission (ARPES) and spin-resolved ARPES measurements combined with band structure calculations, we have obtained a comprehensive understanding of the electronic structure and spin polarization property for the surface states of SnTaS2. The low-energy electronic states are mainly governed by surface states, with two from the S-terminated surface and four from the Sn-terminated surface. These surface states give rise to interesting Fermi surface topology, with three pockets located at Gamma over bar, M over bar, and K over bar for the S-terminated surface, and two pockets surrounding r and K over bar for the Sn-terminated surface. We also discovered that two surface states crossing the Fermi level exhibit spin polarization. Considering the superconducting nature of SnTaS2, our findings suggest its potential as a platform for exploring topological superconductivity and other exotic properties.
Article
Materials Science, Multidisciplinary
Chen Ran, Xinrun Mi, Junying Shen, Honghui Wang, Kunya Yang, Yan Liu, Guiwen Wang, Guoyu Wang, Youguo Shi, Aifeng Wang, Yisheng Chai, Xiaolong Yang, Mingquan He, Xin Tong, Xiaoyuan Zhou
Summary: This study investigates the electrical and thermoelectric transport properties of the ferrimagnetic nodal-line semiconductor Mn3Si2Te6. The Nernst signal in the high-field region is dominated by the anomalous Nernst effect (ANE), while possible signatures of the topological Nernst effect (TNE) are found in the low-field region where the colossal magnetoresistance (CMR) is most apparent.