Article
Chemistry, Multidisciplinary
Ju Hyang Park, Kyung Eun Sung, Ki Hak Kim, Jong Ryeol Kim, Jongbok Kim, Geon Dae Moon, Dong Choon Hyun
Summary: This work presents the fabrication of AuNR@MSNs with independent sensitivities to pH and NIR light for reversible drug release. The inclusion of thermosensitive and pH-sensitive gatekeepers allows controlled drug release under specific conditions.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Engineering, Biomedical
Yekui Zhou, Yuanwei Zhang, Wenhai Lin, Samuel J. Kesseli, Ling Huang, Yang Zhao, Xikuang Yao, Kai Huang, Gang Han
Summary: This study reports the first wavelength-selective sequential photolysis from single gold nanoparticles, demonstrating their ability to sequentially release multiple payloads in living cells. By rational design of diverse photocleavable linkers, this system can potentially be extended to sequential release of various types of payloads. The work provides a new tool for better orderly controlling cellular events that require high spatiotemporal precision.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Xu Han, Gerard Boix, Mateusz Balcerzak, Oscar Hernando Moriones, Mary Cano-Sarabia, Pilar Cortes, Neus Bastus, Victor Puntes, Montserrat Llagostera, Inhar Imaz, Daniel Maspoch
Summary: This study reports the development of a metal-organic framework based composite for the controlled release of iodine, which exhibits antibacterial properties without causing drug resistance. The composite was successfully integrated into a polymer to create antibacterial films, which showed effective long-term release of iodine. In vitro tests confirmed the antibacterial activity of these films against gram-positive and gram-negative bacteria.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
Xiaoqiong Huang, Lei Xu, Xiaoran Yu, Yiming Li, Ziqing Huang, Ruogu Xu, Wenyi Zeng, Zhengchuan Zhang, Weichang Li, Feilong Deng
Summary: Treatment for chronic diabetic wounds remains a clinical challenge. A multifunctional hydrogel with two-stage sequential release upon NIR stimulation, antibacterial activity and pro-angiogenic efficacy has been developed. This hydrogel consists of covalently crosslinked bilayer structure with peptide-functionalized gold nanorods embedded in each layer.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Elias A. Halabi, Ralph Weissleder
Summary: Highly multiplexed, cyclic fluorescence imaging has improved our understanding of human diseases. However, current cyclic methods have limitations such as long quenching times and extensive wash steps. This study presents a new series of fluorochromes that can be efficiently inactivated by a single light pulse, allowing for fast and controllable quenching without the need for washing or additional chemicals.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Oluwasesan Adegoke, Niamh Nic Daeid
Summary: A novel fluorescence aptasensor was developed for ultrasensitive detection of arsenic (As) contamination, with the probe successfully applied in environmental and biological samples. By optimizing the probe composition, selective and quantitative analysis of As(III) was achieved with high sensitivity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ahmed Refaat, Blanca del Rosal, Jathushan Palasubramaniam, Geoffrey Pietersz, Xiaowei Wang, Simon E. Moulton, Karlheinz Peter
Summary: Smart drug delivery systems utilizing near-infrared light-responsive liposomal gold nanorods show potential for targeted therapy of cancer and cardiovascular diseases with minimal adverse effects. This novel platform combines light-triggered protein release with photothermal thrombolytic effects for site-specific thrombolysis, offering a promising approach for advanced medical treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Engineering, Biomedical
Yihong Jiang, Junchao Liu, Jinbao Qin, Jiahao Lei, Xing Zhang, Zhijue Xu, Weimin Li, Xiaobing Liu, Ruihua Wang, Bo Li, Xinwu Lu
Summary: This study reports a new treatment approach for venous malformation using CD31 antibody-conjugated gold nanorods for photothermal therapy. The results indicate that this nanoplatform suppresses proliferation and activates the apoptosis pathway in venous malformation. Moreover, significant therapeutic effects were achieved in in vivo experiments with mice.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Christopher Tiburski, Astrid Boje, Sara Nilsson, Zafer Say, Joachim Fritzsche, Henrik Strom, Anders Hellman, Christoph Langhammer
Summary: This study investigates the differential effects of photothermal rate enhancement on various catalysts and demonstrates how this effect can be controlled by adjusting the catalyst operation point. Experimental results show that small fluctuations in reactor temperature or temperature gradients across a sample may significantly impact photothermal rate enhancement.
Article
Chemistry, Multidisciplinary
Xiuzhao Yin, Taojian Fan, Nannan Zheng, Jing Yang, Li Yan, Shuqing He, Fujin Ai, Junqing Hu
Summary: Precision nanomedicine provides a solution for tumor recurrence and wound repair after cancer surgery. Palladium nanoparticles (Pd NPs) with photothermal and photodynamic therapy (PTT/PDT) were synthesized and loaded with doxorubicin (DOX) to form a smart anti-tumor hydrogel (Pd/DOX@hydrogel). The hydrogel, composed of agarose and chitosan, can be used for both PTT and PDT, as well as photo-induced chemotherapy, effectively inhibiting tumor growth and promoting wound healing.
NANOSCALE ADVANCES
(2023)
Article
Biophysics
Salvatore Petralia, Giuseppe Forte, Morena Aiello, Giuseppe Nocito, Sabrina Conoci
Summary: Bioconjugate gold-based nanostructures that combine the plasmonic photothermal effect with photothermal-triggered DNA delivery are promising materials for medical applications. In this study, DNA-modified gold nanorods were prepared using surface hybridization to create a photo-delivery system for single stranded oligonucleotides. The presence of cationic charges on the surfactant at the gold surface was found to induce a remarkable de-hybridization of DNA strands.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Nisha Chander, Johannes Morstein, Jan S. Bolten, Andrej Shemet, Pieter R. Cullis, Dirk Trauner, Dominik Witzigmann
Summary: Incorporation of photoswitchable-phosphatidylcholine analogs in conventional lipid nanoparticles can generate photoactivatable LNPs, allowing light-induced drug release at specific sites, which shows promising potential for clinical development.
Article
Chemistry, Physical
Amir H. Milani, Jennifer M. Saunders, Nam T. Nguyen, Shanglin Wu, Brian R. Saunders
Summary: The study demonstrates the potential of using sub-50 nm photoacid/base generator nanoparticles to selectively trigger swelling and positive charge production within host hydrogels, adding various functionalities and controlling the bending angle of monolayer actuators through mass fraction.
CHEMISTRY OF MATERIALS
(2021)
Article
Engineering, Chemical
Otavio A. Silva, Michelly G. Pella, Ketul C. Popat, Matt J. Kipper, Adley F. Rubira, Alessandro F. Martins, Heveline D. M. Follmann, Rafael Silva
Summary: This study presents a simple and effective method to prepare cell-compatible drug nanocarriers using human hair as a sustainable keratin source. The extracted rod-shaped keratin nanoparticles (KNPs) demonstrated improved properties compared to KNPs prepared using alkaline methods. They exhibited cytocompatibility towards adipose mesenchymal stem cells and healthy cells, and were found to be a suitable carrier for the anticancer drug berberine. The photothermal properties of the KNPs enhanced the drug release and cytotoxicity against colon adenocarcinoma cells.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Philipp Neidinger, Joshua Davis, Dominik Voll, Esa A. Jaatinen, Sarah L. Walden, Andreas N. Unterreiner, Christopher Barner-Kowollik
Summary: This study introduces a gold nanorod-driven methodology to induce free radical polymerization in water using near infrared light. The process utilizes photothermal conversion and heat transfer to generate radicals, allowing control over the molecular weight and reaction conversion of the polymers. The results demonstrate the potential of this initiation mechanism for inducing polymerization in biological environments.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Veerasikku Gopal Deepagan, Meike N. Leiske, Nicholas L. Fletcher, David Rudd, Terence Tieu, Nicholas Kirkwood, Kristofer J. Thurecht, Kristian Kempe, Nicolas H. Voelcker, Anna Cifuentes-Rius
Summary: Introduction of xanthate-functionalized poly(cyclic imino ethers)s (PCIEs) provides a new method for synthesizing highly monodisperse and fluorescent gold nanoclusters (AuNCs). These PCIE-AuNCs exhibit good colloidal stability, biocompatibility, and antifouling properties, showing potential for various theranostic applications.
Review
Nanoscience & Nanotechnology
Anna Cifuentes-Rius, Anal Desai, Daniel Yuen, Angus P. R. Johnston, Nicolas H. Voelcker
Summary: Induced tolerogenic dendritic cells offer a promising immunotherapy for autoimmune diseases, with nanomedicine presenting an alternative approach to overcome cost and customization limitations. By targeting dendritic cells with nanoparticles, this technology has the potential to address critical issues in organ transplantation and prevalent autoimmune disorders.
NATURE NANOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Terence Tieu, Swati Irani, Kayla L. Bremert, Natalie K. Ryan, Marcin Wojnilowicz, Madison Helm, Helmut Thissen, Nicolas H. Voelcker, Lisa M. Butler, Anna Cifuentes-Rius
Summary: Research in nanomedicine has predominantly focused on cancer therapeutics, but many nanoscale drug delivery systems have not yet translated to clinical settings. Lack of key clinical tumor elements in current in vivo models hinders assessment of drug response. This study uses patient-derived explants (PDE) for evaluating the efficacy of siRNA delivery systems.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Public, Environmental & Occupational Health
Travis L. Massey, Monica K. Borucki, Samuel Y. Paik, Kyle W. Fuhrer, Mihail Bora, Staci R. Kane, Razi-Ul M. Haque, Salmaan H. Baxamusa
Summary: The study found that heat treatment at 75 degrees Celsius can effectively inactivate coronaviruses on FFRs without affecting fit or filtration efficiency, but exposure to radiant heat sources may lead to rapid degradation. Additionally, wear time and the number of donning/doffing cycles are important factors that can impact FFR fit and should be further investigated.
ANNALS OF WORK EXPOSURES AND HEALTH
(2021)
Article
Multidisciplinary Sciences
Helena de Puig, Rose A. Lee, Devora Najjar, Xiao Tan, Luis R. Soekensen, Nicolaas M. Angenent-Mari, Nina M. Donghia, Nicole E. Weckman, Audrey Ory, Carlos F. Ng, Peter Q. Nguyen, Angelo S. Mao, Thomas C. Ferrante, Geoffrey Lansberry, Hani Sallum, James Niemi, James J. Collins
Summary: The miSHERLOCK is a low-cost CRISPR-based POC diagnostic platform that can rapidly detect SARS-CoV-2 and its variants with high sensitivity in just 1 hour. This modular system can be quickly adapted to different viruses and variants, and is complemented by a smartphone application for output interpretation and result reporting.
Article
Chemistry, Physical
Xavier Lepro, Chantel Aracne-Ruddle, Daniel Malone, Haley Hamza, Eric Schaible, Steven F. Buchsbaum, Alicia Calonico-Soto, John Bigelow, Eric Meshot, Salmaan Baxamusa, Michael Stadermann
Summary: Carbon nanotubes possess exceptional mechanical properties, but when bundled together in macroscopic ensembles, their strength significantly decreases. This study presents a strategy using polymer reinforcement to enhance the strength of yarns and sheets made of carbon nanotubes. The results show improved mechanical properties and reduced bundle rearrangement, indicating the potential of this method for enhancing the performance of hierarchical nanostructured materials.
Article
Biotechnology & Applied Microbiology
Evan M. Zhao, Angelo S. Mao, Helena de Puig, Kehan Zhang, Nathaniel D. Tippens, Xiao Tan, F. Ann Ran, Isaac Han, Peter Q. Nguyen, Emma J. Chory, Tiffany Y. Hua, Pradeep Ramesh, David B. Thompson, Crystal Yuri Oh, Eric S. Zigon, Max A. English, James J. Collins
Summary: The use of eukaryotic toehold switches (eToeholds) allows for efficient induction of gene translation in eukaryotic cells, capable of distinguishing the presence of RNA transcripts under various circumstances. Through optimization of RNA annealing, up to 16-fold induction of transgene expression was achieved.
NATURE BIOTECHNOLOGY
(2022)
Article
Engineering, Biomedical
Yufei Xue, Hua Bai, Bo Peng, Terence Tieu, Jiamin Jiang, Shiping Hao, Panpan Li, Mark Richardson, Jonathan Baell, Helmut Thissen, Anna Cifuentes, Lin Li, Nicolas H. Voelcker
Summary: This study describes a step-changing solution to the challenge of controlled drug release using porous silicon nanoparticles (pSiNPs). The covalent conjugation of different stimulus-cleavable linkers and an anticancer drug to pSiNPs resulted in improved stability and highly controlled release behavior, leading to excellent tumor growth inhibition.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Electrical & Electronic
W. E. Fenwick, R. J. Deri, S. H. Baxamusa, D. L. Pope, M. C. Boisselle, D. M. Dutra, N. P. Allen, M. Crowley, P. Thiagarajan, T. Hosoda
Summary: The contribution of facet defect currents to the overall generation-recombination current in laser diodes operating near 800 nm was experimentally quantified. The results showed that the ideality factor of facet currents is much greater than 2, while the ideality factor of currents associated with the interior of the laser diode stripes is 2.
SEMICONDUCTOR SCIENCE AND TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
De-Xiang Zhang, Terence Tieu, Lars Esser, Marcin Wojnilowicz, Chieh-Hua Lee, Anna Cifuentes-Rius, Helmut Thissen, Nicolas H. Voelcker
Summary: In this study, a method for modifying the internal and external surfaces of porous silicon nanoparticles (pSiNPs) was developed. The modified pSiNPs showed excellent colloidal stability in a cell culture medium and the drug release kinetics could be fine-tuned by the combination of internal and external surface modifications. Moreover, the drug-loaded and peptide-functionalized nanoparticles exhibited enhanced cytotoxicity against prostate carcinoma cells.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Ishdeep Kaur, Terence Tieu, Veerasikku G. Deepagan, Muhammad A. Ali, Fahad Alsunaydih, David Rudd, Maliheh A. Moghaddam, Laure Bourgeois, Timothy E. Adams, Kristofer J. Thurecht, Mehmet Yuce, Anna Cifuentes-Rius, Nicolas H. Voelcker
Summary: Despite the clinical benefits of chemotherapeutics, drug resistance remains a major challenge in breast cancer treatment. Nanomedicines, such as porous silicon nanoparticles (pSiNPs), offer a targeted and effective approach by delivering multiple therapeutics and minimizing drug resistance. In this study, breast cancer-targeted pSiNPs co-loaded with an anticancer drug and gold nanoclusters (AuNCs) were engineered. The combination of hyperthermia and chemotherapy using targeted pSiNPs showed higher cell-killing efficacy compared to monotherapy and a nontargeted system with combined therapeutics. These findings highlight the potential of targeted pSiNPs as a versatile platform for personalized medicine.
Article
Engineering, Manufacturing
Nicole Cassada, Caleb Anderson, London Kubicek, David Hobby, Clint Frye, Salmaan Baxamusa, Jack Kotovsky, Kathy Jackson, Ian Ladner, Todd Bandhauer
Summary: Thermal management is a major challenge in high-power microdevice development, but microchannel heat sinks (MCHSs) offer a promising solution. This article investigates the use of silicon carbide (SiC) microchannels to dissipate high heat fluxes. The results demonstrate that SiC MCHSs can achieve low thermal resistances, allowing for efficient heat dissipation from high-power-density microelectronic devices.
IEEE TRANSACTIONS ON COMPONENTS PACKAGING AND MANUFACTURING TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Crystal Chu, Salmaan Baxamusa, Claire Witherel
Summary: The impact of the coronavirus SARS-CoV-2 on life, society, and the world continues to be debated, but it has spurred global scientists to innovate, particularly in the field of materials science. This special issue of MRS Bulletin highlights materials innovation in diagnostics, prevention, and treatment of SARS-CoV-2 infection over the last 18 months.
Review
Pharmacology & Pharmacy
Terence Tieu, Yingkai Wei, Anna Cifuentes-Rius, Nicolas H. Voelcker
Summary: RNA interference and siRNA therapeutics have brought new hope for many difficult-to-treat diseases. Nanoparticles have been utilized to overcome barriers in siRNA delivery, resulting in numerous promising preclinical successes.
ADVANCED THERAPEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Nathan J. Ray, Jae-Hyuck Yoo, Salmaan Baxamusa, Hoang T. Nguyen, Selim Elhadj, Eyal Feigenbaum
Summary: A multistep deposit/dewet process utilizing thermally driven solid-state diffusional dewetting and Ostwald ripening has been proposed to control spatial parameters of nanoparticle ensembles in plasmonic arrays, providing unprecedented control over particular particle size and spacing in large-scale applications.
ACS APPLIED NANO MATERIALS
(2021)
