Article
Oncology
Kelsie Raspin, Liesel M. FitzGerald, James R. Marthick, Matt A. Field, Roslyn C. Malley, Annette Banks, Shaun Donovan, Russell J. Thomson, Georgea R. Foley, Janet L. Stanford, Joanne L. Dickinson
Summary: A rare variant (rs78589034) was identified as significantly associated with increased prostate cancer risk, potentially affecting EZH2 function in prostate tissue. This provides evidence for the variant as a potential therapeutic target.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Maryam Alidoust, Leila Hamzehzadeh, Asma Khorshid Shamshiri, Fahimeh Afzaljavan, Mohammad Amin Kerachian, Azar Fanipakdel, Seyed Amir Aledavood, Abolghasem Allahyari, Alireza Bari, Hooman Moosanen Mozaffari, Ladan Goshayeshi, Alireza Pasdar
Summary: This study examined the association between certain polymorphisms and haplotypes of the SMAD7 gene and the risk of colorectal cancer. The results showed that the rs4939827 variant of the SMAD7 gene was associated with an increased risk of colorectal cancer. Haplotype analysis also revealed significant associations between certain SNP combinations and colorectal cancer risk.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Craig C. Teerlink, Jeff Stevens, Rolando Hernandez, Julio C. Facelli, Lisa A. Cannon-Albright
Summary: A rare intronic variant of the CELF4 gene was significantly associated with colorectal cancer (CRC) risk and shown to segregate within a high-risk pedigree. This provides further support for the role of this variant in CRC risk.
CANCER EPIDEMIOLOGY
(2021)
Article
Oncology
Zhao Liu, Yihan Zhao, Hongli Song, Huaxue Miao, Yingying Wang, Chuntian Tu, Tianyun Fu, Juliang Qin, Bing Du, Min Qian, Hua Ren
Summary: This study identified functional SNPs related to colorectal cancer and discovered that HNRNPK and other proteins can specifically bind to these SNPs, regulating the expression of the SMAD7 gene. Specifically, knockdown of HNRNPK inhibits cell proliferation and clonal formation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Eun Hyo Jin, Yoon Jin Choi, Joo Hyun Lim, Cheol Min Shin, Kyungdo Han, Dong Ho Lee
Summary: Active control of metabolic syndrome (MetS) can reduce the risk of colorectal cancer (CRC). Individuals who recover from MetS have a lower risk of CRC compared to those with persistent MetS. Resolving high blood pressure, abdominal obesity, and blood sugar levels can prevent CRC, while normalizing lipid profile does not independently decrease CRC risk. Therefore, controlling MetS is crucial for CRC prevention.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Long H. Nguyen, Yin Cao, Jinhee Hur, Raaj S. Mehta, Daniel R. Sikavi, Yiqing Wang, Wenjie Ma, Kana Wu, Mingyang Song, Edward L. Giovannucci, Eric B. Rimm, Walter C. Willett, Wendy S. Garrett, Jacques Izard, Curtis Huttenhower, Andrew T. Chan
Summary: The study found that in a cohort of young women, dietary interactions with gut sulfur-metabolizing bacteria may play a role in early-onset colorectal carcinogenesis, possibly beginning in adolescence.
Article
Medicine, General & Internal
Chin-Chia Wu, Cheng-Hung Lee, Ta-Wen Hsu, Chia-Chou Yeh, Mei-Chen Lin, Chun-Ming Chang, Jui-Hsiu Tsai
Summary: The study found that patients without colorectal cancer who underwent colectomy surgery seemed to have a reduced risk of developing type 2 diabetes, especially those who underwent right or transverse colectomies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Naiqi Zhang, Jan Sundquist, Kristina Sundquist, Jianguang Ji
Summary: This study investigated whether the use of proguanil and atovaquone could reduce the risk of CRC in individuals with a family history of the disease, and found a significant negative association between proguanil/atovaquone use and CRC risk. Furthermore, there were significant dose- and duration-response correlations observed in the study.
Article
Oncology
Marco Dicanio, Matteo Giaccherini, Alyssa Clay-Gilmour, Angelica Macauda, Juan Sainz, Mitchell J. Machiela, Malwina Rybicka-Ramos, Aaron D. Norman, Agata Tyczynska, Stephen J. Chanock, Torben Barington, Shaji K. Kumar, Parveen Bhatti, Wendy Cozen, Elizabeth E. Brown, Anna Suska, Eva K. Haastrup, Robert Z. Orlowski, Marek Dudzinski, Ramon Garcia-Sanz, Marcin Kruszewski, Joaquin Martinez-Lopez, Katia Beider, Elzbieta Iskierka-Jazdzewska, Matteo Pelosini, Sonja Berndt, Malgorzata Razny, Krzysztof Jamroziak, S. Vincent Rajkumar, Artur Jurczyszyn, Annette Juul Vangsted, Pilar Garrido Collado, Ulla Vogel, Jonathan N. Hofmann, Mario Petrini, Aleksandra Butrym, Susan L. Slager, Elad Ziv, Edyta Subocz, Graham G. Giles, Niels Frost Andersen, Grzegorz Mazur, Marzena Watek, Fabienne Lesueur, Michelle A. T. Hildebrandt, Daria Zawirska, Lene Hyldahl Ebbesen, Herlander Marques, Federica Gemignani, Charles Dumontet, Judit Varkonyi, Gabriele Buda, Arnon Nagler, Agnieszka Druzd-Sitek, Xifeng Wu, Katalin Kadar, Nicola J. Camp, Norbert Grzasko, Rosalie G. Waller, Celine Vachon, Federico Canzian, Daniele Campa
Summary: The aim of this study was to identify novel pleiotropic variants involved in multiple myeloma (MM) risk. Through analysis of 28,684 single nucleotide polymorphisms (SNPs), DNAJB4-rs34517439-A was found to be associated with an increased risk of developing MM.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Lei Xu, Qi-Xin Wu, Xue Li, Yu-Jing Fang, Ruo-Lin Zhou, Meng-Meng Che, Ting Ma, Cai-Xia Zhang
Summary: This study found a significant inverse association between serum FMN and colorectal cancer risk, while serum riboflavin or vitamin B-2 sum was not associated with colorectal cancer risk. Individuals with a lower PLP level or an adequate folate level could be more sensitive to the protective role of vitamin B-2.
Article
Oncology
Wan Qin, Ben Zhao, Duanrui Wang, Jiamin Liu, Yilu Zhou, Wenjun Zhu, Yongbiao Huang, Hong Qiu, Xianglin Yuan
Summary: This study investigated the relationship between gene polymorphisms involved in immune regulation signaling and the clinical outcome of metastatic colorectal cancer patients treated with bevacizumab-based chemotherapy. The results showed that the CD274:rs2297136 polymorphism was significantly associated with the progression-free survival and overall survival of patients. Additionally, a diagnostic model based on genetic variants and clinical characteristics accurately predicted patient survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Mariusz Berdynski, Piotr Krawczyk, Krzysztof Safranow, Beata Borzemska, Jacek P. Szaflik, Karolina Nowakowska-Zawrocka, Cezary Zekanowski, Joanna Giebultowicz
Summary: This study revealed that a variant of ALDH3A1 is associated with keratoconus risk in the Polish population, and another variant is associated with an earlier age of diagnosis for keratoconus. The differences in allele frequency between populations may contribute to the difference in disease prevalence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Xiangwei Li, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Lina Jansen
Summary: The results of this case-control study suggest that cumulative lifetime excess weight plays a greater role in the risk of colorectal cancer than estimated by traditional BMI measurements at a single point in time.
Article
Biochemistry & Molecular Biology
Liuyang Zhao, Xiang Zhang, Yunfei Zhou, Kaili Fu, Harry Cheuk-Hay Lau, Tommy Wai-Yiu Chun, Alvin Ho-Kwan Cheung, Olabisi Oluwabukola Coker, Hong Wei, William Ka-Kei Wu, Sunny Hei Wong, Joseph Jao-Yiu Sung, Ka Fai To, Jun Yu
Summary: Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer patients. P. micra was found to promote colorectal tumorigenesis in mice by inducing colonocyte proliferation and altering Th17 immune response. It may act as a potential prognostic biomarker for poor survival of CRC patients.
Review
Oncology
Iris Lansdorp-Vogelaar, Reinier Meester, Lucie de Jonge, Andrea Buron, Ulrike Haug, Carlo Senore
Summary: Risk-based colorectal cancer screening can optimize resource allocation and improve the benefit-harm ratio. Reliable risk prediction models and participation are essential for successful implementation. While recognizing the limitations of current approaches, introducing tailored strategies within screening programmes is feasible and may lead to substantial improvements.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Respiratory System
Anna Guyatt, Catherine John, Alexander T. Williams, Nick Shrine, Nicola F. Reeve, Ian Sayers, Ian Hall, Louise Wain, Nuala Sheehan, Frank Dudbridge, Martin D. Tobin
Summary: This study investigated the causal relationship between eosinophils and various respiratory phenotypes. The findings suggest a potential causal link between elevated eosinophils and ACO, moderate-to-severe asthma, and reduced lung function. However, the heterogeneity of the results calls for caution, as other mechanisms may also contribute to respiratory health impairment.
Review
Surgery
Peige Song, Yazhou He, Davies Adeloye, Yuefeng Zhu, Xinxin Ye, Qian Yi, Kazem Rahimi, Igor Rudan, Global Hlth Epidemiol Res Grp GHERG
Summary: The study aimed to estimate the global and regional prevalence of abdominal aortic aneurysms (AAAs) in 2019 and evaluate associated factors. The global prevalence of AAA among people aged 30 to 79 years was 0.92%, with a total of 35.12 million AAA cases in 2019. Smoking, male sex, family history of AAA, advanced age, hypertension, hypercholesterolemia, obesity, cardiovascular disease, cerebrovascular disease, claudication, peripheral artery disease, pulmonary disease, and renal disease were associated with AAA. The Western Pacific region had the highest AAA prevalence, while the African region had the lowest prevalence.
Article
Gastroenterology & Hepatology
Yuhao Sun, Shuai Yuan, Xuejie Chen, Jing Sun, Rahul Kalla, Lili Yu, Lijuan Wang, Xuan Zhou, Xiangxing Kong, Therese Hesketh, Gwo-tzer Ho, Kefeng Ding, Malcolm Dunlop, Susanna C. Larsson, Jack Satsangi, Jie Chen, Xiaoyan Wang, Xue Li, Evropi Theodoratou, Edward L. Giovannucci
Summary: This study investigated the associations between genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD). The results showed that high genetic risk and unhealthy lifestyle were associated with increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC). However, for individuals with high genetic risk, adhering to a healthy lifestyle can reduce the risk by nearly 50%.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Letter
Oncology
Rachel H. Horton, Malcolm G. Dunlop, Richard S. Houlston, Anneke Lucassen, Margaret McCartney, Alan McNeill, Amit Sud
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Rongqi Zhang, Daniel Boakye, Nan Yang, Xuan Zhou, Yajing Zhou, Fangyuan Jiang, Lili Yu, Lijuan Wang, Jing Sun, Shuai Yuan, Jie Chen, Ashleigh C. Hamilton, Helen G. Coleman, Susanna C. Larsson, Julian Little, Malcolm G. Dunlop, Edward L. Giovannucci, Evropi Theodoratou, Xue Li
Summary: This study systematically evaluated the associations between environmental and genetic factors and the risk of EOCRC and EOCRA. It identified 12 risk factors and 3 protective factors for EOCRC. No significant associations were found between the examined genetic variants and EOCRC risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Oncology
Wanxin Li, Xuan Zhou, Shuai Yuan, Lijuan Wang, Lili Yu, Jing Sun, Jie Chen, Qian Xiao, Zhongxiao Wan, Ju-Sheng Zheng, Cai-Xia Zhang, Susanna C. Larsson, Susan M. Farrington, Philip Law, Richard S. Houlston, Ian Tomlinson, Ke-Feng Ding, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: This study uses forward and reverse Mendelian randomization analysis to discover a causal relationship between genetic susceptibility and two microbiota taxa related to colorectal adenoma, highlighting the importance of further studies exploring the causal mechanisms linking host genetic variation with the gut microbiome and susceptibility to colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Biochemistry & Molecular Biology
Jing Sun, Lijuan Wang, Xuan Zhou, Lidan Hu, Shuai Yuan, Zilong Bian, Jie Chen, Yingshuang Zhu, Susan M. Farrington, Harry Campbell, Kefeng Ding, Dongfeng Zhang, Malcolm G. Dunlop, Evropi Theodoratou, Xue Li
Summary: This study identified three novel genetic variants and three genes associated with colorectal cancer (CRC) through a systematic genome-wide analysis. These genetic variants significantly influenced the expression of their respective genes in colon tissue and interacted with environmental factors such as smoking and alcohol drinking. The findings provide important insights into the genetic architecture of CRC.
HUMAN MOLECULAR GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Andrea Gelemanovic, Tatjana Catipovic Ardalic, Ajka Pribisalic, Caroline Hayward, Ivana Kolcic, Ozren Polasek
Summary: Infectious diseases remain a threat to global human health, and host genetic factors play a role in determining susceptibility, severity, and outcome. A genome-wide meta-analysis of 4624 subjects was conducted, identifying 29 infection-related genetic associations, primarily rare variants. Notably, genes with known roles in the immune response were detected, suggesting that understanding rare variants could aid in predicting an individual's susceptibility to infectious diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Correction
Genetics & Heredity
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Stephanie Schmit, Virginia Diez-Obrero, Li Hsu, Juan Fernandez-Tajes, Claire Palles, Kitty Sherwood, Sarah Briggs, Victoria Svinti, Kevin Donnelly, Susan Farrington, James Blackmur, Peter Vaughan-Shaw, Xiao-ou Shu, Jirong Long, Qiuyin Cai, Xingyi Guo, Yingchang Lu, Peter Broderick, James Studd, Jeroen Huyghe, Tabitha Harrison, David Conti, Christopher Dampier, Mathew Devall, Fredrick Schumacher, Marilena Melas, Gad Rennert, Mireia Obon-Santacana, Vicente Martin-Sanchez, Ferran Moratalla-Navarro, Jae Hwan Oh, Jeongseon Kim, Sun Ha Jee, Keum Ji Jung, Sun-Seog Kweon, Min-Ho Shin, Aesun Shin, Yoon-Ok Ahn, Dong-Hyun Kim, Isao Oze, Wanqing Wen, Keitaro Matsuo, Koichi Matsuda, Chizu Tanikawa, Zefang Ren, Yu-Tang Gao, Wei-Hua Jia, John Hopper, Mark Jenkins, Aung Ko Win, Rish Pai, Jane Figueiredo, Robert Haile, Steven Gallinger, Michael Woods, Polly Newcomb, David Duggan, Jeremy Cheadle, Richard Kaplan, Timothy Maughan, Rachel Kerr, David Kerr, Iva Kirac, Jan Bohm, Lukka-Pekka Mecklin, Pekka Jousilahti, Paul Knekt, Lauri Aaltonen, Harri Rissanen, Eero Pukkala, Johan Eriksson, Tatiana Cajuso, Ulrika Hanninen, Johanna Kondelin, Kimmo Palin, Tomas Tanskanen, Laura Renkonen-Sinisalo, Brent Zanke, Satu Mannisto, Demetrius Albanes, Stephanie Weinstein, Edward Ruiz-Narvaez, Julie Palmer, Daniel Buchanan, Elizabeth Platz, Kala Visvanathan, Cornelia Ulrich, Erin Siegel, Stefanie Brezina, Andrea Gsur, Peter Campbell, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner, Martha Slattery, John Potter, Konstantinos Tsilidis, Matthias Schulze, Marc Gunter, Neil Murphy, Antoni Castells, Sergi Castellvi-Bel, Leticia Moreira, Volker Arndt, Anna Shcherbina, Mariana Stern, Bens Pardamean, Timothy Bishop, Graham Giles, Melissa Southey, Gregory Idos, Kevin McDonnell, Zomoroda Abu-Ful, Joel Greenson, Katerina Shulman, Flavio Lejbkowicz, Kenneth Offit, Yu-Ru Su, Robert Steinfelder, Temitope Keku, Bethany van Guelpen, Thomas Hudson, Heather Hampel, Rachel Pearlman, Sonja Berndt, Richard Hayes, Marie Elena Martinez, Sushma Thomas, Douglas Corley, Paul Pharoah, Susanna Larsson, Yun Yen, Heinz-Josef Lenz, Emily White, Li Li, Kimberly Doheny, Elizabeth Pugh, Tameka Shelford, Andrew Chan, Marcia Cruz-Correa, Annika Lindblom, David Hunter, Amit Joshi, Clemens Schafmayer, Peter Scacheri, Anshul Kundaje, Deborah Nickerson, Robert Schoen, Jochen Hampe, Zsofia Stadler, Pavel Vodicka, Ludmila Vodickova, Veronika Vymetalkova, Nickolas Papadopoulos, Chistopher Edlund, William Gauderman, Duncan Thomas, David Shibata, Amanda Toland, Sanford Markowitz, Andre Kim, Stephen Chanock, Franzel van Duijnhoven, Edith Feskens, Lori Sakoda, Manuela Gago-Dominguez, Alicja Wolk, Alessio Naccarati, Barbara Pardini, Liesel FitzGerald, Soo Chin Lee, Shuji Ogino, Stephanie Bien, Charles Kooperberg, Christopher Li, Yi Lin, Ross Prentice, Conghui Qu, Stephane Bezieau, Catherine Tangen, Elaine Mardis, Taiki Yamaji, Norie Sawada, Motoki Iwasaki, Christopher Haiman, Loic Le Marchand, Anna Wu, Chenxu Qu, Caroline McNeil, Gerhard Coetzee, Caroline Hayward, Ian Deary, Sarah Harris, Evropi Theodoratou, Stuart Reid, Marion Walker, Li Yin Ooi, Victor Moreno, Graham Casey, Stephen Gruber, Ian Tomlinson, Wei Zheng, Malcolm Dunlop, Richard Houlston, Ulrike Peters
Article
Genetics & Heredity
Lili Yu, Lijuan Wang, Jing Sun, Xuan Zhou, Yeting Hu, Lidan Hu, Yazhou He, Chunqing Lin, Jie Chen, Xiaolin Xu, Malcolm G. Dunlop, Evropi Theodoratou, Kefeng Ding, Xue Li
Summary: This study developed a risk score based on m6A-related gene expression signatures for predicting the overall survival of colorectal cancer (CRC) patients. The risk score was significantly associated with CRC survival and had predictive value in different age, sex, and tumor stage groups. Furthermore, high-risk patients showed distinct patterns of immune cell composition and tumor microenvironment compared to low-risk patients.
FRONTIERS IN GENETICS
(2023)
Article
Gastroenterology & Hepatology
Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, T. O. P. P. I. C. Study Group, Ibd-biom Consortium, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi
Summary: This study aimed to investigate the DNA methylation alterations associated with Crohn's disease (CD) recurrence following surgery. The results showed differentially methylated positions and differentially variable positions in patients with CD recurrence. The study also validated the previously reported CD-associated methylome.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Letter
Surgery
Adam D. Gerrard, Malcolm G. Dunlop, Farhat V. N. Din
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
A. D. Gerrard, Y. Maeda, J. Miller, F. Gunn, E. Theodoratou, C. Noble, L. Porteous, S. Glancy, P. MacLean, R. Pattenden, M. G. Dunlop, F. V. N. Din
Summary: Single- and double-faecal immunochemical test (FIT) strategies were tested in high-risk symptomatic patients. A double-FIT strategy reduced missed colorectal cancers by 50.0 per cent and all significant bowel pathology by 30.0 per cent, while improving prioritization to investigation.
BRITISH JOURNAL OF SURGERY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Tatijana Zemunik, Nikolina Pleic, Mirjana Babic Leko, Ivana Gunjaca, Vesela Torlak, Ante Punda, Ozren Polasek, Thibaud Boutin, Caroline Hayward
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Nikolina Pleic, Mirjana Babic Leko, Ivana Gunjaca, Thibaud Boutin, Vesela Torlak, Antonela Matana, Ante Punda, Ozren Polasek, Caroline Hayward, Tatijana Zemunik
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
