Article
Clinical Neurology
Yan Su, Yikun Guo, Zhuoyou Chen, Min Zhang, Jianfang Liu, Qian Wang, Tian Yao
Summary: This study found that pre-existing small vessel disease (SVD) may be associated with the 3-month prognosis of acute cardioembolic stroke (CES) patients. Patients with SVD are more likely to have a poor outcome.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Clinical Neurology
Hanan Alhazmi, Alexandre Bani-Sadr, Thomas Bochaton, Alexandre Paccalet, Claire Crola Da Silva, Marielle Buisson, Camille Amaz, Roxana Ameli, Yves Berthezene, Omer Faruk Eker, Michel Ovize, Tae-Hee Cho, Norbert Nighoghossian, Laura Mechtouff
Summary: The study found that SVS length and admission MMP-9 level may improve the prediction of CE subtype, which closely resembles the ESUS subtype. Factors such as current smoking, tandem occlusion, SVS length, and admission MMP-9 level were inversely associated with the CE subtype. These results suggest a common cardiac embolic source for CE subtype and ESUS.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Eric L. Harshfield, Caroline J. Sands, Anil M. Tuladhar, Frank-Erik de Leeuw, Matthew R. Lewis, Hugh S. Markus
Summary: Cerebral small vessel disease is a major cause of vascular cognitive impairment and dementia. Metabolomics can be used to identify novel risk factors, predict disease progression and severity, and provide new insights into disease pathogenesis and treatment approaches.
Article
Clinical Neurology
Adam de Havenon, Alicia Castonguay, Raul Nogueira, Thanh N. Nguyen, Joey English, Sudhakar Reddy Satti, Erol Veznedaroglu, Jeffrey L. Saver, J. Mocco, Pooja Khatri, Eva Mistry, Osama O. Zaidat
Summary: A post hoc analysis of stroke patients undergoing endovascular therapy revealed that those with premorbid disability were more likely to avoid accumulating further disability but had a higher chance of death compared to patients without disability.
Article
Clinical Neurology
Nevine El Nahas, Hossam Shokri, Tamer Roushdy, Noha Dawood, Amr Zaki, Mehdi Farhoudi, Elyar Sadeghi Hokmabadi, Amal Al Hashmi, Waldemar Brola, Krystian Kosno, Cristian Falup-Pecurariu, Bogdan Ciopleias, Joan Montaner, Soledad Perez-Sanchez, Manoj Mittal, Kandis Dowd, Annie Banke, Nicholas Vigilante, James Siegler, Atilla Ozcan Ozdemir, Ozlem Aykac, Zehra Uysal Kocabas, Donoband Melgarejo, Analia Cardozo, Lorena Peralta, Hany Aref, Valeria Caso
Summary: This study examined sex differences in stroke risk factors, severity, and outcome among a large number of patients. It also compared stroke characteristics among women in different age groups and across different countries.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Ruoyao Cao, Yao Lu, Peng Qi, Yanyan Wang, Hailong Hu, Yun Jiang, Min Chen, Juan Chen
Summary: The study aimed to validate the value of collateral circulation and B-type natriuretic peptide (BNP) in predicting clinical outcomes in patients with acute ischemic stroke (AIS) and their biomarker value for stroke subtypes before endovascular treatment (EVT). The results showed that the modified collateral circulation scoring system on four-dimensional computed tomography angiography (4D CTA-CS) and BNP could be independent predictors of clinical outcomes in AIS patients and determine stroke subtypes. The combination of BNP and 4D CTA-CS had the highest predictive value compared to collateral status or BNP alone.
Article
Clinical Neurology
Pinni Yang, Zhengbao Zhu, Yuhan Zang, Xiaoqing Bu, Tian Xu, Chongke Zhong, Aili Wang, Hao Peng, Daoxia Guo, Xiaowei Zheng, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He
Summary: This study found that elevated serum complement C3 levels were associated with increased risks of adverse clinical outcomes in patients with ischemic stroke, suggesting that serum complement C3 may serve as a valuable prognostic biomarker for ischemic stroke.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lina Zheng, Xinyi Leng, Ximing Nie, Hongyi Yan, Xuan Tian, Yuesong Pan, Zhonghua Yang, Miao Wen, Yuehua Pu, Weibin Gu, Zhongrong Miao, Thomas W. Leung, Liping Liu
Summary: This study aimed to investigate the correlation between the burden of cerebral small vessel disease (CSVD) and outcomes after endovascular treatment (EVT) for acute ischemic stroke (AIS). The results showed that a moderate-to-severe CSVD burden was not associated with functional dependence or death at 90 days, but was associated with a higher risk of early neurological deterioration.
EUROPEAN RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
E. Gurkas, C. K. Akpinar, A. O. Ozdemir, O. Aykac, A. Onalan
Summary: The aim of this study was to analyze and determine the rate of cardioembolic cause in patients with large vessel occlusion (LVO) treated with mechanical thrombectomy. The study found that cardioembolic cause was the leading cause of acute ischemic stroke with large vessel occlusion. Further research is needed to explore possible sources of cardioembolism, especially in cryptogenic strokes.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Susan Klapproth, Lukas Meyer, Helge Kniep, Matthias Bechstein, Anna Kyselyova, Uta Hanning, Gerhard Schoen, Leander Rimmele, Jens Fiehler, Gabriel Broocks
Summary: This study compares the effects of long-term blood glucose (HbA1c) and serum blood glucose on early edema formation and functional outcome in ischemic stroke patients. The results show that elevated short-term blood glucose levels are associated with aggravated early edema and worse functional outcome, while HbA1c levels are not related to edema. This suggests that short-term blood glucose level may be used as a target for adjuvant therapy in ischemic stroke patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Neuroimaging
Carlos Perez-Vega, Ricardo A. Domingo, Shashwat Tripathi, Andres Ramos-Fresnedo, Samir Kashyap, Alfredo Quinones-Hinojosa, Michelle P. Lin, W. Christopher Fox, Rabih G. Tawk
Summary: For patients with acute ischemic stroke due to large-vessel occlusion, high blood glucose levels at admission may lead to worse clinical outcomes, including a higher risk of symptomatic intracranial hemorrhage and mortality after undergoing mechanical thrombectomy. Glucose levels at admission appear to be a prognostic factor in these patients, with further studies needed to evaluate its control as a modifiable risk factor.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neuroimaging
Victor Schulze-Zachau, Alex Brehm, Nikolaos Ntoulias, Nadja Krug, Ioannis Tsogkas, Kristine Ann Blackham, Markus A. Moehlenbruch, Jessica Jesser, Amedeo Cervo, Kornelia Kreiser, Katharina Althaus, Errikos Maslias, Patrik Michel, Guillaume Saliou, Christoph Riegler, Christian H. Nolte, Ilko Maier, Ala Jamous, Riitta Rautio, Pauli Ylikotila, Kyle M. Fargen, Stacey Q. Wolfe, Davide Castellano, Andrea Boghi, Daniel P. O. Kaiser, Ani Cuberi, Jan S. Kirschke, Julian Schwarting, Nicola Limbucci, Leonardo Renieri, Sami Al Kasab, Alejandro M. Spiotta, Isabel Fragata, Tania Rodriquez-Ares, Christoph Johannes Maurer, Ansgar Berlis, Manuel Moreu, Alfonso Lopez-Frias, Carlos Perez-Garcia, Christian Commodaro, Marco Pileggi, Justin Mascitelli, Flavio Giordano, Walter Casagrande, Cynthia P. Purves, Maxim Bester, Fabian Flottmann, Peter T. Kan, Gautam Edhayan, Jeremy Hofmeister, Paolo Machi, Marius Kaschner, Daniel Weiss, Mira Katan, Urs Fischer, Marios-Nikos Psychogios
Summary: This study compares the incidence and outcome of vessel perforation during thrombectomy between medium vessel occlusion (MeVO) and large vessel occlusion (LVO). It finds that perforation is more frequent in MeVO thrombectomy and is associated with better functional outcomes. Navigation beyond the occlusion site and retraction of stent retriever/aspiration catheter are common procedural steps that lead to perforation.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2023)
Article
Clinical Neurology
Huanwen Chen, Mihir Khunte, Marco Colasurdo, Gaurav Jindal, Ajay Malhotra, Dheeraj Gandhi, Seemant Chaturvedi
Summary: This study investigates the association of osteoarthritis with the utilization and outcomes of endovascular thrombectomy (EVT) therapy. The results showed that patients with osteoarthritis were less likely to receive EVT treatment compared to those without osteoarthritis. However, for patients who received EVT treatment, osteoarthritis was not significantly associated with discharge outcomes but was marginally associated with lower in-hospital mortality.
Article
Nutrition & Dietetics
Bianca Depieri Balmant, Danielle Cristina Fonseca, Ana Paula Aguiar Prudencio, Ilanna Marques Rocha, Leticia Callado, Juliana Tepedino Martins Alves, Raquel Susana Matos de Miranda Torrinhas, Eduardo Ferreira Borba, Dan Linetzky Waitzberg
Summary: This study investigated the relationship between gut microbiota, intestinal permeability, food intake, and inflammatory markers in inactive SLE patients. The results showed that Megamonas genus was enriched in the inactive SLE group, with Megamonas funiformis associated with all evaluated laboratory tests. Plasma zonulin was associated with C3 levels, and sodium intake was negatively associated with C3 and C4 levels. These findings suggest that increased Megamonas funiformis abundance, elevated plasma zonulin, and higher sodium intake may contribute to reduced C3 complement levels in women with inactive SLE.
Article
Clinical Neurology
Dapeng Sun, Raynald, Xiaochuan Huo, Baixue Jia, Xu Tong, Gaoting Ma, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Thanh N. Nguyen, Zhongrong Miao, ANGEL ACT Study Grp
Summary: This study compared the clinical and safety outcomes between men and women with anterior circulation large vessel occlusion (LVO) treated with endovascular treatment (EVT) in China. The results showed no significant sex differences in clinical outcomes such as modified Rankin Scale distribution, successful reperfusion, symptomatic intracranial hemorrhage, and mortality within 90 days. However, men had a longer procedure duration than women. Subgroup analysis revealed that women tended to have a better outcome than men in patients with lower stroke severity.
Article
Clinical Neurology
Lukas Holmegaard, Tara M. Stanne, Ulf Andreasson, Henrik Zetterberg, Kaj Blennow, Christian Blomstrand, Katarina Jood, Christina Jern
Summary: The study found distinct protein signatures in the plasma of patients with cryptogenic stroke and LAA stroke, with RANTES, IL-4, and IFN-gamma contributing the most significantly in both subtypes. Additionally, eotaxin and MCP-1 may serve as markers of occult atherosclerosis in cryptogenic stroke.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Anna Stokowska, Lina Bunketorp Kall, Christian Blomstrand, Joel Simren, Michael Nilsson, Henrik Zetterberg, Kaj Blennow, Milos Pekny, Marcela Pekna
Summary: Plasma NfL levels are associated with impairment in balance, gait, and cognitive domains after stroke, with higher levels predicting meaningful improvement in balance and gait capacity. Elevated NfL levels also show a positive predictive value for cognitive improvement, suggesting its potential as a biomarker in the late phase after stroke.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Editorial Material
Immunology
Faith H. Brennan, Liam G. Coulthard, Ali M. Alawieh, Orly Reiner, Marcela Pekna
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marcela Pekna, Anna Stokowska, Milos Pekny
Summary: Ischemic stroke and hypoxic-ischemic encephalopathy are major causes of neurological disability. While plasticity responses in spared brain regions contribute to functional recovery after brain injury, secondary neurodegeneration in remote regions can hinder long-term outcomes. The C3a receptor signaling plays a dual role in the acute and chronic phases after ischemic injury, with the potential for therapeutic modulation to improve outcomes.
NEUROCHEMICAL RESEARCH
(2021)
Review
Neurosciences
Noriko Shinjyo, Wataru Kagaya, Marcela Pekna
Summary: The complement system plays a critical role in the CNS, but aberrant activation may lead to neurodegenerative diseases. The effects of infection-induced complement activation on neuronal functioning are still unclear, and may have protective or harmful consequences depending on the context.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Milos Pekny, Ulrika Wilhelmsson, Anna Stokowska, Turgut Tatlisumak, Katarina Jood, Marcela Pekna
Summary: Research on monitoring blood NfL levels in stroke patients has shown that elevated levels are associated with poor clinical outcomes and can predict future functional improvement, but caution is needed in interpretation. NfL levels at different stages reflect various neurobiological processes.
Review
Cell Biology
Marcela Pekna, Milos Pekny
Summary: The complement system plays critical roles in the central nervous system, including regulating astrocyte activity. Astrocytes can send and receive complement-related signals by expressing complement proteins and receptors, affecting their environment and neuronal functioning.
Review
Neurosciences
Markus Aswendt, Ulrika Wilhelmsson, Frederique Wieters, Anna Stokowska, Felix Johannes Schmitt, Niklas Pallast, Yolanda de Pablo, Lava Mohammed, Mathias Hoehn, Marcela Pekna, Milos Pekny
Summary: The restoration of functional connectivity is crucial for functional recovery after stroke. This study investigated the role of reactive astrocytes in functional connectivity and recovery after ischemic stroke.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Immunology
Andrea Pozo-Rodrigalvarez, YiXian Li, Anna Stokowska, Jingyun Wu, Verena Dehm, Hana Sourkova, Harry Steinbusch, Carina Mallard, Henrik Hagberg, Milos Pekny, Marcela Pekna
Summary: Perinatal asphyxia leading to hypoxic-ischemic neonatal encephalopathy is a major cause of brain injury in newborns, potentially resulting in long-lasting neurodegeneration. Activation of C3aR signaling may reduce neurodegeneration and modulate reactive gliosis in the brain, providing a potential therapeutic target for treating neonatal brain injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Annie Pedersen, Emelie Almkvist, Lukas Holmegaard, Cecilia Lagging, Petra Redfors, Christian Blomstrand, Katarina Jood, Hans Samuelsson, Christina Jern
Summary: This study found that post-stroke fatigue (PSF) is common in the long term after ischemic stroke and has a complex interplay with sex and several other outcomes. Future studies should focus on causal relationships and interventions towards fatigue and coexisting features.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Article
Clinical Neurology
Tara M. Stanne, Annelie Angerfors, Bjorn Andersson, Cecilia Brannmark, Lukas Holmegaard, Christina Jern
Summary: This study profiles inflammation-related plasma proteins in ischemic stroke patients and controls, finding differentially regulated proteins during the acute-phase and later time points. These proteins may be involved in the pathogenesis and inflammatory processes of stroke.
Article
Biochemistry & Molecular Biology
Marcela Pekna, Sumen Siqin, Yolanda de Pablo, Anna Stokowska, Asa Torinsson Naluai, Milos Pekny
Summary: This study found that the effects of complement peptide C3a on astrocytes depend highly on their reactive state. After ischemia, C3a down-regulated the expression of Gfap, C3, and Nes in astrocytes. Furthermore, C3a increased the expression of Tnf and Il1b in naive astrocytes and the expression of Nes in astrocytes exposed to LPS.
NEUROCHEMICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Malin C. Erlandsson, Karin M. E. Andersson, Nina Y. Oparina, Venkataragavan Chandrasekaran, Tibor Saghy, Anastasios Damdimopoulos, Maria-Jose Garcia-Bonete, Zakaria Einbeigi, Sofia T. Silfversward, Marcela Pekna, Gergely Katona, Maria I. Bokarewa
Summary: This study reveals the important role of nuclear survivin in maintaining the effector phenotype of IFN gamma-producing T cells through the regulation of glucose utilization. It provides a new strategy to counteract IFN gamma-dependent inflammation in autoimmunity.
Article
Multidisciplinary Sciences
Giacomo Gravina, Maryam Ardalan, Tetyana Chumak, Anders K. Nilsson, Joakim C. Ek, Hanna Danielsson, Pernilla Svedin, Milos Pekny, Marcela Pekna, Karin Savman, Ann Hellstrom, Carina Mallard
Summary: In this study, proteomic alterations in mouse brain after S. epidermidis infection and in preterm infant blood were investigated. LCN2 was identified as a crucial protein associated with cerebrovascular changes and astrocyte reactivity in mice. Further analysis showed that LCN2 was linked to blood C-reactive protein levels in human preterm infants.
Article
Medicine, Research & Experimental
Anna Stokowska, Markus Aswendt, Daniel Zucha, Stephanie Lohmann, Frederique Wieters, Javier Moran Suarez, Alison L. Atkins, YiXian Li, Maria Miteva, Julia Lewin, Dirk Wiedermann, Michael Diedenhofen, Asa Torinsson Naluai, Pavel Abaffy, Lukas Valihrach, Mikael Kubista, Mathias Hoehn, Milos Pekny, Marcela Pekna
Summary: Despite advances in acute care, ischemic stroke remains a major cause of long-term disability. Approaches targeting both neuronal and glial responses are needed to enhance recovery and improve long-term outcome. The complement C3a receptor (C3aR) plays a role in inflammation regulation and has both inhibitory and facilitatory effects on functional recovery after ischemic stroke.
JOURNAL OF CLINICAL INVESTIGATION
(2023)