The EphB4 Receptor Tyrosine Kinase Promotes Lung Cancer Growth: A Potential Novel Therapeutic Target

EGFR-mutated lung cancer: a paradigm of molecular oncology

(2015)   Oncotarget

Prognostic Significance of the Combined Score of Endothelial Expression of Nucleolin and CD31 in Surgically Resected Non-Small Cell Lung Cancer

(2013) Hongyun Zhao et al.   PLoS One

Critical Role for the Receptor Tyrosine Kinase EPHB4 in Esophageal Cancers

(2012) R. Hasina et al.   CANCER RESEARCH

MET Increases the Sensitivity of Gefitinib-Resistant Cells to SN-38, an Active Metabolite of Irinotecan, by Up-Regulating the Topoisomerase I Activity

(2012) Asao Sakai et al.   Journal of Thoracic Oncology

ALK-Mutated Non-Small-Cell Lung Cancer: A New Strategy for Cancer Treatment

(2012) Luis Cabezón-Gutiérrez et al.   LUNG

Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma

(2012) Masashi Ishikawa et al.   LUNG CANCER

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer

(2012) Charles M Rudin et al.   NATURE GENETICS

In cancer drug resistance, germline matters too

(2012) Emily H Cheng et al.   NATURE MEDICINE

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex

(2012) Guo Li et al.   Nature Communications

Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series

(2011) Bernard Barlaam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EphB3 Is Overexpressed in Non-Small-Cell Lung Cancer and Promotes Tumor Metastasis by Enhancing Cell Survival and Migration

(2011) X.-D. Ji et al.   CANCER RESEARCH

Complex expression patterns of Eph receptor tyrosine kinases and their ephrin ligands in colorectal carcinogenesis

(2011) Nirmitha I. Herath et al.   EUROPEAN JOURNAL OF CANCER

Molecular mechanism of the schedule-dependent synergistic interaction in EGFR-mutant non-small cell lung cancer cell lines treated with paclitaxel and gefitinib

(2011) Hua Cheng et al.   Journal of Hematology & Oncology

The role of the c-Met pathway in lung cancer and the potential for targeted therapy

(2011) Martin Sattler et al.   Therapeutic Advances in Medical Oncology

Inhibitors of the tyrosine kinase EphB4. Part 3: Identification of non-benzodioxole-based kinase inhibitors

(2010) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

EphA2Mutation in Lung Squamous Cell Carcinoma Promotes Increased Cell Survival, Cell Invasion, Focal Adhesions, and Mammalian Target of Rapamycin Activation

(2010) Leonardo Faoro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Receptor Inhibitor Gefitinib Added to Chemoradiotherapy in Locally Advanced Head and Neck Cancer

(2010) Ezra E.W. Cohen et al.   JOURNAL OF CLINICAL ONCOLOGY

Converging Evidence for Efficacy from Parallel EphB4-Targeted Approaches in Ovarian Carcinoma

(2010) Whitney A. Spannuth et al.   MOLECULAR CANCER THERAPEUTICS

Prognostic and predictive values of pERK1/2 and pAkt-1 expression in non-small cell lung cancer patients treated with adjuvant chemotherapy

(2010) Yan Shi et al.   TUMOR BIOLOGY

Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression

(2009) S. R. Kumar et al.   CANCER RESEARCH

Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers

(2009) Syed Mahfuzul Alam et al.   GYNECOLOGIC ONCOLOGY

Clinical Features and Outcome of Patients With Non–Small-Cell Lung Cancer Who Harbor EML4-ALK

(2009) Alice T. Shaw et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung

(2009) Yoshihiro Minamiya et al.   LUNG CANCER

The Significance of EphB4 and EphrinB2 Expression and Survival in Head and Neck Squamous Cell Carcinoma

(2008) Eric J. Yavrouian et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Inhibitors of the tyrosine kinase EphB4. Part 1: Structure-based design and optimization of a series of 2,4-bis-anilinopyrimidines

(2008) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibitors of the tyrosine kinase EphB4. Part 2: Structure-based discovery and optimisation of 3,5-bis substituted anilinopyrimidines

(2008) Catherine Bardelle et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade

(2008) J. S. Scehnet et al.   BLOOD

Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers

(2008) S M Alam et al.   BRITISH JOURNAL OF CANCER

Irinotecan Plus Carboplatin Versus Oral Etoposide Plus Carboplatin in Extensive Small-Cell Lung Cancer: A Randomized Phase III Trial

(2008) Andreas Hermes et al.   JOURNAL OF CLINICAL ONCOLOGY