Article
Biochemistry & Molecular Biology
Yitang Yan, Jingli Liu, Arianna Lawrence, Michael J. Dykstra, Rick Fannin, Kevin Gerrish, Charles J. Tucker, Erica Scappini, Darlene Dixon
Summary: This study found that continuous exposure to cadmium in vitro can potentially malignantly transform benign human uterine leiomyoma cells. The cells exposed to cadmium exhibited specific growth characteristics and dysregulated gene expression indicative of progression towards a cancer phenotype.
Article
Oncology
Jordi Gonzalez-Molina, Paula Hahn, Raul Maia Falcao, Okan Gultekin, Georgia Kokaraki, Valentina Zanfagnin, Tirzah Braz Petta, Kaisa Lehti, Joseph W. W. Carlson
Summary: This study explored the impact of fibrillar collagens on uterine leiomyosarcoma (uLMS) and found that uLMS tumors have low collagen density and increased expression of collagen-remodeling genes compared to uterine leiomyomas (LM).The overexpression of matrix metalloproteinase-14 (MMP14) in uLMS was found to support uLMS cell proliferation, and uLMS cells were found to be less sensitive to changes in collagen substrate stiffness. Additionally, enhanced basal yes-associated protein 1 (YAP) activity was observed in uLMS cells, which sustains their growth in low-stiffness substrates. These findings suggest that matrix remodeling and YAP may be potential therapeutic targets for uLMS.
MOLECULAR ONCOLOGY
(2023)
Article
Obstetrics & Gynecology
Maria Cristina Carbajo-Garcia, Zaira Garcia-Alcazar, Ana Corachan, Javier Monleon, Alexandra Trelis, Amparo Faus, Antonio Pellicer, Hortensia Ferrero
Summary: The study demonstrates that SAHA inhibits cell proliferation, cell cycle, ECM formation, and TGF-/53 signaling in human uterine leiomyoma primary cells, suggesting the potential utility of histone deacetylase inhibition in the treatment of uterine leiomyoma.
FERTILITY AND STERILITY
(2022)
Article
Multidisciplinary Sciences
Chika Sawa, Sachiko Yofu, Keisuke Kiriyama, Keita Sutoh, Tomomi Saito, Satomi Kishi, Mariko Gunji, Yuriko Inoue, Masahito Sugi, Seiji Shioda, Kazuho Honda
Summary: The study shows that externally administered water-soluble nuclear crude extract (SNE) can suppress cell growth in cancer and noncancer cells in vitro. Flow cytometry analysis of nuclear DNA content indicates that SNE causes an increase in cells in the S phase and a decrease in the G2/M phase, suggesting that cell growth inhibition is due to cell cycle delay rather than apoptosis.
Article
Environmental Sciences
Zemin Li, Han Yin, Yang Shen, Mulan Ren, Xiaolan Xu
Summary: The study identified potential molecular targets and signal pathways by which phenolic environmental estrogens promote the proliferation of uterine leiomyoma cells. Both BPA and NP activated the PI3K-AKT signaling pathway and promoted cell cycle progression, leading to disordered cell cycle regulation. In addition, phenolic estrogen stimulated the upregulation of inflammatory factors in uterine leiomyomas.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Endocrinology & Metabolism
Mengxue Jiang, Zhijian Kuang, Yaohui He, Yin Cao, Tingyan Yu, Jidong Cheng, Wen Liu, Wei Wang
Summary: This study reveals that SNAPIN plays a crucial role in regulating insulin secretion and beta cell proliferation, with its expression influenced by age and diabetes. The function of SNAPIN is achieved through its impact on cell cycle regulation, suggesting it might be a potential pharmacotherapeutic target for diabetes mellitus.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Cristina Carbajo-Garcia, Lucia de Miguel-Gomez, Elena Juarez-Barber, Alexandra Trelis, Javier Monleon, Antonio Pellicer, James M. Flanagan, Hortensia Ferrero
Summary: H3K27ac is involved in the pathogenesis and maintenance of uterine leiomyoma (UL), and reversal of histone deacetylation upregulates the expression of tumor suppressor genes, suggesting it as a therapeutic approach for UL.
Article
Multidisciplinary Sciences
Md Soriful Islam, Maclaine Parish, Joshua T. Brennan, Briana L. Winer, James H. Segars
Summary: Fibrosis in uterine fibroids can be restricted by inhibiting fibrotic processes, and Epigallocatechin gallate (EGCG) has shown promise as a drug for uterine fibroids. This study investigates the effects and mechanisms of EGCG on fibroid cell fibrosis and finds that EGCG reduces the expression of fibrotic proteins and regulates key signaling pathways. Furthermore, EGCG exhibits greater anti-fibrotic effects compared to synthetic inhibitors.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Quaker E. Harmon, Stacy A. Patchel, Sheri Denslow, Frankie LaPorte, Tracy Cooper, Lauren A. Wise, Ganesa Wegienka, Donna D. Baird
Summary: This study investigates the association between serum vitamin D and uterine fibroid growth, incidence, and loss. Higher levels of serum vitamin D are associated with reduced fibroid growth and incidence, but the findings are limited by the small number of participants with sufficient vitamin D levels. Interventional trials are needed to confirm the efficacy of vitamin D supplementation in fibroid treatment.
FERTILITY AND STERILITY
(2022)
Article
Medicine, Research & Experimental
Wei Yan, Li Song, Huihan Wang, Wei Yang, Liang Hu, Ying Yang
Summary: In this study, it was found that miRNA-181b-5p carried by extracellular vesicles in the peripheral blood of ALL patients can enter ALL cells and promote the malignancy of ALL cells by enhancing proliferation, migration, and invasion abilities.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Yi-Fen Chiang, Hsin-Yuan Chen, Mohamed Ali, Tzong-Ming Shieh, Yun-Ju Huang, Kai-Lee Wang, Hsin-Yi Chang, Tsui-Chin Huang, Yong-Han Hong, Shih-Min Hsia
Summary: BHT, a synthetic phenolic antioxidant commonly used in food and cosmetics, has been found to potentially promote the progression of leiomyoma by increasing extracellular matrix production and matrix metalloproteinase expression. This effect may be mediated through the activation of the PI3K/Akt and MAPK signaling pathways.
Article
Biochemistry & Molecular Biology
Sadia Afrin, Malak El Sabah, Ahmed Manzoor, Mariko Miyashita-Ishiwata, Lauren Reschke, Mostafa A. Borahay
Summary: The aim of this study was to determine the cellular and molecular mechanisms by which adipocytes contribute to the initiation and promotion of uterine leiomyoma tumors. The results showed that adipocytes promote inflammation, fibrosis, and angiogenesis in leiomyoma cells by upregulating associated factors and transferring free fatty acids. Adipocyte-leiomyoma cell interaction increases the phosphorylation of NF-.B and enhances cell proliferation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Yingji Chen, Ying Ji, Suo Liu, Yicai Liu, Wei Feng, Longyu Jin
Summary: PTBP3 is overexpressed in LUSC tissues and its high expression is significantly correlated with poor prognosis. PTBP3 knockdown results in decreased cell proliferation rate. Bioinformatics analysis reveals that PTBP3 is involved in cell cycle regulation in LUSC.
CANCER CELL INTERNATIONAL
(2022)
Review
Oncology
Jin Zhang, Jieya Liu, Hongying Zhang, Jiao Wang, Hui Hua, Yangfu Jiang
Summary: Collagens, as the main components of extracellular matrix in the tumor microenvironment, play crucial roles in tumor progression. Both fibrillar and nonfibrillar collagens are involved, with the nonfibrillar network-forming collagens, such as type IV and type VIII collagens, frequently overexpressed in human cancers, promoting tumor cell proliferation, adhesion, invasion, metastasis, and angiogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Acoustics
C. Russo, S. Camilli, F. G. Martire, A. Di Giovanni, L. Lazzeri, M. Malzoni, E. Zupi, C. Exacoustos
Summary: The study aimed to correlate the ultrasound appearance of highly vascularized uterine myomas with histopathological diagnosis, highlighting the importance of combining lesion characteristics and patient age for differential diagnosis of typical myomas, benign variants, and malignant lesions.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Sofia Candel, Mallory Karr, Laurent Brard, Jongjin Anne Thomson, Kathleen Groesch, Andrea Braundmeier-Fleming
OBSTETRICS AND GYNECOLOGY
(2017)
Article
Multidisciplinary Sciences
Annie E. Newell-Fugate, Katherine Lenz, Cassandra Skenandore, Romana A. Nowak, Bryan A. White, Andrea Braundmeier-Fleming
Article
Endocrinology & Metabolism
Shaheen Alanee, Ahmed El-Zawahry, Danuta Dynda, Ali Dabaja, Kevin McVary, Mallory Karr, Andrea Braundmeier-Fleming
Article
Multidisciplinary Sciences
A. Braundmeier-Fleming, Nathan T. Russell, Wenbin Yang, Megan Y. Nas, Ryan E. Yaggie, Matthew Berry, Laurie Bachrach, Sarah C. Flury, Darlene S. Marko, Colleen B. Bushell, Michael E. Welge, Bryan A. White, Anthony J. Schaeffer, David J. Klumpp
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Shaheen Alanee, Ahmed El-Zawahry, Danuta Dynda, Kevin McVary, Mallory Karr, Andrea Braundmeier-Fleming
PROSTATE CANCER AND PROSTATIC DISEASES
(2019)
Meeting Abstract
Obstetrics & Gynecology
Ticara Onyewuenyi, Jennifer Addo, Nhung Le, Allen Ghareeb, J. Ricardo Loret de Mola, Andrea Braundmeier-Fleming
OBSTETRICS AND GYNECOLOGY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Brittany Idusuyi, Nhung Le, Yuan Yuan Gong, Allen Ghareeb, J. Ricardo Loret de Mola, Andrea Braundmeier-Fleming
OBSTETRICS AND GYNECOLOGY
(2019)
Meeting Abstract
Obstetrics & Gynecology
Aileen Portugal, Nhung Le, Yuan Yuan Gong, Kathleen Groesch, J. Ricardo Loret de Mola, Andrea Braundmeier-Fleming
OBSTETRICS AND GYNECOLOGY
(2019)
Article
Urology & Nephrology
Bradley Holland, Mallory Karr, Kristin Delfino, Danuta Dynda, Ahmed El-Zawahry, Andrea Braundmeier-Fleming, Kevin McVary, Shaheen Alanee
Article
Multidisciplinary Sciences
Ruizhong Miao, Taylor C. Badger, Kathleen Groesch, Paula L. Diaz-Sylvester, Teresa Wilson, Allen Ghareeb, Jongjin Anne Martin, Melissa Cregger, Michael Welge, Colleen Bushell, Loretta Auvil, Ruoqing Zhu, Laurent Brard, Andrea Braundmeier-Fleming
Article
Agriculture, Dairy & Animal Science
Andrea G. Braundmeier-Fleming, Cassandra S. Skenandore, Lesly Gil, Victoria Jacobsen, Melissa Cregger, Taylor Badger, Mallory Karr, Guoyao Wu, Stephen B. Smith, Annie E. Newell-Fugate
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2020)
Meeting Abstract
Obstetrics & Gynecology
Kaitlin Gibson, Katelyn Nicole Pratt, Ruoqing Zhu, Melissa Cregger, Laurent Brard, Andrea Braundmeier-Fleming
OBSTETRICS AND GYNECOLOGY
(2019)
Meeting Abstract
Urology & Nephrology
Shaheen Alanee, Bradley Holland, Kristin Delfino, Danuta Dynda, Ahmed El-Zawahry, Andrea Braundmeier, Kevin McVary
JOURNAL OF UROLOGY
(2019)
Meeting Abstract
Urology & Nephrology
Shaheen Alanee, Ahmed El-Zawahry, Mallory Karr, Mustafa Deebajah, Ali Dabaja, Danuta Dynda, Kevin Mcvary, Andrea Braundmeier-Fleming
JOURNAL OF UROLOGY
(2018)
Meeting Abstract
Urology & Nephrology
Shaheen Alanee, Ahmed El-Zawahry, Mallory Karr, Mustafa Deebajah, Ali Dabaja, Danuta Dynda, Kevin Mcvary, Andrea Braundmeier-Fleming
JOURNAL OF UROLOGY
(2018)