Review
Chemistry, Physical
Aleksandr Kakinen, Ibrahim Javed, Thomas P. Davis, Pu Chun Ke
Summary: Amyloid diseases are global epidemics with limited solutions for diagnosis, treatment, and prevention;
The research on amyloidosis inhibition has evolved into a new frontier in nanomedicine, offering interdisciplinary research opportunities in materials, chemistry, and biophysics;
Due to the complex and overlapping physiopathologies of amyloid diseases, there is a crucial need for appropriate in vitro and in vivo models to validate novel anti-amyloidosis nanomedicines, and the development of new animal models reflecting the behavioral, symptomatic, and cross-talk hallmarks of amyloid diseases such as Alzheimer's, Parkinson's, and type 2 diabetes.
NANOSCALE HORIZONS
(2021)
Article
Medicine, Research & Experimental
Chintha Venkataramaiah, Sholapuri Payani, Bandila Lakshmi Priya, Jangampalli Adi Pradeepkiran
Summary: The glutamate and dopamine hypotheses are leading theories in the pathophysiology of schizophrenia, and new neuroprotective compounds from medicinal plants could offer benefits. A novel bioactive compound found in Celastrus paniculatus shows potential neuroprotective effects in ketamine-induced schizophrenia, particularly in regulating glutamate metabolism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Polymer Science
Lei Wang, Jae-Young Oh, Hye-Won Yang, Jimin Hyun, Ginnae Ahn, Xiaoting Fu, Jiachao Xu, Xin Gao, Seon-Heui Cha, You-Jin Jeon
Summary: This study evaluated the protective effect of fucoidan from Sargassum fusiforme against ethanol-induced oxidative damage. Results showed that fucoidan effectively decreased the damage to liver cells and increased the survival rate of zebrafish. These findings suggest the potential of fucoidan as an ingredient in the functional food industry.
Article
Multidisciplinary Sciences
Zeng-Hui Wei, Jagadish Koya, Nikita Acharekar, Jesus Trejos, Xing-Duo Dong, Francis A. Schanne, Charles R. Ashby Jr, Sandra E. Reznik
Summary: Alzheimer's disease (AD) is a chronic degenerative brain disorder with no clear pathogenesis or effective cure. The importance of neuroinflammation in the pathogenesis of AD has been recognized. The drug excipient N,N-dimethylacetamide (DMA) has been found to suppress inflammatory responses in vivo. This study investigates the effect of DMA on neuroinflammation and its mechanism of action in in-vitro and ex-vivo models of AD.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ming Tatt Lee, Wei-Hao Peng, Hung-Wei Kan, Cheng-Chun Wu, Deng-Wu Wang, Yu-Cheng Ho
Summary: This article reviews the recent literature on the role of AMPA-glutamatergic neurotransmission in stress-induced maladaptive responses in emotional and mood-associated brain regions.
Article
Biochemistry & Molecular Biology
Heidy Jimenez, Joseph Carrion, Leslie Adrien, Adam Wolin, John Eun, Ezra Cinamon, Eric H. Chang, Peter Davies, An Vo, Jeremy Koppel
Summary: Psychosis occurring in Alzheimer's disease is associated with increased caregiver burden and faster cognitive decline. Previous studies have used agents known to induce psychosis to model psychotic conditions and evaluate their effects on behavior in rodents. This report investigates the impact of antimuscarinic and dopaminergic treatments on locomotion and sensorimotor gating using human tau models. The results suggest that antimuscarinic treatment increases locomotion and tau pathology, while dopaminergic treatment reduces locomotion without affecting sensorimotor gating. Further studies are needed to explore the potential of muscarinic agonists in treating tauopathies like Alzheimer's disease.
Article
Environmental Sciences
Shivani Ghaisas, Dilshan S. Harichandra, Bharathi Palaniswamy, Alexandra Proctor, Huajun Jin, Somak Dutta, Souvarish Sarkar, Monica Langley, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy, Gregory J. Phillips, Anumantha Kanthasamy
Summary: Chronic environmental exposure to manganese can cause severe damage to the central nervous system, and its potential toxic effects on the enteric nervous system have yet to be assessed. The study found that Mn preferentially induced mitochondrial dysfunction in a rat EGC line and resulted in inflammation in the ENS in vivo.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Review
Multidisciplinary Sciences
Rafael Borges Rosa, Emilene Ferreira de Castro, Murilo Vieira da Silva, Denise Caroline Paiva Ferreira, Ana Carolina Gomes Jardim, Igor Andrade Santos, Mikaela dos Santos Marinho, Flavia Batista Ferreira Franca, Lindomar Jose Pena
Summary: The emergence and rapid spread of monkeypox virus (MPXV) outside of endemic areas during the COVID-19 pandemic has created a global health emergency. Scientists have been working on developing in vitro and in vivo models for MPXV research. In vitro models, including 2D and 3D cultures, are cost-effective and can be controlled, but may not fully represent physiological conditions. Therefore, in vivo models are being characterized to meet the demand for studying MPXV. This review summarizes the existing MPXV models and discusses their contributions to understanding pathogenesis, replication, transmission, and antiviral treatment.
Review
Cell Biology
S. Ankul Singh, Swathi Suresh, Chitra Vellapandian
Summary: This review discusses the rising global ozone in densely populated areas of Asia and Africa, and explores the possible neurotoxicity and biomarkers associated with ozone-induced oxidative stress. It also examines the impact of ozone on blood circulation, antibacterial action, immune response, and other aspects, and suggests the need for further research on biomarkers related to ozone and the brain.
AGEING RESEARCH REVIEWS
(2023)
Review
Chemistry, Analytical
Rohini Kumari, Daphika S. Dkhar, Supratim Mahapatra, Divya, Rahul Kumar, Pranjal Chandra
Summary: Reactive oxygen species play an important role in cell signaling but excessive production is associated with various diseases. Traditional detection methods have limitations, while biosensing technology has emerged as a major approach. This review discusses recent biosensors for monitoring reactive oxygen species and highlights the progress of nanotechnology and biomimetic engineering in biosensing.
MICROCHEMICAL JOURNAL
(2022)
Article
Cell Biology
Jeremy Dufau, Joanne X. Shen, Morgane Couchet, Thais De Castro Barbosa, Niklas Mejhert, Lucas Massier, Elena Griseti, Etienne Mouisel, Ez-Zoubir Amri, Volker M. Lauschke, Mikael Ryden, Dominique Langin
Summary: Adipocytes play diverse roles in physiology and pathology, with white, beige, and brown adipocytes differing in their lipid handling and thermogenic capacity. Cultured differentiated preadipocyte cell lines and primary mature adipocytes are used to mimic different types of adipocytes, but challenges remain in culture conditions and limitations. Advances in three-dimensional culture, such as adipose spheroids, provide a more in vivo-like model for studying adipocyte function and morphology.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jing-Hsien Chen, Pei-Tzu Wu, Charng-Cherng Chyau, Pei-Hsuan Wu, Hui-Hsuan Lin
Summary: The aim of this study was to examine the inhibitory effect of Hibiscus sabdariffa leaf extracts (HLE) and ellagic acid (EA) on renal fibrosis. The results showed that EA-enriched HLE reduced renal mesangial cell injury and fibrosis in hyperuricemic nephropathy (HN) by regulating the TGF-beta/Smad signaling pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biology
Andrea Antonosante, Vanessa Castelli, Martina Sette, Margherita Alfonsetti, Mariano Catanesi, Elisabetta Benedetti, Matteo Ardini, Annamaria Cimini, Michele d'Angelo
Summary: The study suggests that PPAR beta/delta antagonist has neuroprotective effects on Parkinson's disease by reducing apoptosis, oxidative stress, and improving mitochondrial function. The animal model experiments confirmed these findings.
BIOLOGICAL RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Roberta Lotti, Claudio Giacinto Atene, Emma Dorotea Zanfi, Matteo Bertesi, Tommaso Zanocco-Marani
Summary: Pemphigus is a life-threatening autoimmune disease characterized by pathogenic autoantibodies targeting specific desmoglein proteins, leading to keratinocyte separation. Various disease models, including in vitro, ex vivo and in vivo mouse models, allow for testing different hypotheses regarding disease initiation and evaluating the efficacy of experimental therapies. These models also help in assessing the pathogenicity of specific Pemphigus autoantibodies and investigating previously unidentified autoantigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Beate Guendel, Xinyuan Liu, Matthias Loehr, Rainer Heuchel
Summary: This review examines the current in vitro models for PDAC, emphasizing the challenges of late diagnosis and treatment resistance in improving patient outcomes. Researchers have established various in vitro and in vivo models for PDAC, with a growing focus on 3D cell culture models like spheroids and organoids.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemical Research Methods
D. Besong Agbo, H. Klafki, G. Poschmann, K. Seyfarth, J. Genius, C. Janssen, K. Stuehler, W. Wurst, H. E. Meyer, M. Klingenspor, J. Wiltfang
ANALYTICAL BIOCHEMISTRY
(2013)
Review
Biochemistry & Molecular Biology
Dan Rujescu, Just Genius, Jens Benninghoff, Ina Giegling
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2012)
Review
Biochemistry & Molecular Biology
J. Genius, I. Giegling, J. Benninghoff, D. Rujescu
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
(2012)
Review
Clinical Neurology
J. Genius, H. Klafki, J. Benninghoff, H. Esselmann, J. Wiltfang
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2012)
Article
Psychiatry
Ilja Spellmann, Dan Rujescu, Richard Musil, Andreas Mayr, Ina Giegling, Just Genius, Peter Zill, Sandra Dehning, Markus Opgen-Rhein, Anja Cerovecki, Annette M. Hartmann, Martin Schaefer, Brigitta Bondy, Norbert Mueller, Hans-Juergen Moeller, Michael Riedel
JOURNAL OF PSYCHIATRIC RESEARCH
(2011)
Article
Biochemistry & Molecular Biology
Minxuan Sun, Sabine M. Hoelter, Jens Stepan, Lillian Garrett, Just Genius, Elisabeth Kremmer, Martin Hrabe de Angelis, Wolfgang Wurst, D. Chichung Lie, Laure Bally-Cuif, Matthias Eder, Dan Rujescu, Jochen Graw
Article
Biochemical Research Methods
Just Genius, Jens Benninghoff, Nadine Reuter, Isabella Braun, Ina Giegling, Annette Hartmann, Hans-Juergen Moeller, Dan Rujescu
Article
Neurosciences
Jens Benninghoff, Angela Gritti, Matteo Rizzi, Giuseppe LaMorte, Robert J. Schloesser, Angelika Schmitt, Stefanie Robel, Just Genius, Rainald Moessner, Peter Riederer, Husseini K. Manji, Heinz Grunze, Dan Rujescu, Hans-Juergen Moeller, Klaus-Peter Lesch, Angelo Luigi Vescovi
NEUROPSYCHOPHARMACOLOGY
(2010)
Article
Medicine, General & Internal
Stephen Salloway, Reisa Sperling, Nick C. Fox, Kaj Blennow, William Klunk, Murray Raskind, Marwan Sabbagh, Lawrence S. Honig, Anton P. Porsteinsson, Steven Ferris, Marcel Reichert, Nzeera Ketter, Bijan Nejadnik, Volkmar Guenzler, Maja Miloslavsky, Daniel Wang, Yuan Lu, Julia Lull, Iulia Cristina Tudor, Enchi Liu, Michael Grundman, Eric Yuen, Ronald Black, H. Robert Brashear
NEW ENGLAND JOURNAL OF MEDICINE
(2014)
Article
Pharmacology & Pharmacy
J. Benninghoff, H. Grunze, C. Schindler, J. Genius, R. J. Schloesser, A. van der Ven, S. Dehning, J. Wiltfang, H. -J. Moeller, D. Rujescu
PHARMACOPSYCHIATRY
(2013)
Article
Multidisciplinary Sciences
Just Genius, Johanna Geiger, Andreas Bender, Hans-Juergen Moeller, Thomas Klopstock, Dan Rujescu
Article
Clinical Neurology
Ilja Spellmann, Dan Rujescu, Richard Musil, Ina Giegling, Just Genius, Peter Zill, Sandra Dehning, Anja Cerovecki, Florian Seemueller, Rebecca Schennach, Annette M. Hartmann, Martin Schaefer, Norbert Mueller, Hans-Juergen Moeller, Michael Riedel
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2014)
Article
Neurosciences
Takashi Uehara, Hiroko Itoh, Tadasu Matsuoka, Dan Rujescu, Just Genius, Tomonori Seo, Tomiki Sumiyoshi
Article
Neurosciences
Takashi Uehara, Tomiki Sumiyoshi, Dan Rujescu, Just Genius, Tadasu Matsuoka, Ichiro Takasaki, Hiroko Itoh, Masayoshi Kurachi