Cis Association of Galectin-9 with Tim-3 Differentially Regulates IL-12/IL-23 Expressions in Monocytes via TLR Signaling

Differential Regulation of Interleukin-12 (IL-12)/IL-23 by Tim-3 Drives TH17 Cell Development during Hepatitis C Virus Infection

(2013) J. M. Wang et al.   JOURNAL OF VIROLOGY

Tim-3 alters the balance of IL-12/IL-23 and drives TH17 cells: Role in hepatitis B vaccine failure during hepatitis C infection

(2013) Jia M. Wang et al.   VACCINE

Glycans, galectins, and HIV-1 infection

(2012) Sachiko Sato et al.   Annals of the New York Academy of Sciences

Tim-3 Pathway Controls Regulatory and Effector T Cell Balance during Hepatitis C Virus Infection

(2012) J. P. Moorman et al.   JOURNAL OF IMMUNOLOGY

Cell Surface Galectin-9 Expressing Th Cells Regulate Th17 and Foxp3+ Treg Development by Galectin-9 Secretion

(2012) Souichi Oomizu et al.   PLoS One

Rapid Decrease of Plasma Galectin-9 Levels in Patients with Acute HIV Infection after Therapy

(2012) Hiroki Saitoh et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin-23: A key cytokine in inflammatory diseases

(2011) Emilie Duvallet et al.   ANNALS OF MEDICINE

Pathogen Recognition by the Innate Immune System

(2011) Himanshu Kumar et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

IL-12p35 Subunit Contributes to Autoimmunity by Limiting IL-27-Driven Regulatory Responses

(2011) R. Vasconcellos et al.   JOURNAL OF IMMUNOLOGY

Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes

(2011) Ying Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tim-3 Negatively Regulates IL-12 Expression by Monocytes in HCV Infection

(2011) Ying Zhang et al.   PLoS One

T-bet, a Th1 transcription factor regulates the expression of Tim-3

(2010) Ana C. Anderson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression

(2010) Bahareh Vali et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

A Crucial Role for Kupffer Cell-Derived Galectin-9 in Regulation of T Cell Immunity in Hepatitis C Infection

(2010) John A. Mengshol et al.   PLoS One

Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection

(2010) H.-T. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation

(2009) M. Nakayama et al.   BLOOD

TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines

(2009) William D. Hastings et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intracellular galectin-9 activates inflammatory cytokines in monocytes

(2009) Ai Matsuura et al.   GENES TO CELLS

A Role for cis Interaction between the Inhibitory Ly49A Receptor and MHC Class I for Natural Killer Cell Education

(2009) Anick Chalifour et al.   IMMUNITY

TLR2 Promotes Th2/Th17 Responses via TLR4 and TLR7/8 by Abrogating the Type I IFN Amplification Loop

(2009) M. H. Wenink et al.   JOURNAL OF IMMUNOLOGY

Gonadectomy of male BALB/c mice increases Tim-3+ alternatively activated M2 macrophages, Tim-3+ T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis

(2008) Sylvia Frisancho-Kiss et al.   BRAIN BEHAVIOR AND IMMUNITY

TIMs: central regulators of immune responses: Figure 1.

(2008) David A. Hafler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE