Article
Biochemistry & Molecular Biology
Jing Feng, Weiqiang Yang, Fuxiao Luan, Fang Ma, Yingjie Wang, Yiquan Zhang, Xuhui Liu, Li Chen, Xiaofeng Hu, Yong Tao
Summary: Diabetic retinopathy is a common and serious complication of diabetes, and there is currently no effective treatment for early stage. However, apelin has been found to potentially reduce vascular leakage by protecting pericytes, which suggests a promising new direction for early treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Zizhong Hu, Xiying Mao, Mingkang Chen, Xinjing Wu, Tianye Zhu, Yu Liu, Zhengyu Zhang, Wen Fan, Ping Xie, Songtao Yuan, Qinghuai Liu
Summary: This study utilized single-cell RNA sequencing to characterize proliferative diabetic retinopathy (PDR) vitreous fibrovascular membranes (FVMs). They identified eight cellular compositions, with microglia as the major cell population. They discovered a profibrotic subpopulation of microglia that was uniquely differentiated from retina-resident microglia and expanded in the PDR setting. Ligand-receptor interactions between the profibrotic microglia and cytokines upregulated in PDR vitreous implicated the involvement of several pathways in the microglial activation within the PDR microenvironment.
Article
Biochemistry & Molecular Biology
Sergio Crespo-Garcia, Nadine Reichhart, Norbert Kociok, Sergej Skosyrski, Antonia M. Joussen
Summary: Increased expression of NTN4 and its receptors in diabetic retina may play a role in stabilizing vascular networks, modulating inflammation, and providing protective effects against cytokine production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Josy Augustine, Evan P. Troendle, Peter Barabas, Corey A. McAleese, Thomas Friedel, Alan W. Stitt, Tim M. Curtis
Summary: Lipid peroxidation can lead to the production of reactive aldehyde species, forming ALEs that play a role in diabetic retinopathy complications. Further research and potential therapeutic approaches are being explored to prevent irreversible damage from occurring.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Immunology
Jinghua Jiao, Honghua Yu, Litong Yao, Lihua Li, Xiaohong Yang, Lei Liu
Summary: The health of the gut microbiome is related to various diseases, including diabetic retinopathy. Recent studies suggest a possible connection between gut microbiome dysbiosis and ocular diseases, leading to novel therapeutic strategies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Sofia Perisset, M. Constanza Potilinski, Juan E. Gallo
Summary: Significant progress has been made in the research and management of diabetic retinopathy in recent years. Neurodegenerative changes prior to microvascular alterations have been established. Lnc-RNAs, which regulate gene expression and impact cellular processes, have been identified as playing a role in diabetic retinopathy development. Further analysis of Lnc-RNAs is crucial for researchers in order to target them and develop specialized therapies for diabetic retinopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Ophthalmology
Pratima Singh Thakur, David Aggarwal, Brijesh Takkar, Sisinthy Shivaji, Taraprasad Das
Summary: This study reviews the evidence suggesting gut dysbiosis in diabetic retinopathy (DR), highlighting differences in gut microbiota between people with and without diabetes, as well as differences between people with DR and without DR. The current evidence on the predictive value of the gut microbiome in the occurrence and progression of DR is limited. Therapeutic avenues targeting the gut-retina axis include lifestyle changes, pharmacologic inhibitors, probiotics, and fecal microbiota transplantation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Enrique Antonio Alfonso-Munoz, Raquel Burggraaf-sanchez de las Matas, Jorge Mataix Boronat, Julio Cesar Molina Martin, Carmen Desco
Summary: The review suggests that antioxidant supplementation in adult Type 1 and Type 2 diabetes mellitus patients without retinopathy or mild-to-moderate nonproliferative DR and without diabetic macular edema has a IIB level of recommendation as a complementary therapy with standard medical care.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Cheng Li, Hongna Cheng, Binay Kumar Adhikari, Shudong Wang, Na Yang, Wenyun Liu, Jian Sun, Yonggang Wang
Summary: This review summarizes the role of the Apelin-APJ system in diabetes and obesity, aiming to provide a better understanding of the mechanism and function of apelin and its receptor in the pathophysiology of diseases.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Ophthalmology
Xinran Qin, Haidong Zou
Summary: Diabetic retinopathy (DR) is a common complication of diabetes and the leading cause of blindness in the working-age population. Increased levels of serum lipopolysaccharides (LPS) are closely associated with the progression of DR, and LPS may contribute to vascular pathology and neurodegeneration in DR by disrupting the blood-retina barrier and dysregulating glial activation.
Review
Physiology
Gonghui Hu, Zhen Wang, Rumin Zhang, Wenping Sun, Xiaoyu Chen
Summary: The apelin/APJ system plays crucial roles in various physiological and pathological functions, such as fluid homeostasis, cardiovascular and metabolic disorders. In addition to forming a complex with its ligand and associated G proteins, APJ may interact with other GPCRs to selectively modulate different signal transduction pathways. Further research on the metabolism and signaling pathways associated with the apelin/APJ system is necessary to provide more precise guidance for the development of clinical drugs.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lin Yan, Haixia Ren, Fangting Yuan, Wenyao Shi, Ying Wang, Hesheng Luo
Summary: Apelin-13 inhibits the spontaneous contractile activity of isolated rat colons by suppressing L-type calcium channels and BKCa channels in colonic smooth muscle cells.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Young Gun Park, Ji-Yeon Lee, Chongtae Kim, Young-Hoon Park
Summary: This study found that experimental diabetic retinopathy causes gradual activation of retinal microglia and migration of macrophages, with the activation changing typically with the progression of the disease.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Ophthalmology
Alan D. Fleming, Joseph Mellor, Stuart J. Mcgurnaghan, Luke A. K. Blackbourn, Keith A. Goatman, Caroline Styles, Amos J. Storkey, Paul M. Mckeigue, Helen M. Colhoun
Summary: In the diabetic retinopathy (DR) screening (DES) programme in Scotland, the support vector machine-based automated grading system (iGradingM) has been proven to be safe, cost-effective, and robust. This study aimed to develop a deep learning-based autograder using images and gradings from DES and compare its performance with iGradingM.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Endocrinology & Metabolism
Haiyan Zhang, Ya Mo
Summary: Diabetic retinopathy (DR) is a microvascular lesion that occurs as a complication of diabetes mellitus. Studies have shown that retinal neurodegeneration occurs early in its pathogenesis, and abnormal retinal function can occur in patients without any signs of microvascular abnormalities. The gut microbiota is involved in the pathophysiological processes of DR and plays a critical role in its development.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Ophthalmology
Yi Chen, Jing Feng, Fangting Li, Hong Yin, Jianhong Liang, Xiaoxin Li
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2015)
Letter
Ophthalmology
Jing Feng, Ying Zhou, Xiaorui Zhang, Yanrong Jiang
ACTA OPHTHALMOLOGICA
(2017)
Article
Ophthalmology
Jing Feng, Xiaoxue Zheng, Bing Li, Yanrong Jiang
ACTA OPHTHALMOLOGICA
(2017)
Letter
Ophthalmology
Jing Feng, Jin-Feng Qu, Yan-Rong Jiang
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2013)
Article
Multidisciplinary Sciences
Jing Feng, Tong Zhao, Yan Zhang, Yan Ma, Yanrong Jiang
Article
Multidisciplinary Sciences
Yi Chen, Jing Feng, Clare Gilbert, Hong Yin, Jianhong Liang, Xiaoxin Li
Article
Medicine, General & Internal
Yong Cheng, Jing Feng, Xuemei Zhu, Jianhong Liang
Article
Ophthalmology
Yalin Zhou, Fei Hong, Xiaojuan Wang, Jing Feng, Dan Zhu, Yajun Xu, Yong Tao
Article
Medicine, General & Internal
Li Chen, Jing Feng, Yanhong Shi, Fuxiao Luan, Fang Ma, Yingjie Wang, Weiqiang Yang, Yong Tao
Summary: In patients with proliferative diabetic retinopathy, intravitreal ranibizumab (IVR) injection significantly reduced EPO levels but did not reach normal levels; there was no significant difference in VEGF levels between the IVR group and the control group. The expressions of EPO and VEGF were significantly reduced in the IVR group compared to the Non-IVR group in fluorescence immunostaining.
FRONTIERS IN MEDICINE
(2021)
Article
Mathematical & Computational Biology
Zhuang Ai, Xuan Huang, Jing Feng, Hui Wang, Yong Tao, Fanxin Zeng, Yaping Lu
Summary: Optical coherence tomography (OCT) is a new tomography technology that plays an important role in retinopathy diagnoses. This paper proposes a fusion network-based retinal OCT classification algorithm using deep learning and artificial intelligence technology to improve the accuracy and adaptability of traditional classification algorithms.
FRONTIERS IN NEUROINFORMATICS
(2022)
Article
Biochemistry & Molecular Biology
Jing Feng, Weiqiang Yang, Fuxiao Luan, Fang Ma, Yingjie Wang, Yiquan Zhang, Xuhui Liu, Li Chen, Xiaofeng Hu, Yong Tao
Summary: Diabetic retinopathy is a common and serious complication of diabetes, and there is currently no effective treatment for early stage. However, apelin has been found to potentially reduce vascular leakage by protecting pericytes, which suggests a promising new direction for early treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Jing Feng, Li Chen, Yanrong Jiang, Yong Tao
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2020)
Editorial Material
Ophthalmology
Jing Feng, Jing Qian, Yanrong Jiang, Mingwei Zhao, Jianhong Liang, Hong Yin, Yi Chen, Wenzhen Yu, Xiaoxin Li
Article
Ophthalmology
Jing Feng, Bing Li, Jing Wen, Yanrong Jiang
OPHTHALMIC RESEARCH
(2018)
