Article
Developmental Biology
Jennifer Kurz, Anna-Carina Weiss, Hauke Thiesler, Fairouz Qasrawi, Lena Deuper, Jaskiran Kaur, Carsten Rudat, Timo H. Luedtke, Irina Wojahn, Herbert Hildebrandt, Mark-Oliver Trowe, Andreas Kispert
Summary: The Notch signaling pathway plays an important role in regulating the expression of Myocd and a group of late SMC structural genes during visceral SMC differentiation in the ureter.
Article
Medicine, Research & Experimental
Ting Wen, Yanyan Duan, Dan Gao, Xinxin Zhang, Xiaoyan Zhang, Liang Liang, Ziyan Yang, Peiran Zhang, Jiayulin Zhang, Jiaxing Sun, Yixuan Feng, Qijun Zheng, Hua Han, Xianchun Yan
Summary: This study aims to elucidate the regulation of Notch signaling in vascular smooth muscle cell phenotypic transition. The researchers found that miR-342-5p promotes vSMC-PT through a negative-feedback regulation of Notch signaling by downregulating FOXO3. In a simulated tumor microenvironment, miR-342-5p was upregulated by tumor cell-derived conditional medium and its blockade abrogated vSMC-PT induced by the medium. These findings suggest that miR-342-5p could be a potential target for cancer therapy.
Article
Agriculture, Multidisciplinary
Ruimen Zhang, Yu Pan, Wanyou Feng, Yimin Zhao, Yanyan Yang, Leyi Wang, Yongwang Zhang, Juanru Cheng, Qinyang Jiang, Zihua Zheng, Mingsheng Jiang, Sufang Yang, Yanfei Deng, Deshun Shi, Yingming Wei
Summary: This study found that HDAC11 plays a critical regulatory role in the proliferation and differentiation of bovine muscle stem cells, and inhibits muscle repair regeneration process. This discovery provides a theoretical basis for the development of new strategies to regulate myogenesis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Immunology
Te Jiang, Zhankui Li, Di Zhao, Bengang Hui, Zhiyuan Zheng
Summary: The study demonstrates that SOX18 modulates the proliferation and migration of airway smooth muscle cells induced by TNF-alpha by regulating the Notch1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Randa M. Breikaa, Kimberly Denman, Yukie Ueyama, Patricia E. McCallinhart, Aiman Q. Khan, Gunjan Agarwal, Aaron J. Trask, Vidu Garg, Brenda Lilly
Summary: This study reveals the essential role of Jag1 in adult endothelial cells in regulating and maintaining smooth muscle cell function in arterial vessels, partially through autoregulation of Notch signaling and influencing cell matrix/adhesion components in smooth muscle cells.
VASCULAR PHARMACOLOGY
(2022)
Article
Clinical Neurology
Yuhua Yang, Honghong Li, Yongteng Xu, Jiatian Xie, Qiang Liu, Zhongshan Shi, Jialin Huang, Jinping Cheng, Siqi Chen, Sitai Chen, Xiaohui Zhao, Shaojian Li, Zhan Zhang, Jinhua Cai, Baixuan He, Wei-Jye Lin, Qingyu Shen, Yi Li, Yamei Tang
Summary: This study investigated the pathological features of cerebral small vessels and the functional roles of Notch signaling in radiation-induced brain injury (RIBI). The results showed that radiation led to vascular malformation and decreased vascular reactivity. Notch inhibition effectively alleviated vasculopathy and relieved cognitive impairment in a RIBI mouse model. These findings suggest that Notch signaling could be a therapeutic target for RIBI.
Article
Biochemistry & Molecular Biology
Xin Xu, Xiao-Qin Liu, Xin-Long Liu, Xu Wang, Wen-Di Zhang, Xiao-Fu Huang, Fang-Yue Jia, Peng Kong, Mei Han
Summary: Considerable evidence suggests that cognitive impairment is primarily a vascular disorder. The depletion of SM22 alpha in VSMCs contributes to their phenotypic switching and inflammation, but the role of VSMCs in cognitive impairment is still uncertain. This study shows a possible link between VSMC phenotypic switching and neurodegenerative diseases, supporting the idea of VSMCs and SM22 alpha as therapeutic targets in cognitive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Cansu Karakaya, Mark C. C. van Turnhout, Valery L. L. Visser, Tommaso Ristori, Carlijn V. C. Bouten, Cecilia M. M. Sahlgren, Sandra Loerakker
Summary: Mechanical stimuli and Notch signaling play important roles in regulating vascular growth and remodeling. This study reveals that cyclic strain decreases Notch signaling and leads to the loss of contractile features in vascular smooth muscle cells. Activation of Notch signaling partially rescues the contractile features of these cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hao Sun, Fangzhou Liu, Zhencan Lin, Zongrui Jiang, Xingzhao Wen, Jie Xu, Zhiqi Zhang, Ruofan Ma
Summary: This study discovers the initiation of meniscus fibrosis in humans at 24 weeks of embryogenesis. Smooth muscle cell clusters are found in the embryonic meniscus, which are proposed to be precursors of progenitor cells in the mature meniscus. The expression of NOTCH3 in smooth muscle cells is identified throughout embryogenesis to adulthood. Inhibition of NOTCH3 signaling inhibits meniscus fibrosis and exacerbates degeneration, indicating its potential as a therapeutic target.
Article
Biochemistry & Molecular Biology
Luigi Borzacchiello, Roberta Veglia Tranchese, Roberta Grillo, Roberta Arpino, Laura Mosca, Giovanna Cacciapuoti, Marina Porcelli
Summary: Recent research has found a correlation between dysregulated Notch and tumor metastasis in colorectal cancer (CRC). The study also showed that S-adenosyl-L-methionine (AdoMet) could act as a potential antimetastatic agent by modulating the expression of miRNA-34a/-34c/-449a and inhibiting the migration of CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Diem Thi Ngoc Huynh, Yujin Jin, Dung Van Nguyen, Chang-Seon Myung, Kyung-Sun Heo
Summary: This study found that ginsenoside Rh1 inhibits the migration and proliferation of rat aortic smooth muscle cells (RASMCs) induced by angiotensin II by suppressing the ROS-mediated ERK1/2/p90RSK signaling pathway.
Article
Cell Biology
Ling You, Yanjie Zheng, Jing Yang, Qian Hou, Lianxia Wang, Yan Zhang, Chunxia Zhao, Ruiqin Xie
Summary: This study found that MDRL alleviates NLRP3 inflammasome activation and apoptosis in VSMCs through the miR-361/SQSTM1/NLRP3 pathway, playing a protective role in the development of atherosclerosis.
MEDIATORS OF INFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Michael Powers, Liu Liu, Dane Deemer, Selina Chen, Aaron Scholl, Masafumi Yoshinaga, Zijuan Liu
Summary: Selenium is an essential micronutrient in mammals and selenite is used to alleviate deficiency symptoms and potentially serve as a chemotherapeutic agent. This study identified selenite as a novel inhibitor of Delta-Notch signaling, showing potential in treating diseases like cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Pengfei Lu, Ping Wang, Bingruo Wu, Yidong Wang, Yang Liu, Wei Cheng, Xuhui Feng, Xinchun Yuan, Miriam M. Atteya, Haleigh Ferro, Yukiko Sugi, Grant Rydquist, Mahdi Esmaily, Jonathan T. Butcher, Ching-Pin Chang, Jack Lenz, Deyou Zheng, Bin Zhou
Summary: This study demonstrates that the deletion of Sox17 in aortic root endothelium in mice leads to underdeveloped aortic root and bicuspid aortic valve, as well as mispositioned left coronary ostium. These defects are caused by reduced proliferation of non-coronary leaflet mesenchyme and aortic root smooth muscle, which are derived from second heart field cardiomyocytes. The study suggests that the SOX17-PDGFB axis plays a critical role in aortic root development and may provide insights into the shared disease mechanism for concurrent anomalous aortic valve and coronary arteries.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Qian Zhou, Wan-Wan Sun, Jia-Cong Chen, Hui-Lu Zhang, Jie Liu, Yan Lin, Peng-Cheng Lin, Bai-Xing Wu, Yan-Peng An, Lin Huang, Wen-Xing Sun, Xin-Wen Zhou, Yi-Ming Li, Yi-Yuan Yuan, Jian-Yuan Zhao, Wei Xu, Shi-Min Zhao
Summary: This study reveals that phenylalanine can modify the insulin receptor and inactivate insulin signaling and glucose uptake, leading to insulin resistance and T2D symptoms. By reversing the inactivating effects of phenylalanine, insulin signaling can be enhanced and T2D symptoms can be relieved. These findings provide new insights into the activation of insulin signaling and the progression of T2D.
NATURE COMMUNICATIONS
(2022)