Article
Multidisciplinary Sciences
Mareike Berger, Pieter Rein ten Wolde
Summary: The study investigates the replication initiation cycles of Escherichia coli at different growth rates and reveals that both the titration mechanism and the activation switch play crucial roles in driving stable replication cycles.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Baojin Ding, Masood Sepehrimanesh
Summary: Nucleocytoplasmic transport plays critical roles in eukaryotic cells, and dysregulation of NCT is implicated in neurodegenerative diseases. Understanding the components and regulation of NCT machinery can help reveal the mechanisms of aging and diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Duoduo Lv, Liyu Chen, Lingyao Du, Lingyun Zhou, Hong Tang
Summary: Hepatocellular carcinoma (HCC) is mainly driven by liver cancer stem cells (LCSCs), which contribute to tumor progression, metastasis, and treatment resistance. However, the regulatory mechanisms of LCSCs in HCC are still unclear. Understanding the signaling pathways responsible for LCSC maintenance and survival may improve patient outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jing Quan, Ann M. Bode, Xiangjian Luo
Summary: The deregulation of fatty acid metabolism is associated with cancer development, with ACSL family members playing different roles in cancer progression, some promoting cancer and some having inhibitory effects, while also participating in cell death processes. ACSLs may serve as important therapeutic targets and biomarkers for cancer treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Physics, Fluids & Plasmas
Andres Delgado-Campos, Alejandro Cuetos
Summary: This study uses computer simulations to investigate the effects of homeostatic mechanisms on the geometrical and structural properties of developing bacterial microcolonies. The study examines the relationship between cellular growth time and these properties. The results suggest that these mechanisms do not have a significant impact on the properties studied, possibly due to the importance of stochastic factors in cell division and growth processes. Additionally, the study highlights the competition between cell growth and diffusion as a key aspect in explaining the structure and geometry of developing bacterial microcolonies.
Article
Green & Sustainable Science & Technology
Clement Cabral, Aghila Sasidharan
Summary: This study examines the impact of corporate governance mechanisms on corporate social performance and finds varying effects of board characteristics and ownership structure on corporate social responsibility in different countries. It supports stewardship theory and agency theory, highlighting the importance of firms' spending on corporate social responsibility activities to protect stakeholders' interests and fulfill their responsibilities towards society.
JOURNAL OF CLEANER PRODUCTION
(2021)
Review
Cell Biology
Rachel Shi, Chengheng Liao, Qing Zhang
Summary: Hypoxia, a common feature of solid tumors, poses a challenge to the efficacy of conventional cancer treatments. The adaptive changes in cells under hypoxic conditions lead to survival, metastasis, and malignant phenotypes of tumors.
Review
Cell Biology
Allison K. Tscherner, Angus D. Macaulay, Chyna S. Ortman, Jay M. Baltz
Summary: The period after ovulation is crucial for the healthy development of embryos, as they are sensitive to cell volume perturbations. Early embryos possess unique mechanisms of cell volume control using glycine and betaine, which undergo major changes post-ovulation. These mechanisms are critical for the normal development of embryos.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Hiroyoshi Nishikawa, Shohei Koyama
Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Medicine, General & Internal
Xiangyu Meng, Dong Yang, Bao Zhang, Yan Zhao, Zhichao Zheng, Tao Zhang
Summary: Malignant tumors have a significant impact on people's survival and prognosis. Exosomes, vesicle structures widely present in human tissues and body fluids, play a role in cell-to-cell communication. Tumor-derived exosomes, through multiple regulatory mechanisms, are involved in the development and progression of cancer, including tumor cell proliferation, invasion, migration, and sensitivity to chemotherapy or radiotherapy. This review discusses the roles and functions of tumor-driven exosomal circular RNAs in cancer, highlighting their potential as cancer biomarkers and novel therapeutic targets.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Engineering, Chemical
Eliot Durand, Lukas Durdina, Greg Smallwood, Mark Johnson, Curdin Spirig, Jacinta Edebeli, Manuel Roth, Benjamin Brem, Yura Sevcenco, Andrew Crayford
Summary: In order to reduce the negative effects of civil aviation on local air quality and human health, a new international standard for non-volatile Particulate Matter (nvPM) emissions has been adopted. This study developed and compared three new system loss correction methodologies using measured Particle-Size-Distribution (PSD) data, highlighting the need for standardization of PSD measurement for regulatory purposes.
JOURNAL OF AEROSOL SCIENCE
(2023)
Article
Microbiology
Daniel G. Mediati, David Lalaouna, Jai J. Tree
Summary: Regulatory RNAs play essential roles in gene regulation in bacteria, adopting diverse mechanisms in different species. Variations in RNA degradation and regulation mechanisms between bacterial species may lead to functional differences in Hfq and other sRNA chaperones.
Article
Plant Sciences
Courtney E. Campany, Jarmila Pittermann, Alex Baer, Helen Holmlund, Eric Schuettpelz, Klaus Mehltreter, James E. Watkins
Summary: The study surveyed 39 fern species in Costa Rican tropical forests to explore epiphytic trait divergence, finding that epiphytic ferns exhibit water conservation traits. Both epiphytic and hemi-epiphytic ferns have adaptations for water stress avoidance through anatomical and structural traits in response to the canopy habitat pressures.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Oncology
Jolien De Wyn, Mark W. Zimmerman, Nina Weichert-Leahey, Carolina Nunes, Belamy B. Cheung, Brian J. Abraham, Anneleen Beckers, Pieter-Jan Volders, Bieke Decaesteker, Daniel R. Carter, Alfred Thomas Look, Katleen De Preter, Wouter Van Loocke, Glenn M. Marshall, Adam D. Durbin, Frank Speleman, Kaat Durinck
Summary: Research on neuroblastoma has identified key factors related to tumor initiation and progression, as well as potential novel drug targets. The study found that roughly half of high-risk neuroblastoma patients exhibit MYCN gene amplification, and certain genes were significantly upregulated during tumor formation, suggesting their potential as targets for therapeutic intervention.
Article
Biology
Derrick T. Sund, Andrew F. Brouwer, Heather M. Walline, Thomas E. Carey, Rafael Meza, Trachette Jackson, Marisa C. Eisenberg
Summary: This study extends a cell cycle model and reveals the effects of human papillomavirus proteins E6 and E7 on the cell cycle. The results suggest that E6 and E7 play important roles in the cell cycle, and E7 can induce cell division even in the absence of growth factors. These mechanisms provide opportunities for developing new treatment targets to prevent HPV-related cancers.
JOURNAL OF THEORETICAL BIOLOGY
(2022)