Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Article
Pharmacology & Pharmacy
Lorena Ortega, Lorena Lobos-Gonzalez, Mauricio Reyna-Jeldes, Daniela Cerda, Erwin De la Fuente-Ortega, Patricio Castro, Giuliano Bernal, Claudio Coddou
Summary: This study demonstrated that docosahexaenoic acid (DHA) has a selective antiproliferative effect on gastric cancer (GC), primarily driven by apoptosis induction. DHA treatment consistently reduced tumor size, ascitic fluid volume, and liver metastasis in an in vivo mouse model. These findings provide promising potential for DHA as a therapeutic agent in GC.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Nutrition & Dietetics
Lingsi Zeng, Honggang Lv, Xubo Wang, Ranran Xue, Cong Zhou, Xia Liu, Hao Yu
Summary: Using Mendelian randomization (MR) analysis, this study found potential causal relationships between levels of fatty acids (FA) and the risk of depression. Specifically, oleic acid (OA) and alpha-linolenic acid (ALA) were identified as potential risk factors for depression, while adrenic acid and eicosapentaenoic acid (EPA) were found to be protective. These findings emphasize the importance of further research to investigate the underlying mechanisms that mediate the association between these fatty acids and depression risk.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Editorial Material
Food Science & Technology
Emanuele Rinninella, Lara Costantini
Summary: The International Scientific Association for Probiotics and Prebiotics (ISAPP) considers polyunsaturated fatty acids (PUFAs) as candidate prebiotics, although there is a lack of complete scientific evidence. Recent partial evidence shows that metabolites of PUFAs can have important health effects in the host, supporting the concept of the prebiotic action of PUFAs.
Review
Food Science & Technology
Ismael Rodriguez-Gonzalez, Beatriz Diaz-Reinoso, Herminia Dominguez
Summary: Marine organisms are valuable sources of long-chain omega-3 polyunsaturated fatty acids, which are increasingly in demand for their health benefits. Seaweeds have a low lipid content, but their high PUFA fraction and low omega-6:omega-3 ratio make them an alternative source. Concentrated lipid extracts provide a practical method without significantly changing dietary habits. The extraction technology plays a key role in the production of seaweed extracts, and the choice of solvent and operational conditions can also extract other lipophilic components, resulting in a final product with interesting biological properties. Utilizing the remaining algal solids as a source of additional nutritional and bioactive compounds is essential for achieving a sustainable process.
FOOD AND BIOPROCESS TECHNOLOGY
(2022)
Article
Obstetrics & Gynecology
J. Stanhiser, A. M. Z. Jukic, D. R. McConnaughey, A. Z. Steiner
Summary: The study found that self-reported use of omega-3 fatty acid supplements was associated with an increased probability of conceiving.
HUMAN REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Jian Fang, Zhuangwei Zhang, Yinyin Cheng, Haitao Yang, Hui Zhang, Zhe Xue, Songtao Lu, Yichen Dong, Chunyan Song, Xiaohong Zhang, Yuping Zhou
Summary: The study found that EPA and DHA have different effects in ulcerative colitis. High-dose EPA can enhance the mucus barrier, regulate the gut microbiome, and relieve inflammation. This suggests that EPA may be a promising adjunctive therapy for ulcerative colitis.
Article
Oncology
Iman Moussa, Rena S. Day, Ruosha Li, Ahmed Kaseb, Prasun K. Jalal, Carrie Daniel-MacDougall, Rikita I. Hatia, Ahmed Abdelhakeem, Asif Rashid, Yun Shin Chun, Donghui Li, Manal M. Hassan
Summary: This study found an inverse association between monounsaturated fatty acid intake and hepatocellular carcinoma (HCC) risk, and a direct association between total polyunsaturated fatty acid intake and HCC risk. Omega-6 PUFA intake was directly associated with HCC risk, while long-chain omega-3 PUFA intake was inversely associated with HCC risk. No significant association was observed for saturated fat and HCC risk.
Article
Nutrition & Dietetics
Kathleen A. Lee-Sarwar, Kasper Fischer-Rasmussen, Klaus Bonnelykke, Hans Bisgaard, Bo Chawes, Rachel S. Kelly, Jessica Lasky-Su, Robert S. Zeiger, George T. O'Connor, Leonard B. Bacharier, Vincent J. Carey, Nancy Laranjo, Augusto A. Litonjua, Scott T. Weiss
Summary: The association between omega-3 fatty acids (n-3) and allergic diseases varies due to genetic variation. This study aimed to identify and validate genetic variants that modify the relationship between n-3 and childhood asthma or atopy. Results showed that certain SNPs in the DPP10 region interacted with n-3 levels in plasma or diet and were associated with atopy in early childhood and at age 6.
Review
Food Science & Technology
Siddhant Dubey, Chiu-Wen Chen, Anil Kumar Patel, Shashi Kant Bhatia, Reeta Rani Singhania, Cheng-Di Dong
Summary: This review summarizes the research advancements in microalgae PUFA production and discusses the potential applications. Various cultivation modes, including heterotrophic, mixotrophic, and photoheterotrophic, are assessed for cost-effective PUFA production. Parameters such as salinity, nutrients, carbon source, and light intensity have significant effects on PUFA accumulation.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Cardiac & Cardiovascular Systems
Yasutaka Nakashima, Yasunari Sakai, Yumi Mizuno, Kenji Furuno, Keiichi Hirono, Shinichi Takatsuki, Hiroyuki Suzuki, Yoshihiro Onouchi, Tohru Kobayashi, Kazuhiro Tanabe, Kenji Hamase, Tomofumi Miyamoto, Ryohei Aoyagi, Makoto Arita, Kenichiro Yamamura, Tamami Tanaka, Hisanori Nishio, Hidetoshi Takada, Shouichi Ohga, Toshiro Hara
Summary: Through lipidomics analysis of 105 KD patients and 65 disease controls, the study found that oxidized phospholipids are associated with the development of coronary arteritis in KD, playing a significant role in its pathogenesis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cell Biology
Kei Ogawa, Kenichi Asano, Satoshi Yotsumoto, Tsuyoshi Yamane, Makoto Arita, Yoshihiro Hayashi, Hironori Harada, Chieko Makino-Okamura, Hidehiro Fukuyama, Kenji Kondo, Tatsuya Yamasoba, Masato Tanaka
Summary: Recent research has shown that neutrophils can transform into double-positive cells expressing neurosupportive genes in the olfactory neuroepithelium (OE) under inflammatory conditions. These double-positive cells, derived from neutrophils, increase significantly during inflammation or tissue damage. Neutrophils change their surface markers and gene expression over time, expressing neurogenesis-related genes in addition to inflammation related genes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Hiroaki Itoh, Keisuke Ishii, Naoya Shigeta, Atsuo Itakura, Hiromi Hamada, Takeshi Nagamatsu, Tomohiko Ishida, Yasuaki Bungyoku, Ali Falahati, Miori Tomisaka, Mikiya Kitamura
Summary: The study evaluated the efficacy and safety of dinoprostone vaginal insert (PROPESS) in pregnant post-term Japanese women requiring cervical ripening. Results showed that PROPESS administration for up to 12 hours significantly increased successful cervical ripening rate, shortened time to vaginal delivery, and reduced the need for uterotonic drugs such as oxytocin.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yoshikazu Johmura, Takehiro Yamanaka, Satotaka Omori, Teh-Wei Wang, Yuki Sugiura, Masaki Matsumoto, Narumi Suzuki, Soichiro Kumamoto, Kiyoshi Yamaguchi, Seira Hatakeyama, Tomoyo Takami, Rui Yamaguchi, Eigo Shimizu, Kazutaka Ikeda, Nobuyuki Okahashi, Ryuta Mikawa, Makoto Suematsu, Makoto Arita, Masataka Sugimoto, Keiichi Nakayama, Yoichi Furukawa, Seiya Imoto, Makoto Nakanishi
Summary: Research has shown that senescent cells rely on glutaminolysis for survival, and inhibiting this process can induce senolysis. Lysosomal membrane damage lowers intracellular pH in senescent cells, inducing KGA expression, leading to glutaminolysis, and ultimately producing ammonia to neutralize low pH and improve cell survival.
Article
Urology & Nephrology
Naohiro Takahashi, Hiroaki Kikuchi, Ayaka Usui, Taisuke Furusho, Takuya Fujimaru, Tamami Fujiki, Tomoki Yanagi, Yoshiaki Matsuura, Kenichi Asano, Kouhei Yamamoto, Fumiaki Ando, Koichiro Susa, Shintaro Mandai, Takayasu Mori, Tatemitsu Rai, Shinichi Uchida, Makoto Arita, Eisei Sohara
Summary: Lipid-metabolizing enzyme Alox15 has been found to be involved in fibrosis in chronic kidney disease, with inhibition of Alox15 and administration of PGD(2) showing potential as novel therapeutic targets for CKD.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Article
Cell Biology
Tamako Nishimura, Takuya Oyama, Hooi Ting Hu, Toshifumi Fujioka, Kyoko Hanawa-Suetsugu, Kazutaka Ikeda, Sohei Yamada, Hiroki Kawana, Daisuke Saigusa, Hiroki Ikeda, Rie Kurata, Kayoko Oono-Yakura, Manabu Kitamata, Kazuki Kida, Tomoya Hikita, Kiyohito Mizutani, Kazuma Yasuhara, Yuko Mimori-Kiyosue, Chitose Oneyama, Kazuki Kurimoto, Yoichiroh Hosokawa, Junken Aoki, Yoshimi Takai, Makoto Arita, Shiro Suetsugu
Summary: Research has shown that I-BAR proteins, especially MIM, generate large EVs by scission of filopodia, containing lysophospholipids and proteins that stimulate cell migration. These filopodia-dependent large EVs, named filopodia-derived vesicles (FDVs), can modify cellular behavior.
DEVELOPMENTAL CELL
(2021)
Article
Microbiology
Fumika Mi-ichi, Kazutaka Ikeda, Hiroshi Tsugawa, Sharmina Deloer, Hiroki Yoshida, Makoto Arita
Summary: This study identified dihydroceramides (Cer-NDSs) containing very long N-acyl chains (C-26 to C-30) as a key metabolite for Entamoeba encystation through state-of-the-art untargeted lipidomics. These Cer-NDSs are critical for generating membrane impermeability, enabling the parasite to exhibit dormancy as a cyst that resists substances and prevents water loss. Ceramide metabolism is essential for Entamoeba to maintain its parasitic lifestyle.
Article
Biochemistry & Molecular Biology
Nobuyuki Okahashi, Masahiro Ueda, Fumio Matsuda, Makoto Arita
Summary: This study developed a method for analyzing lipid A and applied it to Escherichia coli and Bacteroidetes strains. The analysis revealed structural and quantitative differences in lipid A among strains, which appeared to be related to the phylogenetic classification of the strains.
Article
Biochemistry & Molecular Biology
Yutaro Kuwashima, Masataka Yanagawa, Mitsuhiro Abe, Michio Hiroshima, Masahiro Ueda, Makoto Arita, Yasushi Sako
Summary: TRPV1 and TRPV4, as members of the transient receptor potential vanilloid family, exhibit differences in their cellular dynamics, with TRPV1 forming higher-order oligomers more readily and TRPV4 undergoing rapid internalization upon stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Megumi Nakanishi, Takayuki Iriyama, Seisuke Sayama, Shouhei Hanaoka, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Yutaka Osuga
Summary: Uterine degeneration occurs during pregnancy in cases of adenomyosis, causing worsened symptoms, but this degeneration is transient and disappears completely after childbirth.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Review
Hematology
Hiroko Oda, Takeshi Nagamatsu, Yutaka Osuga
Summary: Thrombomodulin (TM) has multiple organ protective roles during pregnancy, aside from its anticoagulation function. Placental TM deficiency is associated with pregnancy complications such as miscarriage, fetal growth restriction, and preeclampsia. Recombinant TM shows promise as a therapeutic target for these conditions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Obstetrics & Gynecology
Minori Kasuya, Naoya Akiba, Takayuki Iriyama, Seisuke Sayama, Kaori Kubota, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Tomoyuki Fujii, Yutaka Osuga
Summary: This study aimed to compare the impact of fetal growth restriction (FGR) and maternal organ dysfunction on the severity of maternal preeclamptic features. The results showed that PE cases preceded by FGR had earlier diagnosis and delivery, but there were no significant differences in maternal morbidities compared to cases without FGR. For early-onset PE, the results were comparable between two groups.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Mari Ichinose, Takayuki Iriyama, Seisuke Sayama, Masatake Toshimitsu, Takahiro Seyama, Kenbun Sone, Keiichi Kumasawa, Takeshi Nagamatsu, Shouhei Hanaoka, Yutaka Osuga
Summary: This is the first report on the imaging findings of early postpartum degeneration of adenomyosis, based on a case of a patient who underwent pregnancy. The magnetic resonance imaging showed cyst-like degenerations with hemorrhagic changes.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yuki Ariyasu, Yuki Sato, Yosuke Isobe, Keisuke Taniguchi, Motoko Yanagita, Makoto Arita
Summary: Metabolic syndrome is associated with the development of chronic kidney disease. This study explores the relationship between renal tertiary lymphoid tissues (TLTs) and metabolic syndrome. The findings suggest that a high-fat diet promotes the formation of TLTs and inflammation in the kidneys, and this process is mediated by sterol O-acyltransferase (SOAT) 1. Inhibiting SOAT1 can attenuate TLT maturation and renal inflammation in mice fed a high-fat diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Obstetrics & Gynecology
Risa Miyatake, Tatsuya Fujii, Keiichi Kumasawa, Mari Ichinose, Masatake Toshimitsu, Seisuke Sayama, Takahiro Seyama, Takayuki Iriyama, Takeshi Nagamatsu, Yutaka Osuga
Summary: Hyperreactio luteinalis (HL) is a rare condition characterized by bilateral ovarian enlargement during pregnancy. It is usually caused by increased production of human chorionic gonadotropin (hCG) associated with gestational trophoblastic diseases or multiple pregnancies. While the prognosis is generally good, obstetric complications such as preeclampsia (PE) and preterm births can occur. Monitoring the sFlt-1/PlGF ratio is found to be useful in managing HL cases associated with PE.
CASE REPORTS IN OBSTETRICS AND GYNECOLOGY
(2023)