Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alayliohlu, Duygu Gezen-Ak, Cedric Annweiler, Fatme Al Anouti, Hana M. A. Fakhoury, Alkiviadis Bais, Dimitrios Kiortsis
Summary: Recent findings suggest that dysregulation of VDBP may contribute to hypovitaminosis D, posing risks for adverse maternal and neonatal outcomes. However, maternal and neonatal VDBP polymorphisms do not seem to directly impact neonatal vitamin D status at birth, although mothers with specific genotypes may exhibit higher 25(OH)D concentrations during delivery. Further research is needed to establish a causal relationship between these polymorphisms and maternal vitamin D status during pregnancy.
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Stefan Pilz, Cedric Annweiler, Fatme Al Anouti
Summary: This study aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on neonatal anthropometric profile at birth. The findings suggest a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in affecting neonatal growth and development. However, no significant effects were observed for maternal VDBP polymorphisms or maternal 25(OH)D concentrations at birth on neonatal anthropometry.
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Emma Hurst, Richard J. Mellanby, Cheryl J. Ashworth
Summary: Recent evidence suggests that vitamin D plays a crucial role in pregnancy, fetal growth, and development in various mammalian species. However, little is known about the changes in maternal vitamin D levels during pregnancy in pigs and its relationship with litter characteristics. This study examined the levels of 25(OH)D in maternal plasma at different gestational days and found a significant increase between days 18 and 30. The study also investigated the association between maternal vitamin D levels and various litter characteristics, such as gilt weight, ovulation rate, mean litter weight, number of live fetuses, prenatal survival rate, and sex ratio of the litter. The results showed that maternal 25(OH)D levels were positively associated with prenatal survival rate on day 60 and inversely associated with gilt weight on day 90. Maternal plasma 25(OH)D levels were also inversely associated with the percentage of male fetuses in the litter on day 90. This study provides valuable insights into the temporal changes in maternal vitamin D levels during pregnancy and its impact on economically important litter characteristics. Understanding the role of vitamin D in fetal growth during key developmental stages is vital for improving reproductive success in livestock species.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Cedric Annweiler, Dimitrios Skoutas, Dimosthenis Evangelidis, Dimitrios Kiortsis
Summary: This study evaluated the impact of VDR gene polymorphisms and 25(OH)D levels on neonatal birth anthropometry, finding that maternal TAQI VDR gene polymorphism significantly affected birth outcomes when maternal 25(OH) concentrations were <50 nmol/L. Additionally, the study revealed that neonatal TAQI polymorphism had an effect when neonatal 25(OH)D levels were <25 nmol/L.
Article
Nutrition & Dietetics
Andrea Aparicio, Diane R. Gold, Scott T. Weiss, Augusto A. Litonjua, Kathleen Lee-Sarwar, Yang-Yu Liu
Summary: The maternal gut microbiome and vitamin D deficiency during pregnancy have been separately associated with health problems. This study analyzed data from pregnant women in the VDAART to investigate the association between vitamin D level and gut microbiome. The results suggest that increasing vitamin D level during pregnancy may protect against the growth of certain bacteria.
Article
Nutrition & Dietetics
Lisa Daneels, Dries S. Martens, Soumia Arredouani, Jaak Billen, Gudrun Koppen, Roland Devlieger, Tim S. Nawrot, Manosij Ghosh, Lode Godderis, Sara Pauwels
Summary: The study found a positive association between maternal vitamin D intake (diet + supplements) and newborn TL, particularly during the first trimester. However, there was no significant association between mean maternal serum 25-OHD concentrations during pregnancy and newborn TL.
Review
Nutrition & Dietetics
Heng Zhang, Shumin Wang, Lingjin Tuo, Qixiao Zhai, Jingjing Cui, Daozhen Chen, Dexiang Xu
Summary: Vitamin D plays an important role in pregnancy, with low levels being associated with adverse pregnancy outcomes. This review summarizes the potential mechanisms of how vitamin D regulates these outcomes and aims to provide a basis for public health intervention strategies.
Review
Nutrition & Dietetics
Alireza Milajerdi, Fatemeh Abbasi, Seyed Mohammad Mousavi, Ahmad Esmaillzadeh
Summary: The study revealed a significant association between vitamin D deficiency and an increased risk of GDM, with the lowest risk found among individuals with serum vitamin D levels within the range of 40-90 nmol/L.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Somia K. Abdelrahiem, Manal E. Sharif, Nadiah ALhabardi, Osama Al-Wutayd, Ishag Adam
Summary: This study aimed to assess the association between vitamin D concentrations and preterm birth (PB) in sub-Saharan Africa. The results showed that lower serum 25(OH)D concentrations were significantly associated with PB, and pregnant women with vitamin D deficiency were at a higher risk of PB.
Article
Medicine, General & Internal
Laura Taban, Dana Stoian, Bogdan Timar, Daniela Amzar, Calin Adela, Alexandru Motofelea, Andreea Borlea, Romain Frisoni, Nadege Laguerre
Summary: This study investigates the presence of steatohepatitis in obese patients and compares the differences between diabetic and non-diabetic patients. It finds a significant correlation between vitamin D deficiency and hepatic steatosis in individuals with morbid obesity. Correcting vitamin D deficiency may have beneficial effects on treating hepatic steatosis, diabetes, and cardiovascular risk in patients with morbid obesity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Allergy
Mengdi Lu, Augusto A. Litonjua, George T. O'Connor, Robert S. Zeiger, Leonard Bacharier, Michael Schatz, Vincent J. Carey, Scott T. Weiss, Hooman Mirzakhani
Summary: Childhood asthma development is affected by a complex interplay of maternal asthma and prenatal vitamin D status. This study suggests that adequate vitamin D intake throughout pregnancy can help reduce the risk of childhood asthma exacerbated by maternal asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Siew Siew Lee, King Hwa Ling, Maiza Tusimin, Raman Subramaniam, Kartini Farah Rahim, Su Peng Loh
Summary: This study examines the independent and combined effects of maternal and neonatal vitamin D deficiency and vitamin-D-related SNPs on neonatal birth anthropometry. The results suggest that maternal vitamin D deficiency is inversely associated with birth weight, head circumference, and crown-heel length, while neonatal SNPs are significantly associated with birth weight and head circumference. A potential interaction between maternal SNP and vitamin D deficiency on head circumference is also observed.
Article
Public, Environmental & Occupational Health
Su H. Chu, Mengna Huang, Rachel S. Kelly, Priyadarshini Kachroo, Augusto A. Litonjua, Scott T. Weiss, Jessica Lasky-Su
Summary: This study found that higher levels of maternal vitamin D in the third trimester are associated with a lower risk of ADHD in offspring, with a stronger effect observed in male offspring.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Endocrinology & Metabolism
Weiwei Tang, Lihong Chen, Wanxia Ma, Dawei Chen, Chun Wang, Yun Gao, Xingwu Ran
Summary: The study found an association between low vitamin D levels and higher prevalence of diabetic foot in Chinese patients with type 2 diabetes mellitus. Vitamin D insufficiency and deficiency were more common in the diabetic foot group, and were not affected by seasons.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Pediatrics
Meng Ni, Qianqian Zhang, Jiuru Zhao, Qianwen Shen, Dongting Yao, Tao Wang, Zhiwei Liu
Summary: The study found that maternal vitamin D deficiency is prevalent in eastern coastal China during the first trimester of pregnancy. The group with vitamin D insufficiency had a higher incidence rate of gestational diabetes and preeclampsia, while the vitamin D deficiency group was more susceptible to intrauterine infection. Importantly, low vitamin D levels in the first trimester of pregnancy were a dependent risk factor for NICU admission.
